Woodline holds 4.0M Tango Therapeutics (TNGX) shares, a 2.5% stake

Rhea-AI Filing Summary

Woodline Partners LP filed an amended Schedule 13G reporting its position in Tango Therapeutics, Inc. common stock. Woodline Partners, a Delaware limited partnership and investment adviser to two master funds, reports beneficial ownership of 4,000,567 shares of Tango common stock, with sole voting and dispositive power over all of these shares and no shared power. Based on an aggregate of 162,814,649 shares of Tango common stock outstanding, Woodline’s holdings represent approximately 2.5% of the class. The outstanding share figure reflects 18,166,667 shares offered under a June 10, 2026 prospectus plus 144,647,982 shares outstanding as of May 6, 2026.

Key Figures

Shares beneficially owned: 4,000,567 shares Ownership percentage: 2.5% Shares outstanding basis: 162,814,649 shares +4 more

7 metrics

Shares beneficially owned 4,000,567 shares Common stock of Tango Therapeutics reported by Woodline Partners

Ownership percentage 2.5% Portion of Tango Therapeutics common stock class held by Woodline Partners

Shares outstanding basis 162,814,649 shares Total Tango Therapeutics common stock used to calculate Woodline’s ownership percentage

Prospectus offering shares 18,166,667 shares Shares of common stock offered under Rule 424(b)(5) prospectus dated June 10, 2026

Previously outstanding shares 144,647,982 shares Common shares outstanding as of May 6, 2026 per Form 10-Q

Sole voting power 4,000,567 shares Shares over which Woodline Partners has sole voting authority

Shared voting power 0 shares Shares over which Woodline Partners has shared voting authority

Key Terms

beneficial owner, sole voting power, sole dispositive power, Investment Adviser, +1 more

5 terms

beneficial owner regulatory

"the beneficial owner of the shares of Common Stock reported herein"

A beneficial owner is the person who ultimately owns or controls a financial asset or property, even if their name isn't directly on official documents. Think of it like someone who secretly holds the keys to a safe deposit box—others may appear to have access, but the true owner is the one who benefits from what's inside. Identifying beneficial owners helps ensure transparency and prevent illegal activities like money laundering or fraud.

sole voting power regulatory

"5 | Sole Voting Power 4,000,567.00"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

sole dispositive power regulatory

"7 | Sole Dispositive Power 4,000,567.00"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

Investment Adviser financial

"12 IA,"

An investment adviser is a person or firm that professionally manages money and gives recommendations about buying, selling, or holding investments. Like a financial coach or guide, they have a legal duty to act in a client's best financial interest, so their advice, fees and potential conflicts can directly affect returns and risk — making their role important for investors who want informed, accountable help with portfolios.

Schedule 13G regulatory

"This statement is filed by Woodline Partners LP on Schedule 13G"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

FAQ

What percentage of Tango Therapeutics (TNGX) does Woodline Partners report owning?

Woodline Partners reports beneficial ownership of 2.5% of Tango Therapeutics’ common stock, based on 162,814,649 shares outstanding, including shares offered under a June 10, 2026 prospectus and previously outstanding shares.

How many Tango Therapeutics (TNGX) shares does Woodline Partners hold?

Woodline Partners reports holding 4,000,567 shares of Tango Therapeutics common stock. It has sole voting and sole dispositive power over all of these shares, with no shared voting or dispositive authority reported.

How was the 2.5% ownership in Tango Therapeutics (TNGX) calculated?

The 2.5% ownership is calculated using a total of 162,814,649 Tango shares outstanding, comprising 18,166,667 shares offered via a June 10, 2026 prospectus and 144,647,982 shares outstanding as of May 6, 2026.

What is Woodline Partners’ role in relation to Tango Therapeutics (TNGX) shares?

Woodline Partners acts as the investment adviser to Woodline Master Fund LP and Woodline Spire Master Fund LP, which directly hold the Tango Therapeutics shares. The filing states it should not be construed as an admission of beneficial ownership under Section 13.

Does Woodline Partners share voting or dispositive power over Tango Therapeutics (TNGX) stock?

No. Woodline Partners reports sole voting power and sole dispositive power over 4,000,567 Tango Therapeutics shares, with 0 shares reported under shared voting or shared dispositive power categories.

What does Item 5 indicate about Woodline Partners’ Tango Therapeutics (TNGX) holdings?

Item 5 indicates that Woodline Partners’ position represents 5 percent or less of Tango Therapeutics’ outstanding common stock, confirming it is below the 5% large-shareholder threshold for this class.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 08/14/2026 - 11:06 AM Accepted by SEC EDGAR 08/14/2026 - 11:05 AM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 3)

Tango Therapeutics, Inc.

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

87583X109

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 87583X109

1

Names of Reporting Persons

Woodline Partners LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 4,000,567.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 4,000,567.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,000,567.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.5 %

12

Type of Reporting Person (See Instructions)

IA, PN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Tango Therapeutics, Inc.
(b)	Address of issuer's principal executive offices: 201 Brookline Ave., Suite 901, Boston, MA 02215
Item 2.
(a)	Name of person filing: This statement is filed by Woodline Partners LP ("Woodline Partners" or the "Reporting Person"), a Delaware limited partnership, and the investment adviser to Woodline Master Fund LP and Woodline Spire Master Fund LP (together, the "Woodline Funds"), with respect to the shares of common stock, par value $0.001 per share ("Common Stock"), of Tango Therapeutics, Inc. (the "Company") directly held by the Woodline Funds. The filing of this statement should not be construed as an admission that any of the foregoing persons or the Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, the beneficial owner of the shares of Common Stock reported herein.
(b)	Address or principal business office or, if none, residence: The address of the business office of Woodline Partners is 4 Embarcadero Center, Suite 3450, San Francisco, CA 94111.
(c)	Citizenship: Woodline Partners is a Delaware limited partnership.
(d)	Title of class of securities: Common Stock, par value $0.001 per share
(e)	CUSIP No.: 87583X109
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: The information required by Item 4(a) is set forth in Row 9 of the cover page for the Reporting Person and is incorporated herein by reference. The percentage set forth in this Schedule 13G is calculated based upon an aggregate of 162,814,649 shares of Common Stock outstanding, which is the sum of (i) the 18,166,667 shares of Common Stock offered pursuant to the Company's Prospectus filed pursuant to Rule 424(b)(5) with the Securities and Exchange Commission (the "SEC") on June 10, 2026 and (ii) the 144,647,982 shares of Common Stock outstanding as of May 6, 2026, as reported in the Company's Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2026 filed with the SEC on May 13, 2026.
(b)	Percent of class: 2.5%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for the Reporting Person and is incorporated herein by reference.
	(ii) Shared power to vote or to direct the vote: The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for the Reporting Person and is incorporated herein by reference.
	(iii) Sole power to dispose or to direct the disposition of: The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for the Reporting Person and is incorporated herein by reference.
	(iv) Shared power to dispose or to direct the disposition of: The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for the Reporting Person and is incorporated herein by reference.
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. See Item 2(a).
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Woodline Partners LP

Signature:	/s/ Erin Mullen
Name/Title:	By: Erin Mullen, General Counsel & Chief Compliance Officer
Date:	08/14/2026