Tango Therapeutics Reports Second Quarter 2026 Financial Results and Provides Business Highlights
Rhea-AI Summary
Tango Therapeutics (NASDAQ:TNGX) reported second quarter 2026 results and advanced its PRMT5 program. Initial Phase 1/2 data showed vopimetostat plus Revolution Medicines’ RAS(ON) inhibitor daraxonrasib achieved a 92% objective response rate and 90% six‑month progression-free survival in MTAP-deleted, RAS-mutant pancreatic cancer, with a generally well-tolerated safety profile. Tango is engaging regulators and its collaborator to define a registrational path and plans a Phase 3 trial design in 2H 2026.
The company held $1.0 billion in cash, cash equivalents and marketable securities as of June 30, 2026. Q2 2026 collaboration revenue was $0 versus $3.2 million a year earlier. Research and development expenses were $37.2 million and general and administrative expenses were $22.6 million, leading to a net loss of $55.3 million ($0.37/share) versus $38.9 million ($0.35/share) in Q2 2025. Key hires include Chief Commercialization Officer Fatma Ocak and Board Chairman Robert Azelby.
Positive
- Vopimetostat + daraxonrasib showed 92% objective response and 90% 6‑month PFS in MTAP‑deleted, RAS‑mutant pancreatic cancer
- Cash, cash equivalents and marketable securities totaled $1.0 billion as of June 30, 2026
- Total assets increased to $1.07 billion from $398.7 million at December 31, 2025
- Stockholders’ equity rose to $1.02 billion from $346.2 million at year‑end 2025
- Addition of Chief Commercialization Officer and new Board Chairman supports late‑stage development and launch readiness
- Multiple 2H 2026 milestones planned, including Phase 3 trial design and new clinical data readouts
Negative
- Collaboration revenue was $0 in Q2 2026, down from $3.2 million in Q2 2025
- Research and development expenses rose to $37.2 million from $32.8 million year over year in Q2
- General and administrative expenses doubled to $22.6 million from $11.3 million in Q2 2025
- Net loss widened to $55.3 million ($0.37/share) from $38.9 million ($0.35/share) in Q2 2025
- Six‑month net loss increased to $100.9 million from $78.7 million in the prior‑year period
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| May 13 | 1Q26 earnings | Positive | -2.5% | Quarterly results, cash position, pipeline milestones, and leadership updates |
| Mar 05 | 4Q25 earnings | Positive | +36.3% | Cash runway, pivotal study plans, collaboration, and leadership developments |
| Nov 04 | 3Q25 earnings | Positive | +0.0% | Clinical efficacy updates, orphan designation, financial results, and financing proceeds |
| Aug 05 | 2Q25 earnings | Positive | +4.9% | Trial dosing milestones, cash reserves, collaboration revenue, and quarterly loss |
| May 12 | 1Q25 earnings | Positive | +14.9% | Pipeline progress, cash runway, quarterly revenue, expenses, and net loss |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Tag-specific earnings reactions were mixed, ranging from a -2.51% decline to a +36.28% gain.
Key Terms
prmt5 inhibitor medical
objective response rate medical
progression-free survival medical
synthetic lethality medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
Company continues to prepare for late-stage clinical advancement of vopimetostat in combination with daraxonrasib for pancreatic cancer following positive Phase 1/2 data
Phase 1/2 data from combination study of vopimetostat + RAS(ON) inhibitors in pancreatic cancer to be presented at 2026 ESMO Congress
Key appointments further position Company for late-stage development and commercialization: Robert Azelby, Chairman of the Board of Directors and Fatma Ocak, Chief Commercialization Officer
Cash position of
BOSTON, Aug. 11, 2026 (GLOBE NEWSWIRE) -- Tango Therapeutics, Inc. (NASDAQ: TNGX) (Tango or the Company), a clinical-stage biotechnology company committed to discovering and delivering the next generation of precision cancer medicines, today reported financial results for the second quarter ended June 30, 2026, and provided business highlights.
"The second quarter marked a pivotal period for Tango, with milestones that validated our PRMT5 inhibitor pipeline and reflect the progress of our maturing organization. Notably, initial Phase 1/2 data showed vopimetostat plus daraxonrasib achieved a
Clinical Pipeline Updates
Vopimetostat – MTAP Selective Once-Daily PRMT5 Inhibitor
- In June, Tango reported initial data from vopimetostat in combination with Revolution Medicines' RAS(ON) inhibitors daraxonrasib or zoldonrasib in patients with MTAP-deleted, RAS-mutant pancreatic cancer. Data demonstrated that vopimetostat in combination with daraxonrasib achieved a
92% objective response rate and90% six-month progression-free survival rate in this patient population, with a generally well-tolerated safety profile. - Based upon the positive Phase 1/2 data, Tango is working internally and has initiated dialogue with regulators and its collaborator Revolution Medicines toward the goal of developing a registrational plan and path forward for vopimetostat plus daraxonrasib in MTAP-deleted pancreatic cancer.
- The Company plans to share data from the Phase 1/2 trial of the combination of vopimetostat plus RAS(ON) inhibitors at the 2026 European Society for Medical Oncology (ESMO) Congress in Madrid, Spain from October 23-27, 2026.
Corporate Updates
- Executive Leadership. Today, the Company announced that it has appointed Fatma Ocak to the role of Chief Commercialization Officer, effective August 17, 2026. In this role, Ms. Ocak will oversee all aspects of launch readiness and oversee key functions, including medical affairs, commercial strategy, and clinical and commercial integration. Prior to joining Tango, she served as Senior Vice President and General Manager, US Oncology at BioNTech. Previously, she held senior executive roles at Novartis across both global and US oncology leadership, driving strategic product positioning, market access, and commercial execution. Throughout her 25-year career in pharmaceuticals, she has specialized in bridging research and development to competitive market execution.
- Board of Directors. In June, the Company strengthened its Board of Directors with the appointment of Robert Azelby, adding more than 30 years of biopharmaceutical leadership experience in oncology commercialization and corporate strategy as Tango prepares to advance vopimetostat into late-stage clinical development. On August 6, 2026, Mr. Azelby was appointed Chairman of the Tango Board of Directors.
Upcoming Expected Milestones
- Present Phase 1/2 data of vopimetostat in combination with RAS(ON) inhibitors at the 2026 ESMO Congress in Madrid, Spain from October 23-27, 2026
- Finalize design of Phase 3 randomized-controlled trial of the combination approach in front-line pancreatic cancer in 2H 2026
- Disclose vopimetostat lung cancer monotherapy data in 2H 2026
- Release initial TNG456 data in glioblastoma and other cancers in 2H 2026
- Initiate Phase 1/2 vopimetostat + ERAS-0015 (Erasca) combination study in 2H 2026
Financial Results
As of June 30, 2026, the Company held
Collaboration revenue was
Research and development expenses were
General and administrative expenses were
Net loss for the three months ended June 30, 2026 was
About Tango Therapeutics
Tango is a clinical-stage biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. For more information, please visit www.tangotx.com.
Forward-Looking Statements
Certain statements in this press release may be considered forward-looking statements. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including all statements regarding the intent, belief, or current expectation of Tango and members of the Tango senior management team. Forward-looking statements are not purely historical and may be accompanied by words such as “may”, “should”, “expect”, “intend”, “will”, “goal”, “estimate”, “anticipate”, “believe”, “predict”, “designed,” “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. For example, implicit or explicit statements concerning the following include or constitute forward-looking statements: Dr. Peters' statements in this press release and statements regarding: (i) the potential of the Company’s PRMT5 molecules, as both standalone treatments and in combination with RAS(ON)-inhibitors; (ii) our plans to continue working internally and with regulators and Tango collaborator Revolution Medicines toward the goal of developing a registrational plan and path forward for vopimetostat plus daraxonrasib in MTAP-deleted pancreatic cancer; (iii) the anticipated impact of recent management and Board of Directors changes; (iv) our expectations around regulatory communications and decisions; (v) our beliefs regarding the timing of upcoming clinical milestones and data disclosures, including our plans to (a) share Phase 1/2 data from the vopimetostat combination trial at the 2026 ESMO Congress, (b) finalize the design of the Phase 3 randomized-controlled trial of the combination approach in front-line pancreatic cancer in the second half of 2026, (c) disclose clinical data in lung cancer from vopimetostat monotherapy in the second half of 2026, (d) disclose initial Phase 1/2 safety and efficacy data from the TNG456 clinical trial in the second half of 2026, and (e) initiate a Phase 1/2 combination clinical trial of vopimetostat and ERAS-0015 (Erasca) in the second half of 2026; and (vi) expectations regarding the anticipated benefits of our molecules. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Tango and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: the benefits of product candidates, as single agents and/or in combination seen in preclinical tests and analyses and current and future clinical trials may not be evident or may differ materially when tested in later preclinical studies or in clinical trials or when used in broader patient populations (if approved for commercial sale); Tango's effectiveness in managing current and future clinical trials, including maintaining anticipated timelines and reporting clinical trial results in the anticipated timeframe (or at all); the Company's reliance on third parties for conducting clinical trials and supplying and producing drug substance and drug product; expectations regarding the benefits and success of current or future collaborations and combination clinical trials and the Company's ability to enter into additional collaboration and supply agreements; Tango’s pipeline products may not be safe and/or effective in humans; the Company's ability to raise capital in the future and the potential delay, scale back or discontinuation of some of our development programs or future commercialization efforts if such funding is not available on acceptable terms (or at all); the Company’s product candidates may cause adverse or other undesirable side effects (or may not show requisite efficacy) that could, among other things, delay or prevent regulatory approval; government regulation, including inadequate funding for or disruptions at the US Food and Drug Administration or other government agencies, may adversely affect our business. Additional information concerning risks, uncertainties and assumptions can be found in Tango’s filings with the Securities and Exchange Commission (SEC), including the risk factors referenced in Tango’s Annual Report on Form 10-K for the fiscal year ended December 31, 2025, as well as other filings we make with the SEC from time to time. You should not place undue reliance on forward-looking statements in this press release, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Tango specifically disclaims any duty to update these forward-looking statements.
Investors:
Elizabeth Hickin
ehickin@tangotx.com
Media:
1AB
Amanda Lazaro
amanda@1abmedia.com
| Unaudited Consolidated Statements of Operations (In thousands, except share and per share data) | ||||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | |||||||||||||||
| 2026 | 2025 | 2026 | 2025 | |||||||||||||
| Collaboration revenue | $ | — | $ | 3,181 | $ | — | $ | 8,573 | ||||||||
| Operating expenses: | ||||||||||||||||
| Research and development | 37,199 | 32,807 | 70,734 | 69,249 | ||||||||||||
| General and administrative | 22,586 | 11,341 | 37,821 | 22,821 | ||||||||||||
| Total operating expenses | 59,785 | 44,148 | 108,555 | 92,070 | ||||||||||||
| Loss from operations | (59,785 | ) | (40,967 | ) | (108,555 | ) | (83,497 | ) | ||||||||
| Other income, net | 4,445 | 2,149 | 7,701 | 4,837 | ||||||||||||
| Loss before income taxes | (55,340 | ) | (38,818 | ) | (100,854 | ) | (78,660 | ) | ||||||||
| Provision for income taxes | (1 | ) | (35 | ) | (2 | ) | (69 | ) | ||||||||
| Net loss | $ | (55,341 | ) | $ | (38,853 | ) | $ | (100,856 | ) | $ | (78,729 | ) | ||||
| Net loss per common share – basic and diluted | $ | (0.37 | ) | $ | (0.35 | ) | $ | (0.68 | ) | $ | (0.71 | ) | ||||
| Weighted average number of common shares outstanding – basic and diluted | 149,875,939 | 110,540,836 | 148,660,404 | 110,494,397 | ||||||||||||
| Unaudited Consolidated Balance Sheets (In thousands) | ||||||||
| June 30, | December 31, | |||||||
| 2026 | 2025 | |||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 345,558 | $ | 112,279 | ||||
| Marketable securities | 668,432 | 230,859 | ||||||
| Restricted cash | — | 428 | ||||||
| Prepaid expenses and other current assets | 17,681 | 10,190 | ||||||
| Total current assets | 1,031,671 | 353,756 | ||||||
| Property and equipment, net | 6,094 | 6,868 | ||||||
| Operating lease right-of-use assets | 33,664 | 35,624 | ||||||
| Restricted cash, net of current portion | 2,139 | 2,139 | ||||||
| Other assets | 312 | 303 | ||||||
| Total assets | $ | 1,073,880 | $ | 398,690 | ||||
| Liabilities and Stockholders' Equity | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 1,810 | $ | 1,182 | ||||
| Accrued expenses and other current liabilities | 15,546 | 17,759 | ||||||
| Operating lease liabilities | 2,943 | 2,738 | ||||||
| Total current liabilities | 20,299 | 21,679 | ||||||
| Operating lease liabilities, net of current portion | 29,049 | 30,832 | ||||||
| Total liabilities | 49,348 | 52,511 | ||||||
| Total stockholders’ equity | 1,024,532 | 346,179 | ||||||
| Total liabilities and stockholders’ equity | $ | 1,073,880 | $ | 398,690 | ||||
