Tango and Erasca Initiate Phase 1/2 Study of Oral PRMT5 Inhibitor Vopimetostat in Combination with Pan-RAS Molecular Glue ERAS-0015

The Tango-sponsored study will determine the combination's maximum tolerated dose and assess antitumor activity, safety and tolerability.

Rhea-AI Summary

Tango Therapeutics (TNGX) and Erasca (ERAS) opened enrollment in a Phase 1/2 trial combining vopimetostat with ERAS-0015 for pancreatic and lung cancers.

The study enrolls patients with pancreatic ductal adenocarcinoma with an MTAP gene deletion, or non-small cell lung cancer with both an MTAP deletion and a RAS mutation. Tango sponsors the multicenter, open-label trial, in which participants and investigators know the treatment given. It includes dose escalation followed by expansion. The primary dose-escalation objective is to determine the combination's maximum tolerated dose; secondary objectives assess antitumor activity, drug exposure, safety and tolerability.

Vopimetostat inhibits PRMT5, while ERAS-0015 targets RAS signaling. Tango reports durable activity with vopimetostat in ongoing studies across multiple MTAP-deleted tumor types, including pancreatic and lung cancers.

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Positive

• Moderate pointVopimetostat has shown durable activity in ongoing studies involving MTAP-deleted pancreatic and lung cancers.
• Minor pointPhase 1/2 combination trial opened enrollment, advancing Tango's vopimetostat development with Erasca's ERAS-0015.

Negative

• None.

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Details

Market Reaction – TNGX

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Key Figures

Study phase: Phase 1/2

Study phase

Phase 1/2

Vopimetostat and ERAS-0015 combination study

Previous Clinical trial Reports

1 past event · Latest: Oct 23

Same Type 1 event

1. Oct 23

   Clinical results

   24h Move

   -16.4%

   Vopimetostat plus daraxonrasib showed an 82% response rate in pancreatic cancer.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Key Terms

prmt5 inhibitor, pancreatic ductal adenocarcinoma, non-small cell lung cancer, mtap deletion, +2 more

6 terms

prmt5 inhibitor medical

"oral PRMT5 inhibitor vopimetostat"

A PRMT5 inhibitor is a drug that blocks the action of the enzyme PRMT5, which controls how some genes are turned on or off by tagging proteins inside cells. For investors, these drugs matter because they can slow or stop the growth of certain cancers and other diseases by reprogramming cell behavior, acting like a dimmer switch for disease-related genes; clinical trial results and approval decisions drive value and risk.

pancreatic ductal adenocarcinoma medical

"MTAP-deleted pancreatic ductal adenocarcinoma (PDAC)"

A fast-growing cancer that starts in the cells lining the pancreas’ small ducts; it is the most common and aggressive form of pancreatic cancer. It matters to investors because its severity and limited treatment options drive high unmet medical need, large potential markets for effective drugs or diagnostics, and strong sensitivity of company valuations to clinical trial results, regulatory approvals, or changes in treatment guidelines—similar to how fixing a main leak can prevent major damage in a building.

non-small cell lung cancer medical

"MTAP-deleted/RAS-mutant non-small cell lung cancer (NSCLC)"

A broad category of lung tumors that grow from the cells lining the airways and make up the majority of lung cancer cases; it includes several subtypes that behave and respond to treatment differently, like different models of the same car family. It matters to investors because its large patient population and variety of treatment options — surgery, traditional chemo, targeted drugs and immunotherapies — create major markets where clinical trial results, drug approvals or changing treatment guidelines can quickly affect a company’s revenue and stock value.

mtap deletion medical

"multiple tumor types with MTAP (methylthioadenosine phosphorylase) deletion"

mtap deletion is the loss of the MTAP gene from a cell’s DNA, which can happen in some cancers. For investors, it matters because that genetic gap often creates a predictable weakness drugs can target, making affected tumors both a potential market for specialized therapies and a marker used by companies to select patients for trials; think of it as a missing bolt that lets a tailored tool work more effectively.

maximum tolerated dose medical

"determine the maximum tolerated dose of the combination regimen"

Maximum tolerated dose is the highest amount of a substance, such as a medication or chemical, that can be used without causing unacceptable side effects or harm. It’s like finding the maximum speed you can drive without risking a ticket or accident. For investors, understanding this concept helps gauge how much risk or exposure is safe or sustainable in a given situation.

pharmacokinetics medical

"assessment of antitumor activity, pharmacokinetics, safety and tolerability"

Pharmacokinetics is the study of how a substance, such as a drug or chemical, moves through and is processed by the body over time. It tracks how it is absorbed, distributed, broken down, and eventually eliminated. For investors, understanding pharmacokinetics helps gauge the effectiveness, safety, and potential risks of new medications or treatments, which can influence a company’s success and valuation in the healthcare industry.

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The study is evaluating the combination in patients with MTAP-deleted pancreatic cancer and MTAP-deleted/RAS mutant non-small cell lung cancer

BOSTON and SAN DIEGO, Nov. 04, 2026 (GLOBE NEWSWIRE) -- Tango Therapeutics, Inc. (NASDAQ: TNGX), a clinical-stage biotechnology company committed to delivering breakthrough targeted therapies that extend and improve the lives of patients with cancer and Erasca, Inc. (Nasdaq: ERAS), a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers, today announced that the Phase 1/2 study of oral PRMT5 inhibitor vopimetostat in combination with pan-RAS molecular glue ERAS-0015 in patients with MTAP-deleted pancreatic ductal adenocarcinoma (PDAC) and MTAP-deleted/RAS-mutant non-small cell lung cancer (NSCLC) is now open for enrollment.

“The encouraging clinical activity, durability and tolerability observed to date with vopimetostat in combination with RAS inhibition reinforce our belief that co-targeting PRMT5 and RAS represents a promising new frontier in the treatment of pancreatic cancer and potentially other RAS-driven cancers,” said Malte Peters, M.D., President and CEO of Tango Therapeutics. “We are thrilled to initiate this study in partnership with Erasca, a company leading the advancement of RAS-targeted therapies, to evaluate vopimetostat with ERAS-0015 and further explore the potential of this clinically validated and synergistic combination approach.”

Jonathan E. Lim, M.D., Erasca’s chairman, CEO, and co-founder added, “Pairing ERAS-0015’s pan-RAS inhibition with vopimetostat’s PRMT5 inhibition creates a complementary, dual-targeted approach with the potential for deeper, more durable responses in patients with these difficult-to-treat cancers. We are excited to work closely with Tango, a leader in the development of PRMT5-targeted therapies, to advance this promising combination and evaluate its potential to deliver meaningful benefit for patients with pancreatic and lung cancers, where new treatment options are urgently needed.”

About the Phase 1/2 Study of Vopimetostat in Combination with ERAS-0015
The Phase 1/2 open-label, multicenter dose-escalation and expansion trial, sponsored by Tango Therapeutics, is designed to evaluate vopimetostat in combination with ERAS-0015 in patients with MTAP-deleted PDAC or RAS-mutant/MTAP-deleted NSCLC. The primary objective of the dose-escalation portion of the study is to determine the maximum tolerated dose of the combination regimen. Secondary objectives include assessment of antitumor activity, pharmacokinetics, safety and tolerability. To learn more about this study, visit clinicaltrials.gov (NCT07897734).

About Vopimetostat
Vopimetostat is an investigational, potentially first- and best-in-class oral, once-daily, PRMT5 inhibitor that is being evaluated as a monotherapy and as a combination therapy in multiple indications. In ongoing clinical studies, vopimetostat has demonstrated a favorable safety and tolerability profile and shown durable activity in multiple tumor types with MTAP (methylthioadenosine phosphorylase) deletion, including pancreatic cancer and lung cancer.

About ERAS-0015
ERAS-0015 is an oral, highly potent pan-RAS molecular glue designed to inhibit RAS signaling with a potential best-in-class profile. Erasca is evaluating ERAS-0015 in the AURORAS-1 Phase 1 trial in patients with RAS-mutant solid tumors. Early dose escalation data in AURORAS-1 demonstrated favorable safety and tolerability, well-behaved, linear PK, and confirmed and unconfirmed responses in multiple patients across multiple tumor types with different RAS mutations, including confirmed and unconfirmed partial responses at doses as low as 8 mg once daily (QD). In preclinical studies versus RMC-6236, ERAS-0015 demonstrated approximately 8-21 times higher binding affinity to cyclophilin A (CypA), approximately 5 times greater potency in RAS inhibition, and greater in vivo antitumor activity in RAS-driven tumor models evidenced by achieving comparable or greater tumor growth inhibition or regression at doses that are as low as approximately one-tenth to one-fifth of the dose of RMC-6236. ERAS-0015 is also designed to prevent resistance against mutant-selective inhibitors through inhibition of RAS wildtype variants. In addition, ERAS-0015 has demonstrated favorable absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetic (PK) properties in multiple animal species.

About Tango Therapeutics
Tango Therapeutics is a clinical-stage biotechnology company dedicated to delivering breakthrough targeted therapies that extend and improve the lives of patients with cancer. Using an approach that focuses on genetic vulnerabilities in cancer, Tango is pursuing PRMT5-targeted therapies designed to address pancreatic and other forms of cancer while sparing healthy normal tissues. For more information, please visit www.tangotx.com.

About Erasca
At Erasca, our name is our mission: To erase cancer. We are a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers. Our company was co-founded by leading pioneers in precision oncology and RAS targeting to create novel therapies and combination regimens designed to comprehensively shut down the RAS/MAPK pathway for the treatment of patients with cancer. We believe our team’s capabilities and experience, further guided by our scientific advisory board which includes the world’s leading experts in the RAS/MAPK pathway, uniquely position us to achieve our bold mission of erasing cancer.

Tango Therapeutics Forward-Looking Statements
Certain statements in this press release may be considered forward-looking statements. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including all statements regarding the intent, belief, or current expectation of Tango Therapeutics and members of the Tango Therapeutics senior management team. Forward-looking statements are not purely historical and may be accompanied by words such as “may”, “should”, “expect”, “intend”, “will”, “goal”, “estimate”, “anticipate”, “believe”, “predict”, “designed,” “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. For example, implicit or explicit statements concerning the following include or constitute forward-looking statements: Dr. Peters’s and Dr. Lim’s statements in this press release and statements regarding: (i) the potential of the Company’s PRMT5 molecules, as both standalone treatments and in combination with RAS inhibitors, including the Company’s belief that co-targeting PRMT5 and RAS represents a promising new frontier in the treatment of pancreatic cancer and potentially other RAS-driven cancers; (ii) expectations regarding the anticipated benefits of the Company’s molecules, development candidates, and product candidates, as both monotherapies and in combination, including the Company’s belief that this combination has the potential to be synergistic; (iii) expectations for vopimetostat and the belief that vopimetostat has the potential to be a first- and best-in-class PRMT5 inhibitor for the treatment of MTAP-deleted cancers; (iv) the Company’s development strategy in PRMT5-targeted therapies; and (v) the Company’s plans, study design, doses, endpoints, and timing for combination trials, including timing of future enrollment. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Tango Therapeutics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: the benefits of product candidates, as single agents and/or in combination seen in preclinical tests and analyses and current and future clinical trials may not be evident or may differ materially when tested in later preclinical studies or in clinical trials or when used in broader patient populations (if approved for commercial sale); the Company’s effectiveness in managing current and future clinical trials, including maintaining anticipated timelines and reporting clinical trial results in the anticipated timeframe (or at all); the Company's reliance on third parties for conducting clinical trials and supplying and producing drug substance and drug product; expectations regarding the benefits and success of current or future collaborations and combination clinical trials; the Company's ability to enter into additional collaboration and supply agreements and to acquire, license, or otherwise obtain rights to additional products, product candidates, or molecules; the Company’s pipeline products may not be safe and/or effective in humans; the Company's ability to raise capital in the future and the potential delay, scale back or discontinuation of some of its development programs or future commercialization efforts if such funding is not available on acceptable terms (or at all); the Company’s product candidates may cause adverse or other undesirable side effects (or may not show requisite efficacy) that could, among other things, delay or prevent regulatory approval; government regulation, including inadequate funding for or disruptions at the U.S. Food and Drug Administration or other government agencies, may adversely affect the Company’s business. Additional information concerning risks, uncertainties and assumptions can be found in the Company’s filings with the Securities and Exchange Commission (SEC), including the risk factors referenced in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2025, as well as other filings the Company makes with the SEC from time to time. You should not place undue reliance on forward-looking statements in this press release, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. The Company specifically disclaims any duty to update these forward-looking statements.

Erasca Forward Looking Statements
Erasca cautions you that statements contained in this press release regarding matters that are not historical facts are forward-looking statements. The forward-looking statements are based on our current beliefs and expectations and include, but are not limited to: the potential for ERAS-0015 and vopimetostat to successfully treat patients with MTAP-deleted pancreatic and lung cancers, and our ability to work with Tango to advance this combination to deliver meaningful benefit for patients; our expectations regarding the potential therapeutic benefits for each of our product candidates, including ERAS-0015; and the potential for ERAS-0015 to be best-in-class. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in our business, including, without limitation: the timing of our clinical data readouts, including for the AURORAS-1 trial, may be delayed; our product candidates, including ERAS-0015, may not demonstrate therapeutic benefits that we expect; any forward-looking statements regarding dose-response relationships reflect current expectations and/or assumptions and are subject to risks and uncertainties that could cause actual results to differ materially; interim, topline and preliminary results of a clinical trial are not necessarily indicative of final results and one or more of the clinical outcomes may materially change as patient enrollment continues, following more comprehensive reviews of the data and as more patient data becomes available, including the risk that an unconfirmed partial response to treatment may not ultimately result in a confirmed partial response to treatment after follow-up evaluations; our approach to the discovery and development of product candidates is based on our singular focus on shutting down the RAS/MAPK pathway, a novel and unproven approach; results from preclinical studies not necessarily being predictive of future results; our assumptions around which programs may have a higher probability of success may not be accurate, and we may expend our limited resources to pursue a particular product candidate and/or indication and fail to capitalize on product candidates or indications with greater development or commercial potential; potential delays in the commencement, enrollment, data readout, and completion of clinical trials and preclinical studies; our dependence on third parties in connection with manufacturing, research, and preclinical and clinical testing; unexpected adverse side effects or inadequate efficacy of our product candidates that may limit their development, regulatory approval, and/or commercialization, or may result in recalls or product liability claims; our planned potentially registration-enabling trials may be delayed based on Food and Drug Administration (FDA) feedback or requirements, as the FDA retains broad discretion to require additional clinical data prior to the conduct of a registrational trial or submission for regulatory approval; even if our planned trials are successful, they may not support regulatory approval; unfavorable results from preclinical studies or clinical trials; the inability to realize any benefits from our current licenses, acquisitions, and collaborations, and any future licenses, acquisitions, or collaborations, and our ability to fulfill our obligations under such arrangements; regulatory developments in the United States and foreign countries; our ability to obtain and maintain intellectual property protection for our product candidates and maintain our rights under intellectual property licenses, including our ability to successfully defend against allegations raised by, or any future litigation initiated by, Revolution Medicines (RevMed) that ERAS-0015 infringes patents held by RevMed or was derived from RevMed trade secrets; the sufficiency of our cash, cash equivalents, and marketable securities; we may use our capital resources sooner than we expect; and other risks described in our prior filings with the Securities and Exchange Commission (SEC), including under the heading “Risk Factors” in our annual report on Form 10-K for the year ended December 31, 2025, and any subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and we undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

Tango Therapeutics Investors:
Elizabeth Hickin
ehickin@tangotx.com

Tango Therapeutics Media:
1AB media
Amanda Lazaro
amanda@1abmedia.com

Erasca Investors:
Joyce Allaire
LifeSci Advisors, LLC
jallaire@lifesciadvisors.com

Erasca Media Contact:
Michael Fitzhugh
LifeSci Communications
mfitzhugh@lifescicomms.com

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

Which patients can enroll in the Tango and Erasca vopimetostat combination trial?

The trial enrolls patients with MTAP-deleted pancreatic ductal adenocarcinoma or RAS-mutant, MTAP-deleted non-small cell lung cancer. It evaluates vopimetostat combined with ERAS-0015.

What is the main objective of Tango's vopimetostat and ERAS-0015 trial?

The primary objective of dose escalation is to determine the combination's maximum tolerated dose. Secondary objectives assess antitumor activity, pharmacokinetics—how the drugs move through the body—and safety and tolerability.