FMR Reports 6.3% Stake in Trevi Therapeutics

FMR LLC amended its Schedule 13G to report beneficial ownership of 8,038,060.69 shares of Trevi Therapeutics common stock, representing 6.3% of the class.

Rhea-AI Filing Summary

FMR LLC amended its Schedule 13G to report beneficial ownership of 8,038,060.69 shares of Trevi Therapeutics common stock, representing 6.3% of the class.

The filing shows Abigail P. Johnson has sole dispositive power over the same share amount, references Exhibit 99 for a 13d-1(k)(1) agreement, and attaches a power of attorney effective April 13, 2026.

Insights

Institutional Ownership Analyst

FMR LLC reports a 6.3% passive stake in Trevi Therapeutics.

The amendment to Schedule 13G/A lists 8,038,060.69 shares beneficially owned, with dispositive authority noted for Abigail P. Johnson. The filing cites an exhibit for a related agreement and a power of attorney effective April 13, 2026.

Institutional schedules like this are informational about holdings; further trading activity will depend on FMR affiliates' decisions and any disclosures in subsequent filings.

Key Figures

Beneficial ownership: 8,038,060.69 shares Percent of class: 6.3% CUSIP: 89532M101 +2 more

5 metrics

Beneficial ownership 8,038,060.69 shares Amount beneficially owned as stated on the Schedule 13G/A

Percent of class 6.3% Percent of Trevi Therapeutics common stock reported on the form

CUSIP 89532M101 CUSIP for Trevi Therapeutics common stock on cover page

Power of Attorney effective April 13, 2026 Date of power of attorney referenced in signature block

Signature date May 5, 2026 Date signatures were provided on the amendment

Key Terms

Schedule 13G/A, Beneficial ownership, Dispositive power, 13d-1(k)(1) agreement

4 terms

Schedule 13G/A regulatory

"Amendment to Schedule 13G/A reporting beneficial ownership"

A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.

Beneficial ownership financial

"Amount beneficially owned: 8038060.69 listed in Item 4"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

Dispositive power regulatory

"Sole Dispositive Power 8,038,060.69 shown on cover"

Dispositive power is the authority to decide the final outcome of an asset, legal claim, contract, or corporate action — in effect the power to dispose of or resolve something. For investors it matters because whoever holds that authority can determine who gets paid, who controls an asset or vote, and how risks and returns are allocated; think of it like holding the key that lets you lock in the winner or loser in a deal.

13d-1(k)(1) agreement regulatory

"Please see Exhibit 99 for 13d-1(k)(1) agreement"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many Trevi Therapeutics (TRVI) shares does FMR LLC report owning?

FMR LLC reports beneficial ownership of 8,038,060.69 shares of Trevi Therapeutics common stock. The filing states this share count directly and ties it to a 6.3% ownership percentage of the outstanding class.

What percentage of TRVI does FMR LLC own according to the amendment?

The amendment reports that FMR LLC owns 6.3% of Trevi Therapeutics' common stock. That percentage is listed on the form alongside the precise share count of 8,038,060.69 shares reported as beneficially owned.

Who is listed with dispositive power over the reported TRVI shares?

The filing shows Abigail P. Johnson as having sole dispositive power over 8,038,060.69 shares. The cover responses indicate sole voting and dispositive power details are provided in Items 5 and 6 on the cover page.

Does the 13G/A amendment reference any supporting exhibits or authorities?

Yes, the amendment references Exhibit 99 for a 13d-1(k)(1) agreement and cites a power of attorney effective April 13, 2026. Signatures are dated May 5, 2026, as shown on the filing.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 05/06/2026 - 11:40 AM EDT Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

TREVI THERAPEUTICS INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

89532M101

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 89532M101

1

Names of Reporting Persons

FMR LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 8,025,496.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 8,038,060.69
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

8,038,060.69

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.3 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP Number(s): 89532M101

1

Names of Reporting Persons

Abigail P. Johnson

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 8,038,060.69
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

8,038,060.69

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.3 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: TREVI THERAPEUTICS INC
(b)	Address of issuer's principal executive offices: 195 CHURCH STREET,16TH FLOOR,NEW HAVEN,CT,USA,06510
Item 2.
(a)	Name of person filing: FMR LLC
(b)	Address or principal business office or, if none, residence: 245 Summer Street, Boston, Massachusetts 02210
(c)	Citizenship: Not applicable
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 89532M101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 8038060.69
(b)	Percent of class: 6.3 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Please see the responses to Items 5 and 6 on the cover page.
	(ii) Shared power to vote or to direct the vote: 0.00
	(iii) Sole power to dispose or to direct the disposition of: 8038060.69
	(iv) Shared power to dispose or to direct the disposition of: 0.00
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of TREVI THERAPEUTICS INC. No one other person's interest in the COMMON STOCK of TREVI THERAPEUTICS INC is more than five percent of the total outstanding COMMON STOCK.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See attached Exhibit 99.
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

FMR LLC

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:	05/05/2026

Abigail P. Johnson

Signature:	Richard Bourgelas
Name/Title:	Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of Abigail P. Johnson*
Date:	05/05/2026

Comments accompanying signature: *This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on April 29,2026, accession number: 0000315066-26-000738.

Exhibit Information

Please see Exhibit 99 for 13d-1(k) (1) agreement.