Twist Bioscience CEO Leproust sells 4,573 shares

The sale covered tax withholding tied to restricted stock unit vesting and was not a discretionary trade.

Available on EDGAR 11/05/2026 - 04:05 PM EST Accepted by SEC EDGAR 11/05/2026 - 04:05 PM EST Learn about SEC filing dates

Rhea-AI Filing Summary

Twist Bioscience Corp (TWST) Chief Executive Officer Emily M. Leproust reported a sale of 4,573 common shares on November 3, 2026, at $135.4020 per share, with 558,187 shares directly held following the transaction. The shares were sold to cover tax withholding tied to restricted stock unit vesting under the issuer’s equity incentive plans; the sale was not discretionary. No Rule 10b5-1 plan is reported.

The reported option positions covered 131,290 underlying common shares at a $23.3300 exercise price, expiring October 23, 2029, and 64,950 underlying common shares at a $67.8500 exercise price, expiring August 31, 2030.

Insider Trade Summary

Net Seller: 4,573 shares

Net Sell 1 txn

Insider Leproust Emily M.

Role Chief Executive Officer

Sold 4,573 shs ($619K)

Share of Position Sold 0.81%

Type	Security	Shares	Price	Value
Sale	Common Stock F1	4,573	$135.402	$619K
Holding	Employee Stock Option (right to buy) F2	--	--	--
Holding	Employee Stock Option (right to buy) F3	--	--	--

Holdings After Transaction: Common Stock — 558,187 shares (Direct); Employee Stock Option (right to buy) — 196,240 contracts (Direct)

Holdings Before and After: Common Stock, 562,760 to 558,187 shares (Direct)

Other Insiders: 5 other insiders reported open-market sales of this stock in the 30 days up to this filing.

Footnotes (3)

1. F1. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.
2. F2. 25% of the shares subject to the option vested on October 24, 2020, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
3. F3. Represents performance stock options granted to the reporting person on September 1, 2020, that vested and became exercisable on December 19, 2022 as a result of the reporting person having met the applicable performance criteria.

Key Figures

Common shares sold: 4,573 shares Sale price: $135.4020 per share Direct shares following transaction: 558,187 shares +4 more

7 metrics

Common shares sold 4,573 shares Sale reported for November 3, 2026

Sale price $135.4020 per share Sale reported for November 3, 2026

Direct shares following transaction 558,187 shares Following the November 3, 2026 transaction

Underlying shares subject to option 131,290 shares Exercise price $23.3300 per share; expiration October 23, 2029

Exercise price $23.3300 per share Option covering 131,290 underlying common shares; expiration October 23, 2029

Underlying shares subject to option 64,950 shares Exercise price $67.8500 per share; expiration August 31, 2030

Exercise price $67.8500 per share Option covering 64,950 underlying common shares; expiration August 31, 2030

Key Terms

sell to cover, Restricted Stock Units, tax withholding obligations, performance stock options

4 terms

sell to cover financial

"funded by a "sell to cover" transaction"

Sell to cover is when a person who receives company stock through options or awards sells just enough shares immediately to pay required taxes, exercise costs, or fees, keeping the rest. Think of it like cashing part of a bonus to cover the tax bill so you can keep the remainder. For investors, it can create predictable small selling pressure and slightly change the number of shares actually held by insiders without increasing long‑term dilution.

Restricted Stock Units technical

"vesting of Restricted Stock Units"

Restricted stock units are a type of company reward where employees are promised shares of stock, but they only fully own these shares after meeting certain conditions, like staying with the company for a set time. They matter because they can become valuable assets and are often used to motivate employees to help the company succeed.

tax withholding obligations financial

"to cover tax withholding obligations"

performance stock options technical

"Represents performance stock options granted to the reporting person"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many TWST shares did Chief Executive Officer Emily M. Leproust sell?

Emily M. Leproust reported selling 4,573 shares on November 3, 2026, at $135.4020 per share. The sale covered tax-withholding obligations linked to restricted stock unit vesting under the issuer’s equity incentive plans and was not discretionary. No Rule 10b5-1 plan is reported.

What is the vesting schedule for Emily M. Leproust’s TWST options?

For the option covering 131,290 underlying shares and expiring October 23, 2029, 25% of the shares subject to the option vested on October 24, 2020, and 1/48 vested on each monthly anniversary thereafter, subject to continuous service through each vesting date.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Leproust Emily M.

(Last) (First) (Middle)

C/O TWIST BIOSCIENCE CORPORATION

681 GATEWAY BLVD.

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Twist Bioscience Corp [ TWST ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Executive Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
11/03/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/03/2026		S		4,573(1)	D	$135.402	558,187	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (right to buy)	$23.33							(2)	10/23/2029	Common Stock	131,290		131,290	D
Employee Stock Option (right to buy)	$67.85							12/19/2022	08/31/2030	Common Stock	64,950		64,950(3)	D

Explanation of Responses:

1. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

2. 25% of the shares subject to the option vested on October 24, 2020, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.

3. Represents performance stock options granted to the reporting person on September 1, 2020, that vested and became exercisable on December 19, 2022 as a result of the reporting person having met the applicable performance criteria.

Remarks:

	/s/ Kendra Fox, as Attorney-in-Fact for Emily M. Leproust	11/05/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)