Veracyte (NASDAQ: VCYT) asks investors to back directors, auditor and larger equity plan

Rhea-AI Filing Summary

Veracyte, Inc. is asking stockholders to vote at a virtual Annual Meeting on June 10, 2026. They will elect nine directors for one-year terms, ratify Ernst & Young LLP as auditor, hold an advisory vote on executive pay, and vote on expanding the 2023 Equity Incentive Plan.

The equity plan amendment would add 3,500,000 shares to the plan, on top of 9,704,039 shares available as of March 31, 2026, supporting continued stock-based compensation. The board is majority independent with an independent chair, fully independent committees, majority voting for uncontested elections, clawback policies, and extensive ESG and risk-oversight practices.

Insights

Corporate governance and compensation analyst

Veracyte seeks modest additional equity capacity alongside robust governance controls.

Veracyte is using this proxy to refresh key governance items and expand its equity plan. Stockholders are asked to elect a fully declassified board to one‑year terms, ratify Ernst & Young LLP, approve executive pay on an advisory basis, and add 3.5 million shares to the 2023 Equity Incentive Plan.

The filing quantifies equity usage and potential dilution. As of March 31, 2026, 1,701,968 options and 3,918,629 full‑value awards were outstanding, with 9,704,039 shares remaining for grant, representing about 19% overhang. The proposed 3,500,000‑share increase equals roughly 4.4% of shares outstanding, framed as covering about one additional year of anticipated grants.

The company highlights structures that may mitigate governance concerns, including no evergreen feature, no option repricing without stockholder approval, no liberal change‑in‑control definition, no dividends on unvested awards, caps on non‑employee director pay, and a clawback policy aligned with Nasdaq and SEC rules. Future proxy results on the equity plan and say‑on‑pay resolution will indicate stockholder sentiment on dilution and pay practices.

Key Figures

Meeting date and time: June 10, 2026, 10:00 a.m. PDT Equity plan share increase: 3,500,000 shares Shares available under 2023 Plan: 9,704,039 shares +5 more

8 metrics

Meeting date and time June 10, 2026, 10:00 a.m. PDT Virtual Annual Meeting of Stockholders

Equity plan share increase 3,500,000 shares Additional shares requested for 2023 Equity Incentive Plan

Shares available under 2023 Plan 9,704,039 shares Available for grant as of March 31, 2026

Equity overhang Approximately 19% Outstanding awards plus available shares vs. shares outstanding on March 31, 2026

Audit fees $2,230,512 Fees to Ernst & Young LLP for year ended December 31, 2025

Employees 755 employees Headcount as of December 31, 2025

Women in workforce 54% Female share of employees as of December 31, 2025

Three-year average burn rate 2.68% Average for 2023–2025 equity grants vs. weighted average shares

Key Terms

Equity Incentive Plan, say on pay, majority voting standard, overhang, +2 more

6 terms

Equity Incentive Plan financial

"to approve an amendment to our Veracyte, Inc. 2023 Equity Incentive Plan"

An equity incentive plan is a program that gives employees, executives or directors the right to receive company stock or options to buy stock as part of their pay. Think of it as offering slices of future company profit to motivate people to boost long‑term performance; for investors it matters because it can align employee goals with shareholder value but also increases the number of shares outstanding, which can dilute existing ownership.

say on pay financial

"a non-binding advisory vote on the compensation paid by us to our named executive officers"

Say on pay is a shareholder vote—typically nonbinding—on a company’s executive compensation package, allowing investors to approve or reject how top managers are paid. Think of it as a public performance review: widespread disapproval can signal poor governance, prompt changes to pay practices, attract activist investors, and influence investor confidence and share value. It matters because it gives owners a direct way to influence compensation that affects company incentives and long-term performance.

majority voting standard regulatory

"We have a majority voting standard for uncontested elections of directors."

overhang financial

"represented approximately 19% of our common stock outstanding, which we refer to as our “overhang.”"

clawback policy regulatory

"We have a clawback policy, adopted in accordance with the Nasdaq Stock Market listing standards"

A clawback policy is a company rule that lets the firm take back pay, bonuses or stock awards from current or former executives if results are later found to be incorrect, misconduct occurred, or targets were missed. It matters to investors because it helps protect the value of their holdings by discouraging risky or fraudulent behavior and ensuring executive rewards reflect real, verified performance—think of it as a return policy for executive pay.

independent registered public accounting firm regulatory

"To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm"

An independent registered public accounting firm is an outside accounting company officially registered with the government regulator to examine and report on a public company's financial records and controls. Investors treat its reports like an impartial inspector’s certificate — they add credibility to financial statements, help spot errors or misleading claims, and reduce the risk that shareholders are relying on unchecked or biased numbers.

Compensation Summary

Compensation details

Key Proposals

• Election of nine directors for one-year terms
• Ratification of Ernst & Young LLP as independent registered public accounting firm for 2026
• Advisory vote to approve compensation of named executive officers
• Approval of amendment to Veracyte, Inc. 2023 Equity Incentive Plan to add 3,500,000 shares

Proxy Statements (DEF 14A): Pay, Votes, and Board Changes →

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

________________________

SCHEDULE 14A INFORMATION

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

(AMENDMENT NO.  )

________________________

Filed by the Registrant x
Filed by a Party other than the Registrant o
Check the appropriate box:
o			Preliminary Proxy Statement
o			Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
x			Definitive Proxy Statement
o			Definitive Additional Materials
o			Soliciting Material under §240.14a-12

VERACYTE, INC.
(Name of Registrant as Specified in its Charter) _____________________________
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
Payment of Filing Fee (Check all boxes that apply):
x			No fee required.
o			Fee paid previously with preliminary materials.
o			Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

6000 Shoreline Court, Suite 300
South San Francisco, CA 94080
(650) 243-6300

Dear Stockholder:

You are cordially invited to attend the Annual Meeting of Stockholders of Veracyte, Inc. that will be held virtually on Wednesday, June 10, 2026, at 10:00 a.m., Pacific Daylight Time. The virtual Annual Meeting can be accessed by visiting www.virtualshareholdermeeting.com/VCYT2026, where you will be able to listen to the meeting live, submit questions and vote online. We believe that a virtual stockholder meeting provides greater access to those who may want to attend, and therefore we have chosen this over an in-person meeting. This approach also lowers costs, enables greater participation and is better for the environment.

The matters to be acted upon are described in the accompanying Notice of Annual Meeting and Proxy Statement.

After reading the Proxy Statement, please vote promptly to ensure that your shares will be represented. Whether or not you plan to attend the meeting, please vote by telephone or the internet, or sign and return a proxy card to ensure your representation at the meeting. Your vote is important.

We look forward to seeing you at the Annual Meeting.

Sincerely yours,

/s/ Marc Stapley

Marc Stapley

Chief Executive Officer

April 22, 2026

6000 Shoreline Court, Suite 300
South San Francisco, CA 94080

Notice of Annual Meeting of Stockholders

to be held Wednesday, June 10, 2026

To the Stockholders of Veracyte, Inc.:

The 2026 Annual Meeting of Stockholders (the ”Annual Meeting”) of Veracyte, Inc., a Delaware corporation (“Veracyte,” the “company,” “we,” “us” or “our”), will be held virtually via the internet at www.virtualshareholdermeeting.com/VCYT2026 on Wednesday, June 10, 2026, at 10:00 a.m., Pacific Daylight Time, for the following purposes:

1			To elect nine directors to serve until the 2027 Annual Meeting of Stockholders or until their successors are duly elected and qualified;
2			To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026;
3			To approve, on a non-binding advisory basis, the compensation paid by us to our named executive officers as disclosed in the Proxy Statement;
4			To approve an amendment to our Veracyte, Inc. 2023 Equity Incentive Plan; and
5			To transact such other business as may properly come before the Annual Meeting and any postponement or adjournment of the Annual Meeting.

Only stockholders of record as of the close of business on April 15, 2026, are entitled to notice of and to vote at the Annual Meeting and any postponement or adjournment thereof.

It is important that your shares be represented at this meeting. Even if you plan to attend the meeting, we hope that you will vote as soon as possible. Voting now will ensure your representation at the Annual Meeting regardless of whether you attend. You may vote on the internet, by telephone or by mailing the enclosed proxy card or voting instruction form. You may also attend the Annual Meeting and vote and submit questions during the Annual Meeting via the internet at www.virtualshareholdermeeting.com/VCYT2026. Please review the instructions on page 79 of the Proxy Statement and your proxy card or voting instruction form regarding each of these voting options.

By Order of the Board of Directors

/s/ Marc Stapley

Marc Stapley

Chief Executive Officer

South San Francisco, California

April 22, 2026

Date

Wednesday,

June 10, 2026

Time

10:00 a.m. Pacific

Daylight Time

Location

www.virtualshareholdermeeting.com/VCYT2026

Record Date

Close of business on

April 15, 2026

IMPORTANT NOTICE

Regarding the availability of proxy materials for the Annual Meeting to be held on June 10, 2026.

The Proxy Statement and Annual Report are available at www.proxyvote.com.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This proxy statement (”Proxy Statement”) contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. When used in this Proxy Statement, the words “may,” “will,” “potentially,” “expect,” “anticipate,” “intend,” “estimate,” “plan,” “project,” “believe,” “continuing,” “ongoing,” “could,” “would,” or the negative of these terms and similar expressions are intended to identify forward-looking statements. These are statements that relate to future events and include but are not limited to, forward-looking statements that involve risks and uncertainties; our ability to execute our short-term and long-term growth strategies; our plans for environmental, corporate governance and social responsibility, and other future events.

These forward-looking statements are only predictions and may differ materially from actual results due to a variety of factors, including, but not limited to, the risks and uncertainties listed in our Annual Report on Form 10-K for the year ended December 31, 2025, filed with the U.S. Securities and Exchange Commission on February 26, 2026, and other reports filed with the U.S. Securities and Exchange Commission. You should not place undue reliance on these forward-looking statements, which speak only as of the date hereof. We undertake no obligation to update these forward-looking statements to reflect subsequent events or circumstances, except as required by law.

Table of Contents

						Page
			Proxy Statement Summary			1
			PROPOSAL ONE Election of Directors			5
			Corporate Governance			14
			2025 Director Compensation			21
			PROPOSAL TWO Ratification of Appointment of Independent Registered Public Accounting Firm			24
			PROPOSAL THREE Advisory Vote on the Compensation of Our Named Executive Officers			26
			PROPOSAL FOUR Approval of Amendment to the Veracyte, Inc. 2023 Equity Incentive Plan			27
			Security Ownership of Certain Beneficial Owners and Management			38
			Executive Officers			41
			Executive Compensation			44
			Equity Compensation Plan Information			71
			Report of the Audit Committee of the Board of Directors			72
			Certain Relationships and Related Party Transactions			73
			Additional Information			74
			Other Matters and Available Information			76
			General Information			77
			Appendix A			A-1

Proxy Statement Summary

This summary highlights information contained elsewhere in this Proxy Statement. You should read the entire Proxy Statement before voting.

Meeting Details

			Date
			Wednesday, June 10, 2026

			Time
			10:00 a.m. Pacific Daylight Time

			Location
			Online at www.virtual shareholdermeeting.com/VCYT2026

			Record Date
			Close of business on April 15, 2026

How to Vote

			By Phone
			Call 1-800-690-6903 by June 9, 2026

			By Mail
			Sign, date and return your proxy card in the enclosed envelope by June 9, 2026

			By Internet
			Visit www.proxyvote.com until June 9, 2026

			Virtually
			Attend the annual meeting at www.virtualshareholdermeeting. com/VCYT2026

Voting Recommendations

			Proposal						Board Recommendation			Page Reference
			1			To elect nine directors to serve until the 2027 Annual Meeting of Stockholders or until their successors are duly elected and qualified			FOR			5
			2			To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026			FOR			24
			3			To approve, on a non-binding advisory basis, the compensation paid by us to our named executive officers as disclosed in this Proxy Statement			FOR			26
			4			To approve an amendment to our Veracyte, Inc. 2023 Equity Incentive Plan			FOR			27

Veracyte 2026 Proxy Statement 1

Proxy Statement Summary

Director Nominees and Board Summary

Committee Membership

Name and Primary Position

Age

Director Since

Independent

Audit

Nominating and Corporate Governance

Compensation

Regulatory and Compliance

Marc Stapley Chief Executive Officer, Veracyte

56

2021

N

Eliav Barr, M.D. Head of Global Clinical Development and Chief Medical Officer, Merck Research Laboratories

61

2022

Y

l

Muna Bhanji, R.Ph. Founder and President, Tiba Global Access LLC

63

2021

Y

l

l

Karin Eastham $ Board of Directors member, Personalis, Inc.

76

2012

Y

l

C

Robert S. Epstein, M.D., M.S. « Board of Directors member, Fate Therapeutics, Inc. and Illumina, Inc.

70

2015

Y

C

Jens Holstein $ Former Chief Financial Officer, BioNTech SE

62

2020

Y

C

l

Evan Jones $ Managing member, jVen Capital, LLC

69

2008

Y

l

l

C

Tom Miller, Ph.D. Co-founder and Chief Executive Officer, Iambic Therapeutics

47

2024

Y

l

Brent Shafer Chair, Baxter International, Inc. and Board of Directors member, Tactile Systems Technology, Inc.

68

2024

Y

l

l Committee Member C Committee Chairperson « Chair of the Board $ Audit Committee Financial Expert

Board Composition

Gender

Age

Tenure

Independence

2 Veracyte 2026 Proxy Statement

Proxy Statement Summary

2025 Financial and Business Highlights and Recent Company Developments

16% Increase in revenue from $445.8M in 2024 to $517.1M in 2025 179,528 Total test volume for 2025, an increase of 18% from the prior year $136.3M Cash generated from operating activities for the full year 2025 $412.9M Cash, cash equivalents and short-term investments as of end of year 2025

•Launched our Decipher test for use in the metastatic population in June 2025, engaging physicians across high-risk biopsy, radical prostatectomy and metastatic patients to further the utility of Decipher in aiding decision-making regarding treatment intensification across all risk categories.

•Transitioned Afirma volume to the v2 transcriptome to improve the efficiency of the Afirma testing business, while providing a platform for future product launches, such as Prosigna LDT.

•Expanded clinical evidence for Decipher Prostate with over 80 publications, posters and presentations, including a presentation at ASTRO 2025 on the first validation data from the BALANCE trial that demonstrated the PAM50 molecular signature predicts hormone therapy benefit in men with recurrent prostate cancer using Decipher GRID and the publication of data from the STAMPEDE trial in Cell showing that the Decipher Prostate Genomic Classifier predicts chemotherapy benefit in patients with metastatic prostate cancer in an effort to help patients avoid unnecessary toxicity.

•Added to the clinical data demonstrating that Prosigna accurately classifies patients’ risk of recurrence with the presentation of ten-year clinical outcomes data from the OPTIMA Prelim study at ESMO Breast Cancer Annual Congress.

•Completed NIGHTINGALE clinical utility trial enrollment for the Percepta Nasal Swab test.

Governance and Board Practices

We are committed to good corporate governance, which strengthens the accountability of our Board of Directors and promotes the long-term interests of our stockholders. The list below highlights our independent board and leadership and other corporate governance practices, as discussed further in this Proxy Statement.

One-Year Terms For all directors commencing at the Annual Meeting Majority Voting Standard For uncontested elections of directors Only Independent Directors On all Board of Directors committees Regular Executive Sessions Conducted by independent directors without management present

•Majority of directors are independent (eight out of nine current directors).

•Board leadership structure with an independent Chair of the Board of Directors.

•All committees of our Board of Directors, including our Regulatory and Compliance Committee, are composed only of independent directors.

Veracyte 2026 Proxy Statement 3

Proxy Statement Summary

•Following approval by our stockholders at the 2023 Annual Meeting of Stockholders (the “2023 Annual Meeting”), we filed a Restated Certificate of Incorporation (the “Restated Certificate”) to implement a declassification of the Board of Directors over a three-year period and provide for the annual election of directors for one-year terms, commencing upon the expiration of the directors’ then-current terms. Beginning with the Annual Meeting, all director nominees will stand for election for only one-year terms, with such terms expiring at the next Annual Meeting of Stockholders.

•Our Nominating and Corporate Governance Committee oversees our programs relating to corporate responsibility and sustainability, including Environmental, Social, and Corporate Governance (“ESG”), in collaboration with our Audit Committee, Compensation Committee, and Regulatory and Compliance Committee on certain ESG matters, as appropriate and as described in each respective committee charter.

•We provide annual reporting on corporate responsibility and sustainability initiatives for those investors who are focused on these topics.

•We employ comprehensive enterprise risk management practices, including oversight of cybersecurity, data privacy, legal, compliance and regulatory matters, and other critical evolving areas, such as corporate sustainability initiatives.

•Independent directors conduct regular executive sessions without management present.

•Directors maintain open communication and strong working relationships among themselves and have regular and direct access to management.

•Directors conduct a robust annual Board of Directors and committee self-assessment process.

•We have a majority voting standard for uncontested elections of directors.

•We have robust related party transaction standards for any direct or indirect involvement of a director or member of management in the company’s business activities.

•We have robust stock ownership guidelines that require our C-Level executive officers and the non-employee directors on our Board of Directors to hold shares of our common stock, as further discussed herein.

•We have a clawback policy, adopted in accordance with the Nasdaq Stock Market listing standards and compliant with the Securities and Exchange Commission (the “SEC”) rules, that provides for the recoupment of certain executive officer incentive compensation in the event we are required to restate our financial statements.

4 Veracyte 2026 Proxy Statement

PROPOSAL ONE

Election of Directors

Directors and Nominees

The number of directors is currently set at nine. Following approval by our stockholders at the 2023 Annual Meeting, we filed a Restated Certificate to implement a declassification of the Board of Directors over a three-year period and provide for the annual election of directors for one-year terms, commencing upon the expiration of the directors’ then-current terms. As of the date of the Annual Meeting, two directors are serving or completing a three-year term and seven directors are serving or completing a one-year term, as follows:

•Robert S. Epstein, M.D., M.S., and Evan Jones were elected to the Board of Directors at our 2023 Annual Meeting, and their three-year terms will expire at the Annual Meeting; and

•Eliav Barr, Muna Bhanji, Karin Eastham, Jens Holstein, Tom Miller, Brent Shafer and Marc Stapley were elected to the Board of Directors at our 2025 Annual Meeting of Stockholders, and their one-year terms will expire at the Annual Meeting.

YOUR VOTE IS IMPORTANT

Our Board

of Directors

recommends a

vote “FOR” this

proposal

Dr. Epstein is currently the Chair of the Board of Directors and will continue to serve in such role following the Annual Meeting. The Nominating and Corporate Governance Committee of the Board of Directors has recommended, and the Board of Directors has designated, Dr. Epstein, Dr. Barr, Ms. Bhanji, Ms. Eastham, Mr. Holstein, Mr. Jones, Dr. Miller, Mr. Shafer and Mr. Stapley as the nominees for directors at the Annual Meeting to serve until the 2027 Annual Meeting or until their successors are duly elected or qualified.

Veracyte 2026 Proxy Statement 5

Proposal One

Director Biographical Information

Names of the director nominees and the other members of the Board of Directors and certain biographical information as of April 15, 2026, are set forth below:

Marc Stapley has served as our Chief Executive Officer since June 1, 2021, and as a member of our Board of Directors since June 8, 2021. He served as the Chief Executive Officer of Helix, Inc., a genomics company, from 2019 to 2021. Prior to that, Mr. Stapley served in key managerial positions at Illumina, Inc., a genetic sequencing company, including as Chief Financial Officer from 2012 to 2017, as Chief Administrative Officer from 2015 to 2017, and as Executive Vice President from 2017 to 2019. From 2009 to 2012, Mr. Stapley served as Senior Vice President, Finance at Pfizer Inc., a pharmaceutical company. Mr. Stapley has served as a member of the board of directors of Glaukos Corporation, an ophthalmic medical technology company, since 2014, and has served as a member of the board of directors of Helix since 2015. Mr. Stapley holds a B.Sc. (Honors) in Mathematics from The University of Reading (England).

We believe that Mr. Stapley is qualified to serve on our Board of Directors due to his significant leadership experience in the diagnostics and genetic sequencing fields, as well as his experience as our Chief Executive Officer and his service on the boards of directors of other life sciences and healthcare companies.

Age: 56

Director Since: 2021

Eliav Barr, M.D., has served on our Board of Directors since August 2022. Dr. Barr has served as Head of Global Clinical Development and Chief Medical Officer at Merck Research Laboratories (“MRL”), a division of Merck & Co., Inc. (“Merck”), since April 2022. He is also the Chairperson of the Late Development Review Committee at MRL, the governance committee that oversees the development programs for pipeline and in-line products in the Cardiovascular, Diabetes/Endocrine/Metabolism, Immunology, Neurology, Oncology, Psychiatry, Respiratory, and Vaccines/Infectious Diseases therapeutic areas. Dr. Barr has held numerous leadership positions within MRL since joining the company in 1995, including serving as Senior Vice President, Global Medical and Scientific Affairs from 2018 to 2022. Prior to joining Merck, Dr. Barr pursued post-doctoral training at the University of Michigan and was on faculty at the University of Chicago. He holds a B.S. from Pennsylvania State University and an M.D. from Jefferson Medical College of Thomas Jefferson University and completed an Internal Medicine residency and Cardiology Fellowship at Johns Hopkins.

We believe that Dr. Barr is qualified to serve on our Board of Directors due to his knowledge of the life sciences industry, his medical experience and his extensive executive and senior management experience in the biopharmaceutical industry.

Age: 61

Director Since: 2022

Committees:

Regulatory and Compliance

6 Veracyte 2026 Proxy Statement

Proposal One

Muna Bhanji, R.Ph., has served on our Board of Directors since March 2021. Ms. Bhanji is the Founder and President of Tiba Global Access LLC, an independent senior advisory focused on commercialization and market access strategy development, serving the biopharmaceutical industry. Her prior experience includes an over 34-year tenure at Merck, during which she held a number of senior leadership roles within the U.S. and Global commercial organizations, including Senior Vice President, Oncology, Senior Vice President, Hospital & Specialty Franchises and Senior Vice President, Global Market Access & Policy. In addition to serving as a director on a private company board, she currently serves on the board of directors of Intellia Therapeutics, Inc., Cytokinetics, Inc., Ardelyx, Inc. and Corus International, an international NGO. Prior to that, she had served on the boards of Possible Health, a Nepal-based NGO and the Foundation of Managed Care Pharmacy and had also chaired Merck’s Supervisory Board in the Netherlands. Ms. Bhanji earned her Bachelor of Pharmacy degree from Rutgers School of Pharmacy and an M.B.A. from St. Joseph’s University.

We believe that Ms. Bhanji is qualified to serve on our Board of Directors due to her extensive experience in strategic roles in the biopharmaceutical industry.

Age: 63

Director Since: 2021

Committees:

Nominating and Corporate Governance

Regulatory and Compliance

Karin Eastham has served on our Board of Directors since December 2012. Ms. Eastham has served on the board of directors of Personalis, Inc., a biotechnology company, since September 2019, and has served as chair of the board of directors of Personalis, Inc. since May 2022. She also has served on the boards of directors of Nektar Therapeutics, a biopharmaceutical company, and Geron Corporation, a biotechnology company. From 2004 to 2008, Ms. Eastham served as Executive Vice President and Chief Operating Officer, and as a member of the Board of Trustees, of the Burnham Institute for Medical Research, a nonprofit corporation engaged in biomedical research. From 1999 to 2004, Ms. Eastham served as Senior Vice President, Chief Financial Officer and Secretary of Diversa Corporation, a biotechnology company. Ms. Eastham previously held similar positions with several life sciences companies. Ms. Eastham also previously served as a member of the board of directors of Illumina, Inc. from 2004 to 2019, MorphoSys AG from 2012 to 2017, Amylin Pharmaceuticals, Inc. from 2005 until its acquisition in 2012, Genoptix, Inc. from 2008 until its acquisition in 2011, Tercica, Inc. from 2003 until its acquisition in 2008, and Trius Therapeutics, Inc. from 2007 until its acquisition in 2013. Ms. Eastham received a B.S. in Accounting and an M.B.A. from Indiana University and is a Certified Public Accountant (inactive).

We believe that Ms. Eastham is qualified to serve on our Board of Directors due to her experience as a director of numerous life sciences companies, as well as her extensive senior management experience in the biopharmaceutical industry.

Age: 76

Director Since: 2012

Committees:

Compensation (Chair) Audit

Veracyte 2026 Proxy Statement 7

Proposal One

Robert S. Epstein, M.D., M.S., has served on our Board of Directors since January 2015 and is Chair of the Board of Directors. Dr. Epstein has served as a strategic consultant to life sciences companies since 2013. From 2010 to 2012, Dr. Epstein served as President of the Medco-UBC Division and as Chief Research and Development Officer of Medco Health Solutions, Inc., a managed healthcare company. Prior to that, Dr. Epstein served as Medco’s Chief Medical Officer from 1997 to 2010. Dr. Epstein has served as a member of the board of directors of Fate Therapeutics, Inc. since March 2014 and Illumina, Inc. since November 2012. Dr. Epstein previously served as a member of the board of directors of Aveo Pharmaceuticals, Inc. from 2012 to 2014 and was Chairman of the Board of Decipher Biosciences, Inc. from 2019 until 2021. Dr. Epstein is the former president of the International Society of Pharmacoeconomics and Outcomes Research, and served on the board of directors of the Drug Information Association and the International Society of Quality of Life. He has also served on the Centers for Disease Control and Prevention Evaluation of Genomic Applications in Practice & Prevention Stakeholder Committee and the Agency for Healthcare Research and Quality Centers for Education and Research on Therapeutics Committee. Dr. Epstein holds a B.S. in Biomedical Science and an M.D. from the University of Michigan, and an M.S. in Preventive Medicine from the University of Maryland.

We believe that Dr. Epstein is qualified to serve on our Board of Directors due to his extensive experience in strategic roles in healthcare companies, his expertise in reimbursement and FDA regulation, and his experience as a director of publicly traded companies in the life sciences industry.

Age: 70

Director Since: 2015

Committees:

Nominating and Corporate Governance (Chair)

Jens Holstein has served on our Board of Directors since August 2020. From 2021 to 2025, Mr. Holstein served as Chief Financial Officer of BioNTech SE, a biotechnology company. Previously, Mr. Holstein served as Chief Financial Officer of MorphoSys AG, a biopharmaceutical company, from 2011 to 2020. From 1995 to 2011, Mr. Holstein held various positions at Fresenius SE & Co. KGaA, a healthcare company, including regional Chief Financial Officer of Fresenius Kabi AG for the EME (Europe/Middle East) region and managing director of Fresenius Kabi Deutschland GmbH. Prior to joining Fresenius, Mr. Holstein spent several years in the consulting industry, with positions in Frankfurt and London. Mr. Holstein served as a director of InflaRx N.V., a biopharmaceutical company, from 2018 to 2020 and on the Advisory Board of Mallia Therapeutics from July 2025 to February 2026. Mr. Holstein currently serves on the Advisory Board of Deutsche Bank AG since August 2024 and on the Advisory Board of Secarna Pharmaceuticals since January 2026. Mr. Holstein holds a diploma in Business Administration from the University of Münster, Germany.

We believe that Mr. Holstein is qualified to serve on our Board of Directors due to his significant experience as the chief financial officer of a publicly traded biopharmaceutical company, as well as his extensive experience in management positions in life science and healthcare companies.

Age: 62

Director Since: 2020

Committees:

Audit (Chair)

Compensation

8 Veracyte 2026 Proxy Statement

Proposal One

Evan Jones has served on our Board of Directors since February 2008. Mr. Jones has also served as Managing Member of jVen Capital, LLC, a life sciences investment company, since 2007. He served as Chief Executive Officer of OpGen, Inc., a genetic analysis company, from 2013 to 2020, and also served as a director from 2009 to 2021. He was a co-founder of Digene Corporation, a biotechnology company focused on women’s health and molecular diagnostic testing, serving as chairman of its board of directors from 1995 until its acquisition in 2007 and served as Chief Executive Officer from 1990 to 2006 and as President from 1990 to 1999. Mr. Jones served as a member of the board of directors of Foundation Medicine, Inc. until its merger with Roche Holdings, Inc. in 2018. Mr. Jones served as a director of Fluidigm Corporation from 2011 to 2017. Mr. Jones currently serves on the board of directors of ProtaGene GmbH, a private company, and Brightside Health, Inc., a private company. Mr. Jones received a B.A. in biochemistry from the University of Colorado and an M.B.A. from The Wharton School at the University of Pennsylvania.

We believe that Mr. Jones is qualified to serve on our Board of Directors due to his knowledge of the life sciences industry and his experience as a chief executive officer and as a board member of other publicly traded and privately held life sciences companies.

Age: 69

Director Since: 2008

Committees:

Regulatory and Compliance (Chair)

Audit

Nominating and Corporate Governance

Tom Miller, Ph.D., has served on our Board of Directors since September 2024. Dr. Miller is a scientist and entrepreneur with a focus on the nexus of AI, chemistry and biology. Since 2020, he has served as Co-founder and Chief Executive Officer of Iambic Therapeutics, a clinical-stage biotechnology company that is disrupting the therapeutics landscape with a unique, AI-driven, drug-discovery platform. Prior to this, he served for over ten years as a professor at the California Institute of Technology (Caltech), receiving tenure, publishing over 140 peer-reviewed articles and patents, and receiving numerous awards for research and entrepreneurial excellence. Dr. Miller earned a B.S. in Chemistry and Mathematics from Texas A&M University and a Ph.D. in Theoretical Chemistry from the University of Oxford.

We believe that Dr. Miller is qualified to serve on our Board of Directors due to his expertise in AI, emerging technologies and data analytics.

Age: 47

Director Since: 2024

Committees:

Regulatory and Compliance

Veracyte 2026 Proxy Statement 9

Proposal One

Brent Shafer has served on our Board of Directors since September 2024. Mr. Shafer is a veteran healthcare industry leader with over 40 years of experience in health information technology, medical devices and other related industries. Mr. Shafer has served as Non-Executive Chair of Baxter International, Inc. since August 2025 and has served as a director of Baxter International, Inc. since May 2022. Shafer served as lead independent director of Baxter International, Inc. from April 2023 to February 2025, prior to his appointment as Interim CEO and Chair of the Board from February 2025 to August 2025. From 2018 to 2021, he was Chairman and Chief Executive Officer of Cerner Corporation, which was acquired by Oracle Corporation. Prior to that, Mr. Shafer held key roles at Royal Philips, the health technology company, including as Chief Executive Officer of Philips North America and of the Philips Home Healthcare Solutions business. Before joining Philips, Mr. Shafer was Vice President and General Manager of Hillrom’s Patient Care Environment Division and worked at GE Medical Systems in key sales, marketing and general management positions. Following early roles at Intermountain Healthcare’s Primary Children’s Hospital and Johnson & Johnson, Mr. Shafer held senior roles at Hewlett-Packard’s Medical Products Group. He currently serves on the board of Tactile Systems Technology, Inc. Mr. Shafer holds a B.S. in Communications from the University of Utah.

We believe that Mr. Shafer is qualified to serve on our Board of Directors due to his extensive experience in health information technologies, medical devices and various healthcare solutions and his experience as a chief executive officer and a board member of other publicly traded companies.

Age: 68

Director Since: 2024

Committees:

Compensation

Required Vote

A director nominee shall be elected to the Board of Directors if the number of votes cast “FOR” such director nominee’s election exceeds the number of votes cast “AGAINST” such director nominee’s election. Abstentions and broker non-votes with respect to any director nominee will have no effect as they are not considered votes cast for the foregoing purpose. This proposal is considered to be a non-routine proposal on which a broker or other nominee does not have discretionary authority to vote.

The Board of Directors recommends a vote “FOR” the election of each of the nine director nominees: Eliav Barr, Muna Bhanji, Karin Eastham, Robert S. Epstein, Jens Holstein, Evan Jones, Tom Miller, Brent Shafer and Marc Stapley.

10 Veracyte 2026 Proxy Statement

Proposal One

Director Nominations

The Board of Directors has as an objective that its membership be composed of experienced and dedicated individuals with a range of backgrounds, perspectives and skills. The Nominating and Corporate Governance Committee has the responsibility to identify, evaluate, recruit and recommend qualified candidates to the Board of Directors for appointment, nomination or election.

The Nominating and Corporate Governance Committee evaluates and selects candidates for director based on their character, judgment, range of backgrounds and experience, business acumen and ability to act on behalf of all stockholders. The Nominating and Corporate Governance Committee believes that nominees for director should have experience, such as experience in management, legal, accounting, finance, marketing, industry, technology and AI or cybersecurity knowledge, that may be useful to our company and the Board of Directors, high personal and professional ethics, and the willingness and ability to devote sufficient time to effectively carry out his or her duties as a director. The Nominating and Corporate Governance Committee also believes that service as a director of other public companies provides experience and perspective that may be useful to our company and the Board of Directors. Our company has no formal diversity policy for Board of Directors members.

The Nominating and Corporate Governance Committee believes it appropriate for at least one, and preferably multiple, members of the Board of Directors to meet the criteria for an “audit committee financial expert” as defined by the SEC rules, and that a majority of the members of the Board of Directors meet the definition of “independent director” under the rules of The Nasdaq Stock Market. The Nominating and Corporate Governance Committee believes it appropriate for certain key members of our management — currently, our Chief Executive Officer — to participate as members of the Board of Directors.

Prior to each Annual Meeting of Stockholders, the Nominating and Corporate Governance Committee identifies director nominees by evaluating the current directors whose term will expire at such Annual Meeting of Stockholders and who are willing to continue in service. These candidates are evaluated based on the criteria described above, including as demonstrated by the candidate’s prior service as a director, and the needs of the Board of Directors with respect to the particular talents and experience of its directors. In the event that a director does not wish to continue in service, or if a vacancy is created on the Board of Directors as a result of a resignation, an increase in the size of the Board of Directors or other event, then the Nominating and Corporate Governance Committee will consider various candidates for Board of Directors membership, including those suggested by the members of the Nominating and Corporate Governance Committee, by other board members, by any search firm engaged by the Nominating and Corporate Governance Committee and by stockholders, as applicable. Each of the nominees presented for election at this Annual Meeting is an incumbent member of the Board of Directors standing for re-election as a director.

In addition, our amended and restated bylaws contain provisions that address the process by which a stockholder may nominate an individual to stand for election to the Board of Directors at an Annual Meeting of Stockholders. In order to nominate a candidate for director, a stockholder must give timely notice in writing to our Secretary and otherwise comply with the procedures set forth in our amended and restated bylaws, including with respect to the form and content of such notice.

In addition, stockholders who intend to solicit proxies in support of director nominees other than the company’s nominees at an Annual Meeting of Stockholders must also comply with the additional requirements of Rule 14a-19(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). To be timely for our 2027 Annual Meeting, our amended and restated bylaws provide that we must have received the stockholder’s notice not earlier than 5:00 p.m. Eastern Time on February 10, 2027, and not later than 5:00 p.m. Eastern Time on March 12, 2027.

Stockholder nominations must be made in accordance with the procedures outlined in, and include the information required by, our amended and restated bylaws and must be addressed to: Secretary, Veracyte, Inc., 6000 Shoreline Court, Suite 300, South San Francisco, California 94080. You may obtain a copy of the full text of this provision of the amended and restated bylaws by writing to our Secretary at the above address.

Veracyte 2026 Proxy Statement 11

Proposal One

Director Expertise, Experience and Attributes

The Board of Directors is comprised of a broad mix of directors with complementary expertise, experience and attributes, as summarized in the table below. This table is not exhaustive and our directors may also have additional skills, experience or attributes in addition to what is set forth below.

Eliav Barr

Muna Bhanji

Karin Eastham

Robert Epstein

Jens Holstein

Evan Jones

Tom Miller

Brent Shafer

Marc Stapley

Skills or Experience

Senior Leadership

Diagnostics

Biopharma

U.S. Healthcare Reimbursement

Global Enterprise

Accounting and Auditing (including Sustainability Reporting)

Public Board

*

*

*

*

Technology, Innovation and AI

Cybersecurity

Regulatory and Risk Oversight

Commercialization and Market Access

Sales and Marketing

*    Public Board Chair Experience

			Skill or Experience			Description
			Senior Leadership			Extensive executive, director or senior management experience in leadership and governance roles across corporate, government or public sector organizations.
			Diagnostics			Expertise in the medical diagnostics industry, including personalized medicine, laboratory services and strategic oversight.
			Biopharma			Significant experience in the biotechnology and life sciences sectors, including leadership in operations and strategic growth.
			U.S. Healthcare Reimbursement			Expertise in U.S. healthcare reimbursement systems, including reimbursement pathways, market access strategies and regulatory compliance.
			Global Enterprise			Experience leading global operations, including international market expansion, cross-border strategy and complex regulatory landscapes.
			Accounting and Auditing (including Sustainability Reporting)			Leadership or senior management experience with demonstrated financial proficiency and expertise, including accounting, auditing and sustainability reporting.
			Public Board			Experience serving on the board(s) of other public corporations, with a strong understanding of fiduciary duties, governance and shareholder engagement.
			Technology, Innovation and AI			Experience in technology strategy, digital transformation, and innovation, including applications of AI and data analytics.
			Cybersecurity			Experience in cybersecurity risk management, including threat assessment, data protection and implementation of security strategies.
			Regulatory and Risk Oversight			Experience in regulatory compliance and enterprise risk management, including oversight of legal, operational and strategic risks.
			Commercialization and Market Access			Experience in bringing products from development to market, including reimbursement and market access.
			Sales and Marketing			Background in leading sales and marketing initiatives, including brand strategy, customer engagement and market positioning.

12 Veracyte 2026 Proxy Statement

Proposal One

Director Tenure and Age Distribution

We also believe that our current Board of Directors composition represents an effective balance with respect to director tenure and age. Recent director additions provide the Board of Directors with fresh perspectives and a range of backgrounds and experiences, while directors with longer tenure provide continuity and valuable insight into our business and strategy. The following table provides information regarding the tenure and age distribution of our Board of Directors as of April 15, 2026.

Majority Voting Standard for Director Elections and Director Resignation Policy

Our amended and restated bylaws provide for a majority voting standard for uncontested elections of directors, which provides that, in uncontested director elections, a director nominee will be elected only if the number of votes cast FOR the director nominee exceeds the number of votes cast AGAINST the director nominee. In addition, we have adopted a Director Resignation Policy, which is intended to address a “holdover director” under the Delaware General Corporation Law (the “DGCL”), which is an incumbent director who fails to receive the requisite number of votes for re-election at an Annual Meeting of Stockholders and is required to remain in office until a successor is duly elected and qualified. Our Director Resignation Policy requires each incumbent director nominee at an Annual Meeting of Stockholders that does not receive the requisite number of shareholder votes for re-election to, promptly after such Annual Meeting of Stockholders, submit a contingent resignation letter with such resignation, effective only upon (i) receipt of the certification of election results for such meeting, certifying such director nominee’s failure to receive the requisite number of votes for re-election and (ii) our Board of Directors’ acceptance of such resignation. Upon receipt of any such contingent resignation letter, our Nominating and Corporate Governance Committee will promptly make a recommendation to our Board of Directors as to whether to accept or reject the resignation, or whether other action should be taken. Our Board of Directors will act on the Nominating and Corporate Governance Committee’s recommendation and publicly disclose its decision and the rationale behind it within 90 days from the date of the certification of the election results.

Director Independence

The Board of Directors has determined that, except for Mr. Stapley, each individual who currently serves as a member of our Board of Directors is, and each individual who served as a member of our Board of Directors in 2025 was, an “independent director” within the meaning of applicable rules of The Nasdaq Stock Market (“Nasdaq”). The Nasdaq independence definition includes a series of objective tests, including that the director is not, and has not been for at least three years, one of our employees and that neither the director nor any of his or her family members has engaged in various types of business dealings with us. As a result, Mr. Stapley is not considered independent as he serves as our Chief Executive Officer. In addition, as required by Nasdaq rules, for each of Ms. Bhanji, Ms. Eastham, Dr. Epstein, Dr. Barr, Mr. Holstein, Mr. Jones, Dr. Miller and Mr. Shafer, the Board of Directors considered their relationships and transactions with us and our security holders and has made a subjective determination that no relationships exist, which, in the opinion of our Board of Directors, would interfere with the exercise of their independent judgment in carrying out the responsibilities of a director. In making these determinations, our Board of Directors reviewed and discussed information provided by the directors with regard to each director’s business and personal activities and relationships as they may relate to us and our management. There are no family relationships among any of our directors or executive officers.

Age

Tenure

Independence

Veracyte 2026 Proxy Statement 13

Corporate Governance

Structure of the Board of Directors

Beginning with the Annual Meeting, all directors will stand for election for one-year terms. Our Board of Directors was previously divided into three classes, with each class serving staggered three-year terms. As part of our regular engagement with our stockholders and our commitment to ESG, including our regular review of our corporate governance structure and evaluation of recent trends in corporate governance, following approval by our stockholders at the 2023 Annual Meeting, we filed a Restated Certificate to implement a declassification of the Board of Directors over a three-year period, and provide for the annual election of directors for one-year terms, commencing upon the expiration of the directors’ then-current terms. The declassification of our Board of Directors began with the directors nominated for election at the 2024 Annual Meeting, and will be effective for all directors as of the Annual Meeting.

Board Leadership Structure and Role in Risk Oversight

Our Nominating and Corporate Governance Committee periodically considers the leadership structure of our Board of Directors and makes such recommendations to our Board of Directors as our Nominating and Corporate Governance Committee deems appropriate. Our Board of Directors believes it is important to have flexibility in selecting the Chair of the Board of Directors and our Board of Directors leadership structure. The Board of Directors believes that it is currently in the best interests of Veracyte and its stockholders for Dr. Epstein, an independent director, to serve as our Chair. Dr. Epstein has served on our Board of Directors since January 2015 and has deep familiarity with our business and our industry, including in-depth knowledge of the issues, opportunities and challenges facing our company and its business, making him well qualified to serve as our Chair. The Board of Directors believes that this leadership structure provides our Board of Directors with significant strengths and an independent leadership perspective. In his capacity as Chair, Dr. Epstein also serves ex officio on all committees of the Board of Directors and chairs executive sessions of the independent directors. The Board of Directors retains the authority to modify this structure as it deems appropriate. In making Board of Directors leadership structure determinations, the Board of Directors considers many factors, including the specific needs of the business and what is in the best interests of our stockholders. Any changes to the leadership structure of our Board of Directors, if made, will be disclosed on the Investor Relations portion of our website and in our proxy materials for the next Annual Meeting of Stockholders. Our Board of Directors, in its sole discretion, may seek input from our stockholders on the leadership structure of the Board of Directors.

Our Board of Directors is responsible for overseeing the overall risk management process at Veracyte. The responsibility for managing risk rests with executive management, while the committees of the Board of Directors and the Board of Directors as a whole participate in the oversight process. The risk oversight process of the Board of Directors builds upon

			GOVERNANCE HIGHLIGHTS
						One-year terms for all directors
						8 of 9 directors are independent
						Board leadership structure with an independent Chair of the Board
						Annual reporting on corporate responsibility and sustainability initiatives
						Comprehensive enterprise risk management practices
						Robust annual Board of Directors and committee self-assessment process
						Majority voting standard for uncontested elections of directors
						Robust related party transaction standards
						Robust stock ownership guidelines for directors and executives

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Corporate Governance

management’s enterprise risk management assessment and mitigation processes, which include reviews of long-term strategic and operational planning, executive talent acquisition, retention, and development, compensation and evaluation, reputational, regulatory and legal compliance including those laws and regulations relating to product and service promotional activities, Medicare billing and reimbursement and provision of laboratory services, cybersecurity, technology and AI, privacy and financial reporting and internal controls. The Board of Directors considers strategic risks and opportunities and regularly receives reports from executive management regarding specific aspects of risk management, including, but not limited to, our ability to expand our platforms, products and services globally, as well as our ability to potentially inform diagnosis and treatment decisions in new oncology indications. Our Board of Directors reviews strategic and operational risk in the context of discussions, question-and-answer sessions and reports from the management team at each regular Board of Directors meeting, receives reports on all significant committee activities at each regular Board of Directors meeting, and evaluates the risks inherent in significant transactions. Management conducts an annual enterprise risk management assessment. In 2025, management enhanced this annual process by using an independent third-party platform to identify and assess key enterprise risks in terms of impact, likelihood and current control effectiveness. Following such assessment, key risk areas were shared with the Board of Directors and management assigned owners to each risk who were tasked with reviewing and assessing the contributing factors, evaluating management’s existing risk mitigation capabilities, identifying risk mitigation enhancement considerations and potential future state activities, assessing resources needed to implement desired mitigation enhancements and tracking performance and mitigation progress.

Each committee of the Board of Directors meets with key management personnel and representatives of outside advisors to oversee risks associated with their respective principal areas of focus both with management present and in separate executive sessions, as described below. We believe this division of responsibilities is an effective approach for addressing the risks we face and that our Board of Directors leadership structure supports this approach. The Audit Committee reviews (i) our major financial risks and enterprise exposures and the steps management has taken to monitor or mitigate such risks and exposures, including our risk assessment and risk management policies, as well as cybersecurity and data privacy risks and risk exposures in other areas, as the Audit Committee deems appropriate from time to time; (ii) our programs for promoting and monitoring compliance with applicable SEC legal and regulatory requirements, as well as major legal regulatory compliance risk exposures and the steps management has taken to monitor or mitigate such exposures; and (iii) the status of any significant legal and regulatory matters and any material reports or inquiries received from regulators or government agencies that reasonably could be expected to have a significant impact on our financial statements. The Compensation Committee reviews major compensation- and human capital-related risk exposures and the steps management has taken to monitor or mitigate such exposures. The Nominating and Corporate Governance Committee reviews and assesses risks relating to our corporate governance practices, reviews and assesses our performance, risks, controls, and procedures relating to corporate responsibility and sustainability, including ESG matters, reviews the independence of our Board of Directors, and reviews and discusses our Board of Directors’ leadership structure and role in risk oversight. The Regulatory and Compliance Committee assists the Board of Directors with oversight of our compliance with corporate legal and regulatory requirements not already overseen by our Audit Committee.

Oversight of Corporate Strategy

One of our Board of Directors’ key responsibilities is overseeing management’s formulation and execution of corporate strategy. Our Board of Directors actively oversees management’s establishment and execution of corporate strategy, including major business and organizational initiatives, annual budget and long-term strategic plans, capital allocation priorities, potential corporate development opportunities and risk management. At its regularly scheduled meetings and throughout the year, our Board of Directors receives information and formal updates from our management and actively engages with the senior leadership team with respect to our corporate strategy. Our Board of Directors’ wide range of skills and experience enhances its ability to support management in the execution and evaluation of our corporate strategy. The independent members of our Board of Directors also hold regularly scheduled executive sessions at which strategy is discussed.

Veracyte 2026 Proxy Statement 15

Corporate Governance

Compensation Committee Interlocks and Insider Participation

The members of our Compensation Committee during 2025 were Karin Eastham, Jens Holstein and Brent Shafer. No member of our Compensation Committee in 2025 was at any time during 2025 or at any other time an officer or employee of ours, and none had or have any relationships with us that are required to be disclosed under Item 404 of Regulation S-K. None of our executive officers has served as a member of the Board of Directors, or as a member of the compensation or similar committee, of any entity that has one or more executive officers who served on our Board of Directors or Compensation Committee during 2025.

Board Meetings

The Board of Directors held seven meetings and acted by written consent three times during 2025. Each director attended at least 75% of the aggregate number of meetings held by the Board of Directors and of the committees on which such director served. The independent directors meet in executive sessions at regularly scheduled meetings of the Board of Directors without the participation of the Chief Executive Officer or other members of management. We do not have a policy that requires the attendance of directors at the Annual Meeting. Seven members of the Board of Directors attended last year‘s Annual Meeting of Stockholders.

Board Committees

Below is a description of each committee of the Board of Directors. The Board of Directors has determined that each director who serves on the Audit, Compensation, Nominating and Corporate Governance, and Regulatory and Compliance Committees is “independent,” as that term is defined for such committee by applicable listing standards of Nasdaq, rules of the SEC, and the applicable written charter for each of these committees. The charters of the Audit, Compensation, Nominating and Corporate Governance, and Regulatory and Compliance Committees are available on the investor section of our website under the corporate governance tab (https://investor.veracyte.com/corporate-governance). Please note, however, that the information contained on the website is not incorporated by reference in, or considered part of, this Proxy Statement. We will also provide copies of these documents and our company’s other corporate governance documents, free of charge, to any stockholder upon written request to Veracyte, Inc., Attention: General Counsel, 6000 Shoreline Court, Suite 300, South San Francisco, California 94080.

AUDIT COMMITTEE AND FINANCIAL EXPERT

The Audit Committee held six meetings during 2025. Our Audit Committee oversees our corporate accounting and financial reporting process and assists our Board of Directors in oversight of the integrity of our financial statements, our compliance with certain legal and regulatory requirements, our independent auditor’s qualifications, independence and performance, and our internal accounting and financial controls. Our Audit Committee is responsible for the appointment, compensation, retention and oversight of our independent auditor. The Board of Directors has determined that each of Mr. Holstein, Ms. Eastham and Mr. Jones are qualified as an “audit committee financial expert” under the definition outlined by the SEC.

Chair: Jens Holstein Members: Karin Eastham Evan Jones

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Corporate Governance

COMPENSATION COMMITTEE

The Compensation Committee held four meetings during 2025. Our Compensation Committee oversees our compensation policies, plans and benefits programs and determines and approves or, in the case of our Chief Executive Officer, makes recommendations to our Board of Directors regarding the compensation of our executive officers. In addition, our Compensation Committee reviews and approves or makes recommendations to our Board of Directors with respect to our major compensation plans, policies and programs and assesses whether our compensation structure establishes appropriate incentives for officers and employees. The Compensation Committee also reviews and recommends non-employee directors’ compensation to the full Board of Directors. The Compensation Committee has the sole authority to select, retain, terminate and approve the fees and other retention terms of consultants as it deems appropriate to perform its duties.

Chair: Karin Eastham Members: Jens Holstein Brent Shafer

NOMINATING AND CORPORATE GOVERNANCE COMMITTEE

The Nominating and Corporate Governance Committee held four meetings during 2025. Our Nominating and Corporate Governance Committee is responsible for making recommendations to our Board of Directors regarding candidates for directorships and the size and composition of the Board of Directors and its committees. In addition, our Nominating and Corporate Governance Committee is responsible for reviewing and making recommendations to our Board of Directors on matters concerning corporate governance and conflicts of interest, as well as recommendations and monitoring related to the company’s Environmental, Social and Corporate Governance (“ESG“) efforts.

Chair: Robert S. Epstein Members: Muna Bhanji Evan Jones

REGULATORY AND COMPLIANCE COMMITTEE

The Regulatory and Compliance Committee held four meetings during 2025. Our Regulatory and Compliance Committee assists our Board of Directors in meeting its responsibilities with regard to oversight of our compliance with healthcare legal and regulatory requirements applicable to our business.

Chair: Evan Jones Members: Muna Bhanji Eliav Barr Tom Miller

Veracyte 2026 Proxy Statement 17

Corporate Governance

Cybersecurity Risk Oversight

The Board of Directors, in coordination with our Audit Committee, oversees our management of risks arising from cybersecurity threats. The Board of Directors and the Audit Committee each receive presentations and reports on cybersecurity risks, which address a wide range of topics, including recent developments, evolving standards, vulnerability assessments, third-party and independent reviews, the threat environment, technological trends and information security considerations arising with respect to our peers and third parties. The Board of Directors and the Audit Committee also receive prompt and timely information regarding any cybersecurity incident that meets established reporting thresholds, as well as ongoing updates regarding any such incident until it has been addressed. On an annual basis, the Board of Directors and the Audit Committee discuss our approach to cybersecurity risk management with the members of management, including our Chief Information Officer.

Our Cybersecurity Executive Leadership Team is composed of the Chief Information Officer, in coordination with our Chief Executive Officer, Chief Financial Officer, Chief Compliance Officer and General Counsel. The team works collaboratively across Veracyte to design and implement programs to protect our information systems from cybersecurity threats and to appropriately respond to any cybersecurity incidents in accordance with our cybersecurity incident response plan. To facilitate the success of our cybersecurity risk management program, multidisciplinary teams throughout Veracyte are engaged to address cybersecurity threats and to respond to cybersecurity incidents, including close collaboration with our chief privacy and data officer. Through ongoing communications with these teams, the Chief Information Officer and the Cybersecurity Executive Leadership Team monitor the prevention, detection, mitigation and remediation of cybersecurity threats and incidents in real time, and report such threats and incidents to the Audit Committee when appropriate.

Veracyte’s Approach to Human Capital Management

Our People

At December 31, 2025, we had 755 employees, of which 159 worked in laboratory operations, 124 in research and development and clinical development, 180 in selling and marketing, and 292 in general and administrative. None of our employees in the U.S. or Israel are the subject of collective bargaining arrangements. Our management considers its relationships with employees to be generally positive.

A Place to Belong

We believe in a collaborative workforce, where people with a broad range of backgrounds and experiences are welcomed, engaged and supported to inspire innovative ideas and decisions, aspiring for an employee population that is reflective of the patient population we serve. Women comprised 54% of our employees and 33% at the Vice President level and above, as of December 31, 2025. Two of our nine directors were women, as of December 31, 2025. Additionally, as of December 31, 2025, 42% of our U.S. employees were non-White. Our U.S. workforce data reflects data from those employee respondents who elected to self-identify. We support employee‑led communities that are open to all and focused on fostering connection, professional development, and engagement across the organization. These efforts complement our broader culture and people initiatives.

We pride ourselves on our strong culture, which encourages innovation, collaboration and mutual respect. We were named one of the Fortune Best Workplaces in BioPharma™ for 2025, reflecting our unwavering commitment to this culture. This award is based solely on employee feedback gathered through an anonymous, third-party survey. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose-driven environment. This is what we call the Veracyte way – it’s about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions. The fundamental values that guide our team and drive our mission to transform cancer care are: we are stronger together; we seek a better way; we care deeply; and we make it happen.

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Corporate Governance

We are committed to supporting our employees’ long-term success by investing in training programs and educational opportunities to help foster personal and professional growth. We have implemented general and job-specific training programs so that employees can gain the necessary qualifications for their position and can continue to develop and grow within the company. We provide specific management training to support new and emerging managers.

Board of Directors Evaluations

We conduct an annual self-evaluation process for our Board of Directors and its committees. In 2025, the Board of Directors enhanced its annual self-evaluation process by engaging an independent third-party provider to facilitate Board of Directors and committee evaluations. As part of this process, each member of our Board of Directors individually completes a detailed survey to assess each director‘s assessment of the performance of the Board of Directors and its committees, their own performance, and the performance of fellow members of the Board of Directors and interaction between the Board of Directors and management. The feedback received is then shared with the Nominating and Corporate Governance Committee, and then presented to and discussed with the full Board of Directors.

Our Board of Directors evaluation process is used:

•by our Board of Directors and Nominating and Corporate Governance Committee to assess the current composition of our Board of Directors and its committees and make recommendations for the qualifications, expertise and characteristics we should seek in identifying potential new director nominees;

•by our Board of Directors and Nominating and Corporate Governance Committee to identify the strengths and areas of opportunity of each member of our Board of Directors and to provide insight into how the contributions of each member of our Board of Directors can be most valuable;

•to identify areas to strengthen the quality of discussion and materials presented to the Board of Directors and its committees so that information they receive enables them to function most effectively and to address the issues they consider most critical; and

•by our Nominating and Corporate Governance Committee as part of its annual review of each director’s performance when considering whether to nominate the director for re-election to the Board of Directors.

Communications with the Board of Directors

If you wish to communicate with the Board of Directors, you may send your communication in writing to: Secretary, Veracyte, Inc., 6000 Shoreline Court, Suite 300, South San Francisco, California 94080. You must include your name and address in the written communication and indicate whether you are our stockholder. The Secretary will review any communications received from a stockholder and all material communications from stockholders will be forwarded to the appropriate director or directors or committee of the Board of Directors based on the subject matter.

Veracyte 2026 Proxy Statement 19

Corporate Governance

Code of Business Conduct and Ethics

We have adopted a Code of Business Conduct and Ethics that applies to all of our officers and employees. The Code of Business Conduct and Ethics sets forth the basic principles that guide the business conduct of our employees. Stockholders may request a free copy of our Code of Business Conduct and Ethics by contacting Veracyte, Inc., Attention: General Counsel, 6000 Shoreline Court, Suite 300, South San Francisco, California 94080.

We maintain a Compliance and Business Ethics hotline and online portal, sometimes referred to as a “whistleblower hotline,” where employees and others may confidentially and anonymously (subject to local legal regulations) report any concerns about potential misconduct. We also maintain a Compliance and Business Ethics page on our website at www.veracyte.com to allow for ease of reporting concerns.

To date, there have been no waivers under our Code of Business Conduct and Ethics. We intend to disclose future amendments to certain provisions of our Code of Business Conduct and Ethics or waivers of such Code granted to executive officers and directors on our website at http://www.veracyte.com within four business days following the date of such amendment or waiver.

Please note that the information contained on the website is not incorporated by reference in, or considered part of, this Proxy Statement.

We require all employees to complete Foreign Corrupt Practices Act training through an online platform.

Corporate Governance Guidelines

Our Board of Directors has adopted Corporate Governance Guidelines that set forth expectations for directors, director independence standards, Board of Directors committee structure and functions, and other policies for the governance of the company. Our Corporate Governance Guidelines are available without charge on the “Investors” section of our website, which is located at https://investor.veracyte.com, by clicking “Governance Overview” in the “Governance” section of our website. Please note that the information contained on the website is not incorporated by reference in, or considered part of, this Proxy Statement.

20 Veracyte 2026 Proxy Statement

2025 Director Compensation

For 2025, our Compensation Committee engaged Aon’s Human Capital Solutions practice, a division of Aon plc (“Aon”), an independent compensation consultant, to provide an analysis of non-employee director compensation, including an analysis of compensation paid to non-employee directors by companies in our peer group (as described in “Compensation Discussion and Analysis—2025 Peer Group”), and an assessment of both the cash and equity compensation and an evaluation of the type of equity instruments being awarded. The following table sets forth cash amounts and the value of equity compensation awarded to, earned by or paid to our non-employee directors for their service in 2025. Mr. Stapley is not included in the table below as he did not receive compensation for service as a director in 2025. The compensation received by Mr. Stapley as an employee is shown in the “Executive Compensation—Summary Compensation Table” below.

			Name			Fees Earned or Paid in Cash ($)			Stock Awards ($)(1)(2)			Total ($)
			Eliav Barr			55,000			249,989			304,989
			Muna Bhanji			60,000			249,989			309,989
			Karin Eastham			75,000			249,989			324,989
			Robert S. Epstein			110,000			249,989			359,989
			Jens Holstein			77,500			249,989			327,489
			Evan Jones			75,000			249,989			324,989
			Tom Miller			55,000			249,989			304,989
			Brent Shafer			57,500			249,989			307,489

(1)Amounts represent the aggregate fair value of the awards computed as of the grant date of each stock award in accordance with Financial Accounting Standards Board Accounting Standards Codification Topic 718 (“ASC 718”) for financial reporting purposes, rather than amounts paid to or realized by the named individual. Our assumptions with respect to the calculation of these values are set forth in Note 9 to Financial Statements in our Annual Report on Form 10-K for the year ended December 31, 2025. There can be no assurance that stock awards will settle (in which case no value will be realized by the individual) or that the value on settlement will approximate the fair value as computed in accordance with ASC 718.

Veracyte 2026 Proxy Statement 21

2025 Director Compensation

(2)The following table sets forth the number of shares of common stock subject to outstanding options or stock awards held by non-employee directors at December 31, 2025:

			Name			Number of Shares (#)
			Eliav Barr			9,321
			Muna Bhanji			9,321
			Karin Eastham			29,321
			Robert S. Epstein			39,321
			Jens Holstein			44,321
			Evan Jones			29,321
			Tom Miller			20,325
			Brent Shafer			20,325

Directors who are employees do not receive any fees or equity awards for their service on the Board of Directors or any committee. In February 2025, our Compensation Committee and Board of Directors reviewed our then-current non-employee director compensation program and competitive market data on the same, and determined to retain the cash retainers, without change from 2024 as set forth below. In February 2025, our Compensation Committee of the Board of Directors also determined to reduce the initial grant for new non-employee directors to $250,000 from $500,000, while retaining the annual equity awards at $250,000. Additionally, beginning in 2025, any initial grant will be prorated based on whole months of service prior to the Annual Meeting, and the six-month service requirement for the annual grant was removed (as detailed below).

Cash Retainers

•$50,000 annual cash retainer for service on our Board of Directors;

•$50,000 additional annual cash retainer for service as the chair of our Board of Directors;

•$20,000 annual cash retainer for the chair of our Audit Committee and $10,000 for each of its other members;

•$15,000 annual cash retainer for the chair of our Compensation Committee and $7,500 for each of its other members;

•$10,000 annual cash retainer for the chair of our Nominating and Corporate Governance Committee and $5,000 for each of its other members;

•$10,000 annual cash retainer for the chair of our Regulatory and Compliance Committee and $5,000 for each of its other members; and

•$25,000 additional annual cash retainer for the lead independent director (as needed).

All annual cash retainers are payable quarterly in arrears and are pro-rated for partial service in any year. We also reimburse our non-employee directors for their reasonable out-of-pocket costs and travel expenses in connection with their attendance at Board of Directors and committee meetings in accordance with our travel policy.

22 Veracyte 2026 Proxy Statement

2025 Director Compensation

Equity Awards

Our compensation policy for non-employee directors for the 2025 fiscal year provided that any non-employee director who first joined our Board of Directors was automatically granted restricted stock units (“RSUs”) valued on the grant date at approximately $250,000 (the “Initial RSUs”), a decrease from $500,000 in 2024, and that the grant is to be prorated based on the number of whole months of service that the director serves on the Board of Directors during the 12 months leading to the next Annual Meeting of Stockholders. The Initial RSUs vest as to one-third of those shares on each of the first, second and third annual anniversaries of the date of grant. In addition, the policy in effect in 2025 provided that on the first business day after each Annual Meeting of Stockholders, each non-employee director who continues to serve on our Board of Directors would be automatically granted RSUs valued on the grant date at approximately $250,000 (the “Annual RSUs”). The Annual RSUs vest in full on the first anniversary of the date of grant or, if earlier, the date of the next Annual Meeting of Stockholders. In 2025, the prior six-month service requirement for the Annual RSUs was removed. The vesting of the RSUs described above will accelerate in full upon a change in control. Pursuant to the terms of the 2023 Plan, no non-employee director may receive equity awards that, when combined with cash compensation received for service as a non-employee director, exceeds $750,000 in value in any calendar year, or $1,500,000 in value in the calendar year in which such director first joins our Board of Directors.

•Initial RSUs - $250,000 prorated based on whole months service prior to the Annual Meeting of Stockholders and vest ratably on the first, second and third annual anniversaries of the grant date; and

•Annual RSUs - $250,000 vest in full on the first anniversary of the grant date or, if earlier, the date of the next Annual Meeting of Stockholders.

In February 2026, our Compensation Committee and Board of Directors reviewed our then-current non-employee director compensation program and competitive market data based on the same approved peer group, and determined that no changes were needed for 2026, therefore the 2025 policy was retained (as detailed above).

Veracyte 2026 Proxy Statement 23

PROPOSAL TWO

Ratification of Appointment of Independent Registered Public Accounting Firm

The Audit Committee has appointed Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026. Ernst & Young LLP has audited our financial statements since 2014. Representatives of Ernst & Young LLP are expected to be present at the Annual Meeting. They will have an opportunity to make a statement, if they desire to do so, and will be available to respond to appropriate questions.

Independent Registered Public Accounting Firm Fees and Services

The following table presents fees billed for professional audit services and other services rendered to us by Ernst & Young LLP for the years ending December 31, 2025 and 2024, respectively.

						Year Ended December 31,
			Fees			2025 ($)			2024 ($)
			Audit Fees(1)			2,230,512			2,615,955
			Audit-related Fees(2)			—			—
			Tax Fees(3)			—			—
			All Other Fees(4)			—			—
			Total			2,230,512			2,615,955

(1)Audit fees include fees and out-of-pocket expenses, whether or not yet invoiced, for professional services provided in connection with the audit of our annual financial statements and review of our quarterly financial statements.

(2)Audit-related fees include fees for consultations on accounting and reporting matters for acquisitions.

(3)Tax fees consist of tax consulting services.

(4)Other fees consist of consultations not related to audit or tax fees and access to an online accounting literature database.

Pre-approval Policies and Procedures

Our Audit Committee’s policy is to pre-approve all audit and permissible non-audit services provided by our independent registered public accounting firm. All of the services provided were pre-approved to the extent required. During the approval process, the Audit Committee considers the impact of the types of services and the related fees on the independence of the independent registered public accounting firm. The services and fees must be deemed compatible with the maintenance of that firm’s independence, including compliance with rules and regulations of the SEC. Throughout the year, the Audit Committee will review any revisions to the estimates of audit and non-audit fees initially approved.

24 Veracyte 2026 Proxy Statement

Proposal Two

Stockholder ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026, is not required by our amended and restated bylaws or otherwise. However, the Board of Directors is submitting the selection of Ernst & Young LLP to the stockholders for ratification as a matter of corporate practice. If the stockholders fail to ratify the appointment, the Audit Committee will reconsider whether or not to retain that firm. Even if the appointment is ratified, the Audit Committee in its discretion may direct the appointment of a different independent registered public accounting firm at any time during the year if the Audit Committee determines that such a change would be in the best interests of our company and our stockholders.

Required Vote

Ratification will require the vote of a majority of the shares present at the Annual Meeting or voting by proxy and entitled to vote at the Annual Meeting. Abstentions will have the same effect as votes “AGAINST” this proposal. Broker non-votes will have no effect on this proposal as they are not considered entitled to vote for the foregoing purpose. This proposal is considered to be a routine proposal on which a broker or other nominee has discretionary authority to vote. Accordingly, we do not expect any broker non-votes to result from this proposal.

The Board of Directors recommends a vote “FOR” ratification of the appointment of Ernst & Young LLP as our Independent Registered Public Accounting Firm.

Veracyte 2026 Proxy Statement 25

PROPOSAL THREE

Advisory Vote on the Compensation of Our Named Executive Officers

In accordance with the rules of the SEC, we are providing stockholders with an opportunity to make a non-binding, advisory vote on the compensation of our named executive officers. This non-binding advisory vote is commonly referred to as a “say on pay” vote.

Stockholders are urged to read the “Executive Compensation” section of this Proxy Statement, which discusses how our executive compensation policies and procedures implement our compensation philosophy and contains tabular information and narrative discussion about the compensation of our named executive officers. The Compensation Committee and the Board of Directors believe that these policies and procedures are effective in implementing our compensation philosophy and in achieving our goals. Accordingly, we ask our stockholders to vote “FOR” the following resolution at the Annual Meeting:

“RESOLVED, that our stockholders approve, on a non-binding advisory basis, the compensation of the named executive officers, as disclosed in the Proxy Statement pursuant to Item 402 of Regulation S-K, including the compensation tables and narrative discussion and the other related disclosures.”

As an advisory vote, this proposal is not binding. However, our Board of Directors and Compensation Committee, which is responsible for designing and administering our executive compensation program, value the opinions expressed by stockholders in their vote on this proposal and will consider the outcome of the vote when making future compensation decisions for our named executive officers.

Required Vote

The non-binding advisory vote on the compensation paid to our named executive officers in 2025, as disclosed in this Proxy Statement, will be determined by the vote of a majority of the shares present at the Annual Meeting or voting by proxy and entitled to vote at the Annual Meeting. Abstentions will have the same effect as votes “AGAINST” this proposal. Broker non-votes will have no effect on this proposal as they are not considered entitled to vote for the foregoing purpose. This proposal is considered to be a non-routine proposal on which a broker or other nominee does not have discretionary authority to vote.

The Board of Directors recommends a vote “FOR” approval, on a non-binding advisory basis, of the compensation of our Named Executive Officers.

26 Veracyte 2026 Proxy Statement

PROPOSAL FOUR

Approval of Amendment to Veracyte, Inc. 2023 Equity Incentive Plan

We are asking our stockholders to approve an amendment to the Veracyte, Inc. 2023 Equity Incentive Plan (the “2023 Plan,” and such amendment, the “Plan Amendment”) to increase the number of shares that may be issued under the 2023 Plan. Our Board of Directors has approved the Plan Amendment, subject to stockholder approval.

Our Board of Directors has determined that it is in the best interests of the company and our stockholders to seek approval of the Plan Amendment to increase the number of shares that may be issued under the 2023 Plan by 3,500,000 shares.

If our stockholders do not approve the Plan Amendment, the number of shares available for grant under the 2023 Plan will not be increased and we will be limited in granting equity using the then-existing shares as a tool to attract and retain key talent.

Rationale for and Reasons Why the Board Recommends a Vote FOR the Plan Amendment

Equity Compensation Is a Critical Element of Our Compensation Program

We believe that our equity incentive compensation program aligns the interests of management, employees and stockholders to create long-term stockholder value. We strongly believe that the approval of the Plan Amendment is essential to our continued success because we otherwise may not have sufficient shares available under our 2023 Plan to attract and retain new employees or to motivate and retain our existing employees.

We believe that our future success and our ability to remain competitive depend on our ability to attract, retain and motivate highly qualified talent in an increasingly competitive market. The use of equity compensation, including the grant of options, RSUs and certain performance-based restricted stock units (“PSUs”), is a cornerstone of our strategy to attract and retain top-caliber employees. We currently grant RSUs to most U.S. employees, a mix of RSUs and PSUs to our executives and RSUs to our non-employee directors. Equity is broadly distributed with more than 50% of equity awards granted to employees below executive level. Employee ownership in Veracyte aligns employee interests with those of our stockholders, incentivizing hard work for Veracyte‘s future growth and success.

If the Plan Amendment is not approved, we may have insufficient shares available to continue to make equity grants to our employees and non-employee directors and may be required to rely more heavily on cash compensation, both in the short-term and mid-term, to maintain market-competitive total compensation. This could impact our ability to attract and retain critical talent, which is essential to drive revenue growth, advance our clinical portfolio and innovate for patients, all of which we believe is designed to transform cancer care for patients in addition to supporting shareholder value creation over time. This increased reliance on cash compensation could reduce funds available for growth and development, demotivate employees and reduce the alignment between employees and stockholders.

Veracyte 2026 Proxy Statement 27

Proposal Four

We Carefully Consider and Forecast Our Need for Shares

As of March 31, 2026, there were 9,704,039 shares of common stock available for grant under the 2023 Plan. After carefully forecasting our anticipated growth rate for the next few years and considering our historical usage and forfeiture rates, we currently believe that the proposed Plan Amendment to increase the share reserve under the 2023 Plan by 3,500,000 shares of common stock will be sufficient for us to make anticipated grants of equity incentive awards under our current compensation program for approximately one additional year. However, a change in business conditions, company strategy, forfeiture rates or equity market performance could alter this projection up or down.

In evaluating the number of shares requested pursuant to the Plan Amendment, our Compensation Committee considered a number of factors, including the costs of the share request as well as an analysis of certain burn rate and dilution metrics as summarized below.

Grant Practices

During the past three fiscal years, we granted equity awards under our 2023 Plan and our 2013 Stock Incentive Plan (the “2013 Plan”), which terminated in connection with the approval of our 2023 Plan, as summarized in the chart below. Our three-year average burn rate was approximately 2.68% for fiscal years 2023 through 2025 (see chart below for a calculation of our three-year burn rate). We define “burn rate” as the number of time-based equity awards granted during the year plus performance-based equity awards granted during the year, assuming target-level achievement, divided by the weighted average total number of shares of common stock outstanding. We believe that our use of equity compensation, across the company, is a strong compensation differentiator that allows us to attract and retain talent at all levels in the company. This also reflects our commitment to a culture of ownership and accountability, to align with all stockholders. Our gross burn rate is aligned with common market practices across the life sciences sector where we compete for talent and has been well within investor expectations historically.

The burn rate figures included below are based on equity awards granted under our 2023 Plan and our 2013 Plan, and exclude potential dilution resulting from shares issued pursuant to our Amended and Restated Employee Stock Purchase Plan (the “ESPP”). As we continue to mature our compensation practices, we strive to achieve a burn rate and overhang at approximately the average rates of our peer group and within the limits recommended by certain independent stockholder advisory groups.

			Fiscal Year			Granted Appreciation Awards (Options and SARs) (#)(1)			Granted Full-Value Awards (RSUs) (#)(2)						Weighted Common Stock Outstanding as of December 31 of the applicable year (#)			Burn Rate (%)
			2023			660,592			1,767,312						72,644,487			3.34
			2024			—			2,220,157						76,484,759			2.90
			2025			—			1,423,977						78,584,291			1.81

(1)All options granted during 2023, 2024 and 2025 included a time-based vesting schedule.

(2)Includes both time-based RSUs and PSUs (assuming target-level achievement) granted during 2023, 2024 and 2025.

28 Veracyte 2026 Proxy Statement

Proposal Four

Potential Dilution

As of March 31, 2026:

•There were 79,791,856 total shares of our common stock outstanding.

•The closing market price of our common stock on March 31, 2026, was $32.21.

•The company’s outstanding stock options have a weighted average per share exercise price of $26.86 and a weighted average remaining contractual term of 4.9 years.

•The following table shows outstanding equity awards granted and outstanding under the 2023 Plan and our 2013 Plan, and the number of shares remaining for grant under our 2023 Plan, in each case as of March 31, 2026.

			Outstanding appreciation awards (options) under all plans (#)						Full value awards outstanding under all plans (including PSUs at target) (#)						Number of shares available for grant under all plans (2023 Plan only) (#)
			1,701,968						3,918,629						9,704,039

Based on this information, as of March 31, 2026, our outstanding equity awards (not including awards under our ESPP) plus shares available for future grant under our 2023 Plan represented approximately 19% of our common stock outstanding, which we refer to as our “overhang.”

Accordingly, our Board of Directors believes that the request to approve the Plan Amendment to add an additional 3,500,000 shares of common stock (4.4% of common stock outstanding as of March 31, 2026) to the 2023 Plan is reasonable and prudent. This number of shares should allow us to continue to grant awards to our employees, consultants, officers and directors, which have been successful in attracting high-performing personnel and generating stockholder value, going forward and to be able to respond to growth, market competition and potential stock price fluctuations, especially in today’s versatile market within our industry.

Good Governance and Compensation Practices

The 2023 Plan contains a number of provisions that we believe are consistent with the interests of our stockholders and good corporate governance and compensation practices, including:

•No evergreen provision;

•No option repricing without stockholder approval;

•No “liberal” change in control definition;

•No dividends on unvested awards;

•No excise tax gross ups;

•No automatic single trigger acceleration on a change in control;

•Requires that stock options and stock appreciation rights have a minimum exercise price of not less than the fair market value of a share on the grant date;

•Limits on non-employee director cash and equity compensation; and

•The ability to claw back awards under our clawback policies and/or any recoupment requirements imposed under applicable law or listing standards.

Veracyte 2026 Proxy Statement 29

Proposal Four

Purpose of the Proposed Plan Amendment

The 2023 Plan enables us to offer equity awards to attract and retain talented employees, directors, consultants, independent contractors and advisors and further align their interests and those of our stockholders by continuing to link a portion of their compensation with our company performance. The Plan Amendment is intended to enable us to continue to achieve these objectives.

Share Increase

As discussed above, we are requesting approval of an increase of 3,500,000 shares for the 2023 Plan to cover anticipated equity awards, such as those for new hires, refresh awards, potential special retention needs, merger and acquisition activities, and non-employee director grants.

If approved by our stockholders, the Plan Amendment will be effective on the date of stockholder approval. We intend to register the additional shares authorized under the 2023 Plan under the Securities Act of 1933, as amended (the “Securities Act”). If our stockholders do not approve the Plan Amendment, the 2023 Plan will continue without amendment.

Summary of the 2023 Plan

The following is a summary of the principal features of the 2023 Plan and reflects the proposed Plan Amendment. This summary, however, does not purport to be a complete description of all of the provisions of the 2023 Plan. It is qualified in its entirety by reference to the full text of the 2023 Plan, as proposed to be amended, a copy of which is attached hereto as Appendix A.

Background and Purpose

The 2023 Plan was adopted by our Board of Directors on April 12, 2023, and became effective on June 8, 2023 (the “Effective Date”), the date it was approved by our stockholders, and will terminate ten years after the date approved by our Board of Directors. The purpose of the 2023 Plan is to provide incentives to attract, retain and motivate eligible persons whose present and potential contributions are important to our success.

Eligibility

Employees, officers, directors, consultants, independent contractors and advisors of Veracyte or any parent, subsidiary or affiliate of Veracyte are eligible to receive awards. As of March 31, 2026, we had six executive officers (as such term is defined under Rule 16a-1(f)), eight non-employee directors, and approximately 800 other employees and 36 other service providers who would be eligible to participate in the 2023 Plan.

Administration

The 2023 Plan will be administered by the Compensation Committee, of which all members are non-employee directors under applicable federal securities laws and outside directors as defined under applicable federal tax laws. The Compensation Committee will act as the plan administrator and have the authority to construe and interpret the 2023 Plan, grant awards, determine the terms and conditions of awards, and make all other determinations necessary or advisable for the administration of the 2023 Plan (subject to the limitations set forth in the 2023 Plan). However, our Board of Directors establishes the terms for the grant of awards to non-employee directors as discussed above under “—2025 Director Compensation.”

Share Reserve

If stockholders approve the Plan Amendment, there will be a cumulative total of 16,306,156 shares of common stock authorized under the 2023 Plan from its original effectiveness through the effectiveness of the Plan Amendment, subject to adjustment only to reflect stock splits and similar events.

30 Veracyte 2026 Proxy Statement

Proposal Four

In addition, the following shares underlying awards granted under the 2023 Plan will become available for grant under the 2023 Plan: (a) shares subject to issuance upon exercise of a stock option or stock appreciation right granted under the 2023 Plan but that cease to be subject to the option or stock appreciation right for any reason other than exercise of the stock option or stock appreciation right; (b) shares subject to awards granted under the 2023 Plan that are forfeited or are repurchased by us at the original issue price; (c) shares subject to awards granted under the 2023 Plan that otherwise terminate without such shares being issued; (d) shares surrendered pursuant to a stockholder-approved exchange program; and (e) shares that are used to pay the exercise price of an award or withheld to satisfy the tax withholding obligations related to an award.

In addition, the following shares underlying awards granted under the 2013 Plan will become available for grant under the 2023 Plan: (a) shares that are subject to awards granted under the 2013 Plan that cease to be subject to such awards by forfeiture or otherwise after the Effective Date; (b) shares issued under the 2013 Plan, including shares issued pursuant to the exercise of stock options, that are forfeited after the Effective Date; (c) shares issued under the 2013 Plan that are repurchased by us at the original issue price after the Effective Date; (d) shares that are subject to awards granted under the 2013 Plan that are settled in cash after the Effective Date; and (e) shares that are subject to awards granted under the 2013 Plan that are used to pay the exercise price of an award or withheld to satisfy the tax withholding obligations related to an award after the Effective Date.

Shares that otherwise become available for grant and issuance shall not include shares subject to awards that initially became available because of our substitution or assumption of awards granted by another company in connection with an acquisition of such company, or otherwise, as permitted under the 2023 Plan.

Equitable Adjustments

As is typical in equity plans, in the event of a change in our common stock via a stock dividend, extraordinary dividend or distribution (whether in cash, shares or other property, other than a regular cash dividend), recapitalization, stock split, reverse stock split, subdivision, combination, consolidation, reclassification, spin-off or similar change in the capital structure of Veracyte without consideration, proportionate adjustments will be made to the number and class of shares reserved for issuance and future grant under the 2023 Plan (including the maximum number and class of ISOs (as defined below)) and the applicable exercise prices of and number and class of shares subject to outstanding awards, subject to any required action by the Board of Directors or our stockholders.

Equity Awards

The 2023 Plan permits us to grant the following types of awards:

Stock Options

The 2023 Plan provides for the grant of Incentive Stock Options (“ISOs”) and Non-qualified Stock Options (“NQSOs”). ISOs may be granted only to our employees or employees of our parent, subsidiaries and affiliates. NQSOs may be granted to eligible employees, consultants and directors of any of our parent, subsidiaries or affiliates. We are able to issue no more than 15,000,000 shares pursuant to the grant of ISOs under the 2023 Plan. The Compensation Committee determines the terms of each option award, provided that ISOs are subject to statutory limitations. The Compensation Committee also determines the exercise price for a stock option, provided that the exercise price of an option may not be less than the fair market value of our common stock on the date of grant (with certain additional requirements for certain ISOs).

Options granted under the 2023 Plan vest at the rate and/or are subject to performance requirements specified by the Compensation Committee, and such vesting schedule is set forth in the stock option agreement to which such stock option grant relates. The Compensation Committee determines the term of stock options granted under the 2023 Plan, up to a term of ten years (with certain additional requirements for certain ISOs).

After the option holder ceases to provide services to us, he or she is able to exercise his or her vested option for the period of time stated in the stock option agreement to which such option relates. Generally, the vested option will remain exercisable for three months after an optionee’s cessation of service, except in the case of termination due to death, disability or termination for cause. An option may not be exercised later than its expiration date.

Veracyte 2026 Proxy Statement 31

Proposal Four

Restricted Stock Units

RSUs represent the right to receive shares of our common stock at a specified date in the future, subject to forfeiture of such right due to termination of employment or failure to achieve specified performance goals. RSUs do not have exercise price. If the RSUs have not been forfeited, then on the date specified in the award agreement we will deliver to the holder of the RSUs shares of our common stock, cash or a combination of our common stock and cash as specified in the applicable award agreement. The Compensation Committee determines the term of RSUs granted under the 2023 Plan, up to a term of ten years.

Restricted Stock Awards

A restricted stock award is an offer by us to sell shares of our common stock subject to restrictions that the Compensation Committee may impose. These restrictions may be based on completion of a specified period of service with us or upon the achievement of performance goals during a performance period. The Compensation Committee determines the price of a restricted stock award. Unless otherwise set forth in the award agreement, vesting will cease on the date the participant no longer provides services to us, and at that time unvested shares will be forfeited to us or subject to repurchase by us.

Stock Bonus Awards

A stock bonus is an award of shares of our common stock for past or future services to us. Stock bonuses can be granted as additional compensation for performance and, therefore, are not issued in exchange for cash. The Compensation Committee determines the number of shares to be issued as stock bonuses and any restrictions on those shares. These restrictions may be based on completion of a specified period of service with us or upon the achievement of performance goals during a performance period. Unless otherwise set forth in the award agreement, vesting ceases on the date the participant no longer provides services to us, and at that time unvested shares will be forfeited to us or subject to repurchase by us.

Stock Appreciation Rights

Stock appreciation rights provide for a payment, or payments, in cash or shares of our common stock to the holder based upon the difference between the fair market value of our common stock on the date of exercise and the stated exercise price of the stock appreciation right. Stock appreciation rights may vest based on time or achievement of performance goals. The Compensation Committee determines the term of stock appreciation rights granted under the 2023 Plan, up to a term of ten years.

Performance Awards

A performance award is an award of a cash bonus or a bonus denominated in shares or units that is subject to performance factors. The award of performance shares may be settled in cash or by issuance of those shares (which may consist of restricted stock). These awards are subject to forfeiture because of termination of employment or failure to achieve the performance conditions.

Performance Factors

The Compensation Committee may establish performance goals from the performance criteria set forth in the 2023 Plan, which include the following: profit before tax; billings; revenue; net revenue or return on operating revenue; earnings (which may include earnings before interest and taxes, earnings before taxes, net earnings, stock-based compensation expenses, depreciation and amortization); operating income; operating margin; operating profit; controllable operating profit or net operating profit; net profit; gross margin; cost, operating expenses or operating expenses as a percentage of revenue; net income; earning per share; total stockholder return or relative total stockholder return; market share or market segment share; return on assets or net assets; the company’s stock price; growth in stockholder value relative to a pre-determined index; return on equity; return on capital or on invested capital; cash flow (including free cash flow or operating cash flows) or cash flow margins; cash conversion cycle; economic value added; individual confidential business objectives; contract awards or backlog; overhead or other expense reduction; credit rating; strategic plan development and implementation; succession plan development and implementation; talent, retention and culture; customer indicators and/or satisfaction; new product invention or innovation; achievement of target levels of discovery and/or development of

32 Veracyte 2026 Proxy Statement

Proposal Four

products and services, including, but not limited to, research or regulatory achievements; attainment of research and development milestones; third-party coverage and/or reimbursement objectives; test volume metrics; improvements in productivity; bookings; attainment of objective operating goals and employee metrics; sales; expenses; balance of cash, cash equivalents and marketable securities; completion of an identified special project; completion of a joint venture or other corporate transaction; employee satisfaction and/or retention; research and development expenses; working capital targets and changes in working capital; net new annual contract value; net expansion rate; and any other metric that is capable of measurement as determined by the Compensation Committee. The Compensation Committee may provide for one or more equitable adjustments to the performance criteria to preserve the Compensation Committee’s original intent regarding such criteria at the time of the initial award grant, such as, but not limited to, adjustments in recognition of unusual or non-recurring items such as acquisition-related activities or changes in applicable accounting rules.

Stockholder Approval Required for Repricing, Exchange and Buyout

The Compensation Committee may not, without the approval of our stockholders, (i) reprice any Options or SARs, (ii) lower the exercise price per share of any award after it is granted, or (iii) cancel any award when the exercise price per share exceeds the fair market value of one share in exchange for cash or another award.

Insider Trading; Clawback Policy

Each participant who receives an award will comply with any and all policies adopted by the company from time to time covering transactions in our securities by employees, officers and/or directors.

All awards will be subject to clawback or recoupment pursuant to any compensation clawback or recoupment policy adopted by the Board of Directors or required by law during the term of the participant’s employment or other service, and in addition to any other remedies available under such policy and applicable law, we may require the cancellation of outstanding awards and the recoupment of any gains realized with respect to awards.

Restrictions on Dividends and Dividend Equivalents

A participant will have no right to payment of stock dividends or stock distributions with respect to unvested shares, and any such dividends or stock distributions will be accrued and paid only at such time, if any, as such unvested shares become vested shares and are no longer subject to restrictions and risk of forfeiture.

Change in Control

If we undergo a Corporate Transaction (as defined in the 2023 Plan), the 2023 Plan provides that outstanding awards shall be subject to the definitive agreement related thereto, and may be assumed, converted, replaced or substituted by the successor or acquiring entity, or by a parent or subsidiary of the successor or acquiring entity, for substantially equivalent awards (including, but not limited to, an award to acquire the same consideration paid to the stockholders pursuant to the Corporate Transaction), in each case after taking into account appropriate adjustments to the exercise price and the number and nature of shares subject to such awards as may be necessary or desirable under applicable law and the Internal Revenue Code, may be fully accelerated or may be settled for their intrinsic value (which may be determined to be zero). In the event such successor or acquiring corporation (if any) refuses to assume, convert, replace or substitute awards, or awards are not settled for their intrinsic value, pursuant to a Corporate Transaction, then such awards shall have their vesting accelerate as to all shares subject to such award (and any applicable right of repurchase fully lapse) immediately prior to the Corporate Transaction, with the acceleration of performance awards based on the greater of actual performance through the date of the Corporate Transaction or target performance, and then such awards will terminate.

Awards need not be treated similarly in a Corporate Transaction and treatment may vary from award to award and/or from participant to participant.

In the event of a Corporate Transaction, the vesting of all awards granted to our non-employee directors will accelerate and such awards will become exercisable (as applicable) in full upon the consummation of such event at such times and on such conditions as the Compensation Committee determines.

Veracyte 2026 Proxy Statement 33

Proposal Four

Foreign Award Recipients

In order to comply with the laws in other countries in which we and our subsidiaries and affiliates operate or have employees or other individuals eligible for awards, the Compensation Committee will have the power and authority to modify the terms and conditions of any award granted to individuals outside the United States to comply with applicable foreign laws, establish subplans and modify exercise procedures and other terms and procedures, and take any action that the Compensation Committee determines to be necessary or advisable to comply with any local governmental regulatory exemptions or approvals.

Transferability of Awards

Unless the Compensation Committee provides otherwise, the 2023 Plan does not allow for the transfer of awards, other than by will or the laws of descent and distribution, and generally only the recipient of an award may exercise it during his or her lifetime.

Grants to Non-Employee Directors

Non-employee directors are eligible to receive any type of award offered under the 2023 Plan except ISOs. No non-employee director may receive awards under the 2023 Plan that, when combined with cash compensation received for service as a non-employee director, exceeds $750,000 in value in any calendar year ($1,500,000 in the calendar year in which such non-employee director first joins the Board of Directors). Awards under the 2023 Plan may be granted to non-employee directors, may be automatically made pursuant to a policy adopted by the Board of Directors, or may be made from time to time as determined at the discretion of the Board of Directors.

Amendment and Termination

The Board of Directors is permitted to amend or terminate the 2023 Plan at any time, subject to stockholder approval where required. In addition, no amendment that is detrimental to a participant in the 2023 Plan may be made to an outstanding award without the consent of the affected participant unless such termination or amendment is necessary to comply with applicable, law, regulation or rule. The 2023 Plan will terminate ten years from April 12, 2023, the date the 2023 Plan was adopted by the Board of Directors.

Federal Income Tax Consequences

The following is a general summary under current law of certain U.S. federal income tax consequences to participants who are citizens or individual residents of the United States relating to the types of equity awards that may be granted under the 2023 Plan. This summary deals with the general tax principles and is provided only for general information. Certain kinds of taxes, such as foreign taxes, state and local income taxes, payroll taxes and the alternative minimum tax, are not discussed.

Nonqualified Stock Options, Stock Appreciation Rights

A recipient of an NQSO or stock appreciation right will not recognize taxable income upon the grant of those awards. However, the participant will recognize ordinary income upon exercise in an amount equal to the difference between the fair market value of the shares and the exercise price on the date of exercise. Any gain or loss recognized on a subsequent disposition of the shares of common stock generally will be short‐term or long‐term capital gain or loss, depending on the length of time the recipient holds the shares.

34 Veracyte 2026 Proxy Statement

Proposal Four

Incentive Stock Options

Neither the grant nor the exercise of an ISO will generally result in any taxable income to the recipient, except that the alternative minimum tax may apply at the time of exercise. The recipient will recognize a capital gain or loss on a later sale or other disposition of such shares provided he or she does not dispose of such shares within two years from the date the option was granted or within one year after the shares were acquired by the recipient. If the shares are not held for the holding period described above, the recipient will recognize ordinary income equal to the lesser of (i) the difference between the fair market value of the shares on the date of exercise and the exercise price, or (ii) the difference between the sales price and the exercise price. Any gain or loss recognized on a subsequent disposition of the shares of common stock generally will be short‐term or long‐term capital gain or loss, depending on the length of time the recipient holds the shares.

Restricted Stock Units

A holder of RSUs does not recognize taxable income when the RSUs are granted. The recipient of the award generally will recognize ordinary income in each year in which the units vest in an amount equal to the fair market value of the shares of common stock received. Any gain or loss recognized on a subsequent disposition of the shares of common stock generally will be short‐term or long‐term capital gain or loss, depending on the length of time the recipient holds the shares.

Other Awards

The grant of restricted stock awards, stock bonus awards and performance shares will generally not be a taxable event. Generally, the recipient will recognize ordinary income equal to the excess of the fair market value over the price paid, if any, in the first taxable year in which his or her interest in the shares underlying the award becomes either (i) freely transferable or (ii) no longer subject to substantial risk of forfeiture (unless, with respect to an award of restricted stock, the recipient elects to accelerate recognition as of the date of grant).

In each of the foregoing cases, we will generally have a corresponding deduction at the time the participant recognizes ordinary income, subject to Section 162(m) of the Internal Revenue Code and the relevant income tax regulations. Section 162(m) places a limit of $1 million on the amount of compensation that we may deduct as a business expense in any year with respect to certain of our current and former executive officers. We may from time to time pay compensation that may not be deductible if the Compensation Committee believes that doing so is in the best interests of our stockholders.

ERISA Information

The 2023 Plan is not subject to the provisions of the Employee Retirement Income Security Act of 1974, as amended.

New Plan Benefits

Our NEOs and members of our Board of Directors have an interest in this proposal by virtue of being eligible to receive equity awards under the 2023 Plan. No awards have been granted that are contingent on the approval of the Plan Amendment. Future awards under the 2023 Plan to executive officers, employees or other eligible participants are discretionary and cannot be determined at this time. Currently, our non-employee directors are entitled to receive cash and equity compensation for their service as directors as described above under “—2025 Director Compensation.”

Veracyte 2026 Proxy Statement 35

Proposal Four

History of Grants Under the 2023 Plan

The following table sets forth the number of shares subject to stock options or restricted stock unit awards granted under the 2023 Plan from its Effective Date, June 8, 2023, through March 31, 2026:

			Name and Position						Number of Securities Underlying Awards (#)
			Marc Stapley, Chief Executive Officer						594,848
			Rebecca Chambers, Chief Financial Officer						265,631
			Phillip Febbo, Chief Scientific and Chief Medical Officer						386,134
			John Leite, Global Chief Commercial Officer						270,315
			Annie McGuire, EVP, General Counsel and Head of Market Access						252,258
			All current executive officers (including named executive officers)						1,769,186
			All current non-employee directors						234,464
			Marc Stapley, Chief Executive Officer, Director and Director Nominee						594,848
			Eliav Barr, Director and Director Nominee						30,468
			Muna Bhanji, Director and Director Nominee						30,468
			Karin Eastham, Director and Director Nominee						30,468
			Robert S. Epstein, Director and Director Nominee						30,468
			Jens Holstein, Director and Director Nominee						30,468
			Evan Jones, Director and Director Nominee						30,468
			Tom Miller, Director and Director Nominee						25,828
			Brent Shafer, Director and Director Nominee						25,828
			Each associate of any of such directors, executive officers or nominees						—
			Each other person who received or is to receive 5% of such options, warrants or rights						—
			All current employees (excluding current executive officers and directors)						3,229,176

36 Veracyte 2026 Proxy Statement

Proposal Four

Equity Compensation Plan Information

The following table provides information about our common stock that may be issued under our equity compensation plans as of December 31, 2025:

						Number of securities to be issued upon exercise of outstanding options, warrants and rights (a)						Weighted-average exercise price of outstanding options, warrants and rights ($)(1)			Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) (#)
			Plan Category
			Equity compensation plans approved by security holders			4,790,556			(2)			26.51			11,833,076			(3)
			Equity compensation plans not approved by security holders			—						—			—
			Total			4,790,556						26.51			11,833,076

(1)The weighted-average exercise price does not reflect the shares that will be issued in connection with the settlement of performance stock units and restricted stock units, since such units have no exercise price.

(2)Excludes purchase rights accruing under the ESPP.

(3)Consists of 10,937,821 shares available for issuance under our 2023 Plan, and 895,255 shares available for purchase under our ESPP.

Required Vote

The approval of the Plan Amendment will be determined by the vote of a majority of the shares present at the Annual Meeting or voting by proxy and entitled to vote at the Annual Meeting. Abstentions will have the same effect as votes “AGAINST” this proposal. Broker non-votes will have no effect on this proposal as they are not considered entitled to vote for the foregoing purpose. This proposal is considered to be a non-routine proposal on which a broker or other nominee does not have discretionary authority to vote.

The Board of Directors recommends a vote “FOR” the approval of the Amendment to the Veracyte, Inc. 2023 Equity Incentive Plan.

Veracyte 2026 Proxy Statement 37

Security Ownership of Certain Beneficial Owners and Management

The following table sets forth information regarding the number of shares of common stock beneficially owned on March 31, 2026, by:

•each person who is known by us to beneficially own 5% or more of our common stock;

•each of our named executive officers and directors; and

•all of our current executive officers and directors as a group.

We have determined beneficial ownership in accordance with SEC rules. Except as indicated by the footnotes below, we believe, based on the information furnished to us, that the persons and entities named in the table below have sole voting and dispositive power with respect to all shares of common stock that they beneficially own, subject to applicable community property laws.

Applicable percentage ownership is based on 79,791,856 shares of common stock outstanding at March 31, 2026. In computing the number of shares of common stock beneficially owned by a person and the percentage ownership of that person, we deemed outstanding shares of common stock subject to options and RSUs held by that person that are currently exercisable or settleable or exercisable or settleable within 60 days of March 31, 2026. We did not deem these shares outstanding, however, for the purpose of computing the percentage ownership of any other person.

Except as otherwise set forth below, the address of each beneficial owner is 6000 Shoreline Court, Suite 300, South San Francisco, California 94080.

38 Veracyte 2026 Proxy Statement

Security Ownership of Certain Beneficial Owners and Management

Name and Address of Beneficial Owner

Number of Shares Beneficially Owned (#)(1)

Percentage of Shares Beneficially Owned (%)

5% Stockholders:

BlackRock, Inc.(2)

11,930,018

15.0

Artisan Partners Limited Partnership(3)

6,263,041

7.8

FMR LLC(4)

5,688,209

7.1

State Street Corporation(5)

4,199,674

5.3

Directors and Named Executive Officers:

Marc Stapley(6)

494,513

*

Rebecca Chambers(7)

207,389

*

Phillip Febbo(8)

87,512

*

John Leite(9)

77,281

*

Annie McGuire(10)

102,362

*

Eliav Barr(11)

41,868

*

Muna Bhanji(12)

29,989

*

Karin Eastham(13)

24,233

*

Robert S. Epstein(14)

83,125

*

Evan Jones(15)

40,041

*

Jens Holstein(16)

52,878

*

Tom Miller(17)

5,503

*

Brent Shafer(18)

5,503

*

All directors and executive officers as a group (14 persons)(19)

1,252,197

1.6

*     Less than 1%

(1)Unless otherwise indicated, includes shares owned by a spouse, minor children and relatives sharing the same home, as well as entities owned or controlled by the named person. Unless otherwise indicated, shares are owned of record and beneficially by the named person.

(2)Based on a Schedule 13G/A filed on August 1, 2025, BlackRock, Inc. has sole voting power with respect to 11,712,378 shares and sole dispositive power with respect to 11,930,018 shares of our common stock. The address of BlackRock, Inc. is 50 Hudson Yards, New York, NY 10001.

(3)Based on a Schedule 13G/A filed on February 3, 2026, Artisan Partners Limited Partnership has shared voting power with respect to 5,457,186 shares and shared dispositive power with respect to 6,263,041 shares of our common stock. The address of Artisan Partners Limited Partnership is 875 E. Wisconsin Ave., Milwaukee, WI 53202.

(4)Based on a Schedule 13G/A filed on February 5, 2026, FMR LLC has sole voting power with respect to 5,682,465 shares and sole dispositive power with respect to 5,688,209 shares of our common stock. The address of FMR LLC is 245 Summer Street, Boston, MA 02210.

(5)Based on a Schedule 13G/A filed on November 10, 2025, State Street Corporation has shared voting power with respect to 3,938,903 shares and shared dispositive power with respect to 4,199,674 shares of our common stock. The address of State Street Corporation is One Congress Street, Suite 1, Boston, MA 02114.

(6)Consists of (i) 151,415 shares of our common stock held by Mr. Stapley, and (ii) options to purchase 343,098 shares of our common stock held by Mr. Stapley that are exercisable within 60 days of March 31, 2026.

(7)Consists of (i) 32,114 shares of our common stock held by Ms. Chambers, and (ii) options to purchase 175,275 shares of our common stock held by Ms. Chambers that are exercisable within 60 days of March 31, 2026.

Veracyte 2026 Proxy Statement 39

Security Ownership of Certain Beneficial Owners and Management

(8)Consists of (i) 32,063 shares of our common stock held by Dr. Febbo, and (ii) options to purchase 55,449 shares of our common stock held by Dr. Febbo that are exercisable within 60 days of March 31, 2026.

(9)Consists of (i) 17,821 shares of our common stock held by Dr. Leite, and (ii) options to purchase 59,460 shares of our common stock held by Dr. Leite that are exercisable within 60 days of March 31, 2026.

(10)Consists of (i) 11,334 shares of our common stock held by Ms. McGuire, and (ii) options to purchase 91,028 shares of our common stock held by Ms. McGuire that are exercisable within 60 days of March 31, 2026.

(11)Consists of 41,868 shares of our common stock held by Dr. Barr.

(12)Consists of 29,989 shares of our common stock held by Ms. Bhanji.

(13)Consists of (i) 4,233 shares of our common stock held by Ms. Eastham, and (ii) options to purchase 20,000 shares of our common stock held by Ms. Eastham that are exercisable within 60 days of March 31, 2026.

(14)Consists of (i) 53,125 shares of our common stock held by Dr. Epstein, and (ii) options to purchase 30,000 shares of our common stock held by Dr. Epstein that are exercisable within 60 days of March 31, 2026.

(15)Consists of (i) 20,041 shares of our common stock held by Mr. Jones, and (ii) options to purchase 20,000 shares of our common stock held by Mr. Jones that are exercisable within 60 days of March 31, 2026.

(16)Consists of (i) 17,878 shares of our common stock held by Mr. Holstein, and (ii) options to purchase 35,000 shares of our common stock held by Mr. Holstein that are exercisable within 60 days of March 31, 2026.

(17)Consists of 5,503 shares of our common stock held by Mr. Miller.

(18)Consists of 5,503 shares of our common stock held by Mr. Shafer.

(19)Consists of (i) 422,887 shares of our common stock, and (ii) options to purchase 829,310 shares of our common stock that are exercisable within 60 days of March 31, 2026.

40 Veracyte 2026 Proxy Statement

Executive Officers

The names of our executive officers, their ages and their positions as of April 15, 2026, are shown below:

Name

Age

Position

Marc Stapley

56

Chief Executive Officer and Director

Rebecca Chambers

48

Chief Financial Officer

Phillip Febbo

59

Chief Scientific Officer and Chief Medical Officer

Kevin Haas

41

Chief Development and Technology Officer

John Leite

54

Global Chief Commercial Officer

Annie McGuire

46

General Counsel and Head of Market Access

Executive Officer Information

For information regarding Mr. Stapley, please refer to “Proposal 1- Election of Directors.”

Rebecca Chambers has served as our Chief Financial Officer since July 2021. In addition to leading the Finance organization, she is responsible for our Strategy and Business Development team. Prior to her appointment, Ms. Chambers served as Chief Financial Officer of Outset Medical, Inc., a medical technology company, from 2019 to 2021. Prior to that, Ms. Chambers served in a number of roles at Illumina, Inc., a genetic tools company, including as the Vice President, Financial Planning and Analysis from 2017 to 2019, as Vice President, Investor Relations and Treasury from 2015 to 2017, and as Senior Director, Investor Relations from 2012 to 2015. Previously, Ms. Chambers served as Head of Investor Relations and Corporate Communications at Myriad Genetics, Inc., a molecular diagnostic company, from 2011 to 2012, and Senior Manager, Investor Relations at Life Technologies, Inc. (now part of Thermo Fisher Scientific) from 2009 to 2010. She also previously held positions with Bank of America, a financial services company, and Millennium Pharmaceuticals, a biopharmaceutical company. Ms. Chambers previously served on the board of Inari Medical, Inc. from 2021 until its acquisition by Stryker in February 2025. Ms. Chambers currently serves on the board of Alamar Biosciences, Inc., a life sciences company. Ms. Chambers holds a B.S. from John Carroll University and an M.B.A. from The S.C. Johnson Graduate School of Management, Cornell University.

Age: 48

Position(s) at Veracyte:

Chief Financial Officer

Position(s) Held Since:

July 2021

Veracyte 2026 Proxy Statement 41

Executive Officers

Phillip Febbo, M.D., has served as our Chief Scientific Officer and Chief Medical Officer since October 2023. Previously, Dr. Febbo was the Chief Medical Officer at Illumina, Inc. from 2018 to 2023. Immediately before joining Illumina, Inc., Dr. Febbo served as CMO of Genomic Health, Inc. from 2013 to 2018. Earlier in his career, Dr. Febbo was a Professor of Medicine and Urology at the University of California, San Francisco. Dr. Febbo currently serves on the board of the Regan Udall Foundation for the FDA and the Conquer Cancer Foundation of ASCO. Dr. Febbo previously served on the board of the American College of Medical Genetics and Genomics Foundation from 2018 to 2023 and as a Director on the board of Varian Medical Systems, Inc. from 2019 to 2021. Dr. Febbo holds a B.A. in Biology from Dartmouth College and an M.D. from UCSF. He completed his internal medicine residency at the Brigham and Women’s Hospital and his fellowship in oncology at the Dana-Farber Cancer Institute. While an Attending Physician in the Genitourinary Oncology Center at Dana-Farber and Instructor at Harvard Medical School, he spent five years as a post-doctoral fellow in Dr. Todd Golub’s laboratory at Dana-Farber and the Whitehead Institute Center for Genomic Research of the Massachusetts Institute of Technology (now the Broad Institute).

Age: 59

Position(s) at Veracyte:

Chief Scientific Officer

Chief Medical Officer

Position(s) Held Since:

October 2023

Kevin Haas, Ph.D., has served as our Chief Development and Technology Officer since March 2026. He oversees our global end-to-end product development strategy, spanning diagnostic assay development, software and bioinformatics, as well as the product development program office. He has more than 15 years of life sciences industry experience, leading teams across technology, research, and development. Before joining Veracyte, Dr. Haas served as Chief Technology Officer at Myriad, a position he held since February 2021, where he led the development of the company’s precision medicine platform and digital health strategy. Prior to that, he held leadership roles in engineering and bioinformatics at both Myriad and Counsyl. He has expertise in creating automated lab technology and AI systems to derive insights from genomics data, and in launching scalable molecular assays. Dr. Haas holds a B.S. from University of Wisconsin-Madison and a Ph.D. in Chemical Engineering from University of California-Berkeley, where he worked on molecular simulation and machine learning to study protein dynamics.

Age: 41

Position(s) at Veracyte:

Chief Development and Technology Officer

Position(s) Held Since:

March 2026

42 Veracyte 2026 Proxy Statement

Executive Officers

John Leite, Ph.D., has served as our Global Chief Commercial Officer since November 2024. Dr. Leite joined Veracyte in September 2022 as Senior Vice President, General Manager, Pulmonology & Market Access and was promoted to Chief Commercial Officer, CLIA in September 2023. Dr. Leite leads all aspects of our diagnostic tests that are performed in our CLIA laboratories in the U.S. and sold as IVD kits outside the U.S. This includes market development, product marketing, reimbursement and sales. From 2020 to 2022, Dr. Leite served as Chief Business Officer for Venn Biosciences Corporation dba Intervene Biosciences, a private-stage diagnostics company, where he was responsible for the company’s commercial, partnership and market access strategy. From 2014 to 2020, Dr. Leite held various leadership positions at Illumina, Inc., where he initially served as Vice President, Oncology, Market Development and Product Development, and then as Vice President, Clinical Business Development. Previously, Dr. Leite served as Vice President of Commercial Strategy and Market Access at Genoptix Medical Laboratories. Dr. Leite holds a B.S. in Biochemistry from Rutgers University and a Ph.D. in Biochemistry and Molecular Genetics from the University of Pittsburgh School of Medicine. In addition, he completed post-doctoral work as a National Research Service Award Fellow at the California Institute of Technology.

Age: 54

Position(s) at Veracyte:

Global Chief Commercial Officer

Position(s) Held Since:

November 2024

Annie McGuire has served as our General Counsel since February 2022. From January 2023 to March 2026, she served as our General Counsel and Chief People Officer. In March 2026, Ms. McGuire stepped down as Chief People Officer and currently serves as our General Counsel and Head of Market Access, while also leading Strategic Alliance Management. Prior to joining Veracyte, Ms. McGuire served as General Counsel and Corporate Secretary at Rakuten Medical, Inc., a biotechnology company developing cellular therapies, from 2021 to 2022. Ms. McGuire previously served as Vice President, Legal at MyoKardia, Inc., a biotechnology company, from 2020 to 2021, through its acquisition by Bristol Myers Squibb. Prior to MyoKardia, Ms. McGuire served in several senior legal positions, including executive compensation, employment, M&A and healthcare, as well as serving as the head of compliance for the bone health and cardiovascular business unit at Amgen, Inc., a global biopharmaceutical company, from 2007 to 2020. Ms. McGuire began her career as an associate at the law firm Proskauer Rose LLP in New York and is admitted to the New York Bar. Ms. McGuire holds a Bachelor’s degree from Pace University and a Juris Doctor from New York Law School.

Age: 46

Position(s) at Veracyte:

General Counsel

Head of Market Access

Position(s) Held Since:

February 2022

Veracyte 2026 Proxy Statement 43

Executive Compensation

Compensation Discussion and Analysis

This Compensation Discussion and Analysis (“CD&A”) provides an overview of our executive compensation philosophy, the objectives of our executive compensation program and each compensation component that we provide. In addition, we explain how and why our Compensation Committee arrived at specific compensation policies and decisions involving our NEOs for the year ended December 31, 2025. This CD&A is intended to be read in conjunction with the immediately following tables, which include historical context of pay.

The following executive officers constituted our named executive officers (“NEOs”) for the year ended December 31, 2025:

Executive Summary

2025 Business Highlights

In 2025, we continued our strong performance through exceptional execution on the top line and bottom line through disciplined financial and budget management with our growth driven primarily by our Decipher and Afirma products.

Total Revenue $517.1M á 16% over 2024 Testing Revenue $493.2M á 18% over 2024 Net Income $66.4M á 175% over 2024 Cash on Hand $412.9M of cash, cash equivalents and short-term investments at end of year

44 Veracyte 2026 Proxy Statement

Executive Compensation

Total Test Volume 179,528 á 18% over 2024, driven by Decipher and Afirma Decipher Prostate Test Validated by 115 Publications demonstrating the clinical validity and utility of the test, making it the most validated gene expression prostate test á 22 publications over 2024 Launched v2 Transcriptome for Afirma testing to improve lab efficiency and provide results for more patients

Other Highlights

Progressed with the launch of our first whole-genome MRD test in Muscle Invasive Bladder Cancer, submitting the technical assessment for TrueMRD to MolDx in March of 2025. Adding MRD to our novel Veracyte Diagnostics Platform will expand our ability to serve patients across the cancer care continuum.

2025 Compensation Highlights

Annual Cash Incentive Compensation Tied to Financial Performance. In 2025, our annual incentive award plan was designed to drive performance on key financial metrics — testing revenue and adjusted EBITDA as a percentage of revenue. These metrics were achieved at 118%. Equity Mix. In 2025, our NEOs were granted a mix of PSUs and RSUs, with the equity mix consisting of 50% PSUs (at target) and 50% RSUs.

Say-on-Pay Results

In 2025, 97.3% of stockholders supported our 2025 say‑on-pay proposal In 2024, 95.2% of stockholders supported our 2024 say‑on-pay proposal In 2023, 97.0% of stockholders supported our 2023 say‑on-pay proposal In 2022, 91.7% of stockholders supported our 2022 say‑on-pay proposal

Veracyte received approximately 97.3% support from stockholders for our 2025 say-on-pay proposal. The Compensation Committee is appreciative of this support and believes it indicates that stockholders are supportive of our pay program structure and the alignment we have created between management and stockholder interests. The Compensation Committee will continue to consider the results of future stockholder votes, along with other forms of stockholder input and feedback, when structuring executive pay.

Veracyte 2026 Proxy Statement 45

Executive Compensation

Executive Compensation Philosophy and Objectives

We have designed our executive compensation program to reward our executive officers, including our NEOs, at a level consistent with our overall strategic and financial performance and to provide remuneration sufficient to attract, retain and motivate them to exert their best efforts in the highly competitive environment in which we operate. We believe in providing competitive compensation packages consisting of a combination of base salary, an annual cash bonus and long-term incentive opportunities in the form of equity awards that are earned over a multi-year period. We believe the approach that has been adopted by our Compensation Committee, with an emphasis on variable cash compensation and equity awards, enables us to attract top talent, motivate successful short-term and long-term performance, satisfy our retention objectives, and align the compensation of our executive officers with our performance and long-term value creation for our stockholders.

Pay Program Overview

We believe that the design and structure of our pay program, and in particular our incentive plans, support our business strategy and organizational objectives while successfully aligning executive focus and interest with that of stockholders. Our compensation programs are designed to reward our executives for superior short- and long- term performance. All pay elements, and the safeguards and governance features of the program, have been carefully chosen and implemented to align with our pay philosophy and objectives.

In doing so, our Compensation Committee uses the following framework to achieve these objectives:

			Base Salary			•Base salaries are set to be competitive within our industry and are important in attracting and retaining talented executives. •Base salaries are fixed amounts paid in cash set with consideration for responsibilities, experience, individual contribution expectations and market data.
			Annual Cash Incentive Compensation			•The annual cash incentive award plan is intended to motivate and reward our executives for the achievement of certain strategic goals of Veracyte set by our Board of Directors. •Our annual incentive award plan is a variable short-term element of total compensation payable in cash as a percentage of base salary designed to drive performance on key financial objectives, including total testing revenue and adjusted EBITDA as a percentage of revenue, also referred to as ”adjusted EBITDA margin.”
			Long-Term Equity Incentive Compensation			•Long-term equity awards incentivize executives to deliver long-term stockholder value while also providing a retention vehicle for our top executive talent. •NEO equity awards are a variable long-term element of total compensation typically delivered as: •50% PSUs (based on achievement of revenue growth, adjusted EBITDA margin and product development metrics over two- and three-year periods) •50% RSUs (vesting over four years)

46 Veracyte 2026 Proxy Statement

Executive Compensation

2025 Target Pay Mix

Consistent with our philosophy of aligning executive pay with Veracyte’s short- and long-term performance, and to align the interests of management and stockholders, our compensation programs are designed such that the majority of executive compensation is in the form of variable, at-risk incentive pay. For 2025, our Compensation Committee structured target pay packages for our Chief Executive Officer and NEOs as follows:

2025 CEO Pay Mix

2025 Other NEO Pay Mix

Note: Includes target annual cash-based incentives and the grant date fair value of annual equity grants.

Compensation Governance

Our Compensation Committee is responsible for oversight of Veracyte’s compensation program and practices. The committee maintains a pay program defined by robust corporate governance and a commitment to stockholder interests. We have committed to numerous practices and safeguards to ensure the compensation program does not misalign those interests. These include:

WHAT WE DO

Pay-for-performance philosophy and culture

An appropriate mix of short- and long-term incentives for our executives

Thresholds and caps for our short- and long-term incentives

Responsible use of shares under our long-term incentive program

Annual risk assessment of our compensation program

Stock ownership guidelines for all executives and non‑executive directors

“Double-trigger” change-in-control provisions

Annual Say-on-Pay vote

Engage an independent compensation consultant

Independent Compensation Committee

Compensation recovery policy to ensure accountability

WHAT WE DON‘T DO

No excise tax gross-ups

No excessive perquisites

No repricing of stock option awards without stockholder approval

No discounted stock option awards

No hedging or pledging of our stock

No dividends or dividend equivalents on unvested equity awards

Veracyte 2026 Proxy Statement 47

Executive Compensation

Compensation Determination Process

Role of the Compensation Committee

Our Compensation Committee oversees our compensation policies, plans and benefits programs and determines and approves or makes recommendations to our Board of Directors regarding the compensation of our executive officers. In addition, our Compensation Committee reviews and approves or makes recommendations to our Board of Directors with respect to our major compensation plans, policies and programs and assesses whether our compensation structure establishes appropriate incentives for officers and employees. The Compensation Committee conducts an annual review of all components of executive compensation for all executive officers and approves compensation for all executive officers other than our Chief Executive Officer, for whom it recommends compensation to the Board of Directors. Chief Executive Officer compensation and overall bonus achievement are then approved by the independent members of our Board of Directors. The Compensation Committee also reviews and recommends non-employee directors’ compensation to the full Board of Directors on an annual basis. The Compensation Committee has the sole authority to select, retain, terminate and approve the fees and other retention terms of consultants as it deems appropriate to perform its duties.

Role of Management

Veracyte’s Chief Executive Officer is involved in the design and implementation of our executive compensation and is typically present at Compensation Committee meetings, except that the Chief Executive Officer is not present during any voting or deliberations on his compensation. In 2025, the Chief Executive Officer conducted performance evaluations and reviewed the analysis and recommendations of Aon with the Compensation Committee, and made recommendations regarding proposed salary, cash bonus opportunities and equity awards for our officers (other than himself). Management also participates in conducting annual risk assessments and ensuring that any risks involving compensation are properly mitigated. The Compensation Committee exercises its business judgment in accepting, rejecting and/or modifying any such executive compensation recommendations and approves all compensation and equity awards for all executive officers other than the Chief Executive Officer.

Role of the Independent Compensation Consultant

The Compensation Committee retains an independent compensation consultant to provide professional expertise regarding a variety of executive compensation and market practices. The Compensation Committee believes that working with an independent compensation consultant furthers our objectives to recruit and retain qualified executives, align their interests with those of stockholders and ensure that their compensation packages will appropriately motivate and reward ongoing achievement of business goals. The independent consultant assists the Compensation Committee in setting compensation and designing a comprehensive plan. In 2025, the Compensation Committee retained Aon to provide the following services:

•Reviewing and modifying the compensation peer group;

•Evaluating executive and director market pay analysis;

•Developing executive and director pay programs;

•Evaluating equity pay market analysis;

•Examining the change in control and severance arrangement; and

•Updating certain proxy disclosures, including this CD&A.

The Compensation Committee annually evaluates the independent compensation consultant’s independence and performance under the applicable SEC and Nasdaq listing standards. Aon and its affiliates did not provide any services to us other than the services described in this Proxy Statement relating to director and executive compensation. The Compensation Committee conducted a specific review of its relationship with Aon in 2025, pursuant to the SEC rules and Nasdaq listing standards, and concluded that Aon’s work for the Compensation Committee did not raise any conflicts of interest.

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Executive Compensation

Use of Competitive Data

To assess the competitiveness of our executive compensation program and compensation levels, our Compensation Committee, with the assistance of Aon, examines the competitive compensation data for senior executives of our peer companies examining overall pay and each pay element. The Compensation Committee uses a peer group to reference and analyze recent market data and understand the marketplace.

The Compensation Committee also considers other factors, such as individual performance, experience, history and scope of responsibility, current market conditions and the specific needs of the business at critical points in time. The Compensation Committee uses its best business judgment in setting pay with the peer group data as a reference point rather than as a specific benchmark or a specific formula for allocated pay across the various elements. The Compensation Committee conducts an annual assessment of the peer group to ensure that it reflects Veracyte’s most current financial and sector-specific standing.

2025 Peer Group

Aon helped the Compensation Committee identify companies similar to us with respect to sector and market capitalization, as well as revenue and headcount, to provide a broad perspective on competitive pay levels and practices. The Compensation Committee also considers criteria from outside investors and the talent market when selecting the final criteria and list of companies. The following criteria were applied in developing the peer group used for 2025 compensation decisions:

•Sector - Biotechnology/Pharmaceuticals, Life Sciences Tools and Services, and Health Care Equipment and Supplies companies;

•Market Capitalization - $600.0 million to $5.0 billion, which was 0.3x to 3.0x; and

•Revenue - 0.5x to 3.0x Veracyte’s projected revenues.

Using these criteria, in July 2024 the following 19 companies were approved to make up our 2025 peer group^:

10x Genomics (TXG)			Adaptive Biotechnologies (ADPT)			Amicus Therapeutics (FOLD)*
BioCryst Pharmaceuticals (BCRX)*			CareDX (CDNA)			Cytek Biosciences (CTKB)
Exact Sciences (EXAS)			Fulgent Genetics (FLGT)			Glaukos (GKOS)
Guardant Health (GH)			Maravai Lifesciences (MRVI)*			Myriad Genetics (MYGN)
Natera (NTRA)			NeoGenomics (NEO)			Nevro (NVRO)*
Pacific Biosciences of California (PACB)			Twist Bioscience (TWST)			Ultragenyx Pharmaceutical (RARE)*
Vericel (VCEL)

^     Invitae was removed from the peer list due to no longer fitting the criteria.

*     New in 2025 based on criteria outlined above.    

At the time of approval, Veracyte was near the 54th percentile for revenue and the 44th percentile for market capitalization, reinforcing the balance in the group of companies.

Veracyte 2026 Proxy Statement 49

Executive Compensation

Consideration of Compensation Risk

Our compensation governance practices provide an appropriate framework for our executives to achieve our strategic goals without encouraging them to take excessive risks in their business decisions.

On an annual basis, the Compensation Committee conducts a thorough risk assessment of our compensation programs and practices to analyze whether they encourage employees to take excessive or inappropriate risks. After conducting this analysis, the Compensation Committee concluded our compensation programs are, on balance, consistent with market practice and do not present material risks to us. The reasons for the Compensation Committee’s determination include the following:

•We structure our compensation programs to consist of both fixed and variable components. The fixed (or base salary) component of our compensation programs is designed to provide income independent of our stock price performance so that employees will not focus exclusively on stock price performance to the detriment of other important business metrics. The variable (cash bonus and equity) components of our compensation programs are designed to reward both short- and long-term company performance, which we believe discourages employees from taking actions that focus only on our short-term success and helps align our employees with our stockholders and focus on our longer-term success.

•We maintain internal controls over the measurement and calculation of financial information, which are designed to prevent this information from being manipulated by any employee, including our executive officers.

•While we generally do not cap cash incentive awards for our sales commissions plans to maximize the incentive for our sales force to meet and exceed their revenue and other commercial objectives, we do maintain internal controls over the determination of sales incentive awards, which we believe helps prevent problematic behaviors.

•Our employees are required to comply with our Code of Conduct, which covers, among other things, accuracy in keeping financial and business records.

•As part of our Insider Trading Policy, we prohibit the trading of derivatives or hedging transactions involving our securities so that our Board of Directors, executive officers and all other employees cannot insulate themselves from the effects of poor stock price performance or engage in trading that is not aligned with value creation for our stockholders.

Elements of Our Executive Compensation Program

To maintain a competitive and comprehensive pay package, we utilize three primary compensation vehicles to reward our executives: base salary, annual cash incentives and long-term equity compensation. When setting our compensation practices, we ensure that our program will focus our executive officers on leading our entire organization toward achieving both short-term and long-term strategic, financial and operational goals, and increasing stockholder value, without encouraging excessive risk-taking.

2025 Base Salaries

Base salaries serve to provide fixed cash compensation to our executive officers for performing their ongoing responsibilities. Base salaries for our executive officers are approved by the Compensation Committee upon the executive joining us, and then reviewed and adjusted, as appropriate, by the Compensation Committee on an annual basis, in consultation with Aon and based on consideration of various factors, including:

•The individual’s role and responsibilities;

•Individual contribution and performance of the past year;

•Overall experience and expertise;

•Current Veracyte base salary;

•Corporate performance; and

•Salaries for similar positions within our peer group and industry.

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Executive Compensation

Our Compensation Committee and, with respect to our Chief Executive Officer, the independent members of the Board of Directors, approved the following base salaries for our NEOs in February 2025 in a similar manner and at similar levels as our company-wide practices.

			Executive			2024 Base Salary ($)			2025 Base Salary ($)			% Change (%)
			Marc Stapley			675,000			700,000			3.7
			Rebecca Chambers			530,400			550,000			3.7
			Phillip Febbo(1)			550,000			561,000			2.0
			John Leite(2)			472,500			510,300			8.0
			Annie McGuire(3)			470,800			500,000			6.2

(1)Dr. Febbo‘s salary increase was to maintain his position relative to market.

(2)Dr. Leite‘s salary increase reflects consideration of his performance and positioning relative to market.

(3)Ms. McGuire’s salary increase is reflective of expanded responsibilities related to product development and positioning relative to market.

2025 Annual Cash Incentives

We provide our executives, including our NEOs, with the opportunity to annually earn cash incentives to encourage the achievement of corporate objectives, and to reward those individuals who significantly impact our corporate results. Payments under our annual bonus plan are based on the achievement of corporate goals established by our Board of Directors. Actual performance against these metrics funds the annual bonus plan pool, and threshold levels of performance must be met for the pool to be funded.

Each of our NEOs participated in our 2025 annual bonus plan. Executive officers who participate in this plan have an established annual incentive target, which is equal to a percentage of their base salary. For 2025, our NEOs had the annual bonus target opportunities set forth in the table below which were unchanged from 2024. The maximum funding under the plan is 150% of target.

			Executive			Target Annual Incentive (as % of base salary)
			Marc Stapley			100
			Rebecca Chambers			55
			Phillip Febbo			55
			John Leite			55
			Annie McGuire			55

2025 Bonus Plan Awards

In February 2025, the independent members of our Board of Directors, on the recommendation of the Compensation Committee, approved corporate goals for our 2025 annual bonus plan. Under the plan, eligible employees, including our NEOs, were eligible to receive a cash bonus if we achieved the corporate goals approved by our Board of Directors, as described in the table below.

Veracyte 2026 Proxy Statement 51

Executive Compensation

The Compensation Committee established total testing revenue as the primary financial performance measure to be used to determine annual cash bonuses as it is the best indicator of our growth and successful execution of our annual operating plan. Total testing revenue was selected in place of total revenue to align with market guidance and in consideration of the unknown impact of concluding operations of our subsidiary in Marseille, France, at the time of plan design. In addition, the Compensation Committee determined adjusted EBITDA margin should replace cash balance as a second key measure to determine annual cash bonuses to reflect our focus on profitability.

With respect to our NEOs, the bonus pool could be funded from 0% to 150% based on achieving certain total testing revenue and adjusted EBITDA margin goals that were pre-established to align with our long-range goals as follows:

												Funding Amount
			Goals			Weighting						75		%	100		%	150		%
			Total Testing Revenue			60		%				$480M			$495M			$525M
			Adjusted EBITDA Margin			40		%				20.7		%	22.0		%	23.0		%

For 2025, the annual incentive bonuses for the NEOs were determined based solely on Veracyte performance and did not include an individual performance multiplier. Actual annual performance bonus awards paid out under the plan could be greater or less than the NEOs’ individual targets, as determined by the independent members of our Board of Directors at their discretion, considering the recommendation of the Compensation Committee. The Board of Directors did not exercise this discretion when determining the final awards for 2025.

In February 2026, the independent members of our Board of Directors, on the recommendation of the Compensation Committee, determined 2025 performance and the resulting cash bonus awards. For 2025, our budget for total testing revenue was $486 million (16.0% year-over-year growth) and our target for executives was set at $495 million (18.1% growth). Our total testing revenue for 2025 was $493 million (an increase of 17.7% over 2024 total testing revenue of $419 million), reflecting 101.4% of budget and 99.6% of target. For 2025, our adjusted EBITDA margin was 27.6%, which exceeded our max of 23% (an increase of 11.7% over 2024 adjusted EBITDA margin of 20.6%, reflecting balance between reinvesting for growth and profitability).

Each metric is calculated individually, and the sum of the calculations determines the potential bonus pool payout:

			Metric			Weighting			Minimum  (75%)			Target (100%)			Maximum  (150%)			Actual			Achievement (% of target payout)
			Total Testing Revenue			60		%	$480M			$495M			$525M			$493M			97		%
			Adjusted EBITDA Margin(1)			40		%	20.7%			22.0%			23.0%			27.6%			150		%
			Total			100%															118		%

(1)Adjusted EBITDA margin is a supplemental measure of financial performance that is not required by, or presented in accordance with, generally accepted accounting principles in the U.S. (“U.S. GAAP”). We compute adjusted EBITDA margin by adjusting the most directly comparable U.S. GAAP measure to remove the impact of certain recurring and non-recurring charges and gains and to adjust for the impact of income tax items related to such adjustments to our U.S. GAAP financial statements. In particular, we exclude amortization of acquired intangible assets, acquisition-related expenses relating to our acquisitions of Decipher Biosciences, HalioDx and C2i Genomics, impairment charges associated with the nCounter license and other biopharmaceutical services related to HalioDx intangible assets, all stock-based compensation and certain costs related to restructuring, as well as depreciation and income tax items from adjusted EBITDA margin.

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Executive Compensation

Based on a review of all goals and accomplishments, the independent members of our Board of Directors and Compensation Committee determined that the financial goals were achieved at 118%. Our NEOs’ earned annual incentives for 2025 were as follows:

						Target FY 2025 Opportunity												Actual Bonus
			Executive			2025 Base Salary ($)			2025 Target Bonus (as a % of base salary)			Target Bonus ($)						Corporate Multiplier (%)			2025 Earned Bonus ($)
			Marc Stapley			700,000			100			700,000						118			826,000
			Rebecca Chambers			550,000			55			302,500						118			356,950
			Phillip Febbo			561,000			55			308,550						118			364,089
			John Leite			510,300			55			280,665						118			331,185
			Annie McGuire			500,000			55			275,000						118			324,500

Equity Compensation

A significant portion of executive pay is delivered as long-term incentives in the form of equity awards, which are designed to align executive officers’ interests with stockholder interests, promote retention through the reward of long-term company performance and encourage ownership in our company.

We grant equity awards in the form of RSUs and PSUs using a mix of 50% time-based and 50% performance-based awards in 2025. The Compensation Committee believes that certain targeted PSUs can provide an appropriate long-term incentive for our executive officers, as PSUs reward our executive officers only to the extent certain performance measures aligned with driving increased stockholder value are met. We believe that RSUs reward our executive officers with long-term stock price appreciation while simultaneously helping us retain our executive officers, as RSUs provide some value to the recipient even if the market price of our common stock declines following the grant date.

The Compensation Committee initially determines the size of equity grants by considering the executive officer’s position and market data of our peer group companies as provided by Aon as well as overall dilution and other inputs. The Compensation Committee then takes into consideration each NEO’s recent performance history, his or her potential for future responsibility and criticality of his or her work to the long-term success of our company and the retention value of outstanding awards. The Compensation Committee uses its judgment to give relative weight to each of these factors as it sets the size of the equity grant to appropriately create an opportunity for reward based on increasing stockholder value. For newly hired or promoted executive officers, the Compensation Committee also takes into consideration the value needed to induce the individual to accept the position and to drive substantial performance.

Veracyte 2026 Proxy Statement 53

Executive Compensation

2025 Equity Grants

In February 2025, the Compensation Committee (and, in the case of our Chief Executive Officer, our Board of Directors), in consultation with Aon and in consideration of governance best practices as well as ongoing market trends and data of our compensation peers, determined to provide NEOs with annual grants that consisted of 50% RSUs and 50% PSUs (“2025 PSUs”). The terms of these 2025 PSUs are described below. The approved annual equity awards were granted to the NEOs, in the following amounts:

			Executive			RSUs (#)			PSUs (#)
			Marc Stapley			90,601			90,601
			Rebecca Chambers			30,200			30,200
			Phillip Febbo			24,160			24,160
			John Leite			36,240			36,240
			Annie McGuire			30,200			30,200

Time-Based Vesting RSUs

The annual RSU awards granted in March 2025 vest as to 1/4 on the first anniversary of March 2, 2025, and then in equal quarterly installments over the following 12 quarters, based on continuing service on each vesting date (until the fourth anniversary of March 2, 2025).

Performance-Based RSUs

In March 2025, we again granted PSUs to certain of our executive officers, referred to as the 2025 PSUs. We continue to use revenue as a performance metric because we believe it is, and continues to be, an important indicator of our strategic long-term growth at this stage in our company’s maturity and it has been an important metric used by investors to assess the health and trajectory of our business. In 2025, we replaced cash balance with adjusted EBITDA margin as an additional performance metric to reflect our focus on profitability. Adjusted EBITDA margin is a core measure of our operating performance and is therefore appropriate for both short- and long-term incentive programs. In the annual cash incentive plan, it emphasizes year-over-year profitability, while in the long-term plan, it reinforces sustained margin expansion and scalable growth over a multi-year period. Additionally, to drive sustained stockholder value growth, we added new product launches, in alignment with our strategic plan, as a third performance metric for the 2025 PSUs.

Consistent with our 2024 PSUs, the 2025 PSUs are split into a two-year measurement period and a three-year measurement period to reward growth and execution over time. Seventy percent of the total number of shares granted as PSUs in 2025 will be earned if revenue growth (40%) and adjusted EBITDA margin (30%) for the two-year period ending December 31, 2026, equal or exceed specified thresholds. Thirty percent of the total number of shares granted as PSUs will be earned if new product launches for the three-year period ending December 31, 2027, equals or exceeds a specified threshold. Achievement between threshold, target and maximum levels of performance of each metric is interpolated, with a maximum achievement level of 150% of the target PSUs for each performance period. At the time these 2025 PSUs were awarded, the Compensation Committee and Board of Directors believed our primary and immediate focus should be on increased, sustained revenue growth across multiple time horizons and with increased attention to profitability. To that end, the Compensation Committee felt the 2025 PSU’s two-year measurement period was the most appropriate length for our growth strategy while also considering the challenges of establishing appropriate financial performance goals beyond two years. To drive further alignment with long-term stockholder value, product goals with a three-year measurement period were introduced for the 2025 PSUs. In the Compensation Committee’s opinion, this structure strikes a reasonable balance between investing for long-term growth and an ongoing focus on medium-term revenue increases and profitability, given the dynamic changes in the diagnostic and testing marketplace. For purposes of the 2025 PSU awards, “Revenue” means our total revenue calculated in accordance with U.S. GAAP, as reported in our annual financial statements for the applicable year, including adjustments for acquisitions or similar transactions and including adjustments

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for the impact of foreign currency exchange and portfolio decisions made by the Board of Directors to discontinue any of the company’s products for which projected revenue was included in the forecast on which the revenue target was based. Adjusted EBITDA margin is calculated by adjusting the most directly comparable U.S. GAAP measure to remove the impact of certain recurring and non-recurring charges and gains, which may include the impact of acquisitions or similar transactions, and to adjust for the impact of income tax items related to such adjustments to our GAAP financial statements.

Weighting

Performance Period

Performance Metric

Rationale

40%

2 years ended December 2026

Revenue Growth - based on total revenue calculated in accordance with U.S. GAAP, including adjustments for acquisitions and similar transactions and including adjustments for the impact of foreign currency exchange

Reflects primary focus on increasing and sustaining revenue growth in the medium-term given the dynamic changes in the diagnostic and testing marketplace

30%

2 years ended December 2026

Adjusted EBITDA Margin – based on reported U.S. GAAP financials and adjusted to remove the impact of certain recurring and non-recurring charges and gains and related impact of income tax items

Reflects focus on sustaining margin expansion and sustained growth over a multi-year period

30%

3 years ended December 2027

New Products – as agreed to by the Board of Directors in the annual strategic plan

Aligns with our strategy to drive long-term growth and stockholder value

Significant Competitive Harm in Disclosing Threshold, Target and Maximum Levels

We have not publicly disclosed the specific PSU performance threshold, target and maximum levels because we believe advance disclosure of the levels could cause significant competitive harm to our business. The levels were purposefully set to be more aggressive than our disclosed guidance and long-term financial plan and are fully achievable only by outperforming such guidance and plan. If specific levels were disclosed, they could be treated as our new guidance or long-term financial plan, which would not align with (i) our purpose of using the PSU performance levels to encourage exceptional outperformance of our rigorous disclosed guidance and plan, and (ii) how we understand the role the PSU performance levels have in our long-term business and strategy. Disclosing the specific levels could also create a retention risk for our Chief Executive Officer and other NEOs, who are crucial to the execution of our next phase of growth by giving insight into the retentive value of the PSU awards. Companies competing for our top executive talent could use the levels’ rigor and the significant challenge of achieving the full award, depending on how many tranches have been earned and what remains of the performance period, to undercut the value of the PSU awards by offering a sign-on bonus or a more easily achievable compensation package to induce our NEOs to leave Veracyte. While we are not disclosing the levels in advance, we plan to appropriately disclose applicable achievements in a fiscal year in the following year’s proxy statement.

Veracyte 2026 Proxy Statement 55

Executive Compensation

Prior Year PSUs – Achievement

The following table and footnotes summarize PSU awards that were eligible to be achieved during 2025:

PSU Awards (Year of Grant)

Performance Period

Performance Metric

Achievement (%)

2023 PSUs(1)

3 years ended December 2025

Revenue calculated in accordance with U.S. GAAP, adjusted for foreign currency exchange impact and portfolio decisions Ending Cash, Cash Equivalents and Short-Term Investment balance as of December 31, 2025, excluding the impact of acquisitions and capital raises and uses

Max of 150% of target level performance of $458 million in Revenue and max of 150% of target level performance of $232 million in Cash 150% PSUs earned; vested in February 2026

2024 PSUs(2)

2 years ended December 2025

Revenue calculated in accordance with U.S. GAAP, adjusted for foreign currency exchange impact and portfolio decisions Ending Cash, Cash Equivalents and Short-Term Investment balance as of December 31, 2025, excluding the impact of acquisitions and capital raises and uses

Max of 150% of target level performance of $475 million in Revenue and max of 150% of target level performance of $280 million in Cash 150% PSUs earned; vest in December 2026

(1)Any achieved PSUs vested upon the date the achievement was certified by the Compensation Committee during the first quarter of 2026, subject to the officer’s continued service to Veracyte.

(2)Achievement of PSUs was certified by the Compensation Committee during the first quarter of 2026 and will vest in December 2026, subject to the officer‘s continued service to Veracyte.

Additional Compensation Practices and Policies

Compensation Recovery Policy

On April 23, 2023, our Board of Directors adopted a compensation recovery policy (the “Clawback Policy”) intended to comply with the requirements of the Dodd-Frank Wall Street Reform and Consumer Protection Act, as implemented by Nasdaq rules and the SEC’s rules and regulations. The Clawback Policy requires us to recover certain incentive-based compensation (as defined in the Clawback Policy) paid or granted to our officers, and such additional employees as may be identified from time to time, in the event we are required to prepare an accounting restatement due to our material noncompliance with any financial reporting requirement under the securities laws. The policy requires each person covered thereby to reimburse or forfeit to us all incentive-based compensation received by them prior to the restatement that exceeds the amount they would have received had their incentive-based compensation been calculated based on the financial restatement. The recovery period extends up to three years prior to the date that it is, or reasonably should have been, concluded that we are required to prepare a restatement. The Clawback Policy applies to incentive-based compensation that is received (as defined in the Clawback Policy) after the effective date of the applicable Nasdaq rules. Per applicable requirements, the Clawback Policy is enforced without consideration of responsibility or fault or lack thereof. The full text of the Clawback Policy is included as Exhibit 97.1 to our Annual Report on Form 10-K for the year ended December 31, 2023.

Hedging, Derivative Securities Transactions, Short Selling and Pledging

Under our Insider Trading Policy, our employees (including our executive officers) and the non-employee members of our Board of Directors are prohibited from engaging in hedging or monetization transactions involving our securities, such as zero-cost collars and forward sale contracts, and may not contribute our securities to exchange funds that could be interpreted as having the effect of hedging in our securities. Further, our employees (including executive officers) and the non-employee members of our Board of Directors are prohibited from engaging in transactions involving options or other derivative securities on our securities, such as puts and calls, whether on an exchange or in any other market and from engaging in short sales of our securities, including short sales “against the box.”

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Also, under our Insider Trading Policy, our employees (including our executive officers) and the non-employee members of our Board of Directors are prohibited from using or pledging our securities as collateral in a margin account or as collateral for a loan. The full text of our Insider Trading Policy is included as Exhibit 19 to our Annual Report on Form 10-K for the fiscal year ended December 31, 2024.

Executive and Board Stock Ownership Guidelines

We maintain stock ownership guidelines for our executive officers and members of our Board of Directors. Under these guidelines, the Chief Executive Officer and each other individual serving as a C-Level executive officer and each member of our Board of Directors must achieve the requirement within five years of becoming subject to the guidelines. We believe these stock ownership guidelines create alignment between our executive officers and members of the Board of Directors and the long-term performance of the company.

			Position			Requirement
			Chief Executive Officer			3x base salary
			C-Level Executive Officers other than Chief Executive Officer			1x base salary
			Non-Employee Members of the Board of Directors			3x annual cash retainer

For the purposes of determining stock ownership levels, the following forms of equity interests are included: shares owned by the officer directly, or held in trust for the benefit of, the officer or director or his or her immediate family members residing in the same household or through trusts, and the “In-the-Money” value of vested stock option awards. Unvested stock options, unvested restricted stock units and unvested performance stock units are not included for the purposes of our stock ownership guidelines. The applicable guidelines must be met within the earliest of five years from: (i) joining Veracyte, (ii) promotion to a C-Level executive officer or (iii) establishment of the guidelines in February 2021. As of December 31, 2025, all non-employee directors and all of our current executive officers who are subject to these requirements were in compliance with our stock ownership guidelines, other than those executive officers whose employment began in 2022 or more recent years, each of whom has sufficient time remaining to meet the required ownership level.

Tax and Accounting Considerations

Deductibility of Executive Compensation

Our Compensation Committee may take into consideration the accounting and tax treatment of the compensation and benefits arrangements of our NEOs. These considerations are in addition to those described above that were material to the pay decisions for the most recent fiscal year.

While the Compensation Committee considers the deductibility of awards as one factor in determining executive compensation, the Compensation Committee also looks at other factors in making its decisions and retains the flexibility to award compensation that it determines to be consistent with the goals of our executive compensation program even if the awards are not deductible by us for tax purposes.

Taxation of “Parachute” Payments and Deferred Compensation

Sections 280G and 4999 of the Internal Revenue Code provide that certain employees, officers and directors, as well as individuals who hold significant equity interests and certain other service providers may be subject to an excise tax if they receive payments or benefits in connection with a change in control that exceed certain prescribed limits, and that we (or a successor) may forfeit a deduction on the amounts subject to this additional tax. Section 409A of the Internal Revenue Code imposes significant additional taxes in the event that an employee, including a named executive officer, director or service provider receives “nonqualified deferred compensation” that does not satisfy the conditions of Section 409A.

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We have not agreed and are not otherwise obligated to provide any named NEO with a “gross-up” or other reimbursement payment for any tax liability that he or she might owe as a result of the application of Sections 280G, 4999 or 409A of the Internal Revenue Code.

Accounting for Stock-Based Compensation

We follow the FASB ASC Topic 718 for our stock-based compensation awards. ASC 718 requires companies to calculate the grant date “fair value” of their stock-based awards using a variety of assumptions. This calculation is performed for accounting purposes and reported in the compensation tables that accompany this CD&A, even though recipients may never realize any value from their awards. ASC 718 also requires companies to recognize the compensation cost of their stock-based awards in their statements of operations over the period that the recipient of the award is required to render service in exchange for the award.

Compensation Committee Report

This report of the Compensation Committee is required by the SEC and, in accordance with the SEC’s rules, will not be deemed to be part of or incorporated by reference by any general statement incorporating by reference this Proxy Statement into any filing under the Securities Act, or under the Exchange Act, except to the extent that we specifically incorporate this information by reference, and will not otherwise be deemed “soliciting material” or “filed” under either the Securities Act or the Exchange Act.

The Compensation Committee has reviewed and discussed with management the Compensation Discussion and Analysis required by Securities and Exchange Commission regulations. Based on its review and discussions, the Compensation Committee recommended to the Board of Directors that the Compensation Discussion and Analysis be included in this Proxy Statement and, through incorporation by reference, in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025.

Submitted by The Compensation Committee of the Board of Directors

Karin Eastham (Chair)

Jens Holstein

Brent Shafer

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Summary Compensation Table

The following table provides information concerning compensation awarded to, earned by or paid to each of our NEOs for 2023, 2024 and 2025.

			Name and Principal Position			Year			Salary ($)						Stock Awards ($)(1)			Option Awards ($)(1)			Non-Equity Incentive Plan Compensation ($)(2)			All Other Compensation ($)(3)			Total ($)
			Marc Stapley Chief Executive Officer			2025			700,000						5,890,877			—			826,000			5,000			7,421,877
						2024			675,000						5,125,868			—			1,012,500			3,000			6,816,368
						2023			650,000						3,703,968			1,927,416			900,250			3,000			7,184,634
			Rebecca Chambers Chief Financial Officer			2025			550,000						1,963,604			—			356,950			5,000			2,875,554
						2024			530,400						2,674,366			—			437,580			3,000			3,645,346
						2023			510,000						1,234,624			642,467			388,493			3,000			2,778,584
			Phillip Febbo Chief Scientific Officer and Chief Medical Officer			2025			561,000						1,570,883			—			364,089			5,000			2,500,972
						2024			550,000						1,782,911			—			453,750			3,000			2,789,661
						2023			137,500						2,335,753			1,206,047			104,741			3,000			3,787,041
			John Leite Global Chief Commercial Officer			2025			510,300						2,356,325			—			331,185			5,000			3,202,810
						2024			472,500						2,228,638			—			389,813			3,000			3,093,951
						2023			421,067						858,051			377,918			264,433			3,000			1,924,469
			Annie McGuire General Counsel and Head of Market Access			2025			500,000						1,963,604			—			324,500			5,000			2,793,104
						2024			470,800						2,228,638			—			388,410			3,000			3,090,848
						2023			440,000						1,111,181			578,214			335,170			16,553			2,481,118

(1)Amounts represent the aggregate fair value of the awards computed as of the grant date of each award in accordance with ASC 718 for financial reporting purposes, rather than amounts paid to or realized by the named individual. Our assumptions with respect to the calculation of these values are set forth in Note 9 to Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2025. There can be no assurance that option awards will be exercised or that RSUs or PSUs will settle (in which case no value will be realized by the individual) or that the value on exercise of options or settlement of RSUs or PSUs will approximate the fair value as computed in accordance with ASC 718. We computed the grant date fair value of PSU awards based on our achievement of the PSU awards‘ performance conditions at 100% of target. If the PSUs were instead valued based on the maximum outcome of the applicable performance condition (i.e., based on maximum level performance), the total amount for the PSU awards reported in this column for 2025 would increase as follows: Mr. Stapley from $2,945,439 to $4,418,158; Ms. Chambers from $981,802 to $1,472,703; Dr. Febbo from $785,442 to $1,178,162; Dr. Leite from $1,178,162 to $1,767,244; and Ms. McGuire from $981,802 to $1,472,703.

(2)The amounts reported in the Non-Equity Incentive Plan Compensation column for 2025 represent annual cash incentives paid to the NEOs as described in “—Compensation Discussion and Analysis—2025 Annual Cash Incentives.”

(3)Other compensation includes matching contributions to 401(k) plans in an amount up to $5,000 per year for 2025.

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Grants of Plan-Based Awards Table

The following table provides information concerning each grant of an award made in 2025 for each of our NEOs under any plan. This information supplements the information about these awards set forth in the Summary Compensation Table.

															Estimated Future Payouts Under Non-Equity Incentive Plan Awards (1)												Estimated Future Payouts Under Equity Incentive Plan Awards(2)									All Other Stock Awards: Number of Shares of Stock or Units (#)			All Other Option Awards: Number of Securities Underlying Options (#)			Exercise or Base Price of Option Awards ($/Share)			Grant Date Fair Value of Stock and Option Awards ($)(3)
			Name			Type of Award			Grant Date			Date of Committee Action			Threshold ($)			Target ($)			Maximum ($)						Threshold (#)			Target (#)			Maximum (#)
			Marc Stapley			Cash									525,000			700,000			1,050,000						—			—			—															—			—			—			—
						RSUs(4)			3/6/2025			2/12/2025			—			—			—						—			—			—			90,601			—			—			2,945,439
						PSUs(5)			3/6/2025			2/12/2025			—			—			—						61,156			90,601			135,902			—			—			—			2,945,439
			Rebecca Chambers			Cash									226,875			302,500			453,750						—			—			—			—			—			—			—
						RSUs(4)			3/6/2025			2/12/2025			—			—			—						—			—			—			30,200			—			—			981,802
						PSUs(5)			3/6/2025			2/12/2025			—			—			—						20,385			30,200			45,300			—			—			—			981,802
			Phillip Febbo			Cash									231,413			308,550			462,825						—			—			—			—			—			—			—
						RSUs(4)			3/6/2025			2/12/2025			—			—			—						—			—			—			24,160			—			—			785,442
						PSUs(5)			3/6/2025			2/12/2025			—			—			—						16,308			24,160			36,240			—			—			—			785,442
			John Leite			Cash									210,499			280,655			420,998						—			—			—			—			—			—			—
						RSUs(4)			3/6/2025			2/12/2025			—			—			—						—			—			—			36,240			—			—			1,178,162
						PSUs(5)			3/6/2025			2/12/2025			—			—			—						24,462			36,240			54,360			—			—			—			1,178,162
			Annie McGuire			Cash									206,250			275,000			412,500						—			—			—			—			—			—			—
						RSUs(4)			3/6/2025			2/12/2025			—			—			—						—			—			—			30,200			—			—			981,802
						PSUs(5)			3/6/2025			2/12/2025			—			—			—						20,385			30,200			45,300			—			—			—			981,802

(1)Reflects threshold, target and maximum cash bonus amounts for 2025 performance under our 2025 bonus plan, as described in “—Compensation Discussion and Analysis-2025 Bonus Plan Awards.” These amounts do not necessarily correspond to the actual amounts that were received by our NEOs.

(2)Reflects threshold, target and maximum amounts for 2025 PSUs awards, as described in “—Compensation Discussion and Analysis—Equity Compensation.”

(3)The amounts reported in this column represent the grant date fair value of each award as computed in accordance with ASC 718. Note that the amounts reported in these columns reflect the accounting cost for these awards and do not correspond to the actual economic value that may be received by our NEOs from the awards. In particular, amounts in this column include the grant date fair value of the 2025 PSUs granted to our NEOs during the year ended December 31, 2025, as computed in accordance with ASC 718, assuming the probable outcome of related performance conditions to be 100% of target for each of the 2025 PSUs.

(4)The RSUs vest at a rate of 1/4th of the total number of RSUs on the one-year anniversary of the vesting commencement date, and vest at a rate of 1/16th of the total number of RSUs on each quarter thereafter. The RSUs are subject to acceleration upon certain events as described in “—Potential Payments upon Termination or Change in Control.”

(5)Seventy percent of the total number of PSUs will vest subject to and upon certification of achievement of the performance metric for the performance period ending December 31, 2026, and 30% of the total number of PSUs will vest subject to and upon the certification of achievement of the performance metric for the performance period ending December 31, 2027, and the continued service of the applicable executive. The PSUs are subject to acceleration upon certain events as described in “—Potential Payments upon Termination or Change in Control.”

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2025 Outstanding Equity Awards at Fiscal Year-End

The following table provides information concerning the outstanding and unexercised stock options, outstanding RSUs and outstanding PSUs that have not vested for each NEO as of December 31, 2025:

									Option Awards															Stock Awards
			Name			Grant Date			Number of Securities Underlying Unexercised Options (# Exercisable)			Number of Securities Underlying Options (# Unexercisable)(1)			Option Exercise Price  ($)			Option Expiration Date						Number of Shares or Units of Stock That Have Not Vested (#)			Market Value of Shares or Units of Stock That Have Not Vested ($)(2)			Equity Incentive Plan Awards: Number of Unearned Shares or Units of Stock That Have Not Vested (#)			Equity Incentive Plan Awards: Market Value or Payout Value of Unearned Shares or Units of Stock That Have Not Vested ($) (3)
			Marc Stapley			6/1/2021			138,051			—			36.60			6/1/2031						—			—			—			—
						3/3/2022			96,586			6,440			26.02			3/3/2032						3,534			148,781			—			—
						3/6/2023			88,597			40,272			23.73			3/6/2033						94,628			3,983,839			—			—			(4)
						3/6/2024																		133,368			5,614,793			51,626			2,173,455			(5)
						3/6/2025																		90,601			3,814,302			90,601			3,814,302			(6)
			Rebecca Chambers			7/19/2021			67,000			—			36.59			7/19/2031						—			—			—			—
						3/3/2022			35,412			2,361			26.02			3/3/2032						1,296			54,562			—			—
						8/5/2022			36,496			—			27.90			8/5/2032						—			—			—			—
						3/6/2023			29,532			13,424			23.73			3/6/2033						31,541			1,327,876			—			—			(4)
						3/6/2024																		69,581			2,929,360			26,936			1,134,006			(5)
						3/6/2025																		30,200			1,271,420			22,650			953,565			(6)
			Phillip Febbo			10/2/2023			46,506			39,352			21.96			10/2/2033						74,455			3,134,556			—			—			(4)
						3/6/2024																		46,388			1,952,935			17,957			755,990			(5)
						3/6/2025																		24,160			1,017,136			24,160			1,017,136			(6)
			John Leite			9/1/2022			34,973			8,071			19.81			9/1/2032						4,819			202,880			—			—
						3/6/2023			17,371			7,897			23.73			3/6/2033						4,928			207,469			—			—
						9/11/2023																		17,221			725,004			—			—			(4)
						3/6/2024																		57,985			2,441,169			22,446			944,977			(5)
						3/6/2025																		36,240			1,525,704			36,240			1,525,704			(6)
			Annie McGuire			2/28/2022			40,417			1,758			27.80			2/28/2032						1,429			60,161			—			—
						8/5/2022			18,248			—			27.90			8/5/2032						—			—			—			—
						3/6/2023			26,578			12,082			23.73			3/6/2033						28,388			1,195,135			—			—			(4)
						3/6/2024																		57,985			2,441,169			22,446			944,977			(5)
						3/6/2025																		30,200			1,271,420			30,200			1,271,420			(6)

(1)Options become exercisable as to 25% of the shares on the first anniversary of the vesting commencement date, and the remaining shares vest at a rate of 1/48th of the total number of shares subject to the options each month thereafter. The options have a term of ten years, subject to earlier termination upon termination of employment. The options are subject to acceleration upon certain specified events; for more information, see “—Potential Payments upon Termination or Change in Control” below.

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(2)Based on a price of $42.10 per share, which was the closing price per share of our common stock as reported by The Nasdaq Global Market on December 31, 2025. RSUs vest and settle as to 25% of the units on the first anniversary of the vesting commencement date, and the remaining RSUs vest and settle at a rate of 1/16th of the total number of shares subject to the units each quarter thereafter. The RSUs are subject to acceleration upon certain specified events; for more information, see “—Potential Payments upon Termination or Change in Control” below.

(3)Based on a price of $42.10 per share, which was the closing price per share of our common stock as reported by The Nasdaq Global Market on December 31, 2025. The PSUs are subject to acceleration upon certain specified events; for more information, see “—Potential Payments upon Termination or Change in Control” below.

(4)For the 2023 PSUs, 40% of the total number of PSUs were eligible to be earned and vest subject to and upon certification of achievement of the performance metric for the performance period ending December 31, 2024, and 60% of the total number of PSUs was eligible to vest subject to and upon the certification of achievement of the performance metric for the performance period ending December 31, 2025 (the “2025 Tranche”) and the continued service of the applicable executive. The 2023 PSUs were eligible to vest between 75% and 150% of the target grant based on the achievement of the performance metrics. The 2025 Tranche was earned at 150% of target achievement and the resulting PSUs are included under the column titled “Equity Incentive Plan Awards: Number of Shares or Units of Stock That Have Not Vested”; they vested in February 2026.

(5)For the 2024 PSUs, 40% of the total number of PSUs were eligible to be earned and vest subject to and upon certification of achievement of the performance metric for the performance period ending December 31, 2025 (the “2025 Tranche”) and 60% of the total number of PSUs will vest subject to and upon the certification of achievement of the performance metric for the performance period ending December 31, 2026 (the “2026 Tranche”) and the continued service of the applicable executive. The 2024 PSUs vest between 75% and 150% of the target grant based on the achievement of the performance metrics. The 2025 Tranche was earned at 150% of target achievement and the resulting PSUs are included under the column titled “Equity Incentive Plan Awards: Number of Shares or Units of Stock That Have Not Vested”; they will vest in December 2026 subject to the continued service of the applicable executive. The performance period for the 2026 Tranche has not yet concluded and such PSUs are reflected at the threshold performance level under the column titled “Equity Incentive Plan Awards: Number of Unearned Shares or Units of Stock That Have Not Vested.”

(6)For the 2025 PSUs, 70% of the total number of PSUs will vest subject to and upon certification of achievement of the performance metric for the performance period ending December 31, 2026 (the “2026 Tranche”) and 30% of the total number of PSUs will vest subject to and upon the certification of achievement of the performance metric for the performance period ending December 31, 2027 (the “2027 Tranche”) and the continued service of the applicable executive. The 2026 Tranche vests between 75% and 150% and 2027 Tranche vests between 50% and 150% of the total grant based on the achievement of the performance metrics. The performance periods for the 2025 PSUs have not yet concluded and such PSUs are reflected at the target performance levels under the column titled “Equity Incentive Plan Awards: Number of Unearned Shares or Units of Stock That Have Not Vested.”

Stock Vested Table

The following table presents, for each of our NEOs, the number of shares of our common stock acquired upon the vesting and settlement of RSUs and PSUs during 2025 and the aggregate value realized upon the vesting and settlement of RSUs and PSUs:

						Stock Awards
			Name			Number of Shares Acquired on Vesting (#)						Value Realized on Vesting ($)(1)
			Marc Stapley			156,964						5,350,931
			Rebecca Chambers			72,769						2,450,142
			Phillip Febbo			61,342						2,096,717
			John Leite			43,194						1,484,031
			Annie McGuire			49,531						1,690,363

(1)The aggregate value realized upon the vesting and settlement of an RSU or PSU is based on the closing price on the Nasdaq Global Market of a share of common stock on the date prior to the day of vesting.

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Employment or Letter Agreements

Marc Stapley

We entered into an employment agreement with Mr. Stapley, our Chief Executive Officer, on May 7, 2021. The agreement provides for base salary, subject to periodic review. Under the employment agreement, Mr. Stapley is also eligible to earn a bonus based on criteria and terms and conditions as may be established by our Board of Directors as well as a grant of restricted stock, stock options and performance-based stock units. We have also entered into a change of control and severance agreement with Mr. Stapley that provides for certain payments and benefits upon a qualifying termination of employment. See “—Potential Payments upon Termination or Change in Control” below for more information.

Rebecca Chambers

We entered into an amended and restated offer letter with Ms. Chambers, our Chief Financial Officer, on August 15, 2021. The letter provides for base salary, subject to periodic review. Under the employment agreement, Ms. Chambers is also eligible to earn a bonus based on criteria and terms and conditions as may be established by our Board of Directors, as well as a grant of restricted stock units, stock options and performance-based stock units. We have also entered into a change of control and severance agreement with Ms. Chambers that provides for certain payments and benefits upon a qualifying termination of employment. See “—Potential Payments upon Termination or Change in Control” below for more information.

Phillip Febbo

We entered into an offer letter with Dr. Febbo, our Chief Scientific Officer and Chief Medical Officer, on September 11, 2023. The letter provides for base salary, subject to periodic review. Pursuant to the offer letter, Dr. Febbo is eligible for a bonus based on criteria and terms and conditions as may be established by our Board of Directors, as well as equity grants subject to approval by our Board of Directors. We have also entered into a change of control and severance agreement with Dr. Febbo that provides for certain payments and benefits upon a qualifying termination of employment. See “—Potential Payments upon Termination or Change in Control” below for more information.

John Leite

We entered into a promotion letter with Dr. Leite when he was promoted to Chief Commercial Officer, CLIA, on August 22, 2023. The letter provides for base salary, subject to periodic review. Dr. Leite is also eligible for an increased target bonus based on criteria and terms and conditions as may be established by our Board of Directors. The promotion letter also provided a grant of 2023 PSUs under the same terms and performance as the PSUs granted to existing executive officers. We have also entered into a change of control and severance agreement with Dr. Leite that provides for certain payments and benefits upon a qualifying termination of employment. See “—Potential Payments upon Termination or Change in Control” below for more information.

Annie McGuire

We entered into an offer letter with Ms. McGuire, our General Counsel and Head of Market Access, on January 9, 2023. The letter provides for base salary, subject to periodic review. Pursuant to the offer letter, Ms. McGuire is also eligible to earn a bonus based on criteria and terms and conditions as may be established by our Board of Directors, as well as equity grants subject to approval by our Board of Directors. We have also entered into a change of control and severance agreement with Ms. McGuire that provides for certain payments and benefits upon a qualifying termination of employment. See “—Potential Payments upon Termination or Change in Control” below for more information.

Equity Grant Timing

The Compensation Committee approves annual equity awards for executives at its first quarter meeting, typically in February, and such awards to our NEOs are generally granted in the first quarter of the fiscal year. In certain circumstances, including the hiring or promotion of an officer, or the granting of special awards, we may approve grants at other times. We do not take material nonpublic information into account when determining the timing and terms of equity awards granted to non-employee directors or NEOs, and we do not time the disclosure of material nonpublic information for the purpose of affecting the value of executive compensation.

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Potential Payments upon Termination or Change in Control

We have entered into change of control and severance agreements with each of our NEOs.

Each of these agreements has an initial term of four years, which term automatically renews for additional one‑year periods unless either party provides written notice of non-renewal at least 60 days prior to the date of automatic renewal and which term extends for one year from a “change of control,” as defined in the agreement, if such change of control occurs within the final 12 months of the initial term or the term as extended through automatic renewal.

Outside of a Change in Control 

Pursuant to each of the agreements, if the NEO is terminated by us without “cause” (as defined in the agreement), or terminates his or her employment for “good reason” (as defined in the agreement), each outside the period beginning two months prior to and ending 12 months following a change of control, or the “change of control period” (as defined in the agreement), he or she is entitled to the following benefits:

Mr. Stapley: (i) 12 months of salary continuation from the termination date, (ii) a lump sum payment equal to his prorated annual bonus for the applicable performance period based on actual corporate performance and (iii) up to 12 months continuation coverage under the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”).

Ms. Chambers, Dr. Febbo, Dr. Leite and Ms. McGuire: (i) 6 months of salary continuation from the termination date and (ii) up to 6 months continuation coverage under COBRA.

During Change in Control Period

Pursuant to each of these agreements, if the NEO is terminated by us without cause, or terminates his or her employment for good reason each during the change of control period, he or she is entitled to the following benefits:

Mr. Stapley: (i) a lump sum severance payment equal to 24 months of salary, (ii) a lump sum payment equal to 200% of the highest of his (A) annual target bonus for the year in which the change of control occurs, (B) annual target bonus for the year in which the termination occurs, or (C) actual bonus for the year prior to the year in which the termination occurs, (iii) accelerated vesting equal to 100% of any outstanding equity awards (and with respect to equity awards subject to performance, assuming “target” level performance, unless provided otherwise in the applicable PSU agreement) and (iv) up to 24 months continuation coverage under COBRA.

Ms. Chambers, Dr. Febbo, Dr. Leite and Ms. McGuire: (i) a lump sum severance payment equal to 18 months of salary from the termination date, (ii) a lump sum payment equal to 150% of the highest of his or her (A) annual target bonus for the year in which the change of control occurs, (B) annual target bonus for the year in which the termination occurs, or (C) actual bonus for the year prior to the year in which the termination occurs and (iii) accelerated vesting equal to 100% of any outstanding equity awards (and with respect to equity awards subject to performance, assuming “target” level performance, unless provided otherwise in the applicable PSU agreement) and (iv) up to 18 months continuation coverage under COBRA.

Upon a change in control of the company, the NEO may be subject to a reduction in compensation as a result of excise tax calculations under the best net after-tax severance approach pursuant to Section 4999 of the Code.

The receipt of the above-described benefits is subject to the NEO executing a release of certain claims against us.

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The following table illustrates the potential payments and benefits our NEOs would be entitled to upon termination of employment or a Change in Control (“CIC”) under each situation listed below. The potential payments assume that the termination and/or termination resulting from a CIC occurred on December 31, 2025, and where applicable, use the closing price of our Common Stock of $42.10 on December 31, 2025, the final trading day of the year. The table is merely an illustrative example of the impact of a hypothetical termination of employment or change in control and qualifying termination. The amounts that would actually be paid upon a termination of employment can only be determined at the time of such termination, based on the facts and circumstances then prevailing. The receipt of the above-described benefits is subject to the NEO executing a release of certain claims against us.

						Upon Qualifying Termination - No Change in Control															Upon Qualifying Termination - Change in Control
			Name			Cash Severance ($)(1)			Continuation of Medical Benefits ($)			Value of Accelerated Vesting ($)(2)			Total ($)						Cash Severance ($)(1)			Continuation of Medical Benefits ($)			Value of Accelerated Vesting ($)(2)			Total ($)
			Marc Stapley			1,526,000			42,336			—			1,568,336						3,425,000			84,672			19,165,609			22,675,281
			Rebecca Chambers			275,000			21,168			—			296,168						1,481,370			63,504			7,818,738			9,363,612
			Phillip Febbo			280,500			21,168			—			301,668						1,522,125			63,504			7,914,648			9,500,277
			John Leite			255,150			21,168			—			276,318						1,350,170			63,504			7,551,267			8,964,941
			Annie McGuire			250,000			8,987			—			258,987						1,332,615			26,962			7,030,743			8,390,320

(1)The cash severance amount related to base salary was determined based on the base salaries in effect on December 31, 2025. For Mr. Stapley, the non-CIC cash severance amount related to his annual bonus outside of a CIC was determined based on his actual annual bonus for 2025, without proration due to the assumed termination date of December 31, 2025. For all NEOs, the CIC cash severance amount related to annual bonus was determined based on the greater of each NEO‘s actual annual bonus for 2024 or the current year target bonus..

(2)The value of accelerated vesting is calculated based on the per share closing price of our common stock on The Nasdaq Stock Market as of December 31, 2025, ($42.10) less, if applicable, the exercise price of each outstanding stock option. In addition, the value of the accelerated vesting of any outstanding PSUs for which the performance period has not yet ended is based on “at target” achievement.

Veracyte 2026 Proxy Statement 65

Executive Compensation

Pay Versus Performance

In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officers (“PEOs”) and Non-PEO NEOs and company performance for the fiscal years listed below. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown.

			Year			Summary Compensation Table Total for Marc Stapley ($)(1)			Summary Compensation Table Total for Bonnie Anderson ($)(1)			Compensation Actually Paid to Marc Stapley ($)(1)(2)(3)			Compensation Actually Paid to Bonnie Anderson ($)(1)(2)(3)			Average Summary Compensation Table Total for Non-PEO NEOs ($)(1)			Average Compensation Actually Paid to Non-PEO NEOs ($)(1)(2)(3)			Value of Initial Fixed $100 Investment based on:(4)						Net Income ($ in millions)			Total Revenue ($ in millions)(⁵)
																								TSR ($)			Peer Group TSR ($)
																								2025			7,421,877									—			9,610,633			—			2,843,110			3,712,712			86.02			124.75			66.4			517.1
			2024			6,816,368			—			14,888,998			—			3,154,952			6,617,801			80.92			93.49			24.1			445.8
			2023			7,184,634			—			9,559,060			—			2,742,803			3,440,029			56.21			94.03			(74.4)			361.1
			2022			4,935,422			—			1,622,674			—			3,725,476			1,450,011			48.49			89.90			(36.6)			296.5
			2021			5,741,940			4,518,093			5,700,065			2,876,781			2,235,504			(434,017)			84.18			100.02			(75.6)			219.5

(1)Bonnie Anderson was our PEO until June 2021. Marc Stapley has been our PEO from June 2021 to present. The individuals comprising the Non-PEO NEOs for each year presented are listed below.

2021

2022

2023 - 2025

Keith Kennedy

Giulia Kennedy

Rebecca Chambers

Giulia Kennedy

Rebecca Chambers

Phillip Febbo

James Erlinger III

Tina Nova

John Leite

Beverly Jane Alley

Annie McGuire

Annie McGuire

Rebecca Chambers

(2)The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized or received by the company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.

(3)Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column below reflect the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table.

			Year			Summary Compensation Table Total for Marc Stapley ($)			Exclusion of Stock Awards and Option Awards for Marc Stapley ($)			Inclusion of Equity Values for Marc Stapley ($)			Compensation Actually Paid to Marc Stapley ($)
			2025			7,421,877			(5,890,877)			8,079,633			9,610,633

			Year			Average Summary Compensation Table Total for Non-PEO NEOs ($)						Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($)						Average Inclusion of Equity Values for Non-PEO NEOs ($)			Average Compensation Actually Paid to Non-PEO NEOs ($)
			2025			2,843,110						(1,963,604)						2,833,206			3,712,712

66 Veracyte 2026 Proxy Statement

Executive Compensation

The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:

			Year			Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Marc Stapley ($)			Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Marc Stapley ($)			Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Marc Stapley ($)			Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Marc Stapley ($)			Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Marc Stapley ($)			Total - Inclusion of Equity Values for Marc Stapley ($)
			2025			7,628,604			1,731,869			—			(1,280,840)			—			8,079,633

			Year			Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)			Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)			Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($)			Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)			Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($)			Total - Average Inclusion of Equity Values for Non-PEO NEOs ($)
			2025			2,542,840			754,439			—			(464,073)			—			2,833,206

(4)The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2025. The comparison assumes $100 was invested for the period starting December 31, 2020, through the end of the listed year in the company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.

(5)We determined Total Revenue to be the most important financial performance measure used to link company performance to Compensation Actually Paid to our PEOs and Non-PEO NEOs in 2025. This performance measure may not have been the most important financial performance measure in prior years, and we may determine a different financial performance measure to be the most important financial performance measure in future years.

Veracyte 2026 Proxy Statement 67

Executive Compensation

Relationship Between Compensation Actually Paid and Performance

The following charts show the relationship between Compensation Actually Paid, Total Stockholder Return, total revenue and net loss for 2021, 2022, 2023, 2024 and 2025.

68 Veracyte 2026 Proxy Statement

Executive Compensation

Tabular List of Most Important Financial and Non-Financial Performance Measures

The following table presents the financial and non-financial performance measures that the company considers to have been the most important in linking Compensation Actually Paid to our PEO and other NEOs for 2025 to company performance. The measures in this table are not ranked.

Total Revenue

Adjusted EBITDA Margin

Testing Revenue

CEO Pay Ratio

Under rules adopted pursuant to the Dodd-Frank Act, we are required to calculate and disclose the total compensation paid to our median paid employee, as well as the ratio of the total compensation paid to the median employee as compared to the total compensation paid to our Chief Executive Officer (the “CEO Pay Ratio”).

The paragraphs that follow describe our methodology and the resulting CEO Pay Ratio.

Measurement Date

We identified the median employee using our employee population on December 31, 2025 (including all employees, whether employed on a full-time, part-time, seasonal or temporary basis). We did not include any contractors or other non-employee workers in our employee population.

Consistently Applied Compensation Measure (“CACM”)

Under the relevant rules, we are required to identify the median employee by use of a “consistently applied compensation measure,” or CACM. We chose a CACM that closely approximates the annual target total direct compensation of our employees. Specifically, we identified the median employee by aggregating, for each employee: a) annual base pay for 2025, b) annual target cash incentive opportunity for 2025, and c) the grant date fair value for equity awards granted in 2025. Cash compensation for new hire employees that commenced employment in 2025 was annualized to reflect a full year.

Methodology and Pay Ratio

On December 31, 2025, the determination date, our principal executive officer was Mr. Marc Stapley, our Chief Executive Officer. For 2025, the total annual compensation for Mr. Stapley was $7,421,877. The total annual compensation of our median employee in 2025 was $196,646. The ratio of these two amounts is approximately 38:1.

This information is being provided for compliance purposes and is a reasonable estimate calculated in a manner consistent with SEC rules, based on our internal records and the methodology described above. The SEC rules for identifying the median compensated employee allow companies to adopt a variety of methodologies, to apply certain exclusions and to make reasonable estimates and assumptions that reflect their employee populations and compensation practices. Accordingly, the pay ratio reported by other companies may not be comparable to the pay ratio reported above, as other companies have different employee populations and compensation practices and may use different methodologies, exclusions, estimates and assumptions in calculating their own pay ratios. Neither the Compensation Committee nor management of the company used the CEO Pay Ratio measure in making compensation decisions.

Veracyte 2026 Proxy Statement 69

Executive Compensation

Limitations on Liability and Indemnification Matters

Our Restated Certificate contains provisions that eliminate the personal liability of our directors to the corporation or our stockholders for monetary damages for breach of fiduciary duty to the fullest extent permitted by the DGCL. Consequently, our directors are not personally liable to us or our stockholders for monetary damages for any breach of fiduciary duties as directors, except liability for:

•any breach of the director’s duty of loyalty to us or our stockholders;

•any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

•unlawful payments of dividends or unlawful stock repurchases or redemptions as provided in Section 174 of the DGCL; or

•any transaction from which the director derived an improper personal benefit.

Our Restated Certificate and our amended and restated bylaws require us to indemnify our directors and officers to the maximum extent not prohibited by the DGCL and allow us to indemnify other employees and agents as authorized by the Board of Directors or by the action of a committee of the Board of Directors or designated officers established by or designated in resolutions approved by the Board of Directors. Subject to certain limitations, our amended and restated bylaws also require us to advance expenses incurred by our directors and officers for the defense of any action for which indemnification is required or permitted.

We have entered, and intend to continue to enter, into separate indemnification agreements with our directors, officers and certain other employees, in addition to the indemnification provided for in our Restated Certificate and amended and restated bylaws. These agreements, among other things, require us to indemnify our directors, officers and certain other employees for certain expenses, including attorneys’ fees, judgments, penalties, fines and settlement amounts actually incurred by these individuals in any action or proceeding arising out of their service to us or any of our subsidiaries or any other company or enterprise to which these individuals provide services at our request. Subject to certain limitations, our indemnification agreements also require us to advance expenses incurred by our directors, officers and certain other employees for the defense of any action for which indemnification is required or permitted.

We believe that provisions of our Restated Certificate, amended and restated bylaws and indemnification agreements are necessary to attract and retain qualified directors, officers and employees. We also maintain directors’ and officers’ liability insurance.

The limitation of liability and indemnification provisions in our Restated Certificate and amended and restated bylaws or in these indemnification agreements may discourage stockholders from bringing a lawsuit against our directors and officers for breach of their fiduciary duty. They may also reduce the likelihood of derivative litigation against our directors and officers, even though an action, if successful, might benefit us and other stockholders. Further, a stockholder’s investment may be adversely affected to the extent that we pay the costs of settlement and damage awards against directors and officers as required by these indemnification provisions.

Insofar as indemnification for liabilities arising under the Securities Act may be permitted for directors, executive officers or persons controlling us, we have been informed that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.

Rule 10b5-1 Sales Plans

Certain of our directors and executive officers have adopted written plans, known as Rule 10b5-1 plans, in which they have contracted with a broker to buy or sell shares of our common stock on a periodic basis. Under a Rule 10b5-1 plan, a broker executes trades pursuant to parameters established by the director or executive officer when entering into the plan, without further direction from them. The director or executive officer may amend or terminate the plan in specified circumstances.

70 Veracyte 2026 Proxy Statement

Equity Compensation Plan Information

See discussion under the section titled “Proposal 4 Approval of Amendment to Veracyte, Inc. 2023 Equity Incentive Plan—Equity Compensation Plan Information.”

Veracyte 2026 Proxy Statement 71

Report of the Audit Committee of the Board of Directors

The Audit Committee acts pursuant to a written charter that was adopted by the Board of Directors. Each member of the Audit Committee qualifies as “independent” under the current listing requirements of The Nasdaq Stock Market.

In performing its functions, the Audit Committee acts in an oversight capacity and necessarily relies on the work and assurances of Veracyte’s management, which has the primary responsibility for financial statements and reports, and of the independent registered public accounting firm, who, in their report, express an opinion on the conformity of Veracyte’s annual financial statements with accounting principles generally accepted in the United States. It is not the duty of the Audit Committee to plan or conduct audits, to determine that Veracyte’s financial statements are complete and accurate and are in accordance with generally accepted accounting principles, or to assess or determine the effectiveness of Veracyte’s internal control over financial reporting.

Within this framework, the Audit Committee has reviewed and discussed with management our audited financial statements as of and for the year ended December 31, 2025. The Audit Committee has also discussed Auditing Standard No. 1301 adopted by the Public Company Accounting Oversight Board (United States) regarding “Communications with Audit Committees.” In addition, the Audit Committee has received the written disclosures and the letter from the independent registered public accounting firm required by applicable requirements of the Public Company Accounting Oversight Board regarding the independent registered public accounting firm’s communications with the Audit Committee concerning independence, and has discussed with the independent registered public accounting firm the independent registered public accounting firm’s independence.

Based on these reviews and discussions, the Audit Committee recommended to the Board of Directors that the audited financial statements be included in our Annual Report on Form 10-K for the year ended December 31, 2025.

Audit Committee

Karin Eastham

Jens Holstein (Chair)

Evan Jones

72 Veracyte 2026 Proxy Statement

Certain Relationships and Related Party Transactions

In addition to the compensation arrangements of our directors and NEOs discussed elsewhere in this Proxy Statement, the following is a description of transactions since January 1, 2025, to which we have been or will be a party, and in which the amount involved exceeded or will exceed $120,000 and in which any of our directors, executive officers, beneficial holders of more than 5% of our capital stock, or entities affiliated with, or immediate family members of, any of the foregoing, had or will have a direct or indirect material interest.

Indemnification Agreements

We have entered into indemnification agreements with our directors and executive officers. These agreements require us to indemnify these individuals to the fullest extent permitted under Delaware law against liabilities that may arise by reason of their service to us, and to advance expenses incurred as a result of any proceeding against them as to which they could be indemnified.

Related Party Transaction Approval

We have a formal policy that our executive officers, directors, director nominees, holders of more than 5% of any class of our voting securities, and any member of the immediate family of and any entity affiliated with any of the foregoing persons, are not permitted to enter into a transaction in which we are or will be a party and in which the amount involved exceeds $120,000 without the prior consent of our Audit Committee. Any request for us to enter into such a transaction must first be presented to our Audit Committee, or if a member of our Audit Committee is involved in the transaction, to the disinterested and independent members of our Board of Directors for review, consideration and approval. In approving or rejecting any such proposal, the disinterested and independent members of our Board of Directors will consider all relevant facts and circumstances reasonably available to them.

Veracyte 2026 Proxy Statement 73

Additional Information

Stockholder Proposals for the 2027 Annual Meeting

If a stockholder wishes to present a proposal to be considered for inclusion in our proxy statement for the 2027 Annual Meeting of Stockholders, the proponent and the proposal must comply with the proxy proposal submission rules of the SEC as set forth in Rule 14a-8. One of the requirements is that the proposal be received by our Secretary no later than February 10, 2027. Proposals we receive after that date will not be included in the proxy statement. We urge stockholders to submit proposals by Certified Mail - Return Receipt Requested.

A stockholder proposal not included in our proxy statement for the 2027 Annual Meeting will not be eligible for presentation at the meeting unless the stockholder gives timely notice of the proposal in writing to our Secretary at our principal executive offices and otherwise complies with the provisions of our Bylaws with respect to the form and content of such proposal. To be timely, our Bylaws provide that we must have received the stockholder’s notice no earlier than 5:00 p.m. Eastern Time on February 10, 2027, and no later than 5:00 p.m. Eastern Time on March 12, 2027, or no earlier than 5:00 p.m. Eastern Time on the 120th day nor later than 5:00 p.m. Eastern Time on the 90th day prior to the first anniversary date of the preceding year’s Annual Meeting of Stockholders; however, if we have not held an Annual Meeting of Stockholders in the previous year or the date of the Annual Meeting of Stockholders is called for a date that is more than 30 days before or more than 60 days after the first anniversary date of the preceding year’s Annual Meeting of Stockholders, we must have received the stockholder’s notice not later than 5:00 p.m. Eastern Time on the later of the 90th day prior to the date of the scheduled Annual Meeting of Stockholders or the 10th day following the earlier of the day on which notice of the Annual Meeting of Stockholders date was mailed or the day of the first public announcement of the Annual Meeting of Stockholders date. An adjournment or postponement of an annual meeting will not commence a new time period or extend any time period for the giving of the stockholder’s notice described above.

The stockholder’s notice must set forth as to each matter the stockholder proposes to bring before the 2027 Annual Meeting the information required by our Bylaws and must be addressed to: Secretary, Veracyte, Inc., 6000 Shoreline Court, Suite 300, South San Francisco, California 94080. You may obtain a copy of the full text of this provision of the Bylaws by writing to our Secretary at the above address. In addition, stockholders who intend to solicit proxies in support of director nominees other than the company’s nominees must also comply with the additional requirements of Rule 14a-19(b) of the Exchange Act. The presiding officer of the meeting may refuse to acknowledge any matter not made in compliance with the foregoing procedure.

74 Veracyte 2026 Proxy Statement

Additional Information

“Householding” – Stockholders Sharing the Same Last Name and Address

The SEC has adopted rules that permit companies and intermediaries (such as brokers) to implement a delivery procedure called “householding.” Under this procedure, multiple stockholders who reside at the same address may receive a single copy of our annual report and proxy materials, including the Notice of Internet Availability, unless the affected stockholder has provided contrary instructions. This procedure reduces printing costs and postage fees, and helps protect the environment as well.

This year, a number of brokers with account holders who are our stockholders will be “householding” our annual report and proxy materials, including the Notice of Internet Availability. A single Notice of Internet Availability and, if applicable, a single set of our annual report and other proxy materials will be delivered to multiple stockholders sharing an address unless contrary instructions have been received from the affected stockholders. Once you have received notice from your broker that it will be “householding” communications to your address, “householding” will continue until you are notified otherwise or until you revoke your consent. Stockholders may revoke their consent at any time by contacting Broadridge by calling (866) 540-7095 or writing to Broadridge, Householding Department, 51 Mercedes Way, Edgewood, New York, 11717.

Veracyte 2026 Proxy Statement 75

Other Matters and Available Information

Available Information

Our financial statements for the year ended December 31, 2025 are included in our Annual Report, which we provide to our stockholders at the same time as this Proxy Statement. We will furnish without charge, upon written request of any person who was a stockholder or beneficial owner of our common stock on the close of business on the Record Date, copies of exhibits to our Annual Report, but will charge a reasonable per page fee. Written requests should be sent to: Investor Relations, Veracyte, Inc., 6000 Shoreline Court, Suite 300, South San Francisco, California 94080. The Annual Report is also available under “SEC Filings” in the “Investors” section of our website at https://investor.veracyte.com/sec-filings.

Other Matters

The Board of Directors does not know of any other business that will be presented at the Annual Meeting. If any other business is properly brought before the Annual Meeting, the proxy holders will vote in accordance with their judgment unless you direct them otherwise. Whether or not you intend to attend the Annual Meeting, we urge you to vote by telephone, the internet, or by signing and mailing the enclosed proxy or voting instruction form promptly.

76 Veracyte 2026 Proxy Statement

General Information

Information about Solicitation and Voting

This Proxy Statement is furnished in connection with the solicitation by the board of directors (“Board of Directors”) of Veracyte, Inc., a Delaware corporation (“we,” “us,” “our,” “the company” or “Veracyte”), of proxies in the accompanying form to be used at our Annual Meeting on Wednesday, June 10, 2026, at 10:00 a.m., Pacific Daylight Time, and any postponement or adjournment thereof (the “Annual Meeting”). To provide greater access to those who may want to attend, the Annual Meeting will be held virtually via the internet at www.virtualshareholdermeeting.com/VCYT2026.

The Notice of Internet Availability of Proxy Materials and this Proxy Statement for the Annual Meeting and the accompanying form of proxy were first distributed and made available on the internet to stockholders on or about April 22, 2026. Our annual report on Form 10-K for the year ended December 31, 2025, (the “Annual Report”) is available with this Proxy Statement by following the instructions in the Notice of Internet Availability of Proxy Materials. Our Annual Report is also available on the SEC’s website at www.sec.gov.

Questions and Answers about the Proxy Materials and the Annual Meeting

What proposals will be voted on at the Annual Meeting?

Four proposals will be voted on at the Annual Meeting:

•The election of nine directors to serve until the 2027 Annual Meeting of Stockholders or until their successors are duly elected and qualified;

•The ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026;

•The approval, on a non-binding advisory basis, of the compensation paid to our named executive officers in 2025, as disclosed in this Proxy Statement; and

•The approval of an amendment to our Veracyte, Inc. 2023 Equity Incentive Plan (the “Plan Amendment”).

What are the Board of Directors’ recommendations?

Our Board of Directors recommends that you vote:

“FOR” election of each of the nominated directors;

“FOR” ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026;

“FOR” the approval, on a non-binding advisory basis, of the compensation of our named executive officers, as disclosed in this Proxy Statement; and

“FOR” the approval of the Plan Amendment.

Veracyte 2026 Proxy Statement 77

General Information

Will there be any other items of business on the agenda?

We do not expect any other items of business, because the deadline for stockholder proposals and nominations has already passed. Nonetheless, in case there is an unforeseen need, the accompanying proxy gives discretionary authority to the persons named on the proxy with respect to any other matters that might be brought before the meeting. Those persons intend to vote that proxy in accordance with their best judgment.

Why did I receive a one-page notice in the mail regarding the internet availability of proxy materials instead of a full set of proxy materials?

In accordance with rules and regulations adopted by the SEC, instead of mailing a printed copy of our proxy materials to all stockholders entitled to vote at the Annual Meeting, we are furnishing the proxy materials to our stockholders over the internet. Accordingly, on or about April 22, 2026, the company will mail the Notice of Internet Availability (the “Notice”) to the company’s stockholders, other than those who previously requested electronic or paper delivery. If you received the Notice by mail, you will not receive a printed copy of the proxy materials. Instead, the Notice will instruct you as to how you may access and review the proxy materials and submit your vote on the internet or by telephone. If you received the Notice by mail and would like to receive a printed copy of the proxy materials, please follow the instructions for requesting such materials included in the Notice. On the date of mailing of the Notice, all stockholders will have the ability to access all of our proxy materials on a website referred to in the Notice. These proxy materials will be available free of charge. We encourage stockholders to take advantage of the availability of the proxy materials on the internet to help reduce the cost of the physical printing and mailing of materials.

Who is entitled to vote?

This year’s Annual Meeting will take place virtually through the internet. We have designed the format of this year’s Annual Meeting to ensure that our stockholders who attend the Annual Meeting will be afforded the same rights and opportunities to participate as they would at an in-person meeting. You are entitled to attend and participate in the Annual Meeting only if you were a stockholder of record as of the close of business on April 15, 2026 (the “Record Date”), or if you hold a valid proxy for the meeting, as described below. Each stockholder is entitled to one vote for each share of our common stock held as of the Record Date. To be admitted to the Annual Meeting at www.virtualshareholdermeeting.com/VCYT2026, you must enter the 16-digit control number found on your proxy card or Notice. If you do not have a control number, please contact the brokerage firm, bank, dealer or other similar organization that holds your account as soon as possible so that you can be provided with a control number.

What is the difference between holding shares as a stockholder of record and as a beneficial owner?

Stockholder of Record. If your shares are registered directly in your name with our transfer agent, Broadridge Corporate Issuer Solutions, Inc., you are considered, with respect to those shares, the “stockholder of record.” As a stockholder of record, you may vote at the Annual Meeting or vote by telephone, by internet or by filling out and returning the proxy card.

Beneficial Owner. If your shares are held in a brokerage account or by a bank or other nominee, you are considered the “beneficial owner” of shares held in street name. As the beneficial owner, you have the right to direct your broker, bank or nominee how to vote your shares by using the voting instruction form included in the mailing. However, the organization that holds your shares is considered the stockholder of record for purposes of voting at the Annual Meeting. Because you are not the stockholder of record, you may not vote your shares at the Annual Meeting unless you request and obtain a valid proxy from the organization that holds your shares giving you the right to vote the shares at the Annual Meeting.

How many votes do I have?

Each share of our common stock that you own as of the close of business on April 15, 2026, entitles you to one vote.

78 Veracyte 2026 Proxy Statement

General Information

How do I vote?

You may vote using any of the following methods:

•By Mail - If you requested printed copies of the proxy materials by mail, stockholders of record may submit proxies by completing, signing and dating each proxy card received and returning it in the prepaid envelope. Sign your name exactly as it appears on the proxy. If you return your signed proxy but do not indicate your voting preferences, your shares will be voted on your behalf “FOR” the election of the nominees for director, “FOR” the ratification of the appointment of the independent registered public accounting firm for the year ending December 31, 2026, “FOR” the approval on a non-binding advisory basis of the compensation of our named executive officers, and “FOR” the approval of the Plan Amendment. Stockholders who hold shares beneficially in street name may provide voting instructions by mail by completing, signing and dating the voting instruction forms provided by their brokers, banks or other nominees. Voting by mail will close based on mail received the day before the meeting date.

•By Telephone - Stockholders of record may submit proxies by following the telephone voting instructions on their proxy cards or Notice. Most stockholders who hold shares beneficially in street name may provide voting instructions by telephone by calling the number specified on the voting instruction form provided by their brokers, banks or nominees. Please check the voting instruction form for telephone voting availability. Please be aware that if you submit voting instructions by telephone, you may incur costs such as telephone access charges for which you will be responsible. The telephone voting facilities will close at 11:59 p.m., Eastern Time, the day before the meeting date.

•By Internet -

Before the Annual Meeting - Stockholders of record may submit proxies by following the internet voting instructions on their proxy cards or Notice. Most stockholders who hold shares beneficially in street name may provide voting instructions by accessing the website specified on the voting instruction form provided by their brokers, banks or nominees. Please check the voting instruction form for internet voting availability. Please be aware that if you vote over the internet, you may incur costs such as internet access charges for which you will be responsible. The internet voting facilities will close at 11:59 p.m., Eastern Time, the day before the meeting date.

During the Annual Meeting - Stockholders of record may attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/VCYT2026 where stockholders may vote and submit questions during the Annual Meeting. The Annual Meeting starts at 10:00 a.m. Pacific Daylight Time. Please have your 16-digit control number found on your proxy card or Notice. Instructions on how to attend and participate via the internet are posted at www.virtualshareholdermeeting.com/VCYT2026. If you are not the stockholder of record, please refer to the voting instructions provided by your nominee to direct your nominee on how to vote your shares. Even if you plan to attend the Annual Meeting, we recommend that you also submit your proxy or voting instructions or vote by telephone or the internet so that your vote will be counted if you later decide not to attend the meeting.

What if I need technical assistance during the Annual Meeting?

We encourage you to access the Annual Meeting before it begins. Online check-in will start shortly before the meeting on June 10, 2026. If you encounter any difficulties accessing the virtual meeting during the check-in or meeting time, please call the technical support number that will be posted on the virtual Annual Meeting log-in page.

Can I change my vote or revoke my proxy?

You may change your vote or revoke your proxy at any time prior to the vote at the Annual Meeting. If you are a stockholder of record and submitted your proxy by mail, you must file with our Secretary a written notice of revocation or deliver, prior to the vote at the Annual Meeting, a valid, later-dated proxy. If you submitted your proxy by telephone or the internet, you may change your vote or revoke your proxy with a later telephone or internet proxy, as the case may be. Attendance at the Annual Meeting will not have the effect of revoking a proxy unless you give written notice of revocation to the Secretary before the proxy is exercised or you vote by written ballot at the Annual Meeting.

If you are a beneficial owner of shares held in street name and you wish to change or revoke your vote, please consult the voting instructions provided with this Proxy Statement or contact your broker, bank or nominee.

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General Information

How are votes counted?

For Proposal 1, you may vote “FOR” or “AGAINST” each of the director nominees. You may also “ABSTAIN” from voting with respect to a director nominee. You are not required to vote the same way with respect to each director nominee. Abstentions and broker non-votes will have no impact on this proposal as they are not considered votes cast for the foregoing purpose and will not be counted as a “FOR” or “AGAINST” vote for this proposal.

For Proposal 2, the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026, you may vote “FOR,” vote “AGAINST” or “ABSTAIN.” Abstentions have the same effect as votes “AGAINST” this proposal. Ratification will require the vote of a majority of the shares present at the Annual Meeting or voting by proxy and entitled to vote at the Annual Meeting. Abstentions will have the same effect as votes “AGAINST” this proposal. Broker non-votes will have no effect on this proposal as they are not considered entitled to vote for the foregoing purpose.

For Proposal 3, the approval, on a non-binding advisory basis, of the compensation paid to our named executive officers, you may vote “FOR,” vote “AGAINST” or “ABSTAIN.” Abstentions have the same effect as votes “AGAINST” this proposal. Broker non-votes will have no effect on this proposal as they are not considered entitled to vote for the foregoing purpose.

For Proposal 4, the approval of the Plan Amendment, you may vote “FOR,” vote “AGAINST” or “ABSTAIN.” Abstentions have the same effect as votes “AGAINST” this proposal. Broker non-votes will have no effect on this proposal as they are not considered entitled to vote for the foregoing purpose.

If you provide specific instructions, your shares will be voted as you instruct. If you sign your proxy card or voting instruction form with no further instructions, your shares will be voted in accordance with the recommendations of the Board of Directors (“FOR” each of the nominees to the Board of Directors, “FOR” the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for 2026, “FOR” approving, on a non-binding advisory basis, the compensation paid to our named executive officers in 2025, and “FOR” the approval of the Plan Amendment, and in the discretion of the proxy holders on any other matters that may properly come before the meeting).

What vote is required to approve each item?

We have a majority voting standard for uncontested elections of directors (Proposal 1), which means that to be elected, a director nominee must receive a majority of the votes cast, i.e. the number of shares voted “FOR” a director nominee must exceed the votes cast “AGAINST” that nominee.

The vote of a majority of the shares of our common stock that are present in person or represented by proxy at the Annual Meeting and entitled to vote at the Annual Meeting is required to ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2026, (Proposal 2), to approve, on a non-binding advisory basis, the resolution on named executive officer compensation (Proposal 3), and to approve the Plan Amendment (Proposal 4).

Abstentions are deemed to be shares present or represented by proxy at the Annual Meeting and entitled to vote at the Annual Meeting. Abstentions will have no effect on Proposal 1 because they are not considered votes cast for such purposes. Abstentions will have the same effect as a vote “AGAINST” Proposals 2, 3 and 4. Broker non-votes, as discussed below, will have no effect on Proposals 1, 2, 3 or 4.

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What are broker non-votes and how are they counted?

If you hold shares beneficially in street name and do not provide your broker or nominee with voting instructions, your shares may constitute “broker non-votes.” Broker non-votes occur when shares held by a broker for a beneficial owner are not voted because the broker did not receive voting instructions from the beneficial owner and lacked discretionary authority to vote the shares. A broker is entitled to vote shares held for a beneficial owner on “routine” matters without instructions from the beneficial owner of those shares. Absent instructions from the beneficial owner of such shares, a broker is not entitled to vote shares held for a beneficial owner on “non-routine” matters. Whether a proposal is considered routine or non-routine is subject to stock exchange rules and final determination by the stock exchange. Even with respect to routine matters, some brokers are choosing not to exercise discretionary voting authority. If a stockholder does not return voting instructions to their broker on how to vote their shares of common stock with respect to a particular proposal, such broker may be prevented from voting, or may otherwise choose not to vote, such shares held by such broker with respect to such proposal, resulting in broker non-votes with respect to such shares. Accordingly, we encourage you to provide voting instructions to your broker, whether or not you plan to attend the Annual Meeting. Proposals 1, 3, and 4 are considered to be “non-routine” such that your broker, bank or other agent may not vote your shares on those proposals in the absence of your voting instructions. Conversely, Proposal 2 is considered to be “routine” and thus if you do not return voting instructions to your broker, your shares may be voted by your broker in its discretion on Proposal 2. Broker non-votes will be counted as present for purposes of determining the presence of a quorum.

Is cumulative voting permitted for the election of directors?

Stockholders may not cumulate votes in the election of directors, which means that each stockholder may vote no more than the number of shares he or she owns for a single director candidate.

What constitutes a quorum?

The presence at the Annual Meeting of the holders of a majority of the shares of common stock outstanding on the Record Date will constitute a quorum. Your shares are counted as present at the Annual Meeting if you are present and vote at the Annual Meeting or if you have properly submitted a proxy. As of the close of business on the Record Date, there were 79,792,167 shares of our common stock outstanding. Both abstentions and broker non-votes are counted for the purpose of determining the presence of a quorum.

How are proxies solicited?

Our employees, officers and directors may solicit proxies. We will pay the cost of printing and mailing proxy materials, and will reimburse brokerage houses and other custodians, nominees and fiduciaries for their reasonable out-of-pocket expenses for forwarding proxy material to the owners of our common stock. At this time, we have not engaged a proxy solicitor. If we do engage a proxy solicitor, we will pay the customary costs associated with such engagement.

How can I find out the results of the voting at the annual meeting?

Preliminary voting results will be announced at the Annual Meeting. Final voting results will be published in our current report on Form 8-K to be filed with the SEC within four business days after the Annual Meeting. If final voting results are not available to us in time to file a Form 8-K within four business days after the meeting, we intend to file a Form 8-K to publish preliminary results and, within four business days after the final results are known to us, file an additional Form 8-K to publish the final results.

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Participating in the Annual Meeting

To participate in the virtual meeting, visit www.virtualshareholdermeeting.com/VCYT2026 and enter the 16-digit control number included on your proxy card or on the instructions that accompanied your proxy materials.

If you wish to submit a question during the Annual Meeting, log in to the virtual meeting platform at www.virtualshareholdermeeting.com/VCYT2026, type your question into the “Ask a Question” field, and click “Submit.” If your question is properly submitted during the relevant portion of the meeting agenda, we will seek to respond to your question during the live webcast. We reserve the right to exclude questions that are irrelevant to meeting matters, irrelevant to our business, or derogatory or in bad taste; that relate to pending or threatened litigation; that are personal grievances; or that are otherwise inappropriate (as determined by the chair of the Annual Meeting). A webcast replay of the Annual Meeting, including the Q&A session, will be archived on the “Investor Relations” section of our website, which is located at https://investor.veracyte.com/investor-relations.

If we experience technical difficulties during the meeting (e.g., a temporary or prolonged power outage), we will determine whether the meeting can be promptly reconvened (if the technical difficulty is temporary) or whether the meeting will need to be reconvened on a later day (if the technical difficulty is more prolonged). In any situation, we will promptly notify stockholders of the decision via www.virtualshareholdermeeting.com/VCYT2026. If you encounter technical difficulties accessing our meeting or asking questions during the meeting, a support line will be available on the login page of the virtual meeting website.

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Appendix A

VERACYTE, INC.

2023 EQUITY INCENTIVE PLAN, AS AMENDED

(ADOPTED BY THE BOARD OF DIRECTORS ON APRIL 12, 2023, AS AMENDED JUNE 12, 2024, JUNE 17, 2025 AND [______], 2026)

1.PURPOSE. The purpose of this Plan is to provide incentives to attract, retain, and motivate eligible persons whose present and potential contributions are important to the success of the Company, and any Parents, Subsidiaries, and Affiliates that exist now or in the future, by offering them an opportunity to participate in the Company’s future performance through the grant of Awards. Capitalized terms not defined elsewhere in the text are defined in Section 28.

2.SHARES SUBJECT TO THIS PLAN

2.1.Number of Shares Available. Subject to Sections 2.5 and 21 and any other applicable provisions hereof, the total number of Shares reserved and available for grant and issuance pursuant to this Plan is 16,306,156 plus (a) Shares that are subject to awards granted under the Prior Plan that cease to be subject to such awards by forfeiture or otherwise after the Effective Date, (b) Shares issued under the Prior Plan, including Shares issued pursuant to the exercise of stock options, that are forfeited after the Effective Date, (c) Shares issued under the Prior Plan that are repurchased by the Company at the original issue price after the Effective Date, (d) Shares that are subject to awards granted under the Prior Plan that are settled in cash after the Effective Date and (e) Shares that are subject to awards under the Prior Plan that are used to pay the Exercise Price of an award or withheld to satisfy the tax withholding obligations related to an award after the Effective Date. As of the Effective Date, no further awards can be granted under the Prior Plan.

2.2.Lapsed, Returned Awards. Shares subject to Awards, and Shares issued under this Plan under any Award, will again be available for grant and issuance in connection with subsequent Awards under this Plan to the extent such Shares: (a) are subject to issuance upon exercise of an Option or SAR granted under this Plan but which cease to be subject to the Option or SAR for any reason other than exercise of the Option or SAR, (b) are subject to Awards granted under this Plan that are forfeited or are repurchased by the Company at the original issue price, (c) are subject to Awards granted under this Plan that otherwise terminate without such Shares being issued, (d) are surrendered pursuant to an Exchange Program, (e) are subject to Awards granted under this Plan that are settled in cash and (f) are subject to Awards granted under this Plan and are used to pay the Exercise Price of an Award or withheld to satisfy the tax withholding obligations related to an Award. For the avoidance of doubt, Shares that otherwise become available for grant and issuance because of the provisions of this Section 2.2 will not include Shares subject to Awards that initially became available because of the substitution clause in Section 21.2 hereof.

2.3.Minimum Share Reserve. At all times the Company will reserve and keep available a sufficient number of Shares as will be required to satisfy the requirements of all outstanding Awards granted under this Plan.

2.4.ISO Limitation. No more than 15,000,000 Shares will be issued pursuant to the exercise of ISOs granted under this Plan.

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2.5.Adjustment of Shares. If the number or class of outstanding Shares is changed by a stock dividend, extraordinary dividend or distribution (whether in cash, shares, or other property, other than a regular cash dividend), recapitalization, stock split, reverse stock split, subdivision, combination, consolidation, reclassification, spin-off, or similar change in the capital structure of the Company, without consideration, then (a) the number and class of Shares reserved for issuance and future grant under this Plan set forth in Section 2.1, (b) the Exercise Prices of and number and class of Shares subject to outstanding Options and SARs, (c) the number and class of Shares subject to other outstanding Awards, and (d) the maximum number and class of Shares that may be issued as ISOs set forth in Section 2.4, will be proportionately adjusted, subject to any required action by the Board or the stockholders of the Company and in compliance with applicable securities laws, provided that fractions of a Share will not be issued.

If, by reason of an adjustment pursuant to this Section 2.5, a Participant’s Award Agreement or other agreement related to any Award, or the Shares subject to such Award, covers additional or different shares of stock or securities, then such additional or different shares, and the Award Agreement or such other agreement in respect thereof, will be subject to all of the terms, conditions, and restrictions which were applicable to the Award or the Shares subject to such Award prior to such adjustment.

3.ELIGIBILITY. ISOs may be granted only to Employees. All other Awards may be granted to Employees, Consultants, Directors, and Non-Employee Directors, provided that such Consultants, Directors, and Non-Employee Directors render bona fide services not in connection with the offer and sale of securities in a capital-raising transaction.

4.ADMINISTRATION.

4.1.Committee Composition; Authority. This Plan will be administered by the Committee or by the Board acting as the Committee. Subject to the general purposes, terms, and conditions of this Plan, and to the direction of the Board, the Committee will have full power to implement and carry out this Plan, except, however, the Board will establish the terms for the grant of an Award to Non-Employee Directors. The Committee will have the authority to:

(a)construe and interpret this Plan, any Award Agreement, and any other agreement or document executed pursuant to this Plan;

(b)prescribe, amend, and rescind rules and regulations relating to this Plan or any Award;

(c)select persons to receive Awards;

(d)determine the form and terms and conditions, not inconsistent with the terms of this Plan, of any Award granted hereunder. Such terms and conditions include, but are not limited to, the Exercise Price, the time or times when Awards may vest (which may be based on performance criteria) and be exercised or settled, any vesting acceleration or waiver of forfeiture restrictions, the method to satisfy tax withholding obligations or any other tax liability legally due, and any restriction or limitation regarding any Award or the Shares relating thereto, based in each case on such factors as the Committee will determine;

(e)determine the number of Shares or other consideration subject to Awards;

(f)determine the Fair Market Value in good faith and interpret the applicable provisions of this Plan and the definition of Fair Market Value in connection with circumstances that impact the Fair Market Value, if necessary;

(g)determine whether Awards will be granted singly, in combination with, in tandem with, in replacement of, or as alternatives to, other Awards under this Plan or any other incentive or compensation plan of the Company or any Parent, Subsidiary, or Affiliate;

(h)grant waivers of Plan or Award conditions;

(i)determine the vesting, exercisability, and payment of Awards;

(j)correct any defect, supply any omission or reconcile any inconsistency in this Plan, any Award or any Award Agreement;

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(k)determine whether an Award has been vested and/or earned;

(l)determine the terms and conditions of any, and to institute any Exchange Program;

(m)reduce or modify any criteria with respect to Performance Factors;

(n)adjust Performance Factors to take into account changes in law and accounting or tax rules as the Committee deems necessary or appropriate to reflect the impact of extraordinary or unusual items, events, or circumstances to avoid windfalls or inequitable results;

(o)adopt terms and conditions, rules, and/or procedures (including the adoption of any subplan under this Plan) relating to the operation and administration of this Plan to accommodate requirements of local law and procedures outside of the United States or to qualify Awards for special tax treatment under laws of jurisdictions other than the United States;

(p)exercise discretion with respect to Performance Awards;

(q)make all other determinations necessary or advisable for the administration of this Plan; and

(r)delegate any of the foregoing to a subcommittee or to one or more executive officers pursuant to a specific delegation as permitted by applicable law, including, but not limited to, Section 157(c) of the Delaware General Corporation Law.

4.2.Committee Interpretation and Discretion. Any determination made by the Committee with respect to any Award will be made in its sole discretion at the time of grant of the Award or, unless in contravention of any express term of this Plan or Award, at any later time, and such determination will be final and binding on the Company and all persons having an interest in any Award under this Plan. Any dispute regarding the interpretation of this Plan or any Award Agreement will be submitted by the Participant or Company to the Committee for review. The resolution of such a dispute by the Committee will be final and binding on the Company and the Participant. The Committee may delegate to one or more executive officers the authority to review and resolve disputes with respect to Awards held by Participants who are not Insiders, and such resolution will be final and binding on the Company and the Participant.

4.3.Section 16 of the Exchange Act. Awards granted to Participants who are subject to Section 16 of the Exchange Act must be approved by two or more “non-employee directors” (as defined in the regulations promulgated under Section 16 of the Exchange Act).

4.4.Documentation. The Award Agreement for a given Award, this Plan, and any other documents may be delivered to, and accepted by, a Participant or any other person in any manner (including electronic distribution or posting) that meets applicable legal requirements.

4.5.Foreign Award Recipients. Notwithstanding any provision of this Plan to the contrary, in order to comply with the laws and practices in other countries in which the Company, its Subsidiaries, and Affiliates operate or have Employees or other individuals eligible for Awards, the Committee, in its sole discretion, will have the power and authority to: (a) determine which Subsidiaries and Affiliates will be covered by this Plan; (b) determine which individuals outside the United States are eligible to participate in this Plan, which may include individuals who provide services to the Company, Subsidiary or Affiliate under an agreement with a foreign nation or agency; (c) modify the terms and conditions of any Award granted to individuals outside the United States or foreign nationals to comply with applicable foreign laws, policies, customs, and practices; (d) establish subplans and modify exercise procedures, vesting conditions, and other terms and procedures to the extent the Committee determines such actions to be necessary or advisable (and such subplans and/or modifications will be attached to this Plan as appendices, if necessary); and (e) take any action, before or after an Award is made, that the Committee determines to be necessary or advisable to obtain approval or comply with any local governmental regulatory exemptions or approvals, provided, however, that no action taken under this Section 4.5 will increase the Share limitations contained in Section 2.1 hereof. Notwithstanding the foregoing, the Committee may not take any actions hereunder, and no Awards will be granted, that would violate the Exchange Act or any other applicable United States securities law, the Code, or any other applicable United States governing statute or law.

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Appendix A

5.OPTIONS. An Option is the right but not the obligation to purchase a Share, subject to certain conditions, if applicable. The Committee may grant Options to eligible Employees, Consultants, and Directors and will determine whether such Options will be “incentive stock options” within the meaning of the Code (“ISOs”) or Nonqualified Stock Options (“NQSOs”), the number of Shares subject to the Option, the Exercise Price of the Option, the period during which the Option may vest and be exercised, and all other terms and conditions of the Option, subject to the following terms of this section.

5.1.Option Grant. Each Option granted under this Plan will identify the Option as an ISO or an NQSO. An Option may be, but need not be, awarded upon satisfaction of such Performance Factors during any Performance Period as are set out in advance in the Participant’s individual Award Agreement. If the Option is being earned upon the satisfaction of Performance Factors, then the Committee will: (a) determine the nature, length, and starting date of any Performance Period for each Option; and (b) select from among the Performance Factors to be used to measure the performance, if any. Performance Periods may overlap and Participants may participate simultaneously with respect to Options that are subject to different performance goals and other criteria.

5.2.Date of Grant. The date of grant of an Option will be the date on which the Committee makes the determination to grant such Option, or a specified future date. The Award Agreement will be delivered to the Participant within a reasonable time after the granting of the Option.

5.3.Exercise Period. Options may be vested and exercisable within the times or upon the conditions as set forth in the Award Agreement governing such Option, provided, however, that no Option will be exercisable after the expiration of ten (10) years from the date the Option is granted and provided further that no ISO granted to a person who, at the time the ISO is granted, directly or by attribution owns more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or of any Parent or Subsidiary (“Ten Percent Stockholder”) will be exercisable after the expiration of five (5) years from the date the ISO is granted. The Committee also may provide for Options to become exercisable at one time or from time to time, periodically or otherwise, in such number of Shares or percentage of Shares as the Committee determines.

5.4.Exercise Price. The Exercise Price of an Option will be determined by the Committee when the Option is granted, provided that: (a) the Exercise Price of an Option will be not less than one hundred percent (100%) of the Fair Market Value of the Shares on the date of grant, and (b) the Exercise Price of any ISO granted to a Ten Percent Stockholder will not be less than one hundred ten percent (110%) of the Fair Market Value of the Shares on the date of grant. Payment for the Shares purchased may be made in accordance with Section 11 and the Award Agreement and in accordance with any procedures established by the Company.

5.5.Method of Exercise. Any Option granted hereunder will be vested and exercisable according to the terms of this Plan and at such times and under such conditions as determined by the Committee and set forth in the Award Agreement. An Option may not be exercised for a fraction of a Share. An Option will be deemed exercised when the Company receives: (a) notice of exercise (in such form as the Committee may specify from time to time) from the person entitled to exercise the Option (and/or via electronic execution through the authorized third-party administrator) and (b) full payment for the Shares with respect to which the Option is exercised (together with applicable withholding taxes). Full payment may consist of any consideration and method of payment authorized by the Committee and permitted by the Award Agreement and this Plan. Shares issued upon exercise of an Option will be issued in the name of the Participant. Until the Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or receive dividends or any other rights as a stockholder will exist with respect to the Shares, notwithstanding the exercise of the Option. The Company will issue (or cause to be issued) such Shares promptly after the Option is exercised. No adjustment will be made for a dividend or other right for which the record date is prior to the date the Shares are issued, except as provided in Section 2.5 of this Plan.

5.6.Termination of Service. If the Participant’s Service terminates for any reason except for Cause or the Participant’s death or Disability, then the Participant may exercise such Participant’s Options, only to the extent that such Options would have been exercisable by the Participant on the date Participant’s Service terminates,

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no later than three (3) months after the date Participant’s Service terminates (or such shorter or longer time period as may be determined by the Committee, with any exercise beyond three (3) months after the date Participant’s employment terminates deemed to be the exercise of an NQSO), but in any event no later than the expiration date of the Options.

(a)Death. If the Participant’s Service terminates because of the Participant’s death (or the Participant dies within three (3) months after Participant’s Service terminates other than for Cause or because of the Participant’s Disability), then the Participant’s Options may be exercised, only to the extent that such Options would have been exercisable by the Participant on the date Participant’s Service terminates, and must be exercised by the Participant’s legal representative, or authorized assignee no later than twelve (12) months after the date Participant’s Service terminates (or such shorter time period or longer time period as may be determined by the Committee), but in any event no later than the expiration date of the Options.

(b)Disability. If the Participant’s Service terminates because of the Participant’s Disability, then the Participant’s Options may be exercised, only to the extent that such Options would have been exercisable by the Participant on the date Participant’s Service terminates, and must be exercised by the Participant (or the Participant’s legal representative or authorized assignee) no later than twelve (12) months after the date Participant’s Service terminates (or such shorter time period not less than six (6) months or longer time period as may be determined by the Committee, with any exercise beyond (a) three (3) months after the date Participant’s employment terminates when the termination of Service is for a Disability that is not a “permanent and total disability” as defined in Section 22(e)(3) of the Code or (b) twelve (12) months after the date Participant’s employment terminates when the termination of Service is for a Disability that is a “permanent and total disability” as defined in Section 22(e)(3) of the Code, deemed to be exercise of an NQSO), but in any event no later than the expiration date of the Options.

(c)Cause. Unless otherwise determined by the Committee, if the Participant’s Service terminates for Cause or if the Committee has reasonably determined in good faith that such cessation of Services has resulted in connection with an act or failure to act constituting Cause (or such Participant’s Services could have been terminated for Cause (without regard to the lapsing of any required notice or cure periods in connection therewith) at the time such Participant terminated Service), then Participant’s Options (whether or not vested) will expire on the date of termination of Participant’s Service or at such later time and on such conditions as are determined by the Committee, but in any event no later than the expiration date of the Options. Unless otherwise provided in an employment agreement, Award Agreement, or other applicable agreement, Cause will have the meaning set forth in this Plan.

(d)Unvested Options. Participant’s unvested Options shall expire on the date of Participant’s termination of Service for any reason (unless Participant’s unvested Options are accelerated upon such termination of Service or are required to remain outstanding for some period post-termination in order to remain eligible for acceleration pursuant to an agreement between Participant and the Company).

5.7.Limitations on Exercise. The Committee may specify a minimum number of Shares that may be purchased on any exercise of an Option, provided that such minimum number will not prevent any Participant from exercising the Option for the full number of Shares for which it is then exercisable.

5.8.Limitations on ISOs. With respect to Awards granted as ISOs, to the extent that the aggregate Fair Market Value of the Shares with respect to which such ISOs are exercisable for the first time by the Participant during any calendar year (under all plans of the Company and any Parent or Subsidiary) exceeds one hundred thousand dollars ($100,000), such Options will be treated as NQSOs. For purposes of this Section 5.8, ISOs will be taken into account in the order in which they were granted. The Fair Market Value of the Shares will be determined as of the time the Option with respect to such Shares is granted. In the event that the Code or the regulations promulgated thereunder are amended after the Effective Date to provide for a different limit on the

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Appendix A

Fair Market Value of Shares permitted to be subject to ISOs, such different limit will be automatically incorporated herein and will apply to any Options granted after the effective date of such amendment.

5.9.Modification, Extension or Renewal. The Committee may modify, extend or renew outstanding Options and authorize the grant of new Options in substitution therefor, provided that any such action may not, without the written consent of a Participant, impair any of such Participant’s rights under any Option previously granted, unless for the purpose of complying with applicable laws and regulations. Any outstanding ISO that is modified, extended, renewed or otherwise altered will be treated in accordance with Section 424(h) of the Code. Subject to prior stockholder approval as is required by Section 18 of this Plan, by written notice to affected Participants, the Committee may reduce the Exercise Price of outstanding Options without the consent of such Participants; provided, however, that the Exercise Price may not be reduced below the Fair Market Value on the date the action is taken to reduce the Exercise Price.

5.10.No Disqualification. Notwithstanding any other provision in this Plan, no term of this Plan relating to ISOs will be interpreted, amended, or altered, nor will any discretion or authority granted under this Plan be exercised, so as to disqualify this Plan under Section 422 of the Code or, without the consent of the Participant affected, to disqualify any ISO under Section 422 of the Code.

6.RESTRICTED STOCK AWARDS. A Restricted Stock Award is an offer by the Company to sell to an eligible Employee, Consultant, or Director Shares that are subject to restrictions (“Restricted Stock”). The Committee will determine to whom an offer will be made, the number of Shares the Participant may purchase, the Purchase Price, the restrictions under which the Shares will be subject, and all other terms and conditions of the Restricted Stock Award, subject to this Plan.

6.1.Restricted Stock Purchase Agreement. All purchases under a Restricted Stock Award will be evidenced by an Award Agreement. Except as may otherwise be provided in an Award Agreement, a Participant accepts a Restricted Stock Award by signing and delivering to the Company an Award Agreement with full payment of the Purchase Price, within thirty (30) days from the date the Award Agreement was delivered to the Participant. If the Participant does not accept such Award within thirty (30) days, then the offer of such Restricted Stock Award will terminate, unless the Committee determines otherwise.

6.2.Purchase Price. The Purchase Price for a Restricted Stock Award will be determined by the Committee and may be less than Fair Market Value on the date the Restricted Stock Award is granted. Payment of the Purchase Price must be made in accordance with Section 11 of this Plan, and the Award Agreement and in accordance with any procedures established by the Company.

6.3.Terms of Restricted Stock Awards. Restricted Stock Awards will be subject to such restrictions as the Committee may impose or are required by law. These restrictions may be based on completion of a specified period of Service with the Company or upon completion of Performance Factors, if any, during any Performance Period as set out in advance in the Participant’s Award Agreement. Prior to the grant of a Restricted Stock Award, the Committee will: (a) determine the nature, length, and starting date of any Performance Period for the Restricted Stock Award; (b) select from among the Performance Factors to be used to measure performance goals, if any; and (c) determine the number of Shares that may be awarded to the Participant. Performance Periods may overlap and a Participant may participate simultaneously with respect to Restricted Stock Awards that are subject to different Performance Periods and having different performance goals and other criteria.

6.4.Termination of Service. Except as may be set forth in the Participant’s Award Agreement, vesting ceases on such date Participant’s Service terminates (unless determined otherwise by the Committee).

7.STOCK BONUS AWARDS. A Stock Bonus Award is an award to an eligible Employee, Consultant, or Director of Shares for Services to be rendered or for past Services already rendered to the Company or any Parent, Subsidiary, or Affiliate. All Stock Bonus Awards will be made pursuant to an Award Agreement. No payment from the Participant will be required for Shares awarded pursuant to a Stock Bonus Award.

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7.1.Terms of Stock Bonus Awards. The Committee will determine the number of Shares to be awarded to the Participant under a Stock Bonus Award and any restrictions thereon. These restrictions may be based upon completion of a specified period of Service with the Company or upon satisfaction of performance goals based on Performance Factors during any Performance Period as set out in advance in the Participant’s Stock Bonus Agreement. Prior to the grant of any Stock Bonus Award the Committee will: (a) determine the nature, length, and starting date of any Performance Period for the Stock Bonus Award; (b) select from among the Performance Factors to be used to measure performance goals; and (c) determine the number of Shares that may be awarded to the Participant. Performance Periods may overlap and a Participant may participate simultaneously with respect to Stock Bonus Awards that are subject to different Performance Periods and different performance goals and other criteria.

7.2.Form of Payment to Participant. Payment may be made in the form of cash, whole Shares, or a combination thereof, based on the Fair Market Value of the Shares earned under a Stock Bonus Award on the date of payment, as determined in the sole discretion of the Committee.

7.3.Termination of Service. Except as may be set forth in the Participant’s Award Agreement, vesting ceases on such date Participant’s Service terminates (unless determined otherwise by the Committee).

8.STOCK APPRECIATION RIGHTS. A Stock Appreciation Right (“SAR”) is an award to an eligible Employee, Consultant, or Director that may be settled in cash or Shares (which may consist of Restricted Stock) having a value equal to (a) the difference between the Fair Market Value on the date of exercise over the Exercise Price multiplied by (b) the number of Shares with respect to which the SAR is being settled (subject to any maximum number of Shares that may be issuable as specified in an Award Agreement). All SARs will be made pursuant to an Award Agreement.

8.1.Terms of SARs. The Committee will determine the terms of each SAR including, without limitation: (a) the number of Shares subject to the SAR, (b) the Exercise Price and the time or times during which the SAR may be settled, (c) the consideration to be distributed on settlement of the SAR, and (d) the effect of the Participant’s termination of Service on each SAR. The Exercise Price of the SAR will be determined by the Committee when the SAR is granted and may not be less than Fair Market Value of the Shares on the date of grant. A SAR may be awarded upon satisfaction of Performance Factors, if any, during any Performance Period as are set out in advance in the Participant’s individual Award Agreement. If the SAR is being earned upon the satisfaction of Performance Factors, then the Committee will: (i) determine the nature, length, and starting date of any Performance Period for each SAR; and (ii) select from among the Performance Factors to be used to measure the performance, if any. Performance Periods may overlap and Participants may participate simultaneously with respect to SARs that are subject to different Performance Factors and other criteria.

8.2.Exercise Period and Expiration Date. A SAR will be exercisable within the times or upon the occurrence of events determined by the Committee and set forth in the Award Agreement governing such SAR. The SAR Agreement will set forth the expiration date, provided that no SAR will be exercisable after the expiration of ten (10) years from the date the SAR is granted. The Committee may also provide for SARs to become exercisable at one time or from time to time, periodically or otherwise (including, without limitation, upon the attainment during a Performance Period of performance goals based on Performance Factors), in such number of Shares or percentage of the Shares subject to the SAR as the Committee determines. Notwithstanding the foregoing, the rules of Section 5.6 also will apply to SARs.

8.3.Form of Settlement. Upon exercise of a SAR, a Participant will be entitled to receive payment from the Company in an amount determined by multiplying (a) the difference between the Fair Market Value of a Share on the date of exercise over the Exercise Price, by (b) the number of Shares with respect to which the SAR is exercised. At the discretion of the Committee, the payment from the Company for the SAR exercise may be in cash, in Shares of equivalent value, or in some combination thereof. The portion of a SAR being settled may be paid currently or on a deferred basis with such interest, if any, as the Committee determines, provided that the terms of the SAR and any deferral satisfy the requirements of Section 409A of the Code to the extent applicable.

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8.4.Termination of Service. Except as may be set forth in the Participant’s Award Agreement, vesting ceases on the date Participant’s Service terminates (unless determined otherwise by the Committee).

9.RESTRICTED STOCK UNITS. A Restricted Stock Unit (“RSU”) is an award to an eligible Employee, Consultant, or Director covering a number of Shares that may be settled by issuance of those Shares (which may consist of Restricted Stock) or in cash. All RSUs will be made pursuant to an Award Agreement.

9.1.Terms of RSUs. The Committee will determine the terms of an RSU including, without limitation: (a) the number of Shares subject to the RSU, (b) the time or times during which the RSU may be settled, (c) the consideration to be distributed on settlement, and (d) the effect of the Participant’s termination of Service on each RSU, provided that no RSU will have a term longer than ten (10) years. An RSU may be awarded upon satisfaction of such performance goals based on Performance Factors during any Performance Period as are set out in advance in the Participant’s Award Agreement. If the RSU is being earned upon satisfaction of Performance Factors, then the Committee will: (i) determine the nature, length, and starting date of any Performance Period for the RSU; (ii) select from among the Performance Factors to be used to measure the performance, if any; and (iii) determine the number of Shares deemed subject to the RSU. Performance Periods may overlap and Participants may participate simultaneously with respect to RSUs that are subject to different Performance Periods and different performance goals and other criteria.

9.2.Form and Timing of Settlement. Payment of earned RSUs will be made as soon as practicable after the date(s) determined by the Committee and set forth in the Award Agreement. The Committee, in its sole discretion, may settle earned RSUs in cash, Shares, or a combination of both. The Committee may also permit a Participant to defer payment under a RSU to a date or dates after the RSU is earned, provided that the terms of the RSU and any deferral satisfy the requirements of Section 409A of the Code to the extent applicable.

9.3.Termination of Service. Except as may be set forth in the Participant’s Award Agreement, vesting ceases on such date Participant’s Service terminates (unless determined otherwise by the Committee).

10.PERFORMANCE AWARDS. A Performance Award is an award to an eligible Employee, Consultant, or Director that is based upon the attainment of performance goals, as established by the Committee, and other terms and conditions specified by the Committee, and may be settled in cash, Shares (which may consist of, without limitation, Restricted Stock), other property, or any combination thereof, and may be cash-based. Grants of Performance Awards will be made pursuant to an Award Agreement.

10.1.Types of Performance Awards. Performance Awards shall include Performance Shares, Performance Units and cash-settled Performance Awards as set forth in Sections 10.1(a), 10.1(b) and 10.1(c) below.

(a)Performance Shares. The Committee may grant Awards of Performance Shares, designate the Participants to whom Performance Shares are to be awarded and determine the number of Performance Shares and the terms and conditions of each such Award.

(b)Performance Units. The Committee may grant Awards of Performance Units, designate the Participants to whom Performance Units are to be awarded and determine the number of Performance Units and the terms and conditions of each such Award.

(c)Cash-Settled Performance Awards. The Committee may also grant cash-settled Performance Awards, designate the Participants to whom cash-settled Performance Awards are to be awarded and determine the terms and conditions of each such Award.

The amount to be paid under any Performance Award may be adjusted on the basis of such further consideration as the Committee shall determine in its sole discretion.

10.2.Terms of Performance Awards. Performance Awards will be based on the attainment of performance goals using the Performance Factors within this Plan that are established by the Committee for the relevant Performance Period. The Committee will determine, and each Award Agreement will set forth, the terms of each

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Performance Award including, without limitation: (a) the amount of any cash bonus, (b) the number of Shares deemed subject to a Performance Award, (c) the Performance Factors and Performance Period that will determine the time and extent to which each Performance Award will be settled, (d) the consideration to be distributed on settlement, and (e) the effect of the Participant’s termination of Service on each Performance Award. In establishing Performance Factors and the Performance Period the Committee will: (i) determine the nature, length, and starting date of any Performance Period; (ii) select from among the Performance Factors to be used and (iii) determine the number of Shares deemed subject to the award of Performance Shares. Each Performance Share will have an initial value equal to the Fair Market Value of a Share on the date of grant. Prior to settlement the Committee will determine the extent to which Performance Awards have been earned. Performance Periods may overlap and Participants may participate simultaneously with respect to Performance Awards that are subject to different Performance Periods and different performance goals and other criteria.

10.3.Termination of Service. Except as may be set forth in the Participant’s Award Agreement, vesting ceases on the date Participant’s Service terminates (unless determined otherwise by the Committee).

11.PAYMENT FOR SHARE PURCHASES. Payment from a Participant for Shares purchased pursuant to this Plan may be made in cash or by cash equivalents or, where expressly approved for the Participant by the Committee and where permitted by law (and to the extent not otherwise set forth in the applicable Award Agreement):

(a)by cancellation of indebtedness of the Company owed to the Participant;

(b)by surrender of shares of the Company held by the Participant that have a Fair Market Value on the date of surrender equal to the aggregate Exercise Price of the Shares as to which said Award will be exercised or settled;

(c)by waiver of compensation due or accrued to the Participant for services rendered or to be rendered to the Company or a Parent, Subsidiary or Affiliate;

(d)by consideration received by the Company pursuant to a broker-assisted or other form of cashless exercise program implemented by the Company in connection with this Plan;

(e)by any combination of the foregoing; or

(f)by any other method of payment as is permitted by applicable law.

The Committee may limit the availability of any method of payment, to the extent the Committee determines, in its discretion, such limitation is necessary or advisable to comply with applicable law or facilitate the administration of this Plan. Unless determined otherwise by the Committee, all payments under any of the methods indicated above shall be made in United States dollars.

12.GRANTS TO NON-EMPLOYEE DIRECTORS.

12.1.Grants and Eligibility. Awards pursuant to this Section 12 shall be granted only to Non-Employee Directors who are eligible to receive any type of Award offered under this Plan except ISOs. Awards pursuant to this Section 12 may be automatically made pursuant to a policy adopted by the Board, or made from time to time as determined in the discretion of the Board.

12.2.Calendar Year Limitation. A Non-Employee Director may not receive Awards under this Plan that, when combined with cash compensation received for service as a Non-Employee Director, exceed (x) $750,000 in value (as described below) in any calendar year, for continuing Non-Employee Directors, or (y) $1,500,000 in value (as described below) in the initial calendar year, for a new Non-Employee Director. The value of Awards for purposes of complying with this maximum will be determined as follows: (a) for Options and SARs, grant date fair value will be calculated using the Black-Scholes valuation methodology or the Company’s regular valuation methodology for determining the grant date fair value of Options for reporting purposes, and (b) for all other Awards other than Options and SARs, grant date fair value will be determined by either (i) calculating the product of the Fair Market Value per Share on the date of grant and the aggregate number of Shares subject to

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the Award, or (ii) calculating the product using an average of the Fair Market Value over a number of trading days and the aggregate number of Shares subject to the Award as determined by the Committee. Awards granted to an individual while they were serving in the capacity as an Employee or while they were a Consultant but not a Non-Employee Director will not count for purposes of the limitations set forth in this Section 12.2.

12.3.Vesting, Exercisability and Settlement. Except as set forth in Section 21, Awards will vest, become exercisable, and be settled as determined by the Board. The Exercise Price of Options and SARs granted to Non-Employee Directors will not be less than the Fair Market Value of the Shares at the time that such Option or SAR is granted.

12.4.Election to Receive Awards in Lieu of Cash. If permitted by the Committee, a Non-Employee Director may elect to receive his or her annual retainer payments and/or meeting fees from the Company in the form of cash or Awards or a combination thereof, as determined by the Committee. Such Awards will be issued under this Plan. An election under this Section 12.4 will be filed with the Company on the form prescribed by the Company.

13.WITHHOLDING TAXES.

13.1.Withholding Generally. Whenever Shares are to be issued in satisfaction of Awards granted under this Plan or a tax event occurs, the Company may require the Participant to remit to the Company, or to the Parent, Subsidiary, or Affiliate, as applicable, employing the Participant an amount sufficient to satisfy applicable U.S. federal, state, local, and international income tax, social insurance, payroll tax, fringe benefits tax, payment on account or other tax-related items (the “Tax-Related Items”) legally due from the Participant prior to the delivery of Shares pursuant to exercise or settlement of any Award. Whenever payments in satisfaction of Awards granted under this Plan are to be made in cash, such payment will be net of an amount sufficient to satisfy applicable withholding obligations for Tax-Related Items. Unless otherwise determined by the Committee, the Fair Market Value of the Shares will be determined as of the date that the taxes are required to be withheld and such Shares shall be valued based on the value of the actual trade or, if there is none, the Fair Market Value of the Shares as of the previous trading day.

13.2.Stock Withholding. The Committee, or its delegate(s), as permitted by applicable law, in its sole discretion and pursuant to such procedures as it may specify from time to time and subject to limitations of local law, may require or permit a Participant to satisfy such Tax Related Items legally due from the Participant, in whole or in part by (without limitation) (a) paying cash, (b) having the Company withhold otherwise deliverable cash or Shares having a Fair Market Value equal to the Tax-Related Items to be withheld, (c) delivering to the Company already-owned shares having a Fair Market Value equal to the Tax-Related Items to be withheld, or (d) withholding from the proceeds of the sale of otherwise deliverable Shares acquired pursuant to an Award either through a voluntary sale or through a mandatory sale arranged by the Company. The Company may withhold or account for these Tax-Related Items by considering applicable statutory withholding rates or other applicable withholding rates, including up to the maximum permissible statutory tax rate for the applicable tax jurisdiction, to the extent consistent with applicable laws.

14.TRANSFERABILITY. Unless determined otherwise by the Committee, an Award may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner other than by will or by the laws of descent or distribution. If the Committee makes an Award transferable, including, without limitation, by instrument to an inter vivos or testamentary trust in which the Awards are to be passed to beneficiaries upon the death of the trustor (settlor) or by gift or by domestic relations order to a Permitted Transferee, such Award will contain such additional terms and conditions as the Committee deems appropriate. All Awards will be exercisable: (a) during the Participant’s lifetime only by the Participant or the Participant’s guardian or legal representative; (b) after the Participant’s death, by the legal representative of the Participant’s heirs or legatees; and (c) in the case of all awards except ISOs, by a Permitted Transferee.

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15.PRIVILEGES OF STOCK OWNERSHIP; RESTRICTIONS ON SHARES.

15.1.Voting and Dividends. No Participant will have any of the rights of a stockholder with respect to any Shares until the Shares are issued to the Participant, except for any Dividend Equivalent Rights permitted by an applicable Award Agreement. Any Dividend Equivalent Rights will be subject to the same vesting or performance conditions as the underlying Award. In addition, the Committee may provide that any Dividend Equivalent Rights permitted by an applicable Award Agreement will be deemed to have been reinvested in additional Shares or otherwise reinvested. After Shares are issued to the Participant, the Participant will be a stockholder and have all the rights of a stockholder with respect to such Shares, including the right to vote and receive all dividends or other distributions made or paid with respect to such Shares; provided, that if such Shares are Restricted Stock, then any new, additional or different securities, or cash dividends, the Participant may become entitled to receive with respect to such Shares by virtue of a stock dividend, cash dividend, stock split or any other change in the corporate or capital structure of the Company will be subject to the same restrictions as the Restricted Stock; provided, further, that the Participant will have no right to such stock dividends, cash dividends or stock distributions with respect to Unvested Shares, and any such dividends or stock distributions will be accrued and paid only at such time, if any, as such Unvested Shares become vested Shares. The Committee, in its discretion, may provide in the Award Agreement evidencing any Award that the Participant will be entitled to Dividend Equivalent Rights with respect to the payment of cash dividends on Shares underlying an Award during the period beginning on the date the Award is granted and ending, with respect to each Share subject to the Award, on the earlier of the date on which the Award is exercised or settled or the date on which it is forfeited provided, that no Dividend Equivalent Right will be paid with respect to the Unvested Shares, and such dividends or stock distributions will be accrued and paid only at such time, if any, as such Unvested Shares become vested Shares. Such Dividend Equivalent Rights, if any, will be credited to the Participant in the form of additional whole Shares as of the date of payment of such cash dividends on Shares.

15.2.Restrictions on Shares. At the discretion of the Committee, the Company may reserve to itself and/or its assignee(s) a right to repurchase (a “Right of Repurchase”) a portion of any or all Unvested Shares held by a Participant following such Participant’s termination of Service at any time within ninety (90) days (or such longer or shorter time determined by the Committee) after the later of the date Participant’s Service terminates and the date the Participant purchases Shares under this Plan, for cash and/or cancellation of purchase money indebtedness, at the Participant’s Purchase Price or Exercise Price, as the case may be.

16.CERTIFICATES. All Shares or other securities whether or not certificated, delivered under this Plan will be subject to such stock transfer orders, legends, and other restrictions as the Committee may deem necessary or advisable, including restrictions under any applicable U.S. federal, state, or foreign securities law, or any rules, regulations, and other requirements of the SEC or any stock exchange or automated quotation system upon which the Shares may be listed or quoted, and any non-U.S. exchange controls or securities law restrictions to which the Shares are subject.

17.ESCROW; PLEDGE OF SHARES. To enforce any restrictions on a Participant’s Shares, the Committee may require the Participant to deposit all certificates representing Shares, together with stock powers or other instruments of transfer approved by the Committee, appropriately endorsed in blank, with the Company or an agent designated by the Company to hold in escrow until such restrictions have lapsed or terminated, and the Committee may cause a legend or legends referencing such restrictions to be placed on the certificates. Any Participant who is permitted to execute a promissory note as partial or full consideration for the purchase of Shares under this Plan will be required to pledge and deposit with the Company all or part of the Shares so purchased as collateral to secure the payment of the Participant’s obligation to the Company under the promissory note, provided, however, that the Committee may require or accept other or additional forms of collateral to secure the payment of such obligation and, in any event, the Company will have full recourse against the Participant under the promissory note notwithstanding any pledge of the Participant’s Shares or other collateral. In connection with any pledge of the Shares, the Participant will be required to execute and deliver a written pledge agreement in such form as the Committee will from time to time approve. The Shares purchased with the promissory note may be released from the pledge on a pro rata basis as the promissory note is paid.

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18.REPRICING; EXCHANGE AND BUYOUT OF AWARDS. The repricing of Options or SARs, including pursuant to an Exchange Program, is not permitted without prior stockholder approval.

19.SECURITIES LAW AND OTHER REGULATORY COMPLIANCE. An Award will not be effective unless such Award is in compliance with all applicable U.S. and foreign federal and state securities and exchange control and other laws, rules, and regulations of any governmental body, and the requirements of any stock exchange or automated quotation system upon which the Shares may then be listed or quoted, as they are in effect on the date of grant of the Award and also on the date of exercise or other issuance. Notwithstanding any other provision in this Plan, the Company will have no obligation to issue or deliver certificates for Shares under this Plan prior to: (a) obtaining any approvals from governmental agencies that the Company determines are necessary or advisable and/or (b) completion of any registration or other qualification of such Shares under any state, federal, or foreign law or ruling of any governmental body that the Company determines to be necessary or advisable. The Company will be under no obligation to register the Shares with the SEC or to effect compliance with the registration, qualification, or listing requirements of any foreign or state securities laws, exchange control laws, stock exchange, or automated quotation system, and the Company will have no liability for any inability or failure to do so.

20.NO OBLIGATION TO EMPLOY. Nothing in this Plan or any Award granted under this Plan will confer or be deemed to confer on any Participant any right to continue in the employ of, or to continue any other relationship with, the Company or any Parent, Subsidiary, or Affiliate or limit in any way the right of the Company or any Parent, Subsidiary, or Affiliate to terminate Participant’s employment or other relationship at any time.

21.CORPORATE TRANSACTIONS.

21.1.Treatment of Awards in the event of Corporate Transaction. In the event of a Corporate Transaction any or all outstanding Awards shall be subject to the definitive agreement related thereto, and may be (a) continued, assumed or replaced by the successor corporation, which assumption or replacement shall be binding on all Participants, provided that the Exercise Price and the number and nature of shares issuable upon exercise of any Option or SAR, or any Award that is subject to Section 409A of the Code, will be adjusted appropriately pursuant to Section 424(a) of the Code and/or Section 409A of the Code, as applicable, (b) substituted by the successor corporation for equivalent awards or substantially similar consideration as was provided to stockholders (after taking into account the existing provisions of the Awards), provided that the Exercise Price and the number and nature of shares issuable upon exercise of any Option or SAR, or any Award that is subject to Section 409A of the Code, will be adjusted appropriately pursuant to Section 424(a) of the Code and/or Section 409A of the Code, as applicable, (c) replaced with substantially similar shares or other property subject to repurchase restrictions no less favorable to the Participant, (d) immediately vested (and exercisable, as applicable) and settled (as applicable), followed by the cancellation of such Awards upon or immediately prior to the effectiveness of such transaction or (e) settled for their intrinsic value (whether or not vested or exercisable) in cash or cash equivalents or equity (including cash or equity subject to deferred vesting and delivery consistent with vesting restrictions applicable to such Awards or the underlying Shares) followed by the cancellation of such Awards and, for the avoidance of doubt, if as of the date of the occurrence of the Corporate Transaction, the Committee determines in good faith that no amount would have been attained upon the exercise of such Award or realization of the Participant’s rights, then such Award may be terminated by the Company without payment, in each case without the Participant’s consent.

In the event such successor or acquiring corporation (if any) refuses to continue, assume, convert, replace or substitute Awards or such Awards are not settled for their intrinsic value, as provided above, pursuant to a Corporate Transaction, then notwithstanding any other provision in this Plan to the contrary, such Awards shall have their vesting accelerate as to all Shares subject to such Award (and any applicable right of repurchase fully lapse) immediately prior to the Corporate Transaction and then such Awards will terminate. For purposes of determining the foregoing acceleration, Performance Awards shall be deemed earned and vested at the greater of (a) 100% of target level performance and (b) actual performance through the date of the Corporate Transaction.

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If an Award vests in lieu of continuation, assumption, conversion, replacement or substitution in connection with a Corporate Transaction, as provided above, the Committee will notify the Participant in writing or electronically that such Award will be exercisable for a period of time determined by the Committee in its sole discretion, and such Award will terminate upon the expiration of such period without consideration.

Any acceleration of payment of an amount that is subject to Section 409A of the Code will be delayed, if necessary, until the earliest time that such payment would be permissible under Section 409A without triggering any additional taxes applicable under Section 409A.

The Board shall have full power and authority to assign the Company’s right to repurchase, right to re-acquire and/or forfeiture rights to such successor or acquiring corporation. Awards need not be treated similarly in a Corporate Transaction and treatment may vary from Award to Award and/or from Participant to Participant.

21.2.Assumption of Awards by the Company. The Company, from time to time, also may substitute or assume outstanding awards granted by another company, whether in connection with an acquisition of such other company or otherwise, by either: (a) granting an Award under this Plan in substitution of such other company’s award, or (b) assuming such award as if it had been granted under this Plan if the terms of such assumed award could be applied to an Award granted under this Plan. Such substitution or assumption will be permissible if the holder of the substituted or assumed award would have been eligible to be granted an Award under this Plan if the other company had applied the rules of this Plan to such grant. In the event the Company assumes an award granted by another company, the terms and conditions of such award will remain unchanged (except that the Purchase Price or the Exercise Price, as the case may be, and the number and nature of Shares issuable upon exercise or settlement of any such Award will be adjusted appropriately pursuant to Section 424(a) of the Code). In the event the Company elects to grant a new Option in substitution rather than assuming an existing option, such new Option may be granted with a similarly adjusted Exercise Price. Substitute Awards will not reduce the number of Shares authorized for grant under this Plan or authorized for grant to a Participant in a calendar year.

21.3.Non-Employee Directors’ Awards. Notwithstanding any provision to the contrary herein, in the event of a Corporate Transaction, the vesting of all Awards granted to Non-Employee Directors will accelerate and such Awards will become exercisable (as applicable) in full prior to the consummation of such event at such times and on such conditions as the Committee determines.

22.ADOPTION AND STOCKHOLDER APPROVAL. This Plan will be submitted for the approval of the Company’s stockholders, consistent with applicable laws, within twelve (12) months before or after the date this Plan is adopted by the Board.

23.TERM OF PLAN/GOVERNING LAW. Unless earlier terminated as provided herein, this Plan will become effective on the Effective Date and will terminate ten (10) years from the date this Plan is adopted by the Board. After this Plan is terminated or expires, no Awards may be granted but Awards previously granted shall remain outstanding in accordance with their applicable terms and conditions and this Plan’s terms and conditions. This Plan and all Awards granted hereunder will be governed by and construed in accordance with the laws of the State of Delaware (excluding its conflict of laws rules).

24.AMENDMENT OR TERMINATION OF PLAN. The Board may at any time terminate or amend this Plan in any respect, including, without limitation, amendment of any form of Award Agreement or instrument to be executed pursuant to this Plan, provided, however, that the Board will not, without the approval of the stockholders of the Company, amend this Plan in any manner that requires such stockholder approval, provided further that a Participant’s Award will be governed by the version of this Plan then in effect at the time such Award was granted. No termination or amendment of this Plan will affect any then-outstanding Award unless expressly provided by the Committee. In any event, no termination or amendment of this Plan or any outstanding Award may adversely affect any then outstanding Award without the consent of the Participant, unless such termination or amendment is necessary to comply with applicable law, regulation, or rule.

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25.NONEXCLUSIVITY OF THIS PLAN. Neither the adoption of this Plan by the Board, the submission of this Plan to the stockholders of the Company for approval, nor any provision of this Plan will be construed as creating any limitations on the power of the Board to adopt such additional compensation arrangements as it may deem desirable, including, without limitation, the granting of stock awards and bonuses otherwise than under this Plan, and such arrangements may be either generally applicable or applicable only in specific cases.

26.INSIDER TRADING POLICY. Each Participant who receives an Award will comply with any policy adopted by the Company from time to time covering transactions in the Company’s securities by Employees, officers, and/or Directors of the Company, as well as with any applicable insider trading or market abuse laws to which the Participant may be subject.

27.ALL AWARDS SUBJECT TO COMPANY CLAWBACK OR RECOUPMENT POLICY. All Awards, subject to applicable law, will be subject to clawback or recoupment pursuant to any compensation clawback or recoupment policy adopted by the Board or required by law during the term of Participant’s employment or other service with the Company that is applicable to officers, Employees, Directors or other service providers of the Company, and in addition to any other remedies available under such policy and applicable law, may require the cancellation of outstanding Awards and the recoupment of any gains realized with respect to Awards.

28.DEFINITIONS. As used in this Plan, and except as elsewhere defined herein, the following terms will have the following meanings:

28.1.“Affiliate” means (a) any entity that, directly or indirectly, is controlled by, controls, or is under common control with, the Company, and (b) any entity in which the Company has a significant equity interest, in either case as determined by the Committee, whether now or hereafter existing.

28.2.“Award” means any award under this Plan, including any Option, Restricted Stock Award, Stock Bonus, Stock Appreciation Right, Restricted Stock Unit or Performance Award.

28.3.“Award Agreement” means, with respect to each Award, the written or electronic agreement between the Company and the Participant setting forth the terms and conditions of the Award, and country-specific appendix thereto for grants to non-U.S. Participants, which will be in substantially a form (which need not be the same for each Participant) that the Committee (or in the case of Award Agreements that are not used for Insiders, the Committee’s delegate(s)) has from time to time approved, and will comply with and be subject to the terms and conditions of this Plan.

28.4.“Board” means the Board of Directors of the Company.

28.5.“Cause” means a determination by the Company (and in the case of Participant who is subject to Section 16 of the Exchange Act, the Committee) that the Participant has committed an act or acts constituting any of the following: (a) willful failure substantially to perform his or her duties and responsibilities to the Company or deliberate violation of a Company policy (including the Company’s code of conduct); (b) commission of any act of fraud, embezzlement, dishonesty or any other willful misconduct that has caused or is reasonably expected to result in material injury to the Company; (c) unauthorized use or disclosure of any proprietary information or trade secrets of the Company or any other party to whom the Participant owes an obligation of nondisclosure as a result of his or her relationship with the Company; (d) misappropriation of a business opportunity of the Company; (e) while providing service to the Company, the provision of material aid to a competitor of the Company; (f) willful breach of any of his or her obligations under any written agreement or covenant with the Company; or (g) failure to cooperate with an internal investigation or an investigation by regulatory or law enforcement authorities after being instructed by the Company to cooperate. The determination as to whether Cause for a Participant’s termination exists will be made in good faith by the Company and will be final and binding on the Participant. This definition does not in any way limit the Company’s or any Parent’s or Subsidiary’s or Affiliate’s ability to terminate a Participant’s Service at any time. Notwithstanding the foregoing, the foregoing definition of “Cause” may, in part or in whole, be modified or replaced in each individual

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employment agreement, Award Agreement, or other applicable agreement with any Participant provided that such document specifically supersedes this definition.

28.6.“Code” means the United States Internal Revenue Code of 1986, as amended, and the regulations promulgated thereunder.

28.7.“Committee” means the Compensation Committee of the Board or those persons to whom administration of this Plan, or part of this Plan, has been delegated as permitted by law.

28.8.“Common Stock” means the common stock of the Company.

28.9.“Company” means Veracyte, Inc., a Delaware corporation, or any successor corporation.

28.10.“Consultant” means any natural person, including an advisor or independent contractor, engaged by the Company or a Parent, Subsidiary, or Affiliate to render services to such entity.

28.11.“Corporate Transaction” means the occurrence of any of the following events: (i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the “beneficial owner” (as defined in Rule 13d-3 of the Exchange Act), directly or indirectly, of securities of the Company representing more than fifty percent (50%) of the total voting power represented by the Company’s then-outstanding voting securities; (ii) the consummation of the sale or disposition by the Company of all or substantially all of the Company’s assets; (iii) the consummation of a merger or consolidation of the Company with any other corporation, other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or its parent) at least fifty percent (50%) of the total voting power represented by the voting securities of the Company or such surviving entity or its parent outstanding immediately after such merger or consolidation or (iv) a change in the effective control of the Company that occurs on the date that a majority of members of the Board is replaced during any twelve (12) month period by members of the Board whose appointment or election is not endorsed by a majority of the members of the Board prior to the date of the appointment or election. For purposes of this definition, if any Person is considered to be in effective control of the Company, the acquisition of additional control of the Company by the same Person will not be considered a Corporate Transaction. For purposes of this definition, Persons will be considered to be acting as a group if they are owners of a corporation that enters into a merger, consolidation, purchase or acquisition of stock, or similar business transaction with the Company. Notwithstanding the foregoing, to the extent that any amount constituting deferred compensation (as defined in Section 409A of the Code) would become payable under this Plan by reason of a Corporate Transaction, such amount will become payable only if the event constituting a Corporate Transaction would also qualify as a change in ownership or effective control of the Company or a change in the ownership of a substantial portion of the assets of the Company, each as defined within the meaning of Code Section 409A, as it has been and may be amended from time to time, and any proposed or final Treasury Regulations and IRS guidance that has been promulgated or may be promulgated thereunder from time to time.

Notwithstanding the foregoing, a transaction shall not constitute a Corporate Transaction if its sole purpose is to change the state of the Company’s incorporation or to create a holding company that will be owned in substantially the same proportions by the persons who held the Company’s securities immediately before such transaction, and a Corporate Transaction shall not be deemed to occur if the Company files a registration statement with the United States Securities and Exchange Commission for the initial or secondary public offering of securities or debt of the Company to the public.

28.12.“Director” means a member of the Board.

28.13.“Disability” means in the case of ISOs, total and permanent disability as defined in Section 22(e)(3) of the Code and in the case of other Awards, that the Participant is unable to engage in any substantial gainful activity by

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reason of any medically determinable physical or mental impairment that can be expected to result in death or can be expected to last for a continuous period of not less than twelve (12) months.

28.14.“Dividend Equivalent Right” means the right of a Participant, granted at the discretion of the Committee or as otherwise provided by the Plan, to receive a credit for the account of such Participant in an amount equal to the cash, stock or other property dividends in amounts equivalent to cash, stock or other property dividends for each Share represented by an Award held by such Participant.

28.15.“Effective Date” means the date this Plan is approved by the stockholders of the Company (which shall be within twelve (12) months of the approval of this Plan by the Board).

28.16.“Employee” means any person, including officers and Directors, providing services as an employee to the Company or any Parent, Subsidiary, or Affiliate. Neither service as a Director nor payment of a director’s fee by the Company will be sufficient to constitute “employment” by the Company.

28.17.“Exchange Act” means the United States Securities Exchange Act of 1934, as amended.

28.18.“Exchange Program” means a program approved by the Company’s stockholders pursuant to which (i) outstanding Awards are surrendered, cancelled, or exchanged for cash, the same type of Award, or a different Award (or combination thereof) or (ii) the exercise price of an outstanding Award is reduced.

28.19.“Exercise Price” means, with respect to an Option, the price at which a holder may purchase the Shares issuable upon exercise of an Option and with respect to a SAR, the price at which the SAR is granted to the holder thereof.

28.20.“Fair Market Value” means, as of any date, the value of a Share, determined as follows:

(a)If such Common Stock was traded over-the-counter on the date in question, then the Fair Market Value shall be equal to the last transaction price quoted for such date by the OTC Bulletin Board or, if not so quoted, shall be equal to the mean between the last reported representative bid and asked prices quoted for such date by the principal automated inter-dealer quotation system on which the Common Stock is quoted or, if the Common Stock is not quoted on any such system, by the OTC Link Quote system;

(b)if such Common Stock is publicly traded and is then listed on a national securities exchange, its closing price on the date of determination on the principal national securities exchange on which the Common Stock is listed or admitted to trading as reported in The Wall Street Journal or such other source as the Committee determines;

(c)if such Common Stock is publicly traded but is neither listed nor admitted to trading on a national securities exchange, the average of the closing bid and asked prices on the date of determination as reported in The Wall Street Journal or such other source as the Committee determines; or

(d)by the Board or the Committee in good faith.

28.21.“Insider” means an officer or Director of the Company or any other person whose transactions in the Company’s Common Stock are subject to Section 16 of the Exchange Act.

28.22.“IRS” means the United States Internal Revenue Service.

28.23.“Non-Employee Director” means a Director who is not an Employee of the Company or any Parent, Subsidiary, or Affiliate.

28.24.“Option” means an Award as defined in Section 5 and granted under this Plan.

28.25.“Parent” means any corporation (other than the Company) in an unbroken chain of corporations ending with the Company if each of such corporations other than the Company owns stock possessing fifty percent (50%) or more of the total combined voting power of all classes of stock in one of the other corporations in such chain.

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28.26.“Participant” means a person who holds an Award under this Plan.

28.27.“Performance Award” means an Award as defined in Section 10 and granted under this Plan.

28.28.“Performance Factors” means any of the factors selected by the Committee and specified in an Award Agreement, from among the following measures, either individually, alternatively or in any combination, applied to the Company as a whole or any business unit or Subsidiary, either individually, alternatively, or in any combination, on a GAAP or non-GAAP basis, and measured, to the extent applicable on an absolute basis or relative to a pre-established target, to determine whether the performance goals established by the Committee with respect to applicable Awards have been satisfied:

(a)profit before tax;

(b)billings;

(c)revenue;

(d)net revenue or return on operating revenue;

(e)earnings (which may include earnings before interest and taxes, earnings before taxes, net earnings, stock-based compensation expenses, depreciation, and amortization);

(f)operating income;

(g)operating margin;

(h)operating profit;

(i)controllable operating profit or net operating profit;

(j)net profit;

(k)gross margin;

(l)cost, operating expenses or operating expenses as a percentage of revenue;

(m)net income;

(n)earning per share;

(o)total stockholder return or relative total stockholder return;

(p)market share or market segment share;

(q)return on assets or net assets;

(r)the Company’s stock price;

(s)growth in stockholder value relative to a pre-determined index;

(t)return on equity;

(u)return on capital or on invested capital;

(v)cash flow (including free cash flow or operating cash flows) or cash flow margins;

(w)cash conversion cycle;

(x)economic value added;

(y)individual confidential business objectives;

(z)contract awards or backlog;

(aa)overhead or other expense reduction;

(bb)credit rating;

(cc)strategic plan development and implementation;

(dd)succession plan development and implementation;

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(ee)talent, retention, and culture;

(ff)customer indicators and/or satisfaction;

(gg)new product invention or innovation;

(hh)achievement of target levels of discovery and/or development of products and services, including, but not limited to, research or regulatory achievements; attainment of research and development milestones;

(ii)third-party coverage and/or reimbursement objectives;

(jj)test volume metrics;

(kk)improvements in productivity;

(ll)bookings;

(mm)attainment of objective operating goals and employee metrics;

(nn)sales;

(oo)expenses;

(pp)balance of cash, cash equivalents, and marketable securities;

(qq)completion of an identified special project;

(rr)completion of a joint venture or other corporate transaction;

(ss)employee satisfaction and/or retention;

(tt)research and development expenses;

(uu)working capital targets and changes in working capital;

(vv)net new annual contract value;

(ww)net expansion rate; and

(xx)any other metric that is capable of measurement as determined by the Committee.

The Committee may provide for one or more equitable adjustments to the Performance Factors to preserve the Committee’s original intent regarding the Performance Factors at the time of the initial award grant, such as but not limited to, adjustments in recognition of unusual or non-recurring items such as acquisition related activities or changes in applicable accounting rules. It is within the sole discretion of the Committee to make or not make any such equitable adjustments.

28.29.“Performance Period” means one or more periods of time, which may be of varying and overlapping durations, as the Committee may select, over which the attainment of one or more Performance Factors will be measured for the purpose of determining a Participant’s right to, and the payment of, a Performance Award.

28.30.“Permitted Transferee” means any child, stepchild, grandchild, parent, stepparent, grandparent, spouse, former spouse, sibling, niece, nephew, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law (including adoptive relationships) of the Employee, any person sharing the Employee’s household (other than a tenant or employee), a trust in which these persons (or the Employee) have more than 50% of the beneficial interest, a foundation in which these persons (or the Employee) control the management of assets, and any other entity in which these persons (or the Employee) own more than 50% of the voting interests.

28.31.“Plan” means this Veracyte, Inc. 2023 Equity Incentive Plan, as amended.

28.32.“Prior Plan” means the Veracyte, Inc. 2013 Stock Incentive Plan.

28.33.“Purchase Price” means the price to be paid for Shares acquired under this Plan, other than Shares acquired upon exercise of an Option or SAR.

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28.34.“Restricted Stock Award” means an Award as defined in Section 6 and granted under this Plan, or issued pursuant to the early exercise of an Option.

28.35.“Restricted Stock Unit” means an Award as defined in Section 9 and granted under this Plan.

28.36.“SEC” means the United States Securities and Exchange Commission.

28.37.“Securities Act” means the United States Securities Act of 1933, as amended.

28.38.“Service” will mean service as an Employee, Consultant, Director, or Non-Employee Director, subject to such further limitations as may be set forth in this Plan or the applicable Award Agreement. Service does not terminate when a Participant goes on a bona fide leave of absence that (a) was approved by the Company in writing or (b) is taken pursuant to a formal policy adopted from time to time by the Company and provided to Participants in writing, if the terms of such leave, as applicable, provide for continued Service crediting, or when continued Service crediting is required by applicable law. However, for purposes of determining whether an Option qualifies to be treated for tax purposes as an ISO, an Employee’s employment will be treated as terminating three months after such Employee commenced leave, unless such Employee’s right to return to active work is guaranteed by law or by a contract. In the case of any Employee on an approved leave of absence, or a reduction in hours worked (for illustrative purposes only, a change in schedule from that of full-time to part-time), the Committee may make such provisions respecting suspension or modification of vesting of the Award while on leave, or during such change in working hours, as it may deem appropriate, except that in no event may an Award be exercised after the expiration of the term set forth in the applicable Award Agreement. A Participant will have terminated Service as of the date such Participant ceases to provide Service (regardless of whether the termination is in breach of local employment laws or is later found to be invalid) and Service will not be extended by any notice period or garden leave mandated by local law, provided, however, that a change in status from and amongst Employee, Consultant, Director or Non-Employee Director will not terminate the Participant’s Service, unless determined by the Committee, in its discretion. The Committee will have sole discretion to determine whether a Participant has ceased to provide Service and the effective date on which the Participant ceased to provide Service.

28.39.“Shares” means shares of the Common Stock and the common stock of any successor entity of the Company.

28.40.“Stock Appreciation Right” means an Award defined in Section 8 and granted under this Plan.

28.41.“Stock Bonus” means an Award defined in Section 7 and granted under this Plan.

28.42.“Subsidiary” means any corporation (other than the Company) in an unbroken chain of corporations beginning with the Company if each of the corporations other than the last corporation in the unbroken chain owns stock possessing fifty percent (50%) or more of the total combined voting power of all classes of stock in one of the other corporations in such chain.

28.43.“Treasury Regulations” means regulations promulgated by the United States Treasury Department.

28.44.“Unvested Shares” means Shares that have not yet vested or are subject to a right of repurchase in favor of the Company (or any successor thereto).

Veracyte 2026 Proxy Statement A-19

FAQ

What proposals are Veracyte (VCYT) stockholders voting on at the 2026 Annual Meeting?

Stockholders will vote on electing nine directors for one-year terms, ratifying Ernst & Young LLP as auditor, approving executive compensation on an advisory basis, and approving an amendment to the 2023 Equity Incentive Plan to increase its share reserve by 3,500,000 shares.

When and how will Veracyte (VCYT) hold its 2026 Annual Meeting of Stockholders?

The 2026 Annual Meeting will be held virtually on June 10, 2026, at 10:00 a.m. Pacific Daylight Time. Stockholders can attend, submit questions, and vote online at www.virtualshareholdermeeting.com/VCYT2026, using the credentials provided in their proxy materials.

What change is Veracyte proposing to the 2023 Equity Incentive Plan?

Veracyte is asking stockholders to approve an amendment increasing the number of shares issuable under the 2023 Equity Incentive Plan by 3,500,000 shares. The company states this additional capacity supports continued equity grants to attract, retain, and motivate employees, executives, and non-employee directors.

How much equity overhang and share availability does Veracyte (VCYT) report?

As of March 31, 2026, Veracyte reports 1,701,968 options and 3,918,629 full-value awards outstanding and 9,704,039 shares available for grant. Together, outstanding awards plus available shares equal about 19% of outstanding common stock, excluding the proposed 3,500,000-share increase.

What governance and board independence features does Veracyte highlight?

Veracyte notes that eight of nine directors are independent and the chair is an independent director. All committees are fully independent, the board uses majority voting in uncontested elections, conducts annual self-evaluations, maintains stock ownership guidelines, and has a clawback policy compliant with Nasdaq and SEC rules.

What are Veracyte’s key human capital and diversity statistics?

As of December 31, 2025, Veracyte had 755 employees, with 54% women and 33% women at vice president level and above. Two of nine directors were women, and 42% of U.S. employees were non-White, based on self-identification data, reflecting a focus on workforce diversity.

How much did Veracyte (VCYT) pay Ernst & Young LLP in audit fees?

For the year ended December 31, 2025, Veracyte reports paying Ernst & Young LLP audit fees totaling $2,230,512. These fees cover the audit of annual financial statements and the review of quarterly financial statements, including related out-of-pocket expenses.