Vertex: Capital World Investors Holds 10.1% Stake

Vertex Pharmaceuticals Inc. amendment to a Schedule 13G/A discloses that Capital World Investors beneficially owns 25,695,015 shares of Common Stock, equal to 10.1% of 254,034,190 shares outstanding as stated in the filing.

Rhea-AI Filing Summary

Vertex Pharmaceuticals Inc. amendment to a Schedule 13G/A discloses that Capital World Investors beneficially owns 25,695,015 shares of Common Stock, equal to 10.1% of 254,034,190 shares outstanding as stated in the filing. The filing lists 25,556,582 shares as sole voting power and 25,695,015 as sole dispositive power. The amendment is signed May 13, 2026.

Insights

Institutional Ownership Analyst

Large passive position disclosed: 10.1% stake by Capital World Investors.

Capital World Investors is shown as beneficial owner of 25,695,015 shares, representing 10.1% of the 254,034,190 shares cited. The filing identifies the investment management entities that comprise CWI and attributes sole voting and dispositive powers.

Institutional holdings at this scale are a visible ownership signal; subsequent filings may show changes in voting or disposition if the stake is increased or reduced.

Corporate Governance Specialist

Filing clarifies voting and dispositive authority within an investment group.

The amendment states CWI has 25,556,582 shares of sole voting power and 25,695,015 of sole dispositive power, listing affiliated investment entities. The statement is attributional and describes managerial relationships within the group.

Any governance impact depends on whether the holder exercises voting rights; the filing itself does not state planned votes or transactions.

Key Figures

Beneficial ownership: 25,695,015 shares Percent of class: 10.1% Shares outstanding (cited): 254,034,190 shares +2 more

5 metrics

Beneficial ownership 25,695,015 shares Amount beneficially owned by Capital World Investors

Percent of class 10.1% Percent of 254,034,190 shares believed outstanding

Shares outstanding (cited) 254,034,190 shares Shares believed to be outstanding as cited in the filing

Sole voting power 25,556,582 shares Shares as to which CWI has sole power to vote

Sole dispositive power 25,695,015 shares Shares as to which CWI has sole power to dispose

Key Terms

Schedule 13G/A, beneficial ownership, sole dispositive power

3 terms

Schedule 13G/A regulatory

"Amendment to a Schedule 13G/A discloses beneficial ownership"

A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.

beneficial ownership financial

"CWI is deemed to be the beneficial owner of 25,695,015 shares"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

sole dispositive power regulatory

"Sole power to dispose or to direct the disposition of: 25,695,015"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What stake does Capital World Investors report in Vertex (VRTX)?

Capital World Investors reports beneficial ownership of 25,695,015 shares of Vertex common stock. The filing states this represents 10.1% of 254,034,190 shares cited as outstanding.

How many votes does Capital World Investors control in VRTX?

CWI is reported to have sole voting power over 25,556,582 shares. The Schedule 13G/A lists this number as the shares for which CWI has sole authority to vote.

When was the Schedule 13G/A amendment signed?

The amendment bears a signature dated May 13, 2026. The filing header also shows a reference date of 03/31/2026 in the provided excerpt.

Does the filing indicate CWI will sell or buy more VRTX shares?

The filing discloses beneficial ownership and voting/dispositive power but does not state any intent to buy or sell additional shares. No transaction plan is described in the excerpt.

Who is Capital World Investors as described in the filing?

The filing describes CWI as a division of Capital Research and Management Company and lists affiliated investment management entities that provide services under the Capital World Investors name.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 05/14/2026 - 01:55 PM EDT Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 4)

Vertex Pharmaceuticals Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

92532F100

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 92532F100

1

Names of Reporting Persons

Capital World Investors

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 25,556,582.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 25,695,015.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

25,695,015.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

10.1 %

12

Type of Reporting Person (See Instructions)

IA

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Vertex Pharmaceuticals Inc.
(b)	Address of issuer's principal executive offices: 50 Northern Avenue, Boston, MA 02210, United States of America
Item 2.
(a)	Name of person filing: Capital World Investors
(b)	Address or principal business office or, if none, residence: 333 SOUTH HOPE STREET, 55TH FLOOR, LOS ANGELES, CALIFORNIA 90071
(c)	Citizenship: N/A
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 92532F100
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 25,695,015 ** **Capital World Investors ("CWI") is a division of Capital Research and Management Company ("CRMC"), as well as its investment management subsidiaries and affiliates Capital Bank and Trust Company, Capital International, Inc., Capital International Limited, Capital International Sarl, Capital International K.K., Capital Group Private Client Services, Inc., and Capital Group Investment Management Private Limited (together with CRMC, the "investment management entities"). CWI's divisions of each of the investment management entities collectively provide investment management services under the name "Capital World Investors." CWI is deemed to be the beneficial owner of 25,695,015 shares or 10.1% of the 254,034,190 shares believed to be outstanding.
(b)	Percent of class: 10.1 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 25,556,582
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 25,695,015
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Capital World Investors

Signature:	Jae Won Chung
Name/Title:	Senior Vice President and Associate General Counsel, Capital Research and Management Company
Date:	05/13/2026