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Aptose Provides Corporate Updates

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Aptose Biosciences, a clinical-stage precision oncology company, has secured a short-term cash advance from CEO Dr. William G. Rice to cover immediate obligations including payroll and continue development of tuspetinib, their oral kinase inhibitor. The advance is non-interest bearing, unsecured, and repayable without penalty. Despite this funding, Aptose warns it may face insolvency proceedings without additional funding in the coming days. The company also announced the resignation of board member Carol Ashe, effective June 16, 2025. The cash advance constitutes a related-party transaction under MI 61-101, though Aptose is exempt from formal valuation and minority shareholder approval requirements.
Aptose Biosciences, un'azienda di oncologia di precisione in fase clinica, ha ottenuto un anticipo di liquidità a breve termine dal CEO Dr. William G. Rice per coprire obblighi immediati, inclusi gli stipendi, e per proseguire lo sviluppo di tuspetinib, il loro inibitore di chinasi orale. L'anticipo non prevede interessi, non è garantito e può essere restituito senza penalità. Nonostante questo finanziamento, Aptose avverte che potrebbe affrontare procedure di insolvenza senza ulteriori fondi nei prossimi giorni. L'azienda ha inoltre annunciato le dimissioni del membro del consiglio Carol Ashe, effettive dal 16 giugno 2025. L'anticipo di liquidità costituisce una transazione con parti correlate secondo MI 61-101, sebbene Aptose sia esentata dai requisiti formali di valutazione e dall'approvazione dei soci di minoranza.
Aptose Biosciences, una empresa de oncología de precisión en etapa clínica, ha asegurado un adelanto de efectivo a corto plazo del CEO Dr. William G. Rice para cubrir obligaciones inmediatas, incluyendo la nómina, y continuar el desarrollo de tuspetinib, su inhibidor oral de quinasa. El adelanto no genera intereses, no está garantizado y es reembolsable sin penalización. A pesar de esta financiación, Aptose advierte que podría enfrentar procedimientos de insolvencia sin fondos adicionales en los próximos días. La compañía también anunció la renuncia del miembro del consejo Carol Ashe, efectiva el 16 de junio de 2025. El adelanto de efectivo constituye una transacción con partes relacionadas bajo MI 61-101, aunque Aptose está exenta de los requisitos formales de valoración y aprobación por parte de accionistas minoritarios.
임상 단계의 정밀 종양학 회사인 Aptose Biosciences는 CEO인 Dr. William G. Rice로부터 급여 등 즉각적인 의무를 충당하고 경구용 키나제 억제제인 tuspetinib 개발을 계속하기 위해 단기 현금 선지급을 확보했습니다. 이 선지급은 무이자이며 담보가 없고 벌칙 없이 상환 가능합니다. 이 자금에도 불구하고 Aptose는 추가 자금이 없으면 며칠 내에 지급불능 절차에 직면할 수 있다고 경고했습니다. 또한 회사는 2025년 6월 16일자로 이사회 멤버인 Carol Ashe의 사임을 발표했습니다. 이 현금 선지급은 MI 61-101에 따른 관련자 거래에 해당하지만, Aptose는 공식 평가 및 소수 주주 승인 요건에서 면제됩니다.
Aptose Biosciences, une entreprise d'oncologie de précision en phase clinique, a obtenu une avance de trésorerie à court terme de la part du PDG Dr William G. Rice pour couvrir des obligations immédiates, y compris la paie, et poursuivre le développement de tuspetinib, leur inhibiteur de kinase oral. Cette avance est sans intérêt, non garantie et remboursable sans pénalité. Malgré ce financement, Aptose avertit qu'elle pourrait faire face à des procédures d'insolvabilité sans financement supplémentaire dans les prochains jours. La société a également annoncé la démission du membre du conseil Carol Ashe, effective le 16 juin 2025. Cette avance de trésorerie constitue une opération avec une partie liée selon la MI 61-101, bien qu'Aptose soit exemptée des exigences formelles d'évaluation et d'approbation des actionnaires minoritaires.
Aptose Biosciences, ein klinisch tätiges Präzisionsonkologie-Unternehmen, hat einen kurzfristigen Vorschuss vom CEO Dr. William G. Rice erhalten, um unmittelbare Verpflichtungen wie Gehaltszahlungen zu decken und die Entwicklung von Tuspetinib, ihrem oralen Kinaseinhibitor, fortzusetzen. Der Vorschuss ist zinsfrei, ungesichert und kann ohne Strafgebühren zurückgezahlt werden. Trotz dieser Finanzierung warnt Aptose, dass das Unternehmen ohne zusätzliche Mittel in den kommenden Tagen Insolvenzverfahren drohen könnten. Das Unternehmen gab außerdem den Rücktritt des Vorstandsmitglieds Carol Ashe zum 16. Juni 2025 bekannt. Der Vorschuss stellt eine Transaktion mit nahestehenden Parteien gemäß MI 61-101 dar, wobei Aptose von den formalen Bewertungs- und Minderheitsaktionärszustimmungsanforderungen befreit ist.
Positive
  • Short-term cash advance secured from CEO to cover immediate obligations
  • Advance is non-interest bearing and can be repaid without penalty
  • Development of clinical-stage oral kinase inhibitor tuspetinib continues
Negative
  • Company warns of potential insolvency without additional funding in coming days
  • Board member Carol Ashe has resigned
  • Company lacks sufficient financial resources to fund planned operations
  • Immediate need for funding indicates severe financial distress

Announces short-term cash advance

SAN DIEGO and TORONTO, June 17, 2025 (GLOBE NEWSWIRE) -- Aptose Biosciences Inc. (“Aptose” or the “Company”) (TSX: APS; OTC: APTOF), a clinical-stage precision oncology company, announced today that the Company has secured a short-term cash advance from Dr. William G. Rice, the Company’s Chairman of the Board, President and Chief Executive Officer (the “Advance”), to support near-term obligations, including payroll, and to enable continued advancement of its clinical-stage oral kinase inhibitor, tuspetinib, while it engages in ongoing negotiations with prospective funding partners.

The Advance is non-interest bearing and the Company may repay the Advance in whole or in part with no penalty at any time and from time to time. The Advance is unsecured, and no securities will be issued in connection with the Advance.

The Advance constitutes a “related-party transaction” within the meaning of Multilateral Instrument 61-101 – Protection of Minority Security Holders in Special Transactions (“MI 61-101”) as Dr. Rice is a related party of the Company under Canadian securities laws. However, the Company is relying on the exemptions from the formal valuation and minority shareholder approval requirements contained in MI 61-101.

Despite this advance, if Aptose does not receive additional funding in the coming days, the Corporation does not expect to have sufficient financial resources to fund planned Company operation and will have certain alternatives that could include insolvency proceedings.

Announces board resignation

Separately, Aptose announced that effective June 16, 2025, Ms. Carol Ashe has resigned as a director of the Company. The Company wishes to thank Ms. Ashe for her valuable contributions during her tenure as an Aptose board member and wishes her every success in her future endeavors.

About Aptose

Aptose Biosciences is a clinical-stage biotechnology company committed to developing precision medicines addressing unmet medical needs in oncology, with an initial focus on hematology. The Company’s lead clinical-stage, oral kinase inhibitor tuspetinib (TUS) has demonstrated activity as a monotherapy and in combination therapy in patients with relapsed or refractory acute myeloid leukemia (AML) and is being developed as a frontline triplet therapy in newly diagnosed AML. For more information, please visit www.aptose.com.

Forward Looking Statements

This press release may contain forward-looking statements within the meaning of Canadian and U.S. securities laws, including, but not limited to, statements relating to the terms of the Advance, including the purpose of the Advance, expectations with respect to the repayment of the Advance, as well as statements relating to the Company’s plans, objectives, expectations and intentions and other statements including words such as “continue”, “expect”, “intend”, “will”, “should”, “would”, “may”, and other similar expressions. Such statements reflect our current views with respect to future events and are subject to risks and uncertainties and are necessarily based upon a number of estimates and assumptions that, while considered reasonable by us are inherently subject to significant business, economic, competitive, political and social uncertainties and contingencies. These risks and uncertainties include, among others: our ability to obtain the capital required for research and operations and to continue as a going concern; the inherent risks in early stage drug development including demonstrating efficacy; development time/cost and the regulatory approval process; the progress of our clinical trials; our ability to find and enter into agreements with potential partners; our ability to attract and retain key personnel; changing market conditions; inability of new manufacturers to produce acceptable batches of GMP in sufficient quantities; unexpected manufacturing defects; and other risks detailed from time-to-time in our ongoing quarterly filings, annual information forms, annual reports and annual filings with Canadian securities regulators and the United States Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should the assumptions set out in the section entitled “Risk Factors” in our filings with Canadian securities regulators and the United States Securities and Exchange Commission underlying those forward-looking statements prove incorrect, actual results may vary materially from those described herein.

These forward-looking statements are made as of the date of this press release and we do not intend, and do not assume any obligation, to update these forward-looking statements, except as required by law. We cannot assure you that such statements will prove to be accurate as actual results and future events could differ materially from those anticipated in such statements. Investors are cautioned that forward-looking statements are not guarantees of future performance and accordingly investors are cautioned not to put undue reliance on forward-looking statements due to the inherent uncertainty therein.

For further information, please contact

Aptose Biosciences Inc.
Susan Pietropaolo
Corporate Communications & Investor Relations
201-923-2049
spietropaolo@aptose.com


FAQ

What is the current financial situation of Aptose Biosciences (APTOF)?

Aptose is in severe financial distress, requiring a short-term cash advance from its CEO for immediate obligations. Without additional funding in coming days, the company warns it may face insolvency proceedings.

Who provided the cash advance to Aptose Biosciences?

Dr. William G. Rice, Aptose's Chairman of the Board, President and Chief Executive Officer, provided the short-term cash advance.

What are the terms of APTOF's cash advance from the CEO?

The advance is non-interest bearing, unsecured, can be repaid in whole or part without penalty, and no securities will be issued in connection with it.

Why did Carol Ashe resign from Aptose's board?

The press release does not specify the reason for Carol Ashe's resignation from the board, which was effective June 16, 2025.

What is tuspetinib and how is it affected by Aptose's financial situation?

Tuspetinib is Aptose's clinical-stage oral kinase inhibitor. The cash advance is intended to enable its continued development, though the company's financial situation threatens its advancement without additional funding.
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