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Aptose Bioscienc Stock Price, News & Analysis

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Welcome to our dedicated page for Aptose Bioscienc news (Ticker: APTOF), a resource for investors and traders seeking the latest updates and insights on Aptose Bioscienc stock.

Aptose Biosciences Inc. (APTOF) is a clinical-stage precision oncology company focused on developing small molecule therapies for hematologic cancers, particularly acute myeloid leukemia (AML). The news flow around Aptose centers on the clinical progress of its lead oral kinase inhibitor tuspetinib (TUS), corporate financing arrangements, and a planned acquisition by Hanmi Pharmaceutical Co. Ltd.

Investors following APTOF news will see regular updates on the TUSCANY Phase 1/2 trial, where tuspetinib is combined with standard dosing of venetoclax and azacitidine (TUS+VEN+AZA) as a triple drug frontline therapy for newly diagnosed AML patients ineligible for induction chemotherapy. Company press releases highlight safety data, complete remission (CR/CRh) rates, minimal residual disease (MRD) negativity, and responses across diverse genetic subtypes, including patients with adverse mutations such as TP53, RAS, FLT3-ITD, NPM1c, and myelodysplasia-related mutations.

The Aptose news stream also includes quarterly financial results, where management discusses research and development spending by program, cash position, and reliance on loan facilities from Hanmi to fund operations. Additional items include announcements of conference presentations at major meetings such as the European Hematology Association (EHA), the European School of Haematology (ESH), and the American Society of Hematology (ASH), where new clinical data from TUSCANY are presented.

Another key category of news involves transaction and governance updates. Aptose has announced an arrangement agreement under which a Hanmi subsidiary will acquire all outstanding common shares not already owned or controlled by Hanmi or its affiliates, subject to shareholder and court approvals. The company also reports outcomes of shareholder meetings and changes in its independent auditor. For readers tracking APTOF, this news page provides a consolidated view of clinical, financial, and corporate developments disclosed by the company.

Rhea-AI Summary
Aptose Biosciences has announced significant progress in its Phase 1/2 TUSCANY trial, evaluating tuspetinib (TUS) in combination with venetoclax and azacitidine for newly diagnosed AML patients. The Cohort Safety Review Committee (CSRC) has approved dose escalation from 80mg to 120mg of TUS following positive safety and efficacy data from initial cohorts. The trial has shown complete remissions (CRs) and minimal residual disease (MRD)-negativity across diverse mutations, with no significant safety concerns or dose-limiting toxicities. Notably, the treatment demonstrated effectiveness in difficult-to-treat populations, including patients with TP53 and RAS mutations. The TUSCANY trial, conducted at 10 leading U.S. clinical sites, aims to enroll 18-24 patients by mid-late 2025. Updated data will be presented at the European Hematology Association Congress in June 2025.
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Rhea-AI Summary
Aptose Biosciences (OTC: APTOF) has been selected to present data from its TUSCANY Phase 1/2 clinical trial at the EHA Congress 2025 in Milan. The trial evaluates tuspetinib (TUS) in combination with venetoclax and azacitidine as a triplet therapy for newly diagnosed AML patients ineligible for chemotherapy. Initial results from the 40mg and 80mg dose cohorts have shown promising outcomes, including safety, complete remissions, and MRD negativity across diverse mutations, particularly in TP53-mutated/CK AML and FLT3-wildtype AML patients. The study is ongoing at 10 leading U.S. clinical sites, with expected enrollment of 18-24 patients by mid-late 2025. The TUS+VEN+AZA triplet is being developed as the only safe and mutation agnostic frontline therapy for treating diverse populations of newly diagnosed AML patients.
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Aptose Biosciences reported Q1 2025 financial results and progress in its TUSCANY clinical trial for tuspetinib (TUS) in combination with venetoclax and azacitidine for frontline AML treatment. The trial showed promising results with 6 out of 7 patients achieving complete remissions across two dose cohorts (40mg and 80mg). Notably, two patients with TP53 mutations showed positive responses. The company reported a reduced net loss of $5.5M compared to $9.6M in Q1 2024, with cash reserves of $4.7M as of March 31, 2025. However, current funding only supports operations until end of May 2025. Aptose was delisted from Nasdaq in April 2025 and now trades on OTC Markets (APTOF) and TSX (APS). Research and development expenses decreased to $2.3M from $6.4M year-over-year.
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FAQ

What is the current stock price of Aptose Bioscienc (APTOF)?

The current stock price of Aptose Bioscienc (APTOF) is $1.57 as of March 10, 2026.

What is the market cap of Aptose Bioscienc (APTOF)?

The market cap of Aptose Bioscienc (APTOF) is approximately 3.1M.

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