Ardelyx Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update

Rhea-AI Summary

Ardelyx (Nasdaq: ARDX) reported full-year 2025 results with total revenue of $407.3 million and IBSRELA revenue of $274.2 million (73% YoY). XPHOZAH generated $103.6 million. Cash and short-term investments were $264.7 million as of December 31, 2025. The company launched a Phase 3 CIC trial (ACCEL) and expects FDA submission timing contingent on results.

Management guided 2026 IBSRELA revenue to $410–$430 million and XPHOZAH to $110–$120 million; net loss was $61.6 million for 2025.

Positive

• IBSRELA revenue +73% YoY to $274.2M in 2025
• Total revenue reached $407.3M in 2025
• Cash and short-term investments of $264.7M as of 12/31/2025
• Launched Phase 3 ACCEL for CIC; first patient dosed Q1 2026
• U.S. patent issued covering tenapanor formulations through 11/26/2042

Negative

• Net loss widened to $61.6M in 2025 from $39.1M
• SG&A expenses increased to $337.2M in 2025
• XPHOZAH revenue declined to $103.6M from $160.9M in 2024

Market Reaction

-7.12% $6.26

15m delay 10 alerts

-7.12% Since News

-13.7% Trough in 1 min

$6.26 Last Price

$6.15 $6.86 Day Range

-$126M Valuation Impact

$1.64B Market Cap

0.1x Rel. Volume

Following this news, ARDX has declined 7.12%, reflecting a notable negative market reaction. Argus tracked a trough of -13.7% from its starting point during tracking. Our momentum scanner has triggered 10 alerts so far, indicating notable trading interest and price volatility. The stock is currently trading at $6.26. This price movement has removed approximately $126M from the company's valuation.

Data tracked by StockTitan Argus (15 min delayed). Upgrade to Silver for real-time data.

Key Figures

IBSRELA 2025 revenue: $274.2 million XPHOZAH 2025 revenue: $103.6 million Total 2025 revenue: $407.3 million +5 more

8 metrics

IBSRELA 2025 revenue $274.2 million Full year 2025, 73% growth vs 2024 ($158.3M)

XPHOZAH 2025 revenue $103.6 million Full year 2025 revenue

Total 2025 revenue $407.3 million Full year 2025 vs $333.6 million in 2024

Cash & investments $264.7 million As of December 31, 2025 vs $250.1 million at 2024 year-end

R&D expenses 2025 $71.5 million Full year 2025 vs $52.3 million in 2024

SG&A expenses 2025 $337.2 million Full year 2025 vs $258.7 million in 2024

Net loss 2025 $61.6 million (−$0.26/share) Full year 2025 vs $39.1 million (−$0.17/share) in 2024

2026 IBSRELA guidance $410–$430 million Expected full-year 2026 revenue, ≥50% growth vs 2025

Market Reality Check

Price: $6.72 Vol: Volume 2,367,339 vs 20-da...

normal vol

$6.72 Last Close

Volume Volume 2,367,339 vs 20-day average 3,100,266 (relative volume 0.76). normal

Technical Price 6.72 is trading above 200-day MA at 5.44 while sitting 20% below the 52-week high and above the midpoint of its 52-week range.

Peers on Argus

ARDX was down 0.22% pre-news while key peers AUPH, CDTX, MNKD, VCEL and VERA sho...

ARDX was down 0.22% pre-news while key peers AUPH, CDTX, MNKD, VCEL and VERA showed small gains (e.g., AUPH +0.56%, MNKD +0.37%, VERA +0.75%). This points to stock-specific dynamics rather than a sector-wide move.

Common Catalyst Peers had routine corporate updates (conference participation, upcoming earnings date) rather than broad biotechnology catalysts.

Previous Earnings Reports

5 past events · Latest: Oct 30 (Positive)

Same Type Pattern 5 events

Date	Event	Sentiment	Move	Catalyst
Oct 30	Q3 2025 earnings	Positive	+1.0%	Strong Q3 revenue, IBSRELA outperformance and increased 2025 guidance.
Aug 04	Q2 2025 earnings	Positive	+16.9%	Robust Q2 growth, higher IBSRELA guidance and added debt flexibility.
May 01	Q1 2025 earnings	Positive	-24.5%	Strong revenue growth but wider net loss driven by commercialization spend.
Feb 20	FY 2024 results	Positive	-10.1%	FY 2024 revenue strength and improved net loss with large peak sales outlook.
Oct 31	Q3 2024 earnings	Positive	+3.8%	Strong Q3 2024 revenue growth and increased product sales for both drugs.

Pattern Detected

Earnings releases have highlighted strong revenue growth but produced mixed stock reactions, with an average move of -2.59% and several notable selloffs on otherwise positive updates.

Recent Company History

Over the last five earnings-related releases, Ardelyx has consistently reported strong growth from IBSRELA and meaningful contributions from XPHOZAH, alongside a solid cash position. Guidance has been repeatedly raised across 2024–2025, and new programs like RDX10531 and CIC expansion have been introduced. Despite this, share reactions were often negative, including moves of -24.5% and -10.06%, underscoring a pattern of volatility and occasional selloffs on good news.

Historical Comparison

-2.6% avg move · Across five prior earnings releases, ARDX averaged a -2.59% move despite recurring revenue beats and...

earnings

-2.6%

Average Historical Move earnings

Across five prior earnings releases, ARDX averaged a -2.59% move despite recurring revenue beats and guidance raises, indicating that strong fundamentals have not always translated into positive price reactions.

Earnings updates show a progression from early commercialization in 2024 to higher 2025 run-rates, repeated IBSRELA guidance raises, and the addition of pipeline assets like RDX10531 and a CIC Phase 3 program alongside expanding cash reserves.

Market Pulse Summary

The stock is down -7.1% following this news. A negative reaction despite solid topline growth would ...

Analysis

The stock is down -7.1% following this news. A negative reaction despite solid topline growth would fit prior patterns where earnings strength did not prevent drawdowns, such as past moves of -24.5% and -10.06%. The market may focus on increased SG&A of $337.2M, higher R&D at $71.5M, and a full‑year net loss of $61.6M, even as 2026 guidance for IBSRELA and XPHOZAH points to continued expansion.

Key Terms

phase 3 trial, chronic idiopathic constipation, supplemental new drug application, investigational new drug, +3 more

7 terms

phase 3 trial medical

"has launched a Phase 3 trial, ACCEL, to assess tenapanor in patients with CIC"

A Phase 3 trial is a large, late-stage test of a new drug or medical treatment done on many people to make sure it really works and is safe. For investors, it matters because a successful Phase 3 usually means the company can ask regulators to sell the product and could earn lots of money, while failure can sharply reduce the company’s value.

chronic idiopathic constipation medical

"to include patients with chronic idiopathic constipation (CIC) and has launched a Phase 3"

Chronic idiopathic constipation is a long-lasting condition where a person has infrequent or difficult bowel movements and no identifiable medical cause; “idiopathic” means doctors cannot find a specific underlying disease. It matters to investors because it represents a sizable, persistent patient population and a steady market for treatments, diagnostics and clinical trials—think of it as a common plumbing problem that creates ongoing demand for better tools and services.

supplemental new drug application regulatory

"intends to submit a Supplemental New Drug Application to the U.S. Food and Drug"

A supplemental new drug application is a request submitted to regulatory authorities to make changes to an existing approved medication, such as adding new uses, strengths, or formulations. For investors, it signals that a pharmaceutical company is seeking approval for new product developments or expanded applications, which can impact the company's future sales, market potential, and stock value.

investigational new drug regulatory

"in advance of an Investigational New Drug submission to the FDA in the second"

An investigational new drug is a medication that is still being tested in clinical trials to determine if it is safe and effective for treating a specific condition. For investors, it represents a potential breakthrough that could lead to a new treatment and significant financial gains if successful, but also carries risks since it has not yet been approved for widespread use.

boxed warning regulatory

"WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS IBSRELA is contraindicated"

A boxed warning is the strongest safety alert a drug regulator places on a medication’s official label to highlight life‑threatening or very serious risks, similar to a bold red flag attached to a product. For investors, it matters because this warning can reduce sales, increase regulatory scrutiny, raise liability and monitoring costs, and change market perception of the drug’s future revenue and risk profile.

placebo-controlled medical

"two randomized, double-blind, placebo-controlled trials of IBS-C."

"Placebo-controlled" describes a testing method where one group receives the actual treatment or intervention, while another group receives a harmless, inactive version called a placebo. This approach helps determine whether the real treatment has genuine effects beyond psychological expectations. For investors, understanding this ensures confidence that reported benefits are real and not influenced by bias or false perceptions.

orange book regulatory

"The patent is listed in the FDA’s Approved Drug Products with Therapeutic Equivalence Evaluations (commonly known as the Orange Book)"

A publicly maintained FDA database that lists approved prescription drugs and notes which versions are considered interchangeable with brand-name products, along with key patent and exclusivity dates. Think of it as a product roster plus an expiration calendar: investors use it to see when a drug’s protection ends and generic competition can enter, which can directly affect a company’s sales, future revenue and stock value.

AI-generated analysis. Not financial advice.

IBSRELA revenue grew 73% in 2025 to $274.2 million and total revenues reached $407.3 million

Patient-first XPHOZAH strategy preserved access and drove growth in total dispenses

Development programs for new IBSRELA indication and next-generation NHE3 inhibitor launched

Company is well capitalized to meet current business objectives

Conference call scheduled for 4:30 PM Eastern Time

WALTHAM, Mass., Feb. 19, 2026 (GLOBE NEWSWIRE) -- Ardelyx, Inc. (Nasdaq: ARDX), a commercial-stage biopharmaceutical company focused on the development and commercialization of innovative medicines that meet significant unmet medical needs, today reported financial results for the fourth quarter and full year ended December 31, 2025, and provided a business update.

“The results we delivered in 2025 reflect our team’s hard work and disciplined execution to bring our medicines to more patients in need, underscored by significant IBSRELA growth, increased adoption of XPHOZAH and rapid advancement of our clinical development programs,” said Mike Raab, president and chief executive officer of Ardelyx. “As we look to build on this strong momentum, we see 2026 as a pivotal opportunity to further evolve our business into a meaningful enterprise built on a broad, thoughtful portfolio of best-in-class medicines. Our long-term strategy remains clear and unwavering: to deliver novel therapies to patients with significant unmet medical needs and generate sustained value for shareholders.”

IBSRELA^® (tenapanor) finishes 2025 with $274.2 million in revenue
Revenue for IBSRELA in 2025 was $274.2 million reflecting 73% growth compared to the $158.3 million reported for the full year 2024. The company recorded $86.6 million in IBSRELA revenue in the fourth quarter of 2025, 61% growth compared to the same period of 2024 and an 11% increase compared to the third quarter of 2025.

Ardelyx expects continued growth in 2026 and beyond, driven by increased depth and breadth of prescribing among target healthcare providers, increased engagement with patients with irritable bowel syndrome with constipation (IBS-C) as well as further improved prescription pull-through. Ardelyx expects full-year 2026 revenue for IBSRELA to be between $410 and $430 million, representing at least 50% growth compared to 2025. As a result of the significant momentum that IBSRELA has generated, the company expects IBSRELA to achieve $1 billion in annual revenue in 2029, with further growth thereafter.

XPHOZAH^® (tenapanor) finishes 2025 with $103.6 million in revenue
Revenue for XPHOZAH in 2025 was $103.6 million reflecting year-over-year growth in total XPHOZAH dispenses, including an increased number of non-Medicare patients on therapy. The company also recorded $27.8 million in revenue in the fourth quarter of 2025.

Ardelyx expects growth in 2026 to be driven by increased clinical conviction and writing among target healthcare prescribers. Ardelyx expects full-year 2026 XPHOZAH revenue to be between $110 and $120 million.

Building a pipeline of important medicines
The company advanced efforts to expand the eligible patient population for IBSRELA to include patients with chronic idiopathic constipation (CIC) and has launched a Phase 3 trial, ACCEL, to assess tenapanor in patients with CIC, dosing the first patient in Q1 2026. Pending the outcome of the Phase 3 trial, Ardelyx intends to submit a Supplemental New Drug Application to the U.S. Food and Drug Administration (FDA) for the CIC indication. Enrollment in ACCEL is expected to be completed by the end of 2026 and topline readout is expected in the second half of 2027.

Ardelyx also launched a development program for RDX10531, a next-generation sodium/hydrogen exchanger 3 (NHE3) inhibitor, in 2025. The company is currently completing pre-clinical development activities in advance of an Investigational New Drug submission to the FDA in the second half of 2026 and initiation of a Phase 1 clinical trial thereafter.

Other Corporate Developments

• United States Patent and Trademark Office issued U.S. Patent No. 12,539,299 titled “Oral Formulations of Tenapanor.” The patent covers the commercial formulations of IBSRELA and XPHOZAH and has an expiration date of November 26, 2042. The patent is listed in the FDA’s Approved Drug Products with Therapeutic Equivalence Evaluations (commonly known as the Orange Book) for both products.
• Four posters were presented at the American Society of Nephrology’s annual Kidney Week, including data from real-world evidence studies demonstrating patient satisfaction and reduction in serum phosphate with XPHOZAH.
• Three posters were presented at the American College of Gastroenterology’s 2025 Annual Meeting supporting the benefits of IBSRELA.
  
  

Full Year 2025 Financial Results

• Cash Position: As of December 31, 2025, the company had total cash, cash equivalents and short-term investments of $264.7 million, compared to total cash, cash equivalents and short-term investments of $250.1 million as of December 31, 2024.
• Revenues: Total revenue for the year ended December 31, 2025 was $407.3 million, compared to $333.6 million in total revenue in 2024, driven by increases in IBSRELA revenue.
  • IBSRELA revenue was $274.2 million, compared to $158.3 million in 2024.
  • XPHOZAH revenue was $103.6 million, compared to $160.9 million in 2024.
  • Other revenues, including product supply, licensing and non-cash royalty revenue related to the sale of future royalties, totaled $29.5 million, compared to $14.4 million in 2024.
• R&D Expenses: Research and development expenses were $71.5 million for the year ended December 31, 2025, compared to $52.3 million for the year ended December 31, 2024. The increase was related to investments in recently announced pipeline programs and increased medical engagement with scientific communities.
• SG&A Expenses: Selling, general and administrative expenses were $337.2 million for the year ended December 31, 2025, compared to $258.7 million for the year ended December 31, 2024. The increase was primarily related to increased costs associated with the ongoing commercialization of IBSRELA and XPHOZAH.
• Net Loss: Net loss for the year ended December 31, 2025 was $61.6 million, or $(0.26) per share, compared to net loss of $39.1 million, or $(0.17) per share, for the year ended December 31, 2024. The net loss for the full year 2025 included share-based compensation expense of $49.0 million.
  
  

Conference Call Details
The company will host a conference call today, February 19, 2026, at 4:30 PM ET to discuss today's announcement. To participate in the conference call, please dial (877) 346-6112 (domestic) or (848) 280-6350 (international) and ask to be joined into the Ardelyx call. A live audio webcast and related presentation materials can also be accessed by visiting the Investor page of the company's website, www.ardelyx.com, and will be available on the website for 30 days following the call.

IMPORTANT SAFETY INFORMATION (IBSRELA)

WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS IBSRELA is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile rats administration of tenapanor caused deaths presumed to be due to dehydration. Avoid use of IBSRELA in patients 6 years to less than 12 years of age. The safety and effectiveness of IBSRELA have not been established in patients less than 18 years of age.

CONTRAINDICATIONS

• IBSRELA is contraindicated in patients less than 6 years of age due to the risk of serious dehydration.
• IBSRELA is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.
  
  

WARNINGS AND PRECAUTIONS
Risk of Serious Dehydration in Pediatric Patients

• IBSRELA is contraindicated in patients below 6 years of age. The safety and effectiveness of IBSRELA in patients less than 18 years of age have not been established. In young juvenile rats (less than 1 week old; approximate human age equivalent of less than 2 years of age), decreased body weight and deaths occurred, presumed to be due to dehydration, following oral administration of tenapanor. There are no data available in older juvenile rats (human age equivalent 2 years to less than 12 years).
• Avoid the use of IBSRELA in patients 6 years to less than 12 years of age. Although there are no data in older juvenile rats, given the deaths in younger rats and the lack of clinical safety and efficacy data in pediatric patients, avoid the use of IBSRELA in patients 6 years to less than 12 years of age.
  
  

Diarrhea
Diarrhea was the most common adverse reaction in two randomized, double-blind, placebo-controlled trials of IBS-C. Severe diarrhea was reported in 2.5% of IBSRELA-treated patients. If severe diarrhea occurs, suspend dosing and rehydrate patient.

MOST COMMON ADVERSE REACTIONS
The most common adverse reactions in IBSRELA-treated patients (incidence ≥2% and greater than placebo) were: diarrhea (16% vs 4% placebo), abdominal distension (3% vs <1%), flatulence (3% vs 1%) and dizziness (2% vs <1%).

INDICATION
IBSRELA (tenapanor) is indicated for the treatment of Irritable Bowel Syndrome with Constipation (IBS-C) in adults.

Please see full Prescribing Information, including Boxed Warning, for additional risk information.

IMPORTANT SAFETY INFORMATION (XPHOZAH)

CONTRAINDICATIONS

XPHOZAH is contraindicated in:

• Pediatric patients under 6 years of age
• Patients with known or suspected mechanical gastrointestinal obstruction
  
  

WARNINGS AND PRECAUTIONS
Diarrhea
Patients may experience severe diarrhea. Treatment with XPHOZAH should be discontinued in patients who develop severe diarrhea.

MOST COMMON ADVERSE REACTIONS
Diarrhea, which occurred in 43-53% of patients, was the only adverse reaction reported in at least 5% of XPHOZAH-treated patients with CKD on dialysis across trials. The majority of diarrhea events in the XPHOZAH-treated patients were reported to be mild-to-moderate in severity and resolved over time, or with dose reduction. Diarrhea was typically reported soon after initiation but could occur at any time during treatment with XPHOZAH. Severe diarrhea was reported in 5% of XPHOZAH-treated patients in these trials.

INDICATION
XPHOZAH (tenapanor), 30 mg BID, is indicated to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are intolerant of any dose of phosphate binder therapy.

For additional safety information, please see full Prescribing Information.

About Ardelyx
Ardelyx is a commercial-stage biopharmaceutical company focused on the development and commercialization of innovative medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA^® (tenapanor) and XPHOZAH^® (tenapanor). The company’s pipeline includes the Phase 3 development of tenapanor for chronic idiopathic constipation, and RDX10531, a next-generation NHE3 inhibitor with potential application across multiple therapeutic areas. Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL^® (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada. For more information, please visit https://ardelyx.com/ and connect with us on X (formerly known as Twitter), LinkedIn and Facebook.

Forward Looking Statements
To the extent that statements contained in this press release are not descriptions of historical facts regarding Ardelyx, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor of the Private Securities Reform Act of 1995, including Ardelyx’s current expectations regarding: the year in which IBSRELA will achieve annual U.S. net product sales revenue of $1 billion; the company’s planned label expansion for IBSRELA (tenapanor) to include patients with CIC, pending FDA approval; net product sales revenue for IBSRELA and XPHOZAH for 2026; the company’s ability to deliver sustainable revenue growth, expand its portfolio and deliver meaningful value for shareholders; the timing of the completion of enrollment in the CIC Phase 3 clinical trial and release of topline results; and the timing of an investigational new drug application and initiation of a Phase 1 clinical trial for RDX10531. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that are in some cases beyond our control, that could cause actual outcomes or results to differ materially from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, uncertainties associated with the development of, regulatory process for, and commercialization of drugs in the U.S. and internationally. Ardelyx undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Ardelyx's business in general, please refer to Ardelyx's Annual Report on Form 10-K filed with the Securities and Exchange Commission on February 19, 2026 and its future current and periodic reports to be filed with the Securities and Exchange Commission.

Investor and Media Contact:
Caitlin Lowie
clowie@ardelyx.com

Ardelyx, Inc. Condensed Balance Sheets (in thousands)
	December 31, 2025				December 31, 2024
	(Unaudited)				(1)
Assets
Cash and cash equivalents	$	67,999			$	64,932
Short-term investments		196,690				185,168
Accounts receivable		71,848				57,705
Prepaid commercial manufacturing		14,479				16,378
Inventory		123,107				91,184
Property and equipment, net		2,184				1,495
Right-of-use assets		4,795				2,380
Prepaid and other assets		20,502				16,512
Total assets	$	501,604			$	435,754
Liabilities and stockholders’ equity
Accounts payable	$	19,235			$	16,000
Accrued compensation and benefits		19,108				14,940
Current portion of operating lease liability		1,479				1,562
Deferred revenue		14,905				17,918
Accrued expenses and other liabilities		51,218				35,665
Long-term debt		202,834				150,853
Deferred royalty obligation related to the sale of future royalties		25,876				25,527
Total stockholders’ equity		166,949				173,289
Total liabilities and stockholders’ equity	$	501,604			$	435,754
(1) Derived from the audited financial statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2024.

Ardelyx, Inc. Condensed Statements of Operations (Unaudited) (in thousands, except share and per share amounts)
	Three Months Ended December 31,								Twelve Months Ended December 31,
	2025				2024				2025				2024
Revenues
Product sales, net
IBSRELA	$	86,601			$	53,842			$	274,207			$	158,286
XPHOZAH		27,801				57,161				103,601				160,910
Total product sales, net		114,402				111,003				377,808				319,196
Product supply revenue		9,440				4,188				15,879				11,649
Licensing revenue		23				22				5,088				78
Non-cash royalty revenue related to the sale of future royalties		1,350				916				8,545				2,692
Total revenues		125,215				116,129				407,320				333,615
Costs and operating expenses
Cost of sales(1)		10,849				18,264				39,537				50,556
Research and development		22,856				13,666				71,527				52,317
Selling, general and administrative		86,411				76,074				337,233				258,692
Total costs and operating expenses		120,116				108,004				448,297				361,565
Income (loss) from operations		5,099				8,125				(40,977	)			(27,950	)
Interest expense		(5,759	)			(3,967	)			(20,102	)			(13,006	)
Non-cash interest expense related to the sale of future royalties		(1,818	)			(1,886	)			(8,296	)			(7,088	)
Other income, net		2,078				2,408				8,745				9,174
(Loss) income before provision for income taxes		(400	)			4,680				(60,630	)			(38,870	)
Provision for income taxes		7				35				969				266
Net (loss) income	$	(407	)		$	4,645			$	(61,599	)		$	(39,136	)
Net (loss) income per share of common stock - basic and diluted	$	(0.00	)		$	0.02			$	(0.26	)		$	(0.17	)
Shares used in computing net (loss) income per share - basic		243,614,026				237,370,654				241,033,750				235,232,927
Shares used in computing net (loss) income per share - diluted		243,614,026				244,050,606				241,033,750				235,232,927
(1) Prior year amounts have been reclassified to conform to the current year presentation.

FAQ

How much revenue did Ardelyx (ARDX) report for IBSRELA in 2025?

IBSRELA generated $274.2 million in 2025, a 73% increase year-over-year. According to the company, fourth-quarter IBSRELA revenue was $86.6 million, reflecting 61% growth versus Q4 2024 and an 11% sequential rise from Q3 2025.

What 2026 revenue guidance did Ardelyx (ARDX) give for IBSRELA and XPHOZAH?

Ardelyx guided IBSRELA revenue to $410–$430 million and XPHOZAH to $110–$120 million for full-year 2026. According to the company, guidance reflects expected deeper prescribing and improved prescription pull-through driving growth.

What clinical and development milestones did Ardelyx (ARDX) announce on Feb 19, 2026?

Ardelyx launched Phase 3 ACCEL for CIC and began dosing first patient in Q1 2026. According to the company, ACCEL enrollment is expected to finish by end of 2026 with topline readout in H2 2027.

How strong is Ardelyx's balance sheet after 2025 results (ARDX)?

Ardelyx reported $264.7 million in cash, cash equivalents and short-term investments as of December 31, 2025. According to the company, the cash position is expected to support current business objectives and pipeline activities.

What was Ardelyx's net loss and major cost drivers in 2025 (ARDX)?

Net loss was $61.6 million for 2025, compared to $39.1 million in 2024. According to the company, higher SG&A linked to commercialization and increased R&D investments drove the wider loss.

Did Ardelyx (ARDX) secure patent protection for tenapanor formulations?

Yes; U.S. Patent No. 12,539,299 was issued covering commercial tenapanor formulations, expiring November 26, 2042. According to the company, the patent is listed in the FDA Orange Book for both IBSRELA and XPHOZAH.