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Axogen, Inc. Reports Fourth Quarter and Full-Year 2025 Financial Results

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Axogen (NASDAQ: AXGN) reported fourth-quarter 2025 revenue of $59.9M (+21.3% YoY) and full-year 2025 revenue of $225.2M (+20.2% YoY). Full-year adjusted EBITDA was $27.9M. FDA approved the BLA for Avance on Dec 3, 2025. Axogen completed a public offering raising $133.3M net and used $69.7M to repay a loan. 2026 guidance: revenue at least 18% growth (~$265.7M), gross margin 74–76%, and expected free cash flow positive for the year.

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Positive

  • Revenue +20.2% full-year 2025 to $225.2M
  • Adjusted EBITDA +$8.1M YoY to $27.9M
  • FDA BLA approval for Avance on Dec 3, 2025
  • Completed $133.3M net public offering
  • Repaid $69.7M Oberland loan on Jan 28, 2026

Negative

  • Net loss $15.7M for full-year 2025
  • Gross margin down ~150 bps to 74.3% for 2025
  • Q4 2025 gross margin hit by $1.9M one-time costs

News Market Reaction – AXGN

-8.14%
6 alerts
-8.14% News Effect
-7.8% Trough in 2 hr 16 min
-$157M Valuation Impact
$1.77B Market Cap
0.1x Rel. Volume

On the day this news was published, AXGN declined 8.14%, reflecting a notable negative market reaction. Argus tracked a trough of -7.8% from its starting point during tracking. Our momentum scanner triggered 6 alerts that day, indicating moderate trading interest and price volatility. This price movement removed approximately $157M from the company's valuation, bringing the market cap to $1.77B at that time.

Data tracked by StockTitan Argus on the day of publication.

Key Figures

Q4 2025 Revenue: $59.9M FY 2025 Revenue: $225.2M FY 2025 Gross Margin: 74.3% +5 more
8 metrics
Q4 2025 Revenue $59.9M Fourth quarter 2025, up 21.3% vs Q4 2024
FY 2025 Revenue $225.2M Full-year 2025, up 20.2% vs $187.3M in 2024
FY 2025 Gross Margin 74.3% Full-year 2025 vs 75.8% in 2024
FY 2025 Adjusted EBITDA $27.9M Full-year 2025 vs $19.8M in 2024
One-time BLA Costs $1.9M One-time costs tied to FDA BLA approval of Avance® in 2025
Year-end Cash & Investments $45.5M As of Dec 31, 2025 vs $39.5M a year earlier
Avance Facility Reimbursement $8,965 Hospital outpatient Level 3 Nerve Procedure Code from Jan 1, 2026 (40% YoY increase)
Equity Raise Net Proceeds $133.3M Upsized public offering of 4.6M shares; $69.7M used to repay Oberland loan

Market Reality Check

Price: $31.22 Vol: Volume 1,186,914 is 26% a...
normal vol
$31.22 Last Close
Volume Volume 1,186,914 is 26% above the 20-day average of 941,857. normal
Technical Price 35.38 is trading above the 200-day MA of 20.38 and within 2% of the 52-week high 35.9999.

Peers on Argus

AXGN is up 0.23% with elevated volume, while momentum peers INMD and TNDM in the...
2 Down

AXGN is up 0.23% with elevated volume, while momentum peers INMD and TNDM in the scanner are both down and sector peers show mixed moves. This points to a stock-specific reaction to the earnings release rather than a broad medical devices move.

Previous Earnings Reports

5 past events · Latest: Oct 29 (Positive)
Same Type Pattern 5 events
Date Event Sentiment Move Catalyst
Oct 29 Q3 2025 earnings Positive +23.1% Strong Q3 growth, higher margins, raised full-year guidance and BLA timing update.
Aug 05 Q2 2025 earnings Positive +9.3% Q2 revenue up 18.3% YoY with return to profitability and improved gross margin.
May 08 Q1 2025 earnings Neutral -23.2% Healthy revenue growth but lower gross margin and ongoing net loss despite improvement.
Feb 25 FY 2024 earnings Positive +11.7% Solid 2024 growth, improved losses, positive adjusted earnings and Avance BLA acceptance.
Nov 07 Q3 2024 earnings Positive -13.4% Revenue growth and higher adjusted EBITDA but softer gross margin and ongoing net loss.
Pattern Detected

Earnings releases have often been followed by sizeable moves, with mostly positive reactions to strong revenue/guidance, but occasional sharp selloffs on mixed margin or loss profiles.

Recent Company History

Over the last five earnings cycles, Axogen has delivered consistent double‑digit revenue growth and gradually improving profitability metrics. Prior quarters in 2025 featured rising gross margin, positive net income in Q2–Q3, and repeated guidance raises tied to Avance® BLA progress. Market reactions ranged from strong gains after Q3 2025 and 2024 full‑year results to sharp drops when margins tightened or losses widened. Today’s Q4 and full‑year 2025 report, with 20%+ annual revenue growth and detailed Avance® reimbursement and capital actions, fits this pattern of earnings as a key catalyst.

Historical Comparison

+1.5% avg move · In the past five earnings releases, AXGN moved an average of 1.48%. Today’s 0.23% move sits well wit...
earnings
+1.5%
Average Historical Move earnings

In the past five earnings releases, AXGN moved an average of 1.48%. Today’s 0.23% move sits well within that range, suggesting a typical earnings-day reaction so far.

Earnings updates show a progression from growing revenue with losses toward improving adjusted profitability, alongside advancement of the Avance® BLA from acceptance to full FDA approval.

Regulatory & Risk Context

Active S-3 Shelf
Shelf Active
Active S-3 Shelf Registration 2026-01-21

An automatic, effective Form S-3ASR shelf filed on 2026-01-21 allows Axogen to issue common stock, preferred stock, debt securities, and warrants in multiple future offerings with terms set in prospectus supplements. Proceeds are generally earmarked for corporate purposes such as working capital and capital expenditures.

Market Pulse Summary

The stock moved -8.1% in the session following this news. A negative reaction despite solid topline ...
Analysis

The stock moved -8.1% in the session following this news. A negative reaction despite solid topline growth would fit prior instances where margin pressure or losses overshadowed revenue gains. Full‑year gross margin of 74.3%, down from 75.8%, and a $15.7M net loss could drive concern even with stronger adjusted EBITDA. Recent equity financing and use of proceeds to retire the $69.7M Oberland loan, plus ongoing shelf capacity, could add dilution worries that sometimes accelerate downside moves.

Key Terms

biologics license application, acellular nerve allograft, cms, asc-based procedures, +2 more
6 terms
biologics license application regulatory
"With the FDA’s approval of our Biologics License Application for Avance®..."
A biologics license application is a formal request submitted to regulatory authorities seeking approval to market a new biological medicine, such as vaccines or treatments made from living organisms. It is a comprehensive review process that evaluates the safety, effectiveness, and manufacturing quality of the product. For investors, receiving approval signals that a biological therapy can be sold to the public, potentially leading to revenue growth and market success.
acellular nerve allograft medical
"the FDA approved the BLA for Avance® (acellular nerve allograft-arwx)."
An acellular nerve allograft is a medical tissue used to repair damaged nerves, made from donor nerve tissue that has been processed to remove all living cells. This leaves a structural framework that guides nerve growth without provoking a strong immune response. While primarily a medical term, its relevance to investors may relate to advancements in regenerative treatments or biotech companies developing innovative nerve repair solutions.
cms regulatory
"Effective January 1, 2026, CMS created a new Level 3 Nerve Procedure Code..."
The Centers for Medicare & Medicaid Services (CMS) is the U.S. federal agency that sets rules, payment rates and coverage decisions for major public health insurance programs; think of it as both a giant insurer and the rulebook maker for how many healthcare providers and drug makers get paid by government programs. Its policy changes and reimbursement decisions can materially affect revenue, profit forecasts and valuations for hospitals, insurers, device makers and drug companies, so investors watch CMS announcements closely.
asc-based procedures medical
"35% to $6,157 for ASC-based procedures."
ASC-based procedures are surgeries and medical treatments performed in ambulatory surgery centers — outpatient clinics designed for patients who don’t need an overnight hospital stay. Think of them like getting a routine car tune-up at a neighborhood shop instead of a full-service dealership: faster, lower-cost, and more predictable. For investors, growth in ASC-based procedures can signal higher throughput, lower provider costs, and improved profit potential for companies that operate or sell equipment to these centers.
public offering financial
"Axogen closed an upsized public offering with the sale of 4.6 million shares..."
A public offering is when a company sells shares to the general public through the stock market, either by issuing new shares to raise cash or by letting existing owners sell their stakes. Think of it like a business opening its doors to many new owners at once: it can bring in money for growth but also increases the number of shares available, which can change the stock price and dilute existing ownership — key factors investors watch closely.
free cash flow financial
"we expect to be free cash flow positive for the full-year."
Free cash flow is the amount of money a company has left over after paying all its expenses and investing in its business, like buying equipment or updating facilities. It shows how much cash is available to reward shareholders, pay down debt, or save for future growth. This helps investors understand if a company is financially healthy and able to grow.

AI-generated analysis. Not financial advice.

ALACHUA, Fla. and TAMPA, Fla., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Axogen, Inc. (NASDAQ: AXGN), a global leader in developing and marketing innovative surgical solutions for the restoration of peripheral nerve function, today reported financial results and business highlights for the fourth quarter and full-year ended December 31, 2025.

Fourth Quarter Financial Results

  • Fourth quarter 2025 revenue was $59.9 million, a 21.3% increase compared to the fourth quarter 2024 revenue, and a 0.3% decrease over the third quarter 2025 revenue.
  • Fourth quarter 2025 gross margin was 74.1%, down from 76.1% for the fourth quarter of 2024, and down from 76.6% in the third quarter of 2025.
  • Gross margin reflects one-time costs of approximately $1.9 million, or 3% for the fourth quarter of 2025, related to the U.S. Food and Drug Administration (“FDA”) Biologics License Application (“BLA”) approval of Avance®, of which 67% are non-cash and relate to the vesting of certain stock compensation awards containing FDA BLA approval of Avance® milestones.
  • Net loss for the fourth quarter of 2025 was $13.2 million, or $0.28 per share, compared to a Net income of $0.5 million, or $0.01 per share for the fourth quarter of 2024.
  • Adjusted net income for the fourth quarter of 2025 and 2024 were both $3.5 million, or $0.07 per share.
  • Adjusted EBITDA was $6.5 million for the fourth quarter 2025, compared to $6.7 million for the fourth quarter of 2024.
  • Cash and cash equivalents, restricted cash, and investments increased $5.7 million during the fourth quarter of 2025.

“2025 was a remarkable year of financial and operational achievement for Axogen, as we attained or progressed every objective expected of our strategic plan. With the FDA’s approval of our Biologics License Application for Avance® as the only implantable biologic indicated for treatment of peripheral nerve discontinuities, and the continued demonstration of the effectiveness and predictability of our market development strategies, we are confident we have a foundation for future growth and advancement of our mission to make restoration of peripheral function a standard of care,” commented Michael Dale, President and CEO of Axogen, Inc. “Importantly for shareholders, we exited 2025 financially stronger and positioned to continue our important work profitably while generating positive cash flow.”

Full-Year Financial Results

  • Full-year 2025 revenue was $225.2 million, a 20.2% increase compared to 2024 revenue of $187.3 million.
  • Gross margin was 74.3% for the full-year 2025, compared to 75.8% in 2024.
  • Gross margin reflects one-time costs of approximately $1.9 million, or 1% for the full-year 2025, related to the FDA BLA approval of Avance®, of which 67% are non-cash and relate to the vesting of certain stock compensation awards containing FDA BLA approval of Avance® milestones.
  • Net loss for the full-year 2025 was $15.7 million, or $0.34 per share, compared to $10.0 million, or $0.23 per share for 2024.
  • Adjusted net income was $14.4 million for the full-year 2025, or $0.29 per share, compared to $5.9 million for the full-year, or $0.13 per share for 2024.
  • Adjusted EBITDA was $27.9 million for the full-year 2025, compared to $19.8 million for 2024.
  • As of December 31, 2025, cash and cash equivalents, restricted cash, and investments was $45.5 million, as compared to $39.5 million as of December 31, 2024, an increase of $6.0 million.

Summary of Business Highlights

  • Fourth quarter and full-year 2025 revenue growth was broad-based, including double-digit growth in all markets, which includes Extremities, Oral Maxillofacial & Head and Neck, and Breast.
  • Expanded coverage and reimbursement for peripheral nerve repair using synthetic conduits and allografts, increasing the total number of newly covered lives in 2025 to approximately 19.8 million and raising commercial payer coverage to more than 65%.
  • On December 3, 2025, the FDA approved the BLA for Avance® (acellular nerve allograft-arwx).
  • Effective January 1, 2026, CMS created a new Level 3 Nerve Procedure Code, increasing Avance facility reimbursement 40% year-over-year to $8,965 for hospital outpatient and 35% to $6,157 for ASC-based procedures.
  • On January 23, 2026, Axogen closed an upsized public offering with the sale of 4.6 million shares of common stock, yielding net proceeds of $133.3 million. From these net proceeds, $69.7 million were used to fully repay and terminate our Oberland loan facility on January 28, 2026. Remaining funds will be available for working capital, capital expenditures, and other general corporate purposes.

2026 Financial Guidance

We expect 2026 revenue growth to be at least 18%, or $265.7 million, for the full-year and gross margin to be in the range of 74% to 76%. Additionally, we expect to be free cash flow positive for the full-year.

Conference Call

The Company will host a conference call and webcast for the investment community today at 8:00 a.m. ET. Investors interested in participating in the conference call by phone may do so by dialing toll free at (877) 407-0993 or use the direct dial-in number at (201) 689-8795. Those interested in listening to the conference call live via the internet may do so by visiting the Investors page of the Company’s website at www.axogeninc.com and clicking on the webcast link.

Following the conference call, a replay will be available in the Investors section of the Company’s website at www.axogeninc.com under Investors.

About Axogen

Axogen (AXGN) is the leading company focused specifically on the science, development and commercialization of technologies for peripheral nerve regeneration and repair. Axogen employees are passionate about providing the opportunity to restore nerve function and quality of life for patients with peripheral nerve injuries by providing innovative, clinically proven and economically effective repair solutions for surgeons and healthcare providers. Peripheral nerves provide the pathways for both motor and sensory signals throughout the body. Every day people suffer traumatic injuries or undergo surgical procedures that impact the function of their peripheral nerves. Physical damage to a peripheral nerve or the inability to properly reconnect peripheral nerves can result in the loss of muscle or organ function, the loss of sensory feeling, or the initiation of pain.

Axogen’s product portfolio includes Avance® (acellular nerve allograft-arwx), Avance® Nerve Graft, Axoguard Nerve Connector®, Axoguard Nerve Protector®, Axoguard HA+ Nerve Protector™, Axoguard Nerve Cap®, and Avive+ Soft Tissue Matrix™.​

For more information, visit www.axogeninc.com.

Cautionary Statements Concerning Forward-Looking Statements

This press release and accompanying earnings call contain “forward-looking” statements as defined in the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, among other things, all statements under the heading “2026 Financial Guidance” and statements regarding our business model optimization plans; market development strategies and objectives; our expectations around the potential positive impact on our business of expanded coverage and reimbursement for peripheral nerve injuries using synthetic conduits or allografts; our ability to sustain growth, operate profitably and generate positive cash flows and fund our market development initiatives; the anticipated use of proceeds from our recent public offering; and our business purpose to restore health and improve quality of life by making restoration of peripheral nerve function an expected standard of care. These statements are based on management’s current expectations or predictions of future conditions, events, or results based on various assumptions and management’s estimates of trends and economic factors in the markets in which we are active, as well as our business plans. Words such as “expects,” “anticipates,” “priorities,” “objectives,” “targets,” “intends,” “plan(s),” “believes,” “seeks,” “estimates,” “projects,” “forecasts,” “continue,” “may,” “should,” “will,” “goals,” and variations of such words and similar expressions are intended to identify such forward-looking statements. Actual results or events could differ materially from those described in any forward-looking statements as a result of various factors, including, without limitation, potential disruptions from global supply chain issues, inflation, hospital staffing challenges, product development timelines, regulatory processes, financial performance, surgeon and product adoption rates, market awareness of our products, the projected TAM for targeted markets, as well as those risk factors described under Part I, Item 1A., “Risk Factors,” in our most recent Annual Report on Form 10-K and other risks and uncertainties that may be detailed from time to time in reports filed by the Company with the SEC. Forward-looking statements are not a guarantee of future performance, and actual results may differ materially from those projected. Forward-looking statements speak only as of the date made and, except as required by applicable law, we assume no responsibility to publicly update or revise any forward-looking statements.

About Non-GAAP Financial Measures

To supplement our condensed consolidated financial statements, we use the non-GAAP financial measures of EBITDA, which measures earnings before interest, income taxes, depreciation and amortization, EBITDA margin, and Adjusted EBITDA, which further exclude noncash stock compensation expense, and Adjusted EBITDA margin. We also use the non-GAAP financial measures of Adjusted Net Income and Adjusted Net Income Per Common Share - diluted which excludes noncash stock compensation expense from Net (Loss) Income and Net (Loss) Income Per Common Share - diluted. These non-GAAP measures are not based on any comprehensive set of accounting rules or principles and should not be considered a substitute for, or superior to, financial measures calculated in accordance with GAAP and may be different from non-GAAP measures used by other companies. In addition, these non-GAAP measures should be read in conjunction with our financial statements prepared in accordance with GAAP. The reconciliations of the non-GAAP measures to the most directly comparable financial measures calculated and presented in accordance with GAAP should be carefully evaluated.

We use these non-GAAP financial measures for financial and operational decision-making and as a means to evaluate period-to-period comparisons. We believe that these non-GAAP financial measures provide meaningful supplemental information regarding our performance and that both management and investors benefit from referring to these non-GAAP financial measures in assessing our performance and when planning, forecasting, and analyzing future periods. We believe these non-GAAP financial measures are useful to investors because (i) they allow for greater transparency with respect to key metrics used by management in its financial and operational decision-making and (ii) they are used by our institutional investors and the analyst community to help them analyze the performance of our business.

Contact:
Axogen, Inc.
InvestorRelations@axogeninc.com

Axogen, Inc.
Condensed Consolidated Balance Sheets
(unaudited)
(in thousands, except share and per share amounts)

 December 31,
2025
 December 31,
2024
Assets   
Current assets:    
Cash and cash equivalents $35,548  $27,554 
Restricted cash  4,000   6,000 
Investments  5,980   5,928 
Accounts receivable, net of allowance for doubtful accounts of $948 and $788, respectively  26,169   24,105 
Inventory  42,373   33,183 
Prepaid expenses and other assets  6,352   2,447 
Total current assets  120,422   99,217 
Property and equipment, net  81,783   84,667 
Operating lease right-of-use assets  12,732   14,265 
Intangible assets, net  6,750   5,579 
Total assets $221,687  $203,728 
    
Liabilities and shareholders’ equity    
Current liabilities:    
Accounts payable and accrued expenses $21,184  $28,641 
Current maturities of long-term lease obligations  2,372   1,969 
Total current liabilities  23,556   30,610 
    
Long-term debt, net of debt discount and financing fees  48,387   47,496 
Long-term lease obligations  16,870   19,221 
Debt derivative liabilities  3,886   2,400 
Other long-term liabilities  141   94 
Total liabilities  92,840   99,821 
    
Shareholders’ equity:    
Common stock, $0.01 par value per share; 100,000,000 shares authorized; 47,199,797 and 44,148,836 shares issued and outstanding, respectively  472   441 
Additional paid-in capital  435,338   394,726 
Accumulated deficit  (306,963)  (291,260)
Total shareholders’ equity  128,847   103,907 
Total liabilities and shareholders’ equity $221,687  $203,728 


Axogen, Inc.
Condensed Consolidated Statements of Operations
(unaudited)
(in thousands, except share and per share amounts)

 Three Months Ended Years Ended
 December 31, 2025 December 31, 2024 December 31, 2025 December 31, 2024
Revenues $59,904  $49,405  $225,208  $187,338 
Cost of goods sold  15,495   11,830   57,855   45,361 
Gross profit  44,409   37,575   167,353   141,977 
Costs and expenses:        
Sales and marketing  27,211   20,051   97,740   78,461 
Research and development  12,376   6,731   32,885   27,767 
General and administrative  14,594   8,866   44,577   39,036 
Total costs and expenses  54,181   35,648   175,202   145,264 
(Loss) income from operations  (9,772)  1,927   (7,849)  (3,287)
Other income (expense):        
Investment income  352   325   1,168   1,141 
Interest expense  (1,718)  (1,801)  (7,702)  (8,206)
Change in fair value of debt derivative liabilities  (2,018)  45   (1,487)  587 
Other (expense) income, net     (46)  167   (199)
Total other expense, net  (3,384)  (1,477)  (7,854)  (6,677)
Net (loss) income $(13,156) $450  $(15,703) $(9,964)
         
Weighted average common shares outstanding — basic  46,929,309   44,876,659   46,050,266   44,257,754 
Weighted average common shares outstanding — diluted  46,929,309   48,064,916   46,050,266   44,257,754 
         
Net (loss) income per common share — basic $(0.28) $0.01  $(0.34) $(0.23)
Net (loss) income per common share — diluted $(0.28) $0.01  $(0.34) $(0.23)


Axogen, Inc.
Reconciliation of GAAP Financial Measures to Non-GAAP Financial Measures
(unaudited)
(in thousands, except share and per share amounts)

  Three Months Ended Years Ended
  December 31, 2025 December 31, 2024 December 31, 2025 December 31, 2024
Net (loss) income $(13,156) $450  $(15,703) $(9,964)
Depreciation and amortization expense  1,727   1,700   6,975   6,734 
Investment income  (352)  (325)  (1,168)  (1,141)
Income tax expense     21   4   97 
Interest expense  1,718   1,801   7,702   8,206 
EBITDA – non-GAAP $(10,063) $3,647  $(2,190) $3,932 
EBITDA margin – non-GAAP  (16.8)%  7.4%  (1.0)%  2.1%
         
Noncash stock-based compensation expense  16,611   3,076   30,112   15,906 
Adjusted EBITDA – non-GAAP $6,548  $6,723  $27,922  $19,838 
Adjusted EBITDA margin – non-GAAP  10.9%  13.6%  12.4%  10.6%
         
Net (loss) income $(13,156) $450  $(15,703) $(9,964)
Noncash stock-based compensation expense  16,611   3,076   30,112   15,906 
Adjusted net income – non-GAAP $3,455  $3,526  $14,409  $5,942 
         
Weighted average common shares outstanding – diluted GAAP  46,929,309   48,064,916   46,050,266   44,257,754 
Weighted average common shares outstanding – diluted non-GAAP (1)  52,230,508   48,064,916   49,812,186   46,197,934 
         
Net (loss) income per common share – diluted – GAAP $(0.28) $0.01  $(0.34) $(0.23)
Noncash stock-based compensation expense  0.35   0.06   0.65   0.36 
Adjusted net income per common share – diluted – non-GAAP (1) $0.07  $0.07  $0.29  $0.13 
__________
(1) Due to a GAAP net loss, antidilutive securities are excluded from GAAP diluted weighted average common shares outstanding for the three months ended December 31, 2025 and the years ended December 31, 2025 and 2024. However, considering the adjusted net income position for the three months ended December 31, 2025 and the years ended December 31, 2025 and 2024, adjusted diluted weighted average common shares outstanding incorporates securities that would have been dilutive for GAAP.

Axogen, Inc.
Condensed Consolidated Statements of Changes in Shareholders’ Equity
(unaudited)
(in thousands, except share amounts)

 Common Stock
 Additional Paid-in
Capital
 Accumulated
Deficit
 Total Shareholders'
Equity
 Shares
 Amount
   
Three Months Ended December 31, 2025            
Balance at September 30, 2025 46,117,283  $461  $414,151  $(293,807) $120,805 
Net loss          (13,156)  (13,156)
Stock-based compensation       16,611      16,611 
Issuance of restricted and performance stock units 606,645   6   (6)      
Exercise of stock options and employee stock purchases under the ESPP 475,869   5   4,582      4,587 
Balance at December 31, 2025 47,199,797  $472  $435,338  $(306,963) $128,847 
       
Year Ended December 31, 2025       
Balance at December 31, 2024 44,148,836  $441  $394,726  $(291,260) $103,907 
Net loss          (15,703)  (15,703)
Stock-based compensation       30,112      30,112 
Issuance of restricted and performance stock units 1,907,707   19   (19)      
Exercise of stock options and employee stock purchases under the ESPP 1,143,254   12   10,519      10,531 
Balance at December 31, 2025 47,199,797  $472  $435,338  $(306,963) $128,847 
             
Three Months Ended December 31, 2024            
Balance at September 30, 2024 44,002,323  $440  $390,677  $(291,710) $99,407 
Net income          450   450 
Stock-based compensation       3,076      3,076 
Issuance of restricted and performance stock units 17,170             
Exercise of stock options and employee stock purchases under the ESPP 129,343   1   973      974 
Balance at December 31, 2024 44,148,836  $441  $394,726  $(291,260) $103,907 
             
Year Ended December 31, 2024            
December 31, 2023 43,124,496  $431  $376,530  $(281,296) $95,665 
Net loss          (9,964)  (9,964)
Stock-based compensation       15,906      15,906 
Issuance of restricted and performance stock units 712,741   7   (7)      
Exercise of stock options and employee stock purchases under the ESPP 311,599   3   2,297      2,300 
Balance at December 31, 2024 44,148,836  $441  $394,726  $(291,260) $103,907 


Axogen, Inc.
Condensed Consolidated Statements of Cash Flows
(unaudited)
(in thousands)

 Years Ended
 December 31, 2025 December 31, 2024
Cash flows from operating activities:   
Net loss $(15,703) $(9,964)
Adjustments to reconcile net loss to net cash provided by operating activities:    
Depreciation  6,660   6,467 
Amortization of right-of-use assets  1,533   1,103 
Amortization of intangible assets  315   267 
Amortization of debt discount and deferred financing fees  891   893 
Provision for bad debts  400   650 
Change in fair value of debt derivative liabilities  1,487   (587)
Investment gains, net  (329)  (155)
Impairment of long-lived assets  64    
Stock-based compensation expense  30,112   15,906 
Change in operating assets and liabilities:    
Accounts receivable  (2,464)  392 
Inventory  (9,190)  (10,163)
Prepaid expenses and other assets  (3,905)  784 
Accounts payable and accrued expenses  (7,158)  125 
Operating lease obligations  (1,937)  (1,603)
Cash paid for interest portion of financing lease obligations  (11)  (4)
Other long-term liabilities  47   424 
Net cash provided by operating activities  812   4,535 
   
Cash flows from investing activities:   
Purchase of property and equipment  (3,745)  (3,101)
Purchase of investments  (13,723)  (5,773)
Proceeds from sale of investments  14,000    
Cash payments for intangible assets  (1,849)  (1,423)
Net cash used in investing activities  (5,317)  (10,297)
   
Cash flows from financing activities:   
Cash paid for debt portion of financing lease obligations  (32)  (10)
Proceeds from exercise of stock options and ESPP stock purchases  10,531   2,300 
Net cash provided by financing activities  10,499   2,290 
Net increase (decrease) in cash and cash equivalents, and restricted cash  5,994   (3,472)
Cash and cash equivalents, and restricted cash, beginning of period  33,554   37,026 
Cash and cash equivalents, and restricted cash, end of period $39,548  $33,554 

FAQ

What did Axogen (AXGN) report for fourth-quarter 2025 revenue?

Axogen reported $59.9 million revenue for Q4 2025, up 21.3% year-over-year. According to Axogen, Q4 revenue was down 0.3% sequentially versus Q3 2025 and contributed to full-year revenue of $225.2 million.

How did FDA approval of Avance affect Axogen (AXGN) in 2025?

FDA approved the BLA for Avance on December 3, 2025, marking a regulatory milestone. According to Axogen, approval generated $1.9M of one-time costs in 2025 and supports reimbursement gains and commercialization efforts in 2026.

What is Axogen's (AXGN) 2026 revenue and margin guidance?

Axogen expects at least 18% revenue growth for 2026, targeting ~$265.7M and gross margin of 74–76%. According to Axogen, the company also expects to be free cash flow positive for the full-year 2026.

How did Axogen (AXGN) strengthen its balance sheet in January 2026?

Axogen completed an upsized public offering yielding $133.3M net proceeds and used $69.7M to repay its Oberland loan. According to Axogen, remaining proceeds will fund working capital, capex, and general corporate purposes.

What were Axogen's (AXGN) profitability metrics for full-year 2025?

Full-year adjusted net income was $14.4M and adjusted EBITDA was $27.9M for 2025. According to Axogen, GAAP net loss was $15.7M, while adjusted measures reflect non-cash and one-time items tied to milestones.

Did reimbursement changes affect Axogen (AXGN) outlook for 2026?

Yes. A new Level 3 nerve procedure code increased facility reimbursement (hospital outpatient and ASC) materially. According to Axogen, CMS changes raised Avance facility reimbursement to $8,965 (hospital) and $6,157 (ASC), improving commercial economics.
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1.63B
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Medical Devices
Electromedical & Electrotherapeutic Apparatus
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United States
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