Axsome Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update

Rhea-AI Summary

Axsome Therapeutics (NASDAQ: AXSM) reported strong commercial growth in 4Q and full year 2025 with $196.0M and $638.5M total net product revenue, up 65% and 66% year-over-year. AUVELITY, SUNOSI, and SYMBRAVO all grew; cash totaled $322.9M. Strategic updates include acquisition of AXS-17 and a PDUFA date of April 30, 2026 for AXS-05 in Alzheimer’s disease agitation.

Positive

• Total net product revenue +66% YoY to $638.5M (FY 2025)
• AUVELITY net sales +74% YoY to $507.1M (FY 2025)
• SUNOSI full year revenue +32% YoY to $124.8M (FY 2025)
• Acquired AXS-17 to expand epilepsy pipeline
• PDUFA target date Apr 30, 2026 for AXS-05 sNDA

Negative

• SG&A increased ~39% YoY to $570.6M (FY 2025)
• Net loss remained $183.2M for FY 2025 despite revenue growth

Key Figures

Total net product revenue: $196.0M Total net product revenue: $638.5M AUVELITY net sales: $155.1M +5 more

8 metrics

Total net product revenue $196.0M Q4 2025, 65% YoY growth

Total net product revenue $638.5M Full year 2025, 66% YoY growth

AUVELITY net sales $155.1M Q4 2025, 68% YoY growth

SUNOSI net revenue $36.7M Q4 2025, 40% YoY growth

SYMBRAVO net sales $6.6M Full year 2025

Net loss $183.2M Full year 2025, $5.99M prior year loss reduced to $3.68/share

Cash and equivalents $322.9M As of December 31, 2025

AUVELITY prescriptions 225,000 Q4 2025, 42% YoY increase

Market Reality Check

Price: $183.72 Vol: Volume 568,073 is slightl...

normal vol

$183.72 Last Close

Volume Volume 568,073 is slightly above the 20-day average of 514,265, suggesting only modest pre‑earnings positioning. normal

Technical Shares at $183.72 trade 4.06% below the 52-week high and 111.2% above the 52-week low, remaining above the 200-day MA of $131.71.

Peers on Argus

AXSM was down 1.32% pre‑release while peers showed mixed moves: LEGN appeared in...

1 Up 1 Down

AXSM was down 1.32% pre‑release while peers showed mixed moves: LEGN appeared in momentum scanners up 8.72%, and CRSP was down 1.87%. This points to stock‑specific drivers rather than a broad sector rotation.

Previous Earnings Reports

5 past events · Latest: Nov 03 (Positive)

Same Type Pattern 5 events

Date	Event	Sentiment	Move	Catalyst
Nov 03	Q3 2025 earnings	Positive	+0.6%	Strong Q3 revenue growth with expanding AUVELITY and SUNOSI sales.
Aug 04	Q2 2025 earnings	Positive	+3.4%	Q2 revenues up 72% YoY with notable AUVELITY strength and SYMBRAVO launch.
May 05	Q1 2025 earnings	Positive	+3.8%	Q1 revenue up 62% YoY and SYMBRAVO FDA approval highlighted.
Feb 18	FY 2024 earnings	Positive	-2.3%	Robust 2024 revenue growth and key approvals but shares fell post‑report.
Nov 12	Q3 2024 earnings	Positive	+9.3%	Q3 2024 revenue up 81% YoY with strong AUVELITY momentum.

Pattern Detected

Earnings reports have generally been received positively, with 4 of the last 5 earnings releases followed by share price gains.

Recent Company History

Over the past five earnings cycles, Axsome has reported consistently rising net product revenue, led by AUVELITY and SUNOSI, and reinforced by SYMBRAVO’s launch. Earnings releases on Nov 3, 2025, Aug 4, 2025, and May 5, 2025 all coincided with positive one‑day moves, while the Feb 18, 2025 full‑year 2024 report saw a pullback despite strong growth. These events also tracked ongoing pipeline advances and key regulatory submissions, similar in structure to today’s update.

Historical Comparison

+3.0% avg move · Over the last 5 earnings releases, AXSM shares moved an average of 2.96%, typically reacting positiv...

earnings

+3.0%

Average Historical Move earnings

Over the last 5 earnings releases, AXSM shares moved an average of 2.96%, typically reacting positively to strong revenue growth and pipeline updates.

Earnings updates have shown steady revenue expansion from Q3 2024 through Q3 2025, driven by AUVELITY and SUNOSI, plus the addition of SYMBRAVO, alongside advancing AXS‑05, AXS‑12, AXS‑14, and solriamfetol programs toward late‑stage milestones.

Market Pulse Summary

This announcement highlights robust commercial execution, with Q4 2025 net product revenue of $196.0...

Analysis

This announcement highlights robust commercial execution, with Q4 2025 net product revenue of $196.0M and full‑year revenue of $638.5M, plus strong AUVELITY and SUNOSI growth. Management still reports a net loss of $183.2M but ends the year with $322.9M in cash. Investors may focus on the April 30, 2026 AXS‑05 PDUFA date, the planned AXS‑12 NDA, and multiple Phase 3 programs as key drivers to monitor.

Key Terms

snda, pdufa, nda, phase 3, +3 more

7 terms

snda regulatory

"sNDA for AXS-05 for the treatment of Alzheimer’s disease agitation granted Priority Review"

A SNDA (Subordination, Non‑Disturbance and Attornment Agreement) is a legal pact among a property owner’s lender, the owner’s tenants, and sometimes the landlord that sets who keeps lease rights if the property is sold or a mortgage is enforced. Think of it as a rulebook that decides whether a tenant can stay and keep paying rent or must answer to a new owner after a foreclosure. For investors, an SNDA matters because it protects predictable rental income, clarifies who has priority on claims against a property, and therefore affects a property’s value and the security of related loans.

pdufa regulatory

"Priority Review with PDUFA target action date of April 30, 2026"

PDUFA, short for the Prescription Drug User Fee Act, is a law that allows drug companies to pay fees to the government to speed up the review process for new medicines. This helps bring important drugs to market more quickly, which can impact their availability and pricing. For investors, PDUFA timelines can influence the timing of a drug’s approval and potential market success.

nda regulatory

"NDA filing for AXS-12 in narcolepsy, and clinical trial progress"

An NDA, or nondisclosure agreement, is a legal contract that keeps certain information private between parties. It’s like a promise not to share sensitive details, helping protect business ideas, strategies, or data from being leaked or used without permission. For investors, NDAs help ensure that confidential information remains secure, enabling trust and open communication during business discussions.

phase 3 medical

"Phase 3, randomized, double-blind, placebo-controlled, multicenter trial evaluating"

Phase 3 is the late-stage clinical testing step for a new drug or medical treatment, where the product is given to large groups of patients to confirm effectiveness, monitor side effects, and compare it to standard care. Successful Phase 3 results are often the final scientific hurdle before regulators decide on approval and market launch—like passing a final exam before graduation—and can sharply change a company's valuation and future revenue prospects.

randomized, double-blind, placebo-controlled medical

"Phase 3, randomized, double-blind, placebo-controlled, multicenter trial evaluating"

A "randomized, double-blind, placebo-controlled" process is a method used to test the effectiveness of a new treatment or intervention. Participants are randomly assigned to different groups, with one receiving the real treatment and the other a fake version, called a placebo. Neither the participants nor the researchers know who is receiving which, which helps ensure unbiased results. For investors, this rigorous approach increases confidence that the findings are accurate and not influenced by guesswork or bias.

open-label medical

"starts with a 12-week open-label AXS-14 treatment period followed by randomization"

Open-label describes a situation where everyone involved in a study or process knows the full details, such as who is receiving a treatment or intervention. For investors, understanding whether a project or product is open-label helps gauge the level of transparency and potential biases, influencing trust and decision-making. It’s like knowing whether a test or experiment is conducted openly or behind closed doors.

orphan drug designation regulatory

"AXS-12 has been granted FDA Orphan Drug designation for narcolepsy."

Orphan drug designation is a special status given to medicines developed to treat rare diseases affecting only a small number of people. This status often provides benefits like faster approval processes and financial incentives, making it more attractive for companies to develop these drugs. For investors, it signals potential for exclusive market rights and reduced competition, which can impact the drug’s profitability.

AI-generated analysis. Not financial advice.

Total 4Q and full year 2025 net product revenue of $196.0 million and $638.5 million, respectively, representing 65% and 66% year-over-year growth

AUVELITY® 4Q and full year 2025 net product sales of $155.1 million and $507.1 million, respectively, representing 68% and 74% year-over-year growth

SUNOSI® 4Q and full year 2025 net product revenue of $36.7 million and $124.8 million, respectively, representing 40% and 32% year-over-year growth

SYMBRAVO® 4Q and full year 2025 net product sales of $4.1 million and $6.6 million, respectively

sNDA for AXS-05 for the treatment of Alzheimer’s disease agitation granted Priority Review with PDUFA target action date of April 30, 2026

Acquired AXS-17, a novel oral GABAA α2,3 receptor positive allosteric modulator

Company to host conference call today at 8:00 AM Eastern

NEW YORK, Feb. 23, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced financial results for the fourth quarter and full year 2025 and provided a general business update.

“Our fourth quarter and full year 2025 results demonstrate strong commercial momentum across our marketed products, and advancement and expansion of our innovative CNS pipeline, which now includes five differentiated product candidates,” said Herriot Tabuteau, MD, Chief Executive Officer of Axsome Therapeutics. “2026 promises to be another eventful year for Axsome with continued commercial execution, and multiple regulatory and clinical milestones including potential FDA action on our sNDA for AXS-05 in Alzheimer’s disease agitation, NDA filing for AXS-12 in narcolepsy, and clinical trial progress across our development portfolio.”

Fourth Quarter and Full Year 2025 Financial Highlights

• Total net product revenue was $196.0 million for the fourth quarter 2025 and $638.5 million for the full year 2025, representing 65% and 66% year-over-year growth. Total net product revenue for the comparable periods in 2024 were $118.8 million and $385.7 million, respectively. The increase was driven by strong growth of AUVELITY and SUNOSI, and contributions from the recent launch of SYMBRAVO.

• AUVELITY net product sales were $155.1 million for the fourth quarter 2025 and $507.1 million for the full year 2025, representing 68% and 74% year-over-year growth, in the third full year of commercial launch. AUVELITY net product sales for the comparable periods in 2024 were $92.6 million and $291.4 million, respectively.

• SUNOSI net product revenue was $36.7 million for the fourth quarter 2025 and $124.8 million for the full year 2025, representing 40% and 32% year-over-year growth. SUNOSI revenue for the fourth quarter consisted of $35.4 million in net product sales and $1.3 million in royalty revenue from sales in out-licensed territories. SUNOSI revenue for the year consisted of $120.1 million in net product sales and $4.7 million in royalty revenue from sales in out-licensed territories. SUNOSI net product revenues for the comparable periods in 2024 were $26.2 million and $94.3 million, respectively, which consisted of $24.7 million and $90.3 million in net product sales.

• SYMBRAVO net product sales were $4.1 million for the fourth quarter 2025 and $6.6 million for the full year 2025.

• Total cost of revenue was $12.3 million for the fourth quarter 2025 and $47.5 million for the full year 2025, compared to $10.5 million and $33.3 million for the fourth quarter and full year 2024.

• Research and development (R&D) expenses were $48.8 million for the fourth quarter 2025 and $183.3 million for the full year 2025, compared to $55.0 million and $187.1 million for the fourth quarter and full year 2024. The decrease for the year primarily reflects the completion of clinical trials for AXS-05 in Alzheimer’s disease agitation and for solriamfetol in ADHD and MDD, partially offset by one-time acquisition-related expenses and higher costs related to AXS-07.

• Selling, general, and administrative (SG&A) expenses were $169.3 million for the fourth quarter 2025 and $570.6 million for the full year 2025, compared to $113.3 million and $411.4 million for the fourth quarter and full year 2024. The increase for the year primarily reflects commercialization activities for AUVELITY, including the sales force expansion and the national launch of our direct-to-consumer advertising campaign, and the commercial launch of SYMBRAVO.

• Net loss was $28.6 million, or $(0.56) per share, for the fourth quarter 2025 and $183.2 million, or $(3.68) per share, for the full year 2025, compared to a net loss of $74.9 million, or $(1.54) per share, for the fourth quarter 2024 and $287.2 million, or $(5.99) per share, for the full year 2024. Net loss for the fourth quarter 2025 includes $22.7 million in stock-based compensation expense compared to $22.0 million in stock-based compensation expense for the fourth quarter 2024. Net loss for the full year 2025 includes $93.8 million in stock-based compensation expense, compared to $85.2 million in stock-based compensation expense for the full year 2024.

• Cash and cash equivalents totaled $322.9 million at December 31, 2025, compared to $315.4 million at December 31, 2024.

• Shares of common stock outstanding were 50,882,766 at December 31, 2025.

Financial Guidance

• Axsome believes that its current cash is sufficient to fund anticipated operations into cash flow positivity, based on the current operating plan.
  

Commercial Highlights

AUVELITY

AUVELITY is the first and only rapid-acting oral NMDA receptor antagonist and sigma-1 receptor agonist approved in the U.S. for the treatment of major depressive disorder.

• Approximately 225,000 prescriptions were written for AUVELITY in the fourth quarter, a 42% increase compared to the fourth quarter of 2024, and an 8% increase compared to the third quarter of 2025.

• Payer coverage for AUVELITY across all channels is currently at approximately 86% of all lives. The proportion of lives covered in the commercial and government (Medicare and Medicaid) channels are approximately 78% and 100%, respectively.

• In response to strong and growing demand in MDD and to support the potential approval and launch of AUVELITY in Alzheimer’s disease agitation, Axsome recently initiated an expansion of the AUVELITY sales force to approximately 600 sales representatives. The expansion is expected to complete in the second quarter of 2026.
  

SUNOSI

SUNOSI is the first and only DNRI approved for the treatment of excessive daytime sleepiness associated with obstructive sleep apnea or narcolepsy.

• Approximately 54,000 prescriptions were written for SUNOSI in the U.S. in the fourth quarter, an 11% increase compared to the fourth quarter of 2024, and a 3% increase compared to the third quarter of 2025.

• Payer coverage for SUNOSI across all channels is currently at approximately 82% of all lives. The proportion of lives covered in the commercial and government channels are approximately 96% and 60%, respectively.

SYMBRAVO

SYMBRAVO is an oral, rapidly absorbed, multi-mechanistic, COX-2 preferential inhibitor and 5-HT_1B/1D agonist approved in the U.S. for the acute treatment of migraine with or without aura in adults.

• Approximately 13,000 prescriptions were written for SYMBRAVO in the fourth quarter of 2025, representing a 147% increase compared to the third quarter of 2025.

• Payer coverage for SYMBRAVO across all channels is currently at approximately 52% of all lives. The proportion of lives covered in the commercial and government channels are approximately 49% and 57%, respectively.

Development Pipeline

Axsome is advancing an industry-leading neuroscience pipeline of multiple, innovative, patent-protected product candidates addressing serious psychiatric and neurological conditions. Recent and anticipated progress for key pipeline programs is summarized below.

AXS-05

AXS-05 (dextromethorphan-bupropion) is Axsome’s novel, oral, investigational N-methyl-D-aspartate (NMDA) receptor antagonist, sigma-1 agonist, and aminoketone CYP2D6 inhibitor being developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation.

• Alzheimer’s Disease Agitation: Axsome’s sNDA for AXS-05 for the treatment of Alzheimer’s disease agitation was accepted for filing and granted Priority Review designation by the U.S. Food and Drug Administration (FDA) with a Prescription Drug User Fee Act (PDUFA) target action date of April 30, 2026. AXS-05 was previously granted FDA Breakthrough Therapy designation for AD agitation.

• Smoking Cessation: Axsome plans to initiate a pivotal Phase 2/3 trial of AXS-05 in smoking cessation in the second quarter of 2026.

Solriamfetol

Solriamfetol is Axsome’s dopamine and norepinephrine reuptake inhibitor (DNRI), TAAR1 agonist, and 5-HT_1A agonist being developed for the treatment of attention deficit hyperactivity disorder (ADHD), major depressive disorder (MDD) with excessive daytime sleepiness (EDS) symptoms, binge eating disorder (BED), and excessive sleepiness associated with shift work disorder (SWD).

• Attention Deficit Hyperactivity Disorder: Axsome plans to conduct two pediatric Phase 3 trials of solriamfetol, one in children and one in adolescents, following a recent Type B meeting with the FDA. The Company plans to initiate both trials in the first half of 2026.

• Major Depressive Disorder with Excessive Daytime Sleepiness symptoms: Axsome is on track to initiate a Phase 3 trial of solriamfetol in MDD patients with EDS symptoms in the first quarter of 2026.

• Binge Eating Disorder: Axsome is conducting the ENGAGE study, a Phase 3, randomized, double-blind, placebo-controlled, multicenter trial evaluating the efficacy and safety of solriamfetol in BED. The Company anticipates topline results from the ENGAGE Phase 3 trial in the second half of 2026.

• Shift Work Disorder: Axsome is conducting the SUSTAIN study, a Phase 3, randomized, double-blind, placebo-controlled, multicenter trial evaluating the efficacy and safety of solriamfetol in SWD in adults. Based on current enrollment trends, the Company anticipates topline results from the SUSTAIN Phase 3 trial in 2027.

AXS-12

AXS-12 (reboxetine) is Axsome’s novel, oral, investigational, highly selective and potent norepinephrine reuptake inhibitor and cortical dopamine modulator being developed for the treatment of narcolepsy.

• Narcolepsy: In December 2025, Axsome received formal pre-NDA meeting minutes from the FDA supporting an NDA submission for AXS-12 in narcolepsy. The Company is on track to submit the NDA this quarter. AXS-12 has been granted FDA Orphan Drug designation for narcolepsy.
  

AXS-14

AXS-14 (esreboxetine) is Axsome’s novel, oral, investigational, highly selective and potent norepinephrine reuptake inhibitor being developed for the management of fibromyalgia. Esreboxetine is the SS-enantiomer of reboxetine.

• Fibromyalgia: In January 2026, Axsome initiated the FORWARD study, a Phase 3, double-blind, placebo-controlled, randomized withdrawal trial evaluating the efficacy and safety of AXS-14 for the management of fibromyalgia. This trial will complement the previously completed parallel-group Phase 2 and Phase 3 trials, both of which met their primary endpoints.
  

AXS-17

AXS-17 is Axsome’s novel oral GABA_A receptor α2,3 subtype-selective positive allosteric modulator (PAM) being developed for the treatment of epilepsy.

• Epilepsy: In November 2025, Axsome acquired AZD7325, now designated AXS-17. The Company has initiated tech transfer activities and Phase 2 trial-enabling activities.
  

Corporate Updates

• In February 2026, Axsome announced that it resolved patent litigation with Alkem Laboratories Ltd. related to Alkem’s Abbreviated New Drug Application (ANDA) for a generic version of SUNOSI. The Company entered into a license and settlement agreement with Alkem, which permits Alkem to begin selling its generic version of SUNOSI on or after September 1, 2040, if pediatric exclusivity is granted, or on or after March 1, 2040, if no pediatric exclusivity is granted, subject to FDA approval and conditions and exceptions customary for agreements of this type.
  

Anticipated Milestones

• Regulatory and Commercial:
  • AXS-12 for narcolepsy, NDA submission (1Q 2026)
  • AXS-05 for Alzheimer’s disease agitation, PDUFA target action (April 30, 2026)

• Clinical Trial Topline Results:
  • Phase 3 ENGAGE trial of solriamfetol in binge eating disorder (2H 2026)
  • Phase 3 SUSTAIN trial of solriamfetol in shift work disorder (2027)

• Clinical Trial Initiations:
  • Phase 3 trial of solriamfetol in MDD with EDS symptoms, initiation (1Q 2026)
  • Pivotal Phase 2/3 trial of AXS-05 in smoking cessation, initiation (2Q 2026)
  • Phase 3 trial of solriamfetol in children with ADHD, initiation (1H 2026)
  • Phase 3 trial of solriamfetol in adolescents with ADHD, initiation (1H 2026)
    

Conference Call Information

Axsome will host a conference call and webcast today at 8:00 a.m. Eastern Time to discuss its fourth quarter and full year 2025 financial results and provide a business update. To participate in the live conference call, please dial (877) 405-1239 (toll-free domestic) or +1 (201) 389-0851 (international). A live webcast of the conference call can be accessed on the “Webcasts & Presentations” page of the “Investors” section of the Company’s website at axsome.com. A replay of the conference call will be available for approximately 30 days following the live event.

About Axsome Therapeutics

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, and multiple late-stage development programs addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X.

Forward Looking Statements

Certain matters discussed in this press release are “forward-looking statements”. The Company may, in some cases, use terms such as “predicts,” “believes,” “potential,” “continue,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should” or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. In particular, the Company’s statements regarding trends and potential future results are examples of such forward-looking statements. The forward-looking statements include risks and uncertainties, including, but not limited to, the commercial success of the Company’s SUNOSI^®, AUVELITY^®, and SYMBRAVO^® products and the success of the Company’s efforts to obtain any additional indication(s) with respect to solriamfetol and/or AXS-05; the Company’s ability to maintain and expand payer coverage; the success, timing and cost of the Company’s ongoing clinical trials and anticipated clinical trials for the Company’s current product candidates, including statements regarding the timing of initiation, pace of enrollment and completion of the trials (including the Company’s ability to fully fund the Company’s disclosed clinical trials, which assumes no material changes to the Company’s currently projected revenues or expenses), futility analyses and receipt of interim results, which are not necessarily indicative of the final results of the Company’s ongoing clinical trials, and/or data readouts, and the number or type of studies or nature of results necessary to support the filing of a new drug application (“NDA”) for any of the Company’s current product candidates; the Company’s ability to fund additional clinical trials to continue the advancement of the Company’s product candidates; the timing of and the Company’s ability to obtain and maintain U.S. Food and Drug Administration (“FDA”) or other regulatory authority approval of, or other action with respect to, the Company’s product candidates, including statements regarding the timing of any NDA submission; the Company’s ability to successfully defend its intellectual property or obtain the necessary licenses at a cost acceptable to the Company, if at all; the Company’s ability to successfully resolve any intellectual property litigation, and even if such disputes are settled, whether the applicable federal agencies will approve of such settlements; the successful implementation of the Company’s research and development programs and collaborations; the success of the Company’s license agreements; the acceptance by the market of the Company’s products and product candidates, if approved; the Company’s anticipated capital requirements, including the amount of capital required for the commercialization of SUNOSI, AUVELITY, and SYMBRAVO and for the Company’s commercial launch of its other product candidates, if approved, and the potential impact on the Company’s anticipated cash runway; the Company’s ability to convert sales to recognized revenue and maintain a favorable gross to net sales; unforeseen circumstances or other disruptions to normal business operations arising from or related to domestic political climate, geo-political conflicts or a global pandemic and other factors, including general economic conditions and regulatory developments, not within the Company’s control. The factors discussed herein could cause actual results and developments to be materially different from those expressed in or implied by such statements. The forward-looking statements are made only as of the date of this press release and the Company undertakes no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.

Axsome Therapeutics, Inc. Selected Consolidated Financial Data

Axsome Therapeutics, Inc. Consolidated Balance Sheets (Unaudited, in thousands, except share and per share amounts)
	December 31, 2025				December 31, 2024
Assets
Current assets:
Cash and cash equivalents	$	322,933			$	315,353
Accounts receivable, net		224,464				142,001
Inventories, net		27,938				15,732
Prepaid and other current assets		13,651				11,978
Total current assets		588,986				485,064
Equipment, net		562				584
Right-of-use asset - operating lease		20,858				5,383
Goodwill		12,042				12,042
Intangible asset, net		40,519				46,894
Non-current inventory and other assets		26,838				18,531
Total assets	$	689,805			$	568,498
Liabilities and stockholders’ equity
Current liabilities:
Accounts payable	$	65,537			$	71,997
Accrued expenses and other current liabilities		232,853				147,987
Operating lease liability, current portion		434				1,835
Contingent consideration, current		10,012				8,285
Short-term borrowings		70,000				—
Total current liabilities		378,836				230,104
Contingent consideration, non-current		77,540				91,680
Loan payable, long-term		117,746				180,710
Operating lease liability, long-term		23,182				6,046
Finance lease liability, long-term		4,206				2,943
Total liabilities		601,510				511,483
Stockholders’ equity:
Preferred stock, $0.0001 par value per share (10,000,000 shares authorized, none issued and outstanding)		—				—
Common stock, $0.0001 par value per share (150,000,000 shares authorized, 50,882,766 and 48,667,587 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively)		5				5
Additional paid-in capital		1,394,251				1,179,797
Accumulated deficit		(1,305,961	)			(1,122,787	)
Total stockholders’ equity		88,295				57,015
Total liabilities and stockholders’ equity	$	689,805			$	568,498

Axsome Therapeutics, Inc. Consolidated Statements of Operations (Unaudited, in thousands, except share and per share amounts)
	Three months ended December 31,								Year ended December 31,
	2025				2024				2025				2024
Revenues:
Product sales, net	$	194,695			$	117,325			$	633,796			$	381,677
Royalty revenue and milestone revenue		1,304				1,441				4,700				4,016
Total revenues		195,999				118,766				638,496				385,693
Operating expenses:
Cost of revenue (excluding amortization and depreciation)		12,329				10,514				47,478				33,303
Research and development		48,791				55,006				183,279				187,077
Selling, general and administrative		169,297				113,271				570,599				411,359
Loss (Gain) in fair value of contingent consideration		(9,068	)			10,985				(2,473	)			28,124
Intangible asset amortization		1,607				1,607				6,375				6,392
Total operating expenses		222,956				191,383				805,258				666,255
Loss from operations		(26,957	)			(72,617	)			(166,762	)			(280,562	)
Interest expense, net		(1,172	)			(2,210	)			(6,557	)			(6,569	)
Loss on debt extinguishment		—				—				(10,385	)			—
Loss before income taxes		(28,129	)			(74,827	)			(183,704	)			(287,131	)
Income tax benefit (expense)		(430	)			(85	)			530				(85	)
Net loss	$	(28,559	)		$	(74,912	)		$	(183,174	)		$	(287,216	)
Net loss per common share, basic and diluted	$	(0.56	)		$	(1.54	)		$	(3.68	)		$	(5.99	)
Weighted average common shares outstanding, basic and diluted		50,631,337				48,541,905				49,747,178				47,914,253

Investors:
Ashley Dong
Director, Investor Relations
(929) 687-1614
adong@axsome.com

Media:
Darren Opland
Senior Director, Corporate Communications
(929) 837-1065
dopland@axsome.com

FAQ

What were Axsome's total net product revenues for 2025 (AXSM)?

Axsome reported $638.5M in total net product revenue for full year 2025, a 66% increase year-over-year. According to the company, growth was driven primarily by AUVELITY, SUNOSI, and the recent launch of SYMBRAVO.

How did AUVELITY perform commercially in Q4 2025 (AXSM)?

AUVELITY generated $155.1M in net product sales in Q4 2025, a 68% year-over-year increase. According to the company, ~225,000 prescriptions were written in Q4, and payer coverage is approximately 86% of lives.

What is the regulatory timeline for AXS-05 in Alzheimer’s disease agitation (AXSM)?

AXS-05 sNDA received Priority Review with a PDUFA target action date of April 30, 2026. According to the company, AXS-05 previously held Breakthrough Therapy designation for AD agitation.

What acquisition did Axsome announce and why does it matter to investors (AXSM)?

Axsome acquired AXS-17, an oral GABAA α2,3 selective PAM, to expand its epilepsy franchise. According to the company, tech transfer and Phase 2 trial–enabling activities have commenced following the November 2025 acquisition.

How much cash did Axsome report at year-end and what does management say about runway (AXSM)?

Axsome reported $322.9M in cash and cash equivalents at December 31, 2025. According to the company, current cash is expected to fund operations into cash flow positivity based on the existing operating plan.

What drove the increase in Axsome's SG&A expenses in 2025 (AXSM)?

SG&A rose to $570.6M in 2025, reflecting sales force expansion, national direct-to-consumer advertising, and SYMBRAVO commercial launch. According to the company, these commercialization activities were the primary contributors to higher SG&A.