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BioLineRx Reports 2025 Financial Results and Provides Corporate Update

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BioLineRx (NASDAQ: BLRX) reported audited 2025 results and corporate updates on March 23, 2026. Key highlights: $20.9 million cash on hand supporting a runway into H1 2027; net loss $2.0 million in 2025 versus $9.2 million in 2024; USPTO Notice of Allowance for a GLIX1 patent extending protection to 2040 (plus possible extension).

The company expects to initiate a Phase 1/2a GLIX1 glioblastoma trial by month-end, with Phase 1 data targeted in H1 2027; motixafortide interim analysis in mPDAC is anticipated in 2026.

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Positive

  • Cash balance of $20.9 million provides runway into first half of 2027
  • Net loss narrowed to $2.0 million in 2025 from $9.2 million in 2024
  • USPTO Notice of Allowance for GLIX1 patent extends protection through 2040
  • GLIX1 Phase 1/2a glioblastoma trial initiation expected by end of March 2026
  • APHEXDA full‑year 2025 sales of $6.7 million produced $1.2 million royalties

Negative

  • Total revenues fell to $1.2 million in 2025 after prior upfront and milestone receipts
  • U.S. commercial operations shutdown left zero sales and marketing expenses in 2025
  • Cash runway only covers operations into H1 2027 without new financing

News Market Reaction – BLRX

-12.45% 5.6x vol
9 alerts
-12.45% News Effect
-9.5% Trough in 3 hr 58 min
-$2M Valuation Impact
$11M Market Cap
5.6x Rel. Volume

On the day this news was published, BLRX declined 12.45%, reflecting a significant negative market reaction. Argus tracked a trough of -9.5% from its starting point during tracking. Our momentum scanner triggered 9 alerts that day, indicating moderate trading interest and price volatility. This price movement removed approximately $2M from the company's valuation, bringing the market cap to $11M at that time. Trading volume was exceptionally heavy at 5.6x the daily average, suggesting significant selling pressure.

Data tracked by StockTitan Argus on the day of publication.

Key Figures

Cash & equivalents: $20.9M APHEXDA sales: $6.7M Royalty revenue: $1.2M +5 more
8 metrics
Cash & equivalents $20.9M Balance sheet as of Dec 31, 2025; runway into H1 2027
APHEXDA sales $6.7M Full-year 2025 product sales generating royalty stream
Royalty revenue $1.2M 2025 revenues from APHEXDA U.S. commercialization by Ayrmid
2025 revenues $1.2M Year ended Dec 31, 2025; down from $15.0M-related items in 2024
R&D expenses $8.1M 2025 vs $9.2M in 2024; lower motixafortide costs, GLIX1 initiation
G&A expenses $3.1M 2025 vs $6.3M in 2024; 50.3% decrease with headcount reduction
Net loss $2.0M Year ended Dec 31, 2025 vs $9.2M net loss in 2024
Phase 1 sample size Up to 30 patients Phase 1 portion of GLIX1 trial in recurrent/progressive GBM

Market Reality Check

Price: $2.42 Vol: Volume 8,146 vs 20-day av...
normal vol
$2.42 Last Close
Volume Volume 8,146 vs 20-day average 10,003 (relative volume 0.81x) suggests no pre-news accumulation spike. normal
Technical Shares at $2.65 trade below the 200-day MA of $3.60 and sit closer to the 52-week low ($2.30) than the high ($7.77).

Peers on Argus

BLRX was down 2.19% while biotech peers showed mixed moves: EDSA +3.23%, THAR +5...
1 Up

BLRX was down 2.19% while biotech peers showed mixed moves: EDSA +3.23%, THAR +5.8%, PRTG -10.39%, MTVA -5.37% in sector snapshot, with only MTVA later flagged on a momentum scan at +4.96% and no related news. This pattern points to stock-specific dynamics rather than a coordinated sector trend.

Previous Earnings Reports

5 past events · Latest: Nov 24 (Positive)
Same Type Pattern 5 events
Date Event Sentiment Move Catalyst
Nov 24 Q3 2025 earnings Positive +7.7% GLIX1 JV, key patent allowance, cash runway and APHEXDA royalties update.
Aug 14 Q2 2025 earnings Positive -4.3% APHEXDA royalty revenues, cash runway and encouraging pancreatic cancer data.
May 27 Q1 2025 earnings Positive +0.6% Net income, financing, reduced expenses and ongoing APHEXDA-driven royalties.
Mar 31 2024 annual results Positive -3.0% Transformational APHEXDA license, revenue surge and large loss reduction.
Nov 25 Q3 2024 earnings Neutral -2.3% Ayrmid license, equity raise and debt restructuring with ongoing net loss.
Pattern Detected

Across 5 recent earnings-related releases, BLRX showed a mixed reaction pattern with an average move of -0.26%, alternating between strong positive and negative responses to fundamentally constructive updates.

Recent Company History

Over the past year, BLRX’s earnings releases have consistently paired financial updates with pipeline progress. Prior reports highlighted APHEXDA royalties, significant operating expense reductions, and an extended cash runway into H1 2027, alongside clinical advances in the CheMo4METPANC pancreatic cancer trial and SCD gene therapy studies. The Q3 2025 update introduced the GLIX1 joint venture and strengthened IP into 2040+. Today’s 2025 annual results continue this pattern, combining leaner operations, a narrower net loss, and GLIX1 entering first-in-human testing.

Historical Comparison

-0.3% avg move · Past 5 earnings updates saw an average move of -0.26% despite frequent positive cash and pipeline ne...
earnings
-0.3%
Average Historical Move earnings

Past 5 earnings updates saw an average move of -0.26% despite frequent positive cash and pipeline news. Today’s annual results similarly blend tighter losses with GLIX1 and motixafortide progress.

Earnings releases have tracked a shift from APHEXDA-heavy commercial figures toward a leaner R&D model focused on GLIX1 in glioblastoma and ongoing CheMo4METPANC and SCD gene-therapy studies.

Market Pulse Summary

The stock dropped -12.4% in the session following this news. A negative reaction despite improved 20...
Analysis

The stock dropped -12.4% in the session following this news. A negative reaction despite improved 2025 loss of $2.0M and cash of $20.9M would fit BLRX’s history of mixed responses to earnings, where the average move has been -0.26%. The market may focus on lower reported revenues versus 2024 and the transition away from in-house APHEXDA sales. Future sentiment could hinge on execution of the GLIX1 Phase 1/2a trial and progress in the CheMo4METPANC study.

Key Terms

phase 1/2a, glioblastoma, dna damage response, blood-brain-barrier, +4 more
8 terms
phase 1/2a medical
"On track to initiate a Phase 1/2a clinical trial of GLIX1 in glioblastoma"
Phase 1/2a is an early stage in testing new medicines or treatments, combining two steps into one process. It helps researchers quickly assess whether a treatment is safe and shows signs of working, while also gathering initial information on the best dosage. For investors, this stage indicates how close a potential new therapy is to becoming available and its initial safety profile.
glioblastoma medical
"clinical trial of GLIX1 for treatment of glioblastoma (GBM) by end of this month"
Glioblastoma is a fast-growing and aggressive type of brain tumor that can affect a person's thinking, movement, or senses. Its seriousness and difficulty to treat can lead to significant health impacts, making it a concern for medical research and drug development. For investors, advances or setbacks in glioblastoma treatments can influence biotech companies and healthcare markets focused on cancer therapies.
dna damage response medical
"by targeting DNA damage response mechanisms"
A DNA damage response is the set of cellular systems that detect and repair breaks or errors in a cell’s genetic material; think of it as a repair crew and alarm system that keeps DNA functioning properly. It matters to investors because drugs that enhance, inhibit, or exploit these repair pathways can change a therapy’s effectiveness, safety, market potential and regulatory risk, affecting the value of biotech and pharmaceutical companies.
blood-brain-barrier medical
"excellent blood-brain-barrier penetration and a favorable safety profile"
A protective layer of tightly joined cells and supporting tissue that controls what substances move from the bloodstream into the brain, acting like a security gate that lets nutrients through but blocks many drugs, toxins and pathogens. For investors, the blood–brain barrier matters because a drug’s ability (or inability) to cross that barrier strongly influences development risk, clinical success, regulatory hurdles, timelines and the potential market size for therapies targeting brain diseases.
cytidine deaminase (cda) medical
"cancers in which cytidine deaminase (CDA) is not over-expressed"
An enzyme that alters cytidine, a building block of DNA/RNA, by removing an amine group; think of it like a factory machine that changes parts so they can be broken down or repurposed. Investors care because this activity can control how fast certain drugs are metabolized, affect drug effectiveness and side effects, and serve as a biomarker that impacts clinical trial results, dosing decisions and regulatory approvals.
parp inhibitors medical
"potential synergistic effect of GLIX1 in combination with PARP inhibitors"
PARP inhibitors are a class of cancer drugs that block an enzyme cells use to repair damaged DNA, effectively preventing cancer cells from fixing themselves and causing them to die. Investors watch them because their clinical approvals, safety profiles, patent status, and tests that identify which patients will benefit determine market size and revenue potential—much like backing a tool that only works on certain problems but can be very valuable when it does.
progression-free survival (pfs) medical
"interim/futility analysis is planned when 40% of progression-free survival (PFS) events"
Progression-free survival (PFS) measures the length of time in a clinical trial or treatment period during which a patient’s disease does not get worse. Investors watch PFS because longer PFS in trials can signal a drug’s effectiveness, influence regulatory approval and reimbursement decisions, and affect commercial value—think of it as how long a product keeps a problem from returning, which helps estimate future sales and competitive advantage.
hematopoietic stem cell (hsc) medical
"for CD34+ hematopoietic stem cell (HSC) mobilization for gene therapies"
A hematopoietic stem cell (HSC) is a primitive cell found in bone marrow and related tissues that acts like a seed or root for the blood system: it can make all types of blood cells (red cells, white cells, platelets) and can copy itself to keep producing them over a lifetime. Investors care because HSCs are the basis for transplants and many regenerative or cancer treatments, so advances, manufacturing capacity, safety and regulatory approval can drive clinical value and commercial opportunity.

AI-generated analysis. Not financial advice.

- On track to initiate Phase 1/2a clinical trial of GLIX1 for treatment of glioblastoma (GBM) by end of this month -

- GLIX1 is positioned to potentially address unmet needs for novel and more effective cancer treatments by targeting DNA damage response mechanisms -

- Management to host conference call today, March 23, at 8:30 am EDT -

TEL AVIV, Israel, March 23, 2026 /PRNewswire/ -- BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a development stage biopharmaceutical company pursuing life-changing therapies in oncology and rare diseases, today reported its audited financial results for the year ended December 31, 2025, and provided a corporate update.

BioLineRx Logo

"Since our last quarterly update, we have been working diligently to move forward with a Phase 1/2a first-in-human clinical trial of GLIX1 in glioblastoma, and I am pleased to report that we expect to initiate the study by the end of this month, with the commencement of patient enrollment shortly thereafter," stated Philip Serlin, Chief Executive Officer of BioLineRx. "GLIX1, the lead asset that we acquired through our collaboration with Hemispherian, is a unique molecule with a novel mechanism of action that targets the DNA repair mechanism in cancer cells and has demonstrated compelling efficacy in numerous pre-clinical models, excellent blood-brain-barrier penetration and a favorable safety profile in toxicology studies. We are eager to establish the safety, recommended dose and proof-of-concept in order to advance this promising candidate through an efficient development pathway.

"In parallel, we continue to conduct pre-clinical activities in support of further development of GLIX1 in additional cancer indications with high unmet needs, and, separately, we are also conducting studies to further investigate and affirm the potential synergistic effect of GLIX1 in combination with PARP inhibitors, as we work to maximize the value of the GLIX1 opportunity.

"In metastatic pancreatic cancer, enrollment has accelerated in the ongoing CheMo4METPANC Phase 2b clinical trial of motixafortide, which is being led by Columbia University and supported by both Regeneron and BioLineRx, and we continue to anticipate that a prespecified interim/futility analysis will read out in 2026. We believe PDAC represents another opportunity to introduce a much-needed new treatment option to patients suffering from a very challenging tumor type, while creating sustained value for our company," Mr. Serlin concluded.

Corporate Updates

  • Announced that it has received Notice of Allowance from the U.S. Patent and Trademark Office (USPTO) for a key patent covering GLIX1 for cancers in which cytidine deaminase (CDA) is not over-expressed beyond a specific threshold, estimated to be 90% of all cancers.
    • Patent preserves BioLineRx's ability to evaluate GLIX1 in other cancers beyond glioblastoma, including both hematological and solid tumor cancer types.
    • Patent further broadens and strengthens GLIX1's patent protection until 2040, with a possible patent-term extension of up to five years.

Financial Updates

  • With $20.9 million on its balance sheet as of December 31, 2025, BioLineRx is maintaining its cash runway guidance into the first half of 2027.

Clinical Updates
GLIX1

  • On track to initiate a Phase 1/2a clinical trial of GLIX1 in glioblastoma by the end of the month.
    • Three renowned academic centers are planned to participate in this clinical trial: Northwestern University, led by Dr. Roger Stupp and Dr. Ditte Primdahl, NYU Langone Health, led by Dr. Alexandra M. Miller and Moffit Cancer Center, led by Dr. Patrick Grogan.
    • The Phase 1 part of the trial is expected to recruit up to 30 patients with recurrent and progressive GBM and other high-grade gliomas. The objective is to establish a maximum tolerated dose (MTD) and/or a recommended dose based on safety, PK/PD and preliminary efficacy. Data from the Phase 1 part of the trial are anticipated in H1 2027.
    • The Phase 2a expansion part of the trial is planned to include various population cohorts, including GBM (newly diagnosed and/or recurrent), as well as additional cancers with/without standard of care (e.g., PARP inhibitors). These cohorts are expected to identify preliminary efficacy, PD assessments and dose optimization data, serving as the basis for rapid and effective advanced clinical development.
  • Pre-clinical activities in support of clinical development for GLIX1 in additional cancer indications are ongoing.

Motixafortide
Pancreatic Ductal Adenocarcinoma (mPDAC)

  • Enrollment has accelerated in the CheMo4METPANC Phase 2b clinical trial, which is being led by Columbia University, and supported by both Regeneron and BioLineRx. The trial is evaluating motixafortide in combination with the PD-1 inhibitor cemiplimab and standard chemotherapy (gemcitabine and nab-paclitaxel).
    • A prespecified interim/futility analysis is planned when 40% of progression-free survival (PFS) events are observed, which the Company continues to anticipate will occur in 2026.

Sickle Cell Disease (SCD) & Gene Therapy

  • Announced that a poster featuring final results from a Phase 1 clinical trial (NCT05618301) evaluating motixafortide as monotherapy and in combination with natalizumab for CD34+ hematopoietic stem cell (HSC) mobilization for gene therapies in sickle cell disease (SCD) was presented at the 67th American Society of Hematology (ASH) Annual Meeting & Exposition in December.

  • A second SCD study, sponsored by St. Jude Children's Research Hospital, continues to enroll patients. The study is a multi-center Phase 1 clinical trial evaluating motixafortide for the mobilization of CD34+ HSCs for gene therapies for patients with SCD (NCT06442761).

APHEXDA Performance Update

  • For the full-year 2025, APHEXDA sales were $6.7 million, which provided royalty revenue to the Company of $1.2 million.

Financial Results for the Year ended December 31, 2025

  • Revenues for the year ended December 31, 2025 were $1.2 million reflecting the royalties paid by Ayrmid from the commercialization of APHEXDA in stem cell mobilization in the U.S. Total revenues in 2025 are not comparable to the same period in 2024, which primarily reflect a portion of the up-front payment received by the Company under the Gloria License Agreement and a milestone payment achieved under the Gloria License Agreement, which collectively amounted to $15.0 million, as well as the up-front payment received under the Ayrmid License Agreement and $6.0 million of net revenues from product sales of APHEXDA in the United States.

  • Cost of revenues for the year ended December 31, 2025 were $0.2 million, compared to cost of revenues of $9.3 million for the year ended December 31, 2024. The cost of revenues in 2025 reflects sub-license fees on royalties paid by Ayrmid from the commercialization of APHEXDA in stem cell mobilization in the U.S. The cost of revenues in 2024 primarily reflects the amortization of intangible assets, sub-license fees on the up-front payment received for the Ayrmid License Agreement, sub-license fees accrued on a milestone payment recorded under the Gloria License Agreement, as well as royalties on net product sales of APHEXDA in the U.S. and cost of goods sold on product sales.

  • Research and development expenses for the year ended December 31, 2025 were $8.1 million, a decrease of $1.1 million, or 11.5%, compared to $9.2 million for the year ended December 31, 2024. The decrease resulted primarily from lower expenses related to motixafortide due to the out-licensing of U.S. rights to Ayrmid, as well as a decrease in payroll and share-based compensation, primarily due to a decrease in headcount, offset by expenses related to initiation of the GLIX1 project.

  • There were no sales and marketing expenses for the year ended December 31, 2025, compared to $23.6 million for the year ended December 31, 2024. The decrease resulted from the shutdown of U.S. commercial operations in the fourth quarter of 2024 following the Ayrmid license agreement.

  • General and administrative expenses for the year ended December 31, 2025 were $3.1 million, a decrease of $3.2 million, or 50.3%, compared to $6.3 million for the year ended December 31, 2024. The decrease resulted primarily from the reversal of a provision for doubtful accounts following receipt of an overdue milestone payment from Gloria, as well as a decrease in payroll and share-based compensation, primarily due to a decrease in headcount, and a decrease in a number of general and administrative expenses.

  • Non-operating income (expenses) for the years ended December 31, 2025 and 2024 primarily relate to fair-value adjustments of warrant liabilities on the Company's balance sheet, as a result of changes in its share price, offset by warrant offering expenses.

  • Net financial income for the year ended December 31, 2025 was $0.2 million, compared to net financial expenses of $7.3 million for the year ended December 31, 2024. Net financial income for 2025 relates to investment income earned on bank deposits and gains on foreign currency (primarily NIS) cash balances due to the appreciation of the NIS against the U.S. dollar during the period, partially offset by interest paid on loans. Net financial expenses for 2024 primarily relate to interest paid on loans, which increased in 2024 due to a one-time $4.0 million charge to interest expense in connection with the November 2024 amendment to loan agreement with BlackRock, partially offset by investment income earned on bank deposits.

  • Net loss for the year ended December 31, 2025 was $2.0 million, compared to $9.2 million for the year ended December 31, 2024.

  • As of December 31, 2025, the Company had cash, cash equivalents, and short-term bank deposits of $20.9 million, sufficient to fund operations, as currently planned, into the first half of 2027.

A copy of the Company's annual report on Form 20-F for the year ended December 31, 2025 has been filed with the U.S. Securities and Exchange Commission at https://www.sec.gov/ and posted on the Company's investor relations website at https://ir.biolinerx.com. The Company will deliver a hard copy of its annual report, including its complete audited consolidated financial statements, free of charge, to its shareholders upon request at IR@biolinerx.com.

Conference Call and Webcast Information
To access the conference call, please dial +1-888-281-1167 from the U.S. or +972-3-918-0685 internationally. A live webcast and a replay of the call can be accessed through the event page on the Company's website. Please allow extra time prior to the call to visit the site and download any necessary software to listen to the live broadcast. The call replay will be available approximately two hours after completion of the live conference call. A dial-in replay of the call will be available until March 25, 2026; please dial +1-888-295-2634 from the US or +972-3-925-5904 internationally.

About BioLineRx
BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX) is a biopharmaceutical company pursuing life-changing therapies in oncology and rare diseases. The Company's lead development asset is GLIX1, a first-in-class, oral, small molecule targeting DNA damage response in glioblastoma and other solid tumors, for which a Phase 1/2a clinical trial is expected to initiate in the first quarter of 2026. GLIX1 is being developed under a collaboration with Hemispherian AS.

The Company's first approved product, APHEXDA® (motixafortide), is indicated in the U.S. for stem cell mobilization for autologous transplantation in multiple myeloma, and is being commercialized by Ayrmid Ltd. (globally, except Asia) and developed by Gloria Biosciences (in Asia). BioLineRx has retained the rights to develop motixafortide in solid tumors, including metastatic pancreatic cancer (PDAC), and has a Phase 2b PDAC trial currently ongoing under a collaboration with Columbia University.

Learn more about who we are, what we do, and how we do it at www.biolinerx.com, or on LinkedIn.  

Forward Looking Statement
Various statements in this release concerning BioLineRx's future expectations constitute "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These statements include words such as "anticipates," "believes," "could," "estimates," "expects," "intends," "may," "plans," "potential," "predicts," "projects," "should," "will," and "would," and describe opinions about future events. These include statements regarding management's expectations, beliefs and intentions regarding, among other things, the expectations with regard to clinical trials of motixafortide and GLIX1, expected timing of clinical readouts, the expected cash runway, and BioLineRx's business strategy. These forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of BioLineRx to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Factors that could cause BioLineRx's actual results to differ materially from those expressed or implied in such forward-looking statements include, but are not limited to: the clinical development, commercialization and market acceptance of GLIX1 and motixafortide including the degree and pace of market uptake of APHEXDA for the mobilization of hematopoietic stem cells for autologous transplantation in multiple myeloma patients; the initiation, timing, progress and results of BioLineRx's preclinical studies, clinical trials and other therapeutic candidate development efforts; BioLineRx's ability to advance GLIX1 and motixafortide into clinical trials or to successfully complete its preclinical studies or clinical trials; whether the clinical trial results for GLIX1 and motixafortide will be predictive of real-world results; BioLineRx's receipt of regulatory approvals for GLIX1 and motixafortide and the timing of other regulatory filings and approvals; whether access to GLIX1 and motixafortide is achieved in a commercially viable manner and whether GLIX1 and motixafortide receives adequate reimbursement from third-party payors; BioLineRx's ability to establish, manage, and maintain corporate collaborations, as well as the ability of BioLineRx's collaborators to execute on their development and commercialization plans; BioLineRx's ability to integrate new therapeutic candidates and new personnel, as well as new collaborations; the interpretation of the properties and characteristics of BioLineRx's therapeutic candidates and of the results obtained with its therapeutic candidates in preclinical studies or clinical trials; the implementation of BioLineRx's business model and strategic plans for its business and therapeutic candidates; the scope of protection that BioLineRx's is able to establish and maintain for intellectual property rights covering its therapeutic candidates and its ability to operate its business without infringing the intellectual property rights of others; estimates of BioLineRx's expenses, future revenues, capital requirements and its need for and ability to access sufficient additional financing; risks related to changes in healthcare laws, rules and regulations in the United States or elsewhere; competitive companies, technologies and BioLineRx's industry; BioLineRx's ability to maintain the listing of its ADSs on Nasdaq; statements as to the impact of the political and security situation in Israel on BioLineRx's business which may exacerbate the magnitude of the factors discussed above. These and other factors are more fully discussed in the "Risk Factors" section of BioLineRx's most recent annual report on Form 20-F filed with the Securities and Exchange Commission on March 23, 2026. In addition, any forward-looking statements represent BioLineRx's views only as of the date of this release and should not be relied upon as representing its views as of any subsequent date. BioLineRx does not assume any obligation to update any forward-looking statements unless required by law.

Contacts:

United States
Irina Koffler
LifeSci Advisors, LLC
IR@biolinerx.com

Israel
Moran Meir
LifeSci Advisors, LLC
moran@lifesciadvisors.com

 

BioLineRx Ltd.

CONSOLIDATED STATEMENTS OF FINANCIAL POSITION







December 31,



2024

2025



in USD thousands

Assets




CURRENT ASSETS                                                                                   




Cash and cash equivalents


10,436

3,250

Short-term bank deposits


9,126

17,626

Trade receivables


2,476

46

Prepaid expenses


443

201

Other receivables


1,478

410

Inventory


3,145

2,148

      Total current assets


27,104

23,681





NON-CURRENT ASSETS




Property and equipment, net


386

160

Right-of-use assets, net


967

696

Intangible assets, net


10,449

16,368

          Total non-current assets


11,802

17,224

          Total assets


38,906

40,905





Liabilities and equity




CURRENT LIABILITIES




Current maturities of long-term loan


4,479

4,479

Accounts payable and accruals:




     Trade


5,583

3,493

     Other


3,131

1,743

Current maturities of lease liabilities


522

234

Warrants


1,691

2,174

          Total current liabilities


15,406

12,123





NON-CURRENT LIABILITIES




Long-term loan, net of current maturities


8,958

4,460

Lease liabilities


1,081

977

          Total non-current liabilities


10,039

5,437





 

COMMITMENTS AND CONTINGENT LIABILITIES




          Total liabilities


25,445

17,560





EQUITY




Equity attributable to owners of the Company:




     Ordinary shares


38,097

73,428

     Share premium


353,693

327,584

     Warrants


5,367

3,686

     Capital reserve


17,547

15,916

     Other comprehensive loss


(1,416)

(1,416)

     Accumulated deficit


(399,827)

(401,002)

          Total equity attributable to owners of the Company


13,461

18,196

Non-controlling interest                                 


-

5,149

          Total equity


13,461

23,345

          Total liabilities and equity


38,906

40,905

 

BioLineRx Ltd.

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS






Year ended December 31,



2023

2024

2025



in USD thousands






REVENUES:





 License revenues


4,610

22,917

1,180

     Product sales, net


190

6,023

-

          Total revenues


4,800

28,940

1,180

COST OF REVENUES


(3,692)

(9,263)

(230)

GROSS PROFIT


1,108

19,677

950

RESEARCH AND DEVELOPMENT EXPENSES                    


(12,519)

(9,149)

(8,093)

SALES AND MARKETING EXPENSES


(25,270)

(23,605)

-

GENERAL AND ADMINISTRATIVE EXPENSES


(6,310)

(6,321)

(3,144)

IMPAIRMENT OF INTANGIBLE ASSETS


(6,703)

(1,010)

-

OPERATING LOSS


(49,694)

(20,408)

(10,287)

NON-OPERATING INCOME (EXPENSES), NET


(10,819)

18,435

8,077

FINANCIAL INCOME


2,068

1,871

1,464

FINANCIAL EXPENSES


(2,169)

(9,119)

(1,280)

LOSS AND COMPREHENSIVE LOSS


(60,614)

(9,221)

(2,026)






ATTRIBUTION OF LOSS AND

     COMPREHENSIVE LOSS





     To owners of the Company


(60,614)

(9,221)

(1,175)

     To non-controlling interests


-

-

(851)



(60,614)

(9,221)

(2,026)








in USD

LOSS PER ORDINARY SHARE – BASIC AND

     DILUTED ATTRIBUTABLE TO OWNERS OF

     THE COMPANY


(0.06)

(0.01)

(0.00)






WEIGHTED AVERAGE NUMBER OF SHARES

     USED IN CALCULATION OF BASIC AND

     DILUTED LOSS PER ORDINARY SHARE


963,365,525

1,198,107,761

2,465,272,604






 

BioLineRx Ltd.

STATEMENTS OF CHANGES IN EQUITY






Equity attributable to owners of the Company




 

 

Ordinary shares

 

Share premium

 

 

Warrants

 

Capital reserve

Other comprehensive
 loss

 

Accumulated deficit

Non-

controlling interest

 

 

Total


in shares 000's

in USD thousands

BALANCE AT JANUARY 1, 2023

922,959

27,100

338,976

1,408

14,765

(1,416)

(329,992)

-

50,841

CHANGES IN 2023:










  Issuance of share capital, net

124,955

3,242

10,847

-

-

-

-

-

14,089

  Warrants exercised

38,182

1,000

5,559

-

-

-

-

-

6,559

  Employee stock options exercised

493

13

45

-

(31)

-

-

-

27

  Employee stock options expired

-

-

55

-

(55)

-

-

-

-

  Share-based compensation        

-

-

-

-

2,321

-

-

-

2,321

  Comprehensive loss for the year

-

-

-

-

-

-

(60,614)

-

(60,614)

BALANCE AT DECEMBER 31, 2023

1,086,589

31,355

355,482

1,408

17,000

(1,416)

(390,606)

-

13,223

CHANGES IN 2024:










  Issuance of share capital, pre-funded

      warrants and warrants, net

174,322

 

4,712

 

(3,060)

 

6,650

 

-

 

-

 

-

 

-

 

8,302

  Pre-funded warrants exercised

74,989

2,009

682

(2,691)

-

-

-

-

-

  Employee stock options exercised

770

21

50

-

(49)

-

-

-

22

  Employee stock options expired

-

-

539

-

(539)

-

-

-

-

  Share-based compensation        

-

-

-

-

1,135

-

-

-

1,135

  Comprehensive loss for the year

-

-

-

-

-

-

(9,221)

-

(9,221)

BALANCE AT DECEMBER 31, 2024

1,336,670

38,097

353,693

5,367

17,547

(1,416)

(399,827)

-

13,461

CHANGES IN 2025:










  Issuance of share capital, pre-funded

      warrants and warrants, net

978,340

27,273

(22,260)

501

-

-

-

-

5,514

Pre-funded warrants exercised

295,804

8,058

(5,876)

(2,182)

-

-

-

-

-

  Employee stock options expired

-

-

2,027

-

(2,027)

-

-

-

-

  Share-based compensation

-

-

-

-

396

-

-

-

396

  Non-controlling interest

-

-

-

-

-

-

-

6,000

6,000

  Comprehensive loss for the year

-

-

-

-

-

-

(1,175)

(851)

(2,026)

BALANCE AT DECEMBER 31, 2025

2,610,814

73,428

327,584

3,686

15,916

(1,416)

(401,002)

5,149

23,345












 

BioLineRx Ltd.

CONSOLIDATED STATEMENTS OF CASH FLOWS




Year ended December 31,


2023

2024

2025


in USD thousands

CASH FLOWS - OPERATING ACTIVITIES




     Loss

(60,614)

(9,221)

(2,026)

     Adjustments required to reflect net cash used in operating

             activities (see appendix below) 

38,006

(34,652)

(6,048)

Net cash used in operating activities

(22,608)

(43,873)

(8,074)





CASH FLOWS - INVESTING ACTIVITIES




     Investments in short-term deposits

(47,588)

(26,350)

(36,644)

     Maturities of short-term deposits

49,329

55,778

28,126

     Purchase of property and equipment

(116)

(53)

(25)

     Purchase of intangible assets

(181)

(1)

(2)

Net cash provided by (used in) investing activities

1,444

29,374

(8,545)





CASH FLOWS - FINANCING ACTIVITIES




     Issuance of share capital, pre-funded warrants and warrants,

            net of issuance costs

14,089

16,357

13,894

     Exercise of warrants

2,928

-

-

     Employee stock options exercised

27

22

-

Proceeds from long-term loan, net of issuance costs

-

19,223

-

     Repayments of loan

(1,543)

(14,433)

(4,498)

     Repayments of lease liabilities

(445)

(511)

(512)

Net cash provided by financing activities

15,056

20,658

8,884





INCREASE (DECREASE) IN CASH AND CASH

     EQUIVALENTS

(6,108)

6,159

(7,735)

CASH AND CASH EQUIVALENTS - BEGINNING

     OF YEAR

10,587

4,255

10,436

EXCHANGE DIFFERENCES ON CASH AND CASH

     EQUIVALENTS

(224)

22

549

CASH AND CASH EQUIVALENTS - END OF YEAR

4,255

10,436

3,250





 

BioLineRx Ltd.

CONSOLIDATED STATEMENTS OF CASH FLOWS




Year ended December 31,


2023

2024

2025


in USD thousands

APPENDIX








Adjustments required to reflect net cash used in

     operating activities: 




Income and expenses not involving cash flows:




Depreciation and amortization

1,384

4,065

523

Loss on disposal of property and equipment

-

-

25

Exchange differences on cash and cash equivalents                      

224

(22)

(549)

Fair value adjustments of warrants

11,054

(18,965)

(8,599)

Share-based compensation

2,321

1,135

396

Interest and exchange differences on short-term

   deposits

15

185

18

Interest on loan

1,148

(1,126)

-

Warrant issuance costs

-

669

702

Exchange differences on lease liabilities

(42)

(31)

177

Intangible assets impairment

6,703

1,010

-

Loss on abandonment of right-of-use asset

-

246

-


22,807

(12,834)

(7,307)





Changes in operating asset and liability items:




Decrease (increase) in trade receivables

(358)

(2,118)

2,430

Decrease (increase) in inventory

(1,953)

(1,192)

997

Decrease (increase) in prepaid expenses and other

   receivables

(959)

(43)

1,310

Increase (decrease) in accounts payable and accruals

5,512

(5,508)

(3,478)

Increase (decrease) in contract liabilities

12,957

(12,957)

-


15,199

(21,818)

1,259


38,006

(34,652)

(6,048)





Supplemental information on interest received in cash

2,020

1,992

1,153

Supplemental information on interest paid in cash

1,111

10,387

1,268





Supplemental information on non-cash transactions:




         Changes in right-of-use asset and lease liabilities

149

327

(57)

         Fair value of exercised warrants (portion related to

         accumulated fair value adjustments)

3,631

-

-

         Intangible asset acquired in connection with GLIX1

         collaboration transaction

-

-

6,000

 

Logo - https://mma.prnewswire.com/media/2154863/BioLineRx_Ltd_Logo.jpg

 

Cision View original content:https://www.prnewswire.com/news-releases/biolinerx-reports-2025-financial-results-and-provides-corporate-update-302721933.html

SOURCE BioLineRx Ltd.

FAQ

When will BioLineRx (BLRX) start the Phase 1/2a GLIX1 glioblastoma trial?

The company expects to initiate the GLIX1 Phase 1/2a glioblastoma trial by the end of March 2026. According to the company, patient enrollment will commence shortly after trial initiation with three academic centers planned to participate.

What does the USPTO Notice of Allowance for GLIX1 mean for BLRX (BLRX)?

It means GLIX1 now has an allowed U.S. patent covering cancers with CDA below a threshold through 2040. According to the company, this broadens IP protection and preserves ability to evaluate GLIX1 across multiple tumor types.

How long is BioLineRx's cash runway after the 2025 results (BLRX)?

BioLineRx reports $20.9 million in cash, funding operations into the first half of 2027. According to the company, this balance underpins current plans but implies limited runway without additional financing or material revenues.

When does BLRX expect Phase 1 GLIX1 data and what will it show?

The company anticipates Phase 1 GLIX1 data in the first half of 2027 focused on safety and recommended dose. According to the company, Phase 1 will assess MTD, PK/PD, and preliminary efficacy in up to 30 patients.

What is the timing for the motixafortide CheMo4METPANC interim analysis (BLRX)?

A prespecified interim/futility analysis is planned when 40% of PFS events are observed, expected in 2026. According to the company, enrollment has accelerated and the analysis is led by Columbia University with Regeneron support.

How did BioLineRx's 2025 revenues and profits (BLRX) compare to 2024?

Revenues dropped to $1.2 million in 2025 versus higher, noncomparable 2024 totals driven by upfront and milestone payments. According to the company, net loss improved to $2.0 million in 2025 from $9.2 million in 2024.
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