Welcome to our dedicated page for C4 Therapeutics news (Ticker: CCCC), a resource for investors and traders seeking the latest updates and insights on C4 Therapeutics stock.
C4 Therapeutics, Inc. reports developments tied to its clinical-stage targeted protein degradation business, including oncology programs designed with its TORPEDO® platform. Recurring company updates cover cemsidomide, an oral IKZF1/3 degrader being studied in relapsed/refractory multiple myeloma, as well as broader degrader-medicine research intended to address disease-causing proteins.
Company news also includes collaboration activity, such as its Roche agreement for degrader-antibody conjugates, along with clinical disclosures, operating and financial results, conference participation, equity inducement grants, and other governance matters under Nasdaq rules.
C4 Therapeutics, Inc. (Nasdaq: CCCC), a clinical-stage biopharmaceutical company, has been included in the NASDAQ Biotechnology Index, effective December 20, 2021. This index tracks notable biotechnology and pharmaceutical companies listed on NASDAQ, requiring eligibility criteria such as minimum market capitalization and average daily trading volume of 100,000 shares. C4 Therapeutics focuses on developing drugs that selectively degrade disease-causing proteins, offering advantages like reduced drug resistance and side effects. The company aims to target cancer and other diseases.
C4 Therapeutics (Nasdaq: CCCC) reported Q3 2021 revenue of $8.5 million, slightly up from $8.4 million YoY. R&D expenses rose to $24.3 million from $23.9 million, driven by pre-clinical costs. G&A expenses surged to $8.5 million from $2.9 million, mainly due to stock-based compensation and professional fees. A net loss of $24.7 million was recorded, with net loss per share at $0.51. The company anticipates submitting an IND application for CFT8634 by year-end 2021 and aims to deliver four clinical programs by the end of 2022.
C4 Therapeutics (Nasdaq: CCCC) reported significant advancements in their clinical programs and financials for Q2 2021. They initiated the Phase 1/2 trial of CFT7455 for hematologic malignancies and received Orphan Drug Designation from the FDA for this therapy. The company reported Q2 revenue of $9.8 million, a slight increase from $9.7 million in the previous year, and a net loss of $22.6 million, up from $10.8 million. A successful public offering yielded $180.8 million, bolstering cash reserves to approximately $499 million by June 30, 2021, supporting their ambitious clinical development plans.
C4 Therapeutics, Inc. (Nasdaq: CCCC) announced that the FDA granted orphan drug designation to its drug CFT7455 for treating multiple myeloma. This designation supports clinical development and provides potential market exclusivity in the U.S. Moreover, CFT7455 is designed to selectively target disease-causing proteins, with an ongoing Phase 1/2 trial aimed at evaluating its safety and anti-tumor activity, intending to enroll approximately 160 patients. C4 Therapeutics aims to improve outcomes for multiple myeloma patients who currently face limited treatment options.
C4 Therapeutics (Nasdaq: CCCC) announced the closing of an underwritten public offering of 4,887,500 shares at $37.00 per share, raising about $180.8 million in gross proceeds. This includes the full exercise of the underwriters' option for an additional 637,500 shares. The offering was managed by J.P. Morgan, Jefferies, Evercore ISI, BMO Capital Markets, and UBS Investment Bank. The funds will be directed towards advancing the company’s innovative small-molecule medicines aimed at degrading disease-causing proteins, a strategy that could potentially enhance cancer treatments.
C4 Therapeutics (Nasdaq: CCCC) presented promising pre-clinical data for its lead compound, CFT7455, at the ICML conference. This orally bioavailable MonoDAC™ demonstrated high binding affinity to cereblon and effective IKZF1/3 degradation in non-Hodgkin’s lymphoma (NHL) models. CFT7455 showed superior efficacy in xenograft models compared to approved therapies, including significant tumor regressions in various NHL subtypes. The Phase 1/2 trial, initiated in June 2021, aims to further assess CFT7455’s potential against multiple myeloma and NHLs, with top-line results expected in 2022.
C4 Therapeutics, Inc. (Nasdaq: CCCC) has announced the pricing of a public offering of 4.25 million shares of common stock at $37.00 each. The offering, expected to yield approximately $157 million in gross proceeds, is set to close around June 21, 2021, pending customary conditions. An option for underwriters to purchase an additional 637,500 shares is included. J.P. Morgan, Jefferies, and other banks are managing the offering. C4T focuses on targeted protein degradation therapies for cancer and other diseases.
C4 Therapeutics, Inc. (Nasdaq: CCCC) announced a proposed public offering of 4,250,000 shares of its common stock, with an option for underwriters to purchase an additional 637,500 shares. The net proceeds will support the company's research and clinical development activities. The offering is dependent on market conditions and has yet to be finalized. Lead managers include J.P. Morgan, Jefferies, Evercore ISI, BMO Capital Markets, and UBS Investment Bank. The registration statement has been filed with the SEC but is not yet effective.
C4 Therapeutics (Nasdaq: CCCC) has announced the successful dosing of the first patient in its clinical trial for CFT7455, an innovative MonoDAC™ treatment targeting IKZF1/3 for multiple myeloma and non-Hodgkin’s lymphomas. This significant milestone marks the company’s first program to advance to clinical trials. The Phase 1/2 trial will assess safety, tolerability, and anti-tumor activity in approximately 160 patients. Preliminary data from this trial is expected in 2022, reflecting C4T's commitment to improving cancer treatment outcomes.
C4 Therapeutics presented new pre-clinical data on CFT8919, a novel EGFR degrader, indicating significant tumor regression in models resistant to current EGFR inhibitors. The results suggest CFT8919 is effective against mutations like L858R, T790M, and C797S. Pre-clinical studies showed 85% degradation of mutant EGFR in tumors following treatment. The company plans to file an IND by mid-2022 and initiate a Phase 1 clinical trial by year-end 2022, aiming to address unmet needs in non-small cell lung cancer therapy.