Welcome to our dedicated page for C4 Therapeutics news (Ticker: CCCC), a resource for investors and traders seeking the latest updates and insights on C4 Therapeutics stock.
C4 Therapeutics, Inc. (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company focused on targeted protein degradation, and its news flow reflects active clinical development, collaborations and capital markets activity. Company updates frequently highlight progress with cemsidomide, an investigational IKZF1/3 degrader in development for relapsed/refractory multiple myeloma and certain lymphomas, as well as broader pipeline and platform achievements.
News for C4 Therapeutics often centers on clinical data milestones, such as Phase 1 results for cemsidomide in combination with dexamethasone, acceptance of data for oral presentation at scientific meetings, and plans for registrational trials like the Phase 2 MOMENTUM study. Releases also cover developments in non-Hodgkins lymphoma cohorts and updates on other degrader programs, including CFT8919 for EGFR-mutant non-small cell lung cancer and CFT1946 for BRAF V600 mutant solid tumors.
Investors following CCCC news will also see collaboration announcements and research milestones. Examples include the clinical trial collaboration and supply agreement with Pfizer to evaluate cemsidomide with elranatamab in multiple myeloma, milestone achievements in partnerships with Biogen, Roche and Merck KGaA, Darmstadt, Germany, and regulatory steps such as IND acceptance for BIIB142, an IRAK4 degrader designed by C4 Therapeutics.
Financial and corporate updates are another key news category. The company regularly reports quarterly financial results, cash runway guidance, equity offerings and changes to its capital structure via press releases and Form 8-K filings. For readers tracking CCCC, this news page aggregates these clinical, scientific, collaboration and financing updates in one place, making it easier to monitor how C4 Therapeutics is advancing its targeted protein degradation pipeline over time.
C4 Therapeutics, Inc. (Nasdaq: CCCC) has appointed Dr. Laura Bessen and Dr. Donna Grogan to its board of directors, enhancing its leadership as it advances targeted protein degradation science. Dr. Bessen brings over 20 years in medical affairs, having launched 11 products at Bristol Myers Squibb. Dr. Grogan, an expert in drug development, has held leadership roles at multiple biopharmaceutical firms. Their appointments signify C4T's commitment to innovative therapies in oncology as it progresses multiple programs in clinical trials.
C4 Therapeutics (Nasdaq: CCCC) announced the dosing of the first patient in its Phase 1/2 clinical trial for CFT8634, a targeted treatment for SMARCB1-perturbed cancers, including synovial sarcoma. This BiDAC™ degrader targets BRD9, deemed 'undruggable.' The trial will focus on CFT8634's safety, tolerability, and anti-tumor activity, enrolling approximately 90 patients. CFT8634 has received orphan drug designation from the FDA, marking a significant advancement in C4T's oncology pipeline and potentially offering new options for patients with limited therapies.
C4 Therapeutics (Nasdaq: CCCC) reported Q1 2022 financial results, with total revenue of $7.7 million compared to $7.4 million in Q1 2021. R&D expenses rose to $26.2 million, up from $20.5 million year-over-year. The net loss increased to $31.6 million or $0.65 per share, compared to a $21.0 million loss in the prior year. As of March 31, 2022, cash, cash equivalents, and marketable securities totaled $421.7 million, expected to fund operations until late 2024. The company continues dose optimization trials for CFT7455 and has initiated a Phase 1/2 trial for CFT8634.
C4 Therapeutics (Nasdaq: CCCC) announced promising early data from its Phase 1/2 trial of CFT7455, a targeted protein degrader aimed at treating multiple myeloma and non-Hodgkin's lymphomas. The trial demonstrated significant drug activity, with some patients showing reductions in serum free light chains by up to 78%. However, dose-limiting toxicities were noted, including Grade 4 neutropenia. The trial aims to optimize dosing to enhance the therapeutic index as patient enrollment continues. A conference to discuss these findings is scheduled for today.
C4 Therapeutics, Inc. (Nasdaq: CCCC) has appointed Utpal Koppikar as an independent board member and chair of the Audit Committee. Koppikar, currently CFO at Atara Biotherapeutics, brings extensive financial expertise and leadership in the biotechnology sector. The appointment aims to enhance corporate governance and support C4T's growth strategies in targeted protein degradation. Following this change, Dr. Elena Prokupets has retired from the board. C4T is advancing its novel degrader medicines using its TORPEDO® platform to transform patient care.
C4 Therapeutics (Nasdaq: CCCC) announced that the FDA has granted orphan drug designation to CFT8634 for treating soft tissue sarcoma. This designation benefits drug development for rare diseases affecting fewer than 200,000 people in the U.S., offering financial incentives and potential market exclusivity. CFT8634 targets BRD9, considered an 'undruggable' target, demonstrating efficacy in preclinical models. The company aims to begin Phase 1/2 trials in the first half of 2022, addressing a critical need as current treatment options for synovial sarcoma patients are limited.
C4 Therapeutics (Nasdaq: CCCC) has announced that its clinical data from the ongoing Phase 1/2 trial of CFT7455 will be presented as a late-breaker poster at the AACR Annual Meeting 2022 from April 8-13 in New Orleans. This includes three oral presentations on the novel IKZF1/3 degrader, along with additional preclinical data on CFT8634 and CFT1946. An investor webcast is scheduled for April 8, 2022, at 2 PM ET to discuss these findings, showcasing the company's commitment to advancing targeted protein degradation in oncology.
C4 Therapeutics reported significant advancements and financial results for 2021, including total revenue of $45.8 million, up from $33.2 million in 2020, primarily due to collaboration agreements. Despite a net loss of $83.9 million, the net loss per share improved to $1.82 from $5.83. The company anticipates its cash reserves of $451.5 million will sustain operations through 2024. Upcoming presentations at the AACR Annual Meeting will showcase clinical data on the CFT7455 trial for hematologic malignancies and pre-clinical data on novel candidates.
C4 Therapeutics (Nasdaq: CCCC) announced key milestones for 2022, including expected initial data for CFT7455, a novel degrader for multiple myeloma and lymphomas. The FDA granted IND clearance for CFT8634, allowing the initiation of its Phase 1 trial in synovial sarcoma. Additionally, CFT1946, targeting BRAF V600X, will enter trials in 2H 2022. With approximately $450 million in cash expected to last until late 2024, the company is poised for growth and innovation.
C4 Therapeutics (Nasdaq: CCCC), a clinical-stage biopharmaceutical company, will present at the 40th Annual J.P. Morgan Healthcare Conference on January 10, 2022, at 10:30 a.m. EST. This conference emphasizes the company's innovative approach to developing small-molecule medicines that selectively degrade disease-causing proteins.
The live webcast can be viewed on the company's website, with a replay available for two weeks post-event. C4 Therapeutics focuses on targeted protein degradation to improve treatment options for cancer and other diseases.