Welcome to our dedicated page for Compugen news (Ticker: CGEN), a resource for investors and traders seeking the latest updates and insights on Compugen stock.
Compugen Ltd (CGEN) is a clinical-stage cancer immunotherapy company that regularly issues news on its drug discovery platform, clinical programs, and strategic collaborations. The company emphasizes its predictive AI/ML-powered computational discovery platform, Unigen™, which it uses to identify novel drug targets and biological pathways for immuno-oncology therapies.
News about Compugen often highlights progress across its key clinical-stage assets. Updates include data and trial milestones for COM701, a potential first-in-class anti-PVRIG Fc-reduced antibody, and COM902, a potential best-in-class Fc-reduced high-affinity anti-TIGIT antibody in Phase 1 development. The company also reports on GS-0321 (previously COM503), a potential first-in-class, high-affinity anti-IL-18 binding protein antibody licensed to Gilead, and on rilvegostomig, a PD-1/TIGIT bispecific antibody in Phase 3 development by AstraZeneca under license from Compugen.
Investors following CGEN news can expect coverage of clinical trial initiations and updates, such as the MAIA-ovarian platform trial evaluating COM701 maintenance therapy in relapsed platinum-sensitive ovarian cancer, pooled analyses of Phase 1 trials in platinum-resistant ovarian cancer, and first-in-human studies of GS-0321 in advanced solid malignancies. Company communications also describe partner-led studies of rilvegostomig in indications including non-small cell lung cancer and bladder cancer.
In addition, Compugen’s news flow includes quarterly financial results, cash runway commentary, amendments to collaboration agreements such as royalty monetization transactions with AstraZeneca, and participation in scientific and investor conferences. The CGEN news page on Stock Titan aggregates these announcements so readers can track clinical, financial, and partnership developments from a single source.
Compugen Ltd. (CGEN) has announced the dosing of the first patient in its Phase 1/2 study, which evaluates the triple combination of COM701, Opdivo®, and BMS-986207. This study aims to assess the safety, tolerability, and preliminary antitumor activity of this novel therapy targeting PVRIG, TIGIT, and PD-1 pathways, believed to enhance anti-tumor immune responses. The cohort expansion phase focuses on specific patient populations, with preliminary data expected by Q4 2021. Compugen partners with Bristol Myers Squibb for this innovative immunotherapy approach.
Compugen Ltd. (CGEN) has announced the dosing of the first patient in a Phase 1 clinical study assessing the combination of its anti-TIGIT antibody, COM902, and anti-PVRIG antibody, COM701, in patients with advanced malignancies. The study aims to evaluate safety, tolerability, pharmacokinetics, and preliminary antitumor activity in patients who have exhausted standard therapies. Initial results from the COM902 monotherapy study are expected in Q4 2021. Compugen's strategy focuses on expanding immunotherapy effectiveness through dual blockade of PVRIG and TIGIT pathways.
Compugen Ltd. (Nasdaq: CGEN) announces it will release its second quarter 2021 financial results on July 28, 2021, before U.S. markets open. Management will host a conference call and webcast at 8:30 AM ET to discuss the results and provide a corporate update. The call can be accessed via telephone or through a live webcast on the company's website. Compugen is focused on cancer immunotherapy with key products like COM701 and COM902 undergoing clinical studies.
Compugen Ltd. (NASDAQ: CGEN) has announced the dosing of the first patient in a combination expansion cohort of its Phase 1 clinical trial for COM701, an anti-PVRIG antibody, in conjunction with Opdivo® (nivolumab). This cohort targets ovarian, breast, endometrial, and colorectal cancers, following encouraging initial results showing complete responses and durable anti-tumor activity. The trial aims to evaluate the safety and efficacy of the therapy in advanced solid tumors, reinforcing Compugen's position in cancer immunotherapy.
Compugen Ltd. (CGEN) presented new research on PVRIG, emphasizing its role as a distinct immune checkpoint that may enhance T-cell expansion. Findings suggest that PVRIG clusters with early memory T cell markers, indicating its potential when used with TIGIT and PD-1 inhibitors for tumors unresponsive to current therapies. The study highlights PVRIG's expression in T cells and its potential to trigger immune responses. The presentation was made at the SITC 2021 seminar.
Compugen Ltd. (Nasdaq: CGEN) presented updated data from its Phase 1 study of COM701, a first-in-class anti-PVRIG antibody, at ASCO 2021. The combination of COM701 with Opdivo® demonstrated a 66.7% disease control rate in 15 evaluable patients, with a notable complete response in a patient with anal squamous cell carcinoma lasting 22 months. The monotherapy showed a 47.2% disease control rate across 36 patients, with preliminary biomarker data indicating enhanced immune response. These findings highlight the potential for COM701 in difficult-to-treat cancers, including ongoing evaluation in immunotherapy-resistant populations.
Compugen Ltd. (Nasdaq: CGEN) announced participation in a virtual event to discuss data from its Phase 1 clinical trial of COM701, an innovative antibody targeting PVRIG. The findings will be presented on June 7, 2021, at the ASCO 2021 Annual Meeting. A fireside chat hosted by Truist Securities analyst Asthika Goonewardene is scheduled for June 8, 2021, featuring key executives from Compugen. The company is focused on developing cancer immunotherapy treatments, including the ongoing studies of COM701 and COM902.
Compugen Ltd. (CGEN) reported Q1 2021 financial results with a net loss of $9.9 million or $0.12 per share, an increase from a $7.1 million loss in Q1 2020. R&D expenses rose to $7.3 million, up from $4.7 million, driven by drug manufacturing and clinical activities. The company has $119.4 million in cash reserves. Upcoming milestones include data readouts for COM701 in various studies and collaboration with Bristol Myers Squibb for a Phase 1b study. Compugen aims to lead in the DNAM axis space with promising clinical data for PVRIG and TIGIT assets.
Compugen Ltd. (NASDAQ: CGEN) announced that Eran Ophir, Ph.D., Vice President of Research and Drug Discovery, will participate in the Society for Immunotherapy of Cancer's online seminar on June 29, 2021. The seminar focuses on 'The TIGIT Pathway' and is part of a series addressing key questions in cancer immunotherapy. Co-chairs include industry experts, and an interactive Q&A session will follow. Compugen, based in Israel, is developing innovative cancer therapies, including its lead anti-PVRIG antibody, COM701, currently in Phase 1 trials.
Compugen Ltd. (CGEN) announced an expansion of its research collaboration with Johns Hopkins University on a novel myeloid target discovered through its predictive computational platform. Initial preclinical studies indicate significant tumor growth inhibition upon genetic deletion of this target, potentially serving as a myeloid immunomodulator. The collaboration aims to further investigate the biological function of this target, enhancing Compugen's immuno-oncology pipeline. The CEO emphasizes the importance of early-stage programs for the company's growth and development in cancer therapies.