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Cerenome Secures In-Network Agreement with Health Care Service Corporation, Expanding CNSide® Contracted Coverage to Over 150 Million Covered Lives

(Moderate)
(Very Positive)
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Cerenome (Nasdaq:CNSY) announced that its subsidiary CNSide Diagnostics signed an in-network provider agreement with Health Care Service Corporation (HCSC), effective August 1, 2026, for the CNSide® cerebrospinal fluid Tumor Cell Enumeration assay. HCSC represents about 27.3 million commercial and Medicare Advantage covered lives.

Combined with prior contracts, CNSide now has contracted access to approximately 153 million covered lives, exceeding Cerenome’s full-year 2026 commercial and Medicare Advantage coverage objective of 150 million lives. According to Cerenome, CNSide’s clinical utility has been supported by 12 peer-reviewed publications, the FORESEE study, and over 11,000 tests performed at more than 120 U.S. cancer institutions since 2020.

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Positive

  • CNSide contracted coverage now approximately 153 million commercial and Medicare Advantage lives
  • 2026 full-year coverage objective of 150 million lives exceeded ahead of schedule
  • HCSC agreement adds access to about 27.3 million covered lives
  • More than 11,000 CNSide tests performed since 2020 at over 120 U.S. cancer institutions

Negative

  • None.

News Market Reaction – CNSY

-0.81%
1 alert
-0.81% Session close to close
$28.08M Market Cap
0.0x Rel. Volume

In the Aug 13 session, CNSY declined 0.81%, reflecting a mild negative market reaction.

Data tracked by StockTitan Argus on the day of publication.

Market Context

Cerenome's prior news event recorded a -1.28% reaction, adding evidence that operational milestones ...
Analysis

Cerenome's prior news event recorded a -1.28% reaction, adding evidence that operational milestones have not necessarily aligned with market response. The historical divergence is a risk; subsequent utilization and reimbursement execution warrant attention.

Key Figures

Agreement effective date: August 1, 2026 HCSC covered lives: 27.3 million covered lives Coverage objective: 150 million covered lives +5 more
8 metrics
Agreement effective date August 1, 2026 HCSC in-network provider agreement
HCSC covered lives 27.3 million covered lives Commercial and Medicare Advantage coverage
Coverage objective 150 million covered lives 2026 full-year contracted coverage objective
Contracted coverage 153 million covered lives Commercial and Medicare Advantage coverage after HCSC agreement
Peer-reviewed publications 12 publications Reported clinical utility support for CNSide
Tests performed More than 11,000 tests Since 2020
U.S. cancer institutions Over 120 institutions Institutions where CNSide tests were performed
Medicare Advantage states 30 states and Washington, D.C. HCSC Medicare Advantage plans

Historical Context

1 past event · Latest: Aug 06 (Positive)
Pattern 1 events
Date Event Sentiment 24h Move Catalyst
Aug 06 RCM services selection Positive -1.3% Selected XiFin for billing and clearinghouse services supporting the CNSide assay platform

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

The available prior news event produced a negative price reaction despite an operationally supportive announcement, indicating divergence from the announcement's apparent direction.

Key Terms

cerebrospinal fluid, tumor cell enumeration, leptomeningeal metastases, laboratory-developed diagnostic tests
4 terms
cerebrospinal fluid medical
"provide the CNSide® Cerebrospinal Fluid (CSF) Tumor Cell Enumeration"
A clear fluid that surrounds and cushions the brain and spinal cord, acting like a protective bath and cleanup system that removes waste and helps circulate nutrients. For investors, cerebrospinal fluid matters because it is a common source of diagnostic markers and a route for delivering or testing neurological drugs; changes in its composition can signal disease or affect a therapy’s development, approval prospects, and market value.
tumor cell enumeration medical
"Cerebrospinal Fluid (CSF) Tumor Cell Enumeration (TCE) assay"
Tumor cell enumeration is the laboratory counting of cancer cells found in a blood sample or tissue, often used to measure how many tumor cells are present or moving through the body. Investors should care because these counts act like a speedometer for a disease — they help indicate whether a therapy is working, how aggressive a cancer is, and can drive demand for diagnostic tests, guiding clinical development and commercial opportunities in oncology.
leptomeningeal metastases medical
"patients with leptomeningeal metastases"
Leptomeningeal metastases occur when cancer cells spread to the thin layers of tissue covering the brain and spinal cord, similar to how weeds can invade the surface layer of soil. This condition often indicates advanced disease and can lead to serious neurological problems. For investors, the presence of such metastases may signal challenges in treatment options and can impact the outlook for related healthcare companies or research developments.
laboratory-developed diagnostic tests medical
"commercial utilization of laboratory-developed diagnostic tests such as CNSide®"
Laboratory-developed diagnostic tests are medical tests that a single clinical laboratory designs, validates, and runs in-house to detect diseases, conditions, or biomarkers for patient care. Think of them like a bakery’s homemade recipe versus a store-bought kit; because they are made and used within one lab, they affect the lab’s service offerings, revenue streams, reimbursement and market access, and are subject to distinct regulatory and quality oversight that matters to investors evaluating diagnostic businesses.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Agreement marks achievement of Cerenome’s full-year 2026 commercial payer coverage objective for CNSide

HOUSTON, Aug. 13, 2026 (GLOBE NEWSWIRE) -- CNSide Diagnostics, LLC, a wholly-owned subsidiary of Cerenome, Inc. (Nasdaq: CNSY) (“Cerenome” or the “Company”), announced today that it has signed an in-network provider agreement with Health Care Service Corporation (“HCSC”), effective August 1, 2026, to provide the CNSide® Cerebrospinal Fluid (CSF) Tumor Cell Enumeration (TCE) assay. HCSC represents approximately 27.3 million commercial and Medicare Advantage covered lives and operates Blue Cross and Blue Shield plans in Texas, Illinois, Montana, New Mexico, and Oklahoma and offers Medicare Advantage plans in 30 states and Washington, D.C. Combined with previously announced agreements, CNSide has now exceeded its 2026 full year objective for contracted commercial and Medicare Advantage coverage of 150 million covered lives.

"The HCSC agreement represents an important milestone in our strategy to expand patient access to CNSide,” said Marc Hedrick, M.D., Cerenome’s President and Chief Executive Officer. “With HCSC, CNSide now has contracted access to approximately 153 million commercial and Medicare Advantage covered lives, exceeding our full-year 2026 coverage objective ahead of schedule. As we continue expanding reimbursement and physician adoption, we believe this national coverage platform provides a strong foundation for increasing CNSide utilization.”

The HCSC agreement represents the latest milestone in CNSide’s strategy to establish broad reimbursement coverage across the U.S. Commercial payer coverage is a key driver of physician adoption, patient access, and commercial utilization of laboratory-developed diagnostic tests such as CNSide®.

The CNSide® CSF Assay Platform supports rapid diagnoses, treatment monitoring, and treatment guidance for patients with leptomeningeal metastases. The superior clinical utility of CNSide® over standard of care has been shown in 12 peer-reviewed publications and prospective multicenter evidence from the FORESEE clinical study, and has been supported by real-world clinical experience.

Since 2020, more than 11,000 CNSide® tests have been performed at over 120 U.S. cancer institutions, supporting clinical decision-making across academic and community oncology practices nationwide.

This test is available exclusively through CNSide Diagnostics, LLC, as a testing service provided to health care professionals in the U.S.

About CNSide Diagnostics, LLC 
CNSide Diagnostics, LLC is a wholly owned subsidiary of Cerenome, Inc. that develops and commercializes proprietary laboratory-developed tests, such as CNSide®, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide® CSF Assay Platform enables quantitative analysis of the cerebrospinal fluid that informs and improves the management of patients with leptomeningeal metastases.   For more information, visit https://www.cnside-dx.com/.

About Cerenome
Cerenome (Nasdaq: CNSY) is a CNS oncology company advancing an integrated platform that combines precision diagnostics, targeted therapeutics, and artificial intelligence to improve outcomes for patients with central nervous system cancers. The Company's CNSide® Diagnostics platform supports the detection, molecular characterization, and longitudinal monitoring of CNS cancers through cerebrospinal fluid-based testing. Its lead therapeutic platform, REYOBIQ™ (rhenium Re186 obisbemeda), is being evaluated in clinical trials for leptomeningeal metastases, recurrent glioblastoma, and pediatric brain cancers. The data & artificial intelligence platform is designed to integrate diagnostic, molecular, imaging, and clinical data into actionable insights that support precision oncology and therapeutic innovation. By integrating commercial diagnostics, targeted therapeutics, proprietary longitudinal data, and artificial intelligence within a single organization, Cerenome is building a differentiated CNS oncology platform designed to improve patient care while creating long-term shareholder value, visit https://www.cerenome.com.

About Health Care Service Corporation
Health Care Service Corporation, a Mutual Legal Reserve Company, is the country's largest customer-owned health insurer, serving more than 27 million people across the United States. HCSC provides coverage options for employers large and small, individuals and families, and Medicare and Medicaid plans. HCSC also offers related health care products and services such as pharmacy solutions, life and dental insurance, and health technology through a network of affiliates and subsidiaries.   For more information, please visit https://www.hcsc.com.

Forward-Looking Statements
This press release contains statements that may be deemed “forward-looking statements” within the meaning of U.S. securities laws, including statements regarding clinical trials, expected operations and upcoming developments. All statements in this press release other than statements of historical fact are forward-looking statements. These forward-looking statements may be identified by future verbs, as well as terms such as “expect,” “potential,” “anticipating,” “planning” and similar expressions or the negatives thereof. Such statements are based upon certain assumptions and assessments made by management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate.   These statements include, without limitation, statements regarding the potential market for the CNSide CSF Assay, the timing in which the CNSide CSF Assay is commercially launched and commercialization is expanded, revenue and corporate profitability expectations including support reimbursements and payments for the CNSide CSF Assay, the development and utility of the CNSide CSF Assay and expectations as to the Company’s future performance, including the next steps in developing the Company’s product candidates.

Investor Contact
CORE IR
IR@cerenome.com


FAQ

What did Cerenome (NASDAQ:CNSY) announce about its CNSide coverage on August 13, 2026?

Cerenome announced that CNSide Diagnostics signed an in-network agreement with Health Care Service Corporation, expanding CNSide® assay coverage. According to Cerenome, this deal helps lift contracted commercial and Medicare Advantage access to about 153 million covered lives, surpassing its 2026 objective of 150 million.

How many covered lives does the HCSC agreement add for Cerenome’s CNSide (CNSY)?

The HCSC agreement represents approximately 27.3 million commercial and Medicare Advantage covered lives. According to Cerenome, HCSC operates Blue Cross and Blue Shield plans in Texas, Illinois, Montana, New Mexico, and Oklahoma and offers Medicare Advantage in 30 states and Washington, D.C., broadening CNSide access.

What is the total contracted coverage for Cerenome’s CNSide® test after the HCSC deal?

After adding HCSC, CNSide has contracted access to approximately 153 million covered lives. According to Cerenome, this exceeds its full-year 2026 commercial and Medicare Advantage coverage objective of 150 million lives and is intended to support broader reimbursement and physician adoption.

When does the Cerenome–HCSC in-network agreement for CNSide® become effective?

The in-network provider agreement between CNSide Diagnostics and Health Care Service Corporation is effective August 1, 2026. According to Cerenome, this start date governs coverage for the CNSide® cerebrospinal fluid Tumor Cell Enumeration assay across HCSC’s commercial and Medicare Advantage membership base.

What clinical role does Cerenome’s CNSide® CSF assay play for cancer patients?

CNSide® supports rapid diagnosis, treatment monitoring, and treatment guidance for patients with leptomeningeal metastases. According to Cerenome, its clinical utility versus standard care is backed by 12 peer-reviewed publications, prospective multicenter FORESEE study data, and real-world use in more than 11,000 tests since 2020.

How widely has Cerenome’s CNSide® test been adopted in U.S. cancer centers?

Since 2020, more than 11,000 CNSide® tests have been performed at over 120 U.S. cancer institutions. According to Cerenome, these include both academic and community oncology practices nationwide, and the test is available exclusively as a service through CNSide Diagnostics for health care professionals.