Crinetics Launches ACRO/TRUTH Educational Initiative to Raise Awareness of Acromegaly Treatment Challenges

Rhea-AI Summary

Crinetics Pharmaceuticals (Nasdaq: CRNX) has launched ACRO/TRUTH, an educational initiative aimed at raising awareness about the challenges faced by acromegaly patients using current standard-of-care treatments. The initiative includes a website featuring patient testimonials and peer-reviewed data on treatment-related symptoms, side effects, and quality-of-life impacts.

The ACRO/TRUTH website provides authentic patient perspectives and clinical insights, addressing topics such as breakthrough symptoms, injection site reactions, and emotional impacts of treatment. It aims to improve communication between healthcare providers and patients, recognizing that patients may hesitate to discuss treatment challenges.

Developed with input from patient organizations like Acromegaly Community, ACRO/TRUTH seeks to empower patients and optimize treatment plans. The initiative will expand to include additional educational offerings, including a speaker's panel.

Positive

• Launch of ACRO/TRUTH educational initiative to raise awareness of acromegaly treatment challenges
• Collaboration with patient organizations like Acromegaly Community to develop the initiative
• Potential for improved patient-doctor communication and treatment optimization

Negative

• None.

Insights

Medical Research Analyst

The launch of ACRO/TRUTH by Crinetics Pharmaceuticals is a strategic move to address the unmet needs in acromegaly treatment. While not directly impacting financials, this initiative could enhance Crinetics' reputation and potentially drive future product adoption.

The focus on patient perspectives and peer-reviewed data highlights the limitations of current injectable treatments, setting the stage for Crinetics' potential oral therapies. This educational effort could create demand for alternative treatments, aligning with Crinetics' pipeline.

Investors should note that this initiative may position Crinetics as a thought leader in acromegaly treatment, potentially strengthening relationships with healthcare providers and patients. However, the direct financial impact is likely minimal in the short term.

Market Research Analyst

The ACRO/TRUTH initiative represents a savvy market positioning strategy for Crinetics. By highlighting the challenges with current acromegaly treatments, they're priming the market for their innovative solutions.

This approach could accelerate market acceptance of Crinetics' potential future products, particularly if they offer improvements over injectable SRLs. The collaboration with patient organizations like Acromegaly Community adds credibility and reach to their efforts.

While not immediately revenue-generating, this initiative could build brand equity and foster loyalty among healthcare providers and patients. Long-term, this could translate into faster adoption rates and market share gains if Crinetics successfully brings new acromegaly treatments to market.

ACRO/TRUTH Provides Authentic Patient Perspectives, Peer-Reviewed Data on Treatment-Related Symptoms, Side Effects and Quality-of-Life Impact of Current Acromegaly Standard-of-Care

SAN DIEGO, Aug. 08, 2024 (GLOBE NEWSWIRE) -- Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX) today announced the launch of the ACRO/TRUTH healthcare provider (HCP) educational website and initiative, the purpose of which is to spotlight the significant challenges and burdens many people living with acromegaly experience when managing their disease with the current standard-of-care, injectable somatostatin receptor ligands (SRLs).

“People living with acromegaly still experience diminished quality of life due to their disease and to the limitations of the treatment options currently available to treat their disease,” said Alan Krasner, M.D., Chief Endocrinologist at Crinetics. “Crinetics is dedicated to bringing forward innovative products to better the lives of patients, and an integral part of that mission is bringing the patient perspective to the forefront.”

The initiative will be anchored with a dynamic website that puts the patient perspective front-and-center through authentic video storytelling, together with peer-reviewed data published by endocrinologists specializing in acromegaly. Topics include details on the incidence and significance of breakthrough symptoms, injection site reactions, common side effects, and the emotional impact associated with treatment. HCPs can also sign up to stay informed on the latest clinical insights and research.

ACRO/TRUTH was informed by numerous interviews with people living with acromegaly and endocrinologists, in addition to published research on the impact of current treatments on patients' lives. The initiative will expand to include additional online and offline educational offerings, such as a speaker’s panel.

Research has shown interactions between HCPs and people living with acromegaly can be impacted by the protracted path to diagnosis and a general lack of information about the disease in the health care community.¹ In turn, people living with acromegaly can be hesitant to discuss the challenges they face while on a prescribed treatment.¹ To help elevate the voices of the patient community, ACRO/TRUTH was created with extensive input from leading patient organizations like Acromegaly Community.

“While diagnosis is the first step to getting better when living with acromegaly, it is critical to empower patients to be active partners in their care journeys immediately following that diagnosis,” said Jill Sisco, president of Acromegaly Community. “Once on a treatment, disease and symptom management can still be challenging for both patients and their healthcare providers. ACRO/TRUTH is an innovative, first-of-its-kind initiative that can lead to an informed conversation between healthcare providers and people living with acromegaly, to ensure treatment plans are optimized to enable productive lives.”

To learn more, visit AcromegalyTruth.com.

ABOUT ACROMEGALY
Acromegaly is a serious rare disease generally caused by a pituitary adenoma, a benign tumor in the pituitary that secretes growth hormone (GH). Excess GH secretion causes excess secretion of IGF-1 from the liver. Prolonged exposure to increased levels of IGF-1 and GH leads to progressive and serious systemic complications, often resulting in bone, joint, cardiovascular, metabolic, cerebrovascular, or respiratory disease. Acromegaly symptoms include headache, joint aches, fatigue, sleep apnea, severe sweating, hyperhidrosis/oily skin, bone and cartilage overgrowth, abnormal growth of hands and feet, enlargement of heart, liver, and other organs and alteration of facial features. Uncontrolled acromegaly results in increased mortality and has a debilitating impact on daily functioning and quality of life.

Surgical removal of pituitary adenomas, if possible, is the preferred initial treatment for most acromegaly patients. Pharmacotherapy is used for patients who are not candidates for surgery, or when surgery is unsuccessful in achieving treatment goals. Approximately 50% of patients with acromegaly prove to be candidates for pharmacotherapy. Injectable depot somatostatin analogues are the most common initial pharmacologic treatment; however, these drugs require monthly depot injections with large gauge needles that are commonly associated with pain, injection site reactions, and an increased burden on the lives of patients.

ABOUT CRINETICS PHARMACEUTICALS
Crinetics Pharmaceuticals is a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics for endocrine diseases and endocrine-related tumors. Crinetics’ lead development candidate, paltusotine, is an investigational, first-in-class, oral, once-daily somatostatin receptor type 2 (SST2) agonist in Phase 3 clinical development for acromegaly and in Phase 2 clinical development for carcinoid syndrome associated with neuroendocrine tumors. Crinetics is also developing atumelnant (CRN04894), an investigational, first-in-class, oral ACTH antagonist, that is currently completing Phase 2 clinical studies for the treatment of congenital adrenal hyperplasia and Cushing’s disease. All of the company’s drug candidates are orally delivered, small molecule new chemical entities resulting from in-house drug discovery efforts, including additional discovery programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves’ disease (including thyroid eye disease), diabetes, obesity and GPCR-targeted oncology indications.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical facts contained in this press release are forward-looking statements including statements regarding the plans for the clinical development of atumelnant and paltusotine, including the therapeutic potential and clinical benefits or safety profile thereof. These forward-looking statements speak only as of the date of this press release and are subject to a number of known and unknown risks, uncertainties and assumptions, including, without limitation, the risks and uncertainties described in the Company’s periodic filings with the Securities and Exchange Commission (“SEC”). The events and circumstances reflected in the Company’s forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. Additional information on risks facing Crinetics can be found under the heading “Risk Factors” in Crinetics’ periodic filings with the SEC, including its annual report on Form 10-K for the year ended December 31, 2023 and quarterly report on Form 10-Q for the quarter ended June 30, 2024. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by applicable law, Crinetics does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.

Investors:
Gayathri Diwakar
Head of Investor Relations
gdiwakar@crinetics.com
(858) 345-6340

Media:
Natalie Badillo
Head of Corporate Communications
nbadillo@crinetics.com
(858) 345-6075 

Reference
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¹ Gurel MH, Bruening PR, Rhodes C, Lomax KG. Patient perspectives on the impact of acromegaly: results from individual and group interviews. Patient Prefer Adherence. 2014;8:53-62. doi:10.2147/PPA.S56740

FAQ

What is the purpose of Crinetics' ACRO/TRUTH initiative for acromegaly (CRNX)?

The ACRO/TRUTH initiative by Crinetics (CRNX) aims to raise awareness about the challenges faced by acromegaly patients using current standard-of-care treatments, providing educational resources for healthcare providers and patients.

What features does the ACRO/TRUTH website offer for acromegaly education (CRNX)?

The ACRO/TRUTH website by Crinetics (CRNX) offers authentic patient video testimonials, peer-reviewed data on treatment-related symptoms and side effects, and information on the emotional impact of acromegaly treatments.

How does ACRO/TRUTH aim to improve acromegaly patient care (CRNX)?

ACRO/TRUTH by Crinetics (CRNX) aims to improve acromegaly patient care by facilitating better communication between healthcare providers and patients, empowering patients to be active partners in their care, and helping to optimize treatment plans.

What future plans does Crinetics have for the ACRO/TRUTH acromegaly initiative (CRNX)?

Crinetics (CRNX) plans to expand the ACRO/TRUTH initiative to include additional online and offline educational offerings, such as a speaker's panel, to further support acromegaly education and awareness.