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CytomX Therapeutics Announces Appointment of Charles Fuchs, M.D., M.P.H., to the Board of Directors

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CytomX Therapeutics (Nasdaq: CTMX) has appointed Charles Fuchs, M.D., M.P.H., a board-certified medical oncologist with over three decades of oncology leadership, to its Board of Directors. Fuchs most recently served as Chief Medical Officer of Tubulis and previously led global oncology and hematology drug development at Genentech and Roche, where he oversaw approvals for therapies including Lunsumio, Columvi, Polivy and Tecentriq.

According to CytomX, his expertise in gastrointestinal oncology is expected to support advancement of varsetatug masetecan (Varseta-M; CX-2051), an EpCAM-directed antibody-drug conjugate for metastatic colorectal cancer, and CX-801, a masked interferon alpha-2b PROBODY cytokine initially in development for metastatic melanoma.

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News Market Reaction – CTMX

+0.31%
6 alerts
+0.31% Session close to close
$705.36M Market Cap
0.3x Rel. Volume

In the Jul 27 session, CTMX gained 0.31%, reflecting a mild positive market reaction. Our momentum scanner triggered 6 alerts that day, indicating moderate trading interest and price volatility.

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SOUTH SAN FRANCISCO, Calif., July 27, 2026 (GLOBE NEWSWIRE) -- CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced the appointment of Charles Fuchs, M.D., M.P.H., to its Board of Directors.

“We are pleased to welcome Dr. Fuchs to our Board,” said Sean McCarthy, D.Phil., chief executive officer and chairman of CytomX Therapeutics. “Dr. Fuchs is a highly accomplished oncology expert and industry leader with more than three decades of experience across academia and global drug development, including advancing multiple cancer therapies from early research through approval. His expertise in oncology product development and specifically in gastrointestinal oncology will be invaluable as we continue to advance Varseta-M and the broader PROBODY therapeutic pipeline to improve patient outcomes.”

Dr. Fuchs has more than three decades of leadership experience across oncology research and biopharmaceutical drug development. Charles most recently served as Chief Medical Officer of Tubulis, where he oversees clinical strategy and pipeline development. Prior to joining Tubulis, he served as Senior Vice President and Global Head of oncology and hematology drug development at Genentech and Roche, where he led multiple novel therapies to approval, including Lunsumio, Columvi, Polivy, and Tecentriq. Before joining the pharmaceutical industry, Dr. Fuchs served as Director of the Yale Cancer Center and Physician in Chief at Smilow Cancer Hospital, where he contributed to the launch of several biotech companies and founded EvolveImmune Therapeutics. Earlier, he held several senior roles at Dana Farber Cancer Institute, including Chief of the Gastrointestinal Cancer Division, and Harvard Medical School, where he built leading research programs in gastrointestinal cancers and cancer epidemiology. Dr. Fuchs also serves as a Senior Advisor to Frazier Life Sciences. He is a board certified medical oncologist, holding an M.D. from Harvard Medical School and an M.P.H. from the Harvard T.H. Chan School of Public Health.

“I am delighted to join CytomX’s Board at this important time for the company,” said Dr. Fuchs. “CytomX has built its highly differentiated PROBODY platform with the potential to meaningfully expand the therapeutic window of cancer therapies and address large patient populations with high unmet need. I am particularly excited to see the potential of the Varseta-M EpCAM ADC program to make an important impact for colorectal cancer patients and I look forward to working with the Board and management team to help advance this product towards pivotal studies and ultimately to regulatory approval.”

About CytomX Therapeutics, Inc.

CytomX is a clinical-stage, oncology-focused biopharmaceutical company focused on developing novel conditionally activated, masked PROBODY® therapeutics designed to be localized to the tumor microenvironment. By pioneering a novel pipeline of localized biologics, powered by its PROBODY therapeutic platform, CytomX’s vision is to create safer, more effective therapies for the treatment of cancer. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), cytokines and T-cell engagers. CytomX’s clinical-stage pipeline includes varsetatug masetecan (Varseta-M; CX-2051) and CX-801. Varseta-M is a masked, conditionally activated ADC armed with a topoisomerase-1 inhibitor payload and directed toward epithelial cell adhesion molecule (EpCAM). EpCAM is a highly expressed tumor antigen that has previously been undruggable due to expression on normal tissues. Varseta-M is designed to open a therapeutic window for this high potential target and is initially being developed for the treatment of metastatic colorectal cancer. Varseta-M was discovered in collaboration with ImmunoGen, now part of AbbVie. CX-801 is a masked interferon alpha-2b PROBODY® cytokine with broad potential applicability in traditionally immuno-oncology sensitive as well as insensitive (cold) tumors. CX-801 is initially being developed for the treatment of metastatic melanoma. CytomX has established strategic collaborations with multiple leaders in oncology, including Amgen, Regeneron and Moderna. For more information about CytomX and how it is working to make conditionally activated treatments the new standard-of-care in the fight against cancer, visit www.cytomx.com and follow us on LinkedIn and X (formerly Twitter).

Company Contact:
Chris Ogden
SVP, Chief Financial Officer
cogden@cytomx.com

Investor Contact:
Precision AQ
Stephanie Ascher
stephanie.ascher@precisionaq.com

Media Contact:
Precision AQ
Colleen Ketchum
colleen.ketchum@precisionaq.com


FAQ

Who was appointed to the CytomX Therapeutics (Nasdaq: CTMX) Board of Directors in July 2026?

CytomX Therapeutics appointed Charles Fuchs, M.D., M.P.H., to its Board of Directors on July 27, 2026. According to CytomX, Fuchs is a veteran oncology leader with extensive academic and industry experience in global cancer drug development and gastrointestinal oncology.

What is Charles Fuchs’ background before joining the CytomX (CTMX) Board?

Before joining CytomX’s Board, Charles Fuchs served as Chief Medical Officer of Tubulis and previously led oncology and hematology drug development at Genentech and Roche. According to CytomX, he also directed Yale Cancer Center and held senior roles at Dana Farber and Harvard Medical School.

How could Charles Fuchs’ appointment impact CytomX Therapeutics’ Varseta-M (CX-2051) program?

CytomX states that Charles Fuchs’ gastrointestinal oncology expertise is relevant to advancing varsetatug masetecan (Varseta-M; CX-2051). According to CytomX, Varseta-M is a masked EpCAM-directed antibody-drug conjugate initially being developed for metastatic colorectal cancer using the company’s PROBODY therapeutic platform.

What cancer drug development experience does new CytomX (CTMX) director Charles Fuchs bring?

Charles Fuchs brings experience leading multiple novel oncology therapies to approval at Genentech and Roche, including Lunsumio, Columvi, Polivy and Tecentriq. According to CytomX, his background spans academia, cancer center leadership, biotech company formation and global pharmaceutical development.

What is CytomX Therapeutics’ PROBODY platform mentioned in the Charles Fuchs appointment news?

CytomX’s PROBODY platform focuses on masked, conditionally activated biologics designed for localized activity in the tumor microenvironment. According to CytomX, this platform underpins candidates such as Varseta-M, an EpCAM-directed ADC, and CX-801, a masked interferon alpha-2b cytokine for metastatic melanoma.

Which pipeline programs are highlighted by CytomX (CTMX) in connection with Charles Fuchs joining the Board?

CytomX highlights varsetatug masetecan (Varseta-M; CX-2051) and CX-801 alongside Charles Fuchs’ appointment. According to CytomX, Varseta-M targets EpCAM in metastatic colorectal cancer, while CX-801 is a masked interferon alpha-2b PROBODY cytokine initially developed for metastatic melanoma.