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Delcath Systems Appoints Martha S. Rook as Chief Operating Officer

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Delcath Systems, Inc. (DCTH) appoints Martha S. Rook as Chief Operating Officer, bringing over 25 years of industry experience in molecular biology and biologics development. Ms. Rook's background includes leadership roles at insitro and Sigilon Therapeutics, with a focus on complex combination products. She also spent 13 years at MilliporeSigma. The Company granted Ms. Rook an equity award of 125,000 shares of common stock.
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NEW YORK, March 18, 2024 /PRNewswire/ -- Delcath Systems, Inc. (Nasdaq: DCTH) (the "Company" or "Delcath"), an interventional oncology company focused on the treatment of primary and metastatic cancers of the liver, is pleased to announce the appointment of Martha S. Rook as its new Chief Operating Officer (COO).

Martha S. Rook, Ph.D., is an experienced industry leader who brings more than 25 years of academic and industry experience in molecular biology, diagnostics development, biologics process development and biologics manufacturing. She joins Delcath from insitro where she served as a Chief Technical Operations Officer and was responsible for core research services, facilities and laboratory operations, quality and project and portfolio management. Prior to insitro, she was with Sigilon Therapeutics, where she served as Chief Technical Operations Officer and was responsible for the analytics, manufacturing, supply chain and quality organizations producing a biologic-device combination product.

"We are thrilled to welcome Martha, a Senior business leader with more than 25 years of experience, to the leadership team," said Gerard Michel, Chief Executive Officer of Delcath. "Her extensive knowledge of the technical, business, and regulatory challenges of supplying complex combination products will be invaluable as we expand the production of HEPZATO KIT and CHEMOSAT."

Martha's experience also includes 13 years at MilliporeSigma, where she held a variety of roles, ultimately serving as vice president and head of the Gene Editing & Novel Modalities Business and led a team developing and providing tools and services for cell and gene therapies from discovery to manufacturing. Martha received her Ph.D. in biochemistry from MIT and holds a B.S. in chemistry from Texas A&M University. She pursued postdoctoral studies in neuroscience as a Lefler Fellow at Harvard Medical School's Center for Neurologic Diseases.

The Company granted Ms. Rook an equity award, previously approved by the Company's Compensation Committee, as a material inducement to her employment in accordance with NASDAQ Listing Rule 5635(c)(4).  The grant totaled the right to purchase 125,000 shares of the Company's common stock and is subject to the terms and conditions of the Company's 2023 Inducement Plan ("Plan").  The options were granted on March 18, 2024, and are subject to an exercise price equal to the closing price of Delcath's common stock on the grant date.   The options have a ten-year term and vest ratably over the 36-month period beginning on the Grant Date, (i.e., 1/36th will vest at the end of each month during said 36-month period), subject to Ms. Rook's continued service with the Company on each respective vesting date.

About Delcath Systems, Inc.
Delcath Systems, Inc. is an interventional oncology company focused on the treatment of primary and metastatic liver cancers. The Company's proprietary products, HEPZATO KIT™ (melphalan for Injection/Hepatic Delivery System), approved for use in the United States by the Food and Drug Administration, and CHEMOSAT Hepatic Delivery System for Melphalan percutaneous hepatic perfusion (PHP), designated under the medical device regulation for use in Europe and the United Kingdom, are designed to administer high-dose chemotherapy to the liver while controlling systemic exposure and associated side effects during a PHP procedure. For more information regarding HEPZATO KIT and its use, including Important Safety Information and Boxed Warning, please visit HEPZATOKIT.com. For more information regarding CHEMOSAT and its use, please visit Chemosat.com.

Contact:
Investor Relations Contact:
Ben Shamsian Lytham Partners
646-829-9701
shamsian@lythampartners.com

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SOURCE Delcath Systems, Inc.

Martha S. Rook is the new Chief Operating Officer of Delcath Systems, Inc.

Martha S. Rook brings over 25 years of experience in molecular biology, diagnostics development, biologics process development, and biologics manufacturing.

Martha S. Rook previously worked at insitro and Sigilon Therapeutics before joining Delcath Systems, Inc.

Delcath Systems, Inc. granted Martha S. Rook an equity award of 125,000 shares of the Company's common stock.

The options were granted on March 18, 2024, with a ten-year term and vesting ratably over a 36-month period, subject to Ms. Rook's continued service with the Company.
Delcath Systems Inc

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About DCTH

delcath systems, inc. (nasdaq- dcth) is a specialty pharmaceutical and medical device company focused on the treatment of primary and metastatic liver cancers. our proprietary product---melphalan hydrochloride for injection for use with the delcath hepatic delivery system (melphalan/hds)---is designed to administer high-dose chemotherapy to the liver while controlling systemic exposure. delcath is in late-stage clinical development in the united states with initial commercial activities in europe, where the melphalan/hds is marketed as a ce marked device under the trade name delcath hepatic chemosat® delivery system for melphalan (chemosat). our commercial strategy for chemosat is to steadily grow clinical adoption in major european markets and utilize physician experience to support appeals for reimbursement. since launch over 250 chemosat treatments have been performed at over 20 leading european cancer centers. in 2016, we launched our focus pivotal study in hepatic dominant ocular