DuPont Expands Bioprocessing Portfolio with Launch of DuPont™ AmberChrom™ TQ1 Chromatography Resin
DuPont (DD) has launched DuPont™ AmberChrom™ TQ1, a new agarose-based chromatography resin designed for purifying oligonucleotides and peptides in biopharma applications. The product offers superior performance features including increased loading capacity, higher throughput, and lower pressure requirements compared to competing products.
The resin is suitable for both benchtop and large-scale commercial purifications, delivering high purity fractions in biomolecule purifications. DuPont has validated the product's performance through comprehensive internal application studies using real-world drug feeds. The resin can be used alongside existing AmberChrom™ XT and CG chromatography resins for various oligonucleotide and peptide purification processes.
DuPont (DD) ha lanciato DuPont™ AmberChrom™ TQ1, una nuova resina cromatografica a base di agarosio progettata per purificare oligonucleotidi e peptidi nelle applicazioni biofarmaceutiche. Il prodotto offre prestazioni superiori, tra cui una maggiore capacità di carico, un flusso più elevato e requisiti di pressione inferiori rispetto ai prodotti concorrenti.
La resina è adatta sia per purificazioni da banco che per processi commerciali su larga scala, garantendo frazioni ad alta purezza nella purificazione di biomolecole. DuPont ha convalidato le prestazioni del prodotto attraverso studi applicativi interni approfonditi utilizzando alimentazioni di farmaci reali. La resina può essere utilizzata insieme alle resine cromatografiche AmberChrom™ XT e CG esistenti per diversi processi di purificazione di oligonucleotidi e peptidi.
DuPont (DD) ha lanzado DuPont™ AmberChrom™ TQ1, una nueva resina cromatográfica a base de agarosa diseñada para purificar oligonucleótidos y péptidos en aplicaciones biofarmacéuticas. El producto ofrece características de rendimiento superiores, incluyendo una mayor capacidad de carga, mayor rendimiento y menores requisitos de presión en comparación con productos competidores.
La resina es adecuada tanto para purificaciones a nivel de banco como para procesos comerciales a gran escala, proporcionando fracciones de alta pureza en la purificación de biomoléculas. DuPont ha validado el rendimiento del producto mediante estudios internos exhaustivos con alimentaciones de fármacos reales. La resina puede usarse junto con las resinas cromatográficas AmberChrom™ XT y CG existentes para diversos procesos de purificación de oligonucleótidos y péptidos.
DuPont (DD)는 생명공학 제약 분야에서 올리고뉴클레오티드와 펩타이드 정제를 위해 설계된 새로운 아가로스 기반 크로마토그래피 수지인 DuPont™ AmberChrom™ TQ1을 출시했습니다. 이 제품은 경쟁 제품에 비해 우수한 성능 특성을 제공하며, 적재 용량 증가, 처리량 향상, 낮은 압력 요구 사항을 포함합니다.
이 수지는 벤치탑 및 대규모 상업용 정제 모두에 적합하며, 생체 분자 정제에서 높은 순도의 분획을 제공합니다. DuPont는 실제 약물 공급원을 사용한 포괄적인 내부 응용 연구를 통해 제품 성능을 검증했습니다. 이 수지는 기존의 AmberChrom™ XT 및 CG 크로마토그래피 수지와 함께 다양한 올리고뉴클레오티드 및 펩타이드 정제 공정에 사용할 수 있습니다.
DuPont (DD) a lancé DuPont™ AmberChrom™ TQ1, une nouvelle résine chromatographique à base d'agarose conçue pour la purification des oligonucléotides et des peptides dans les applications biopharmaceutiques. Ce produit offre des performances supérieures, notamment une capacité de charge accrue, un débit plus élevé et des exigences de pression réduites par rapport aux produits concurrents.
La résine convient aussi bien aux purifications de laboratoire qu'aux purifications commerciales à grande échelle, fournissant des fractions de haute pureté lors de la purification des biomolécules. DuPont a validé les performances du produit grâce à des études internes approfondies utilisant des charges médicamenteuses réelles. La résine peut être utilisée en complément des résines chromatographiques AmberChrom™ XT et CG existantes pour divers processus de purification d'oligonucléotides et de peptides.
DuPont (DD) hat DuPont™ AmberChrom™ TQ1 eingeführt, ein neues auf Agarose basierendes Chromatographieharz, das für die Reinigung von Oligonukleotiden und Peptiden in biopharmazeutischen Anwendungen entwickelt wurde. Das Produkt bietet überlegene Leistungsmerkmale, darunter eine erhöhte Beladekapazität, höhere Durchsatzraten und geringere Druckanforderungen im Vergleich zu Konkurrenzprodukten.
Das Harz eignet sich sowohl für Labor- als auch für großtechnische kommerzielle Reinigungen und liefert hochreine Fraktionen bei der Reinigung von Biomolekülen. DuPont hat die Leistung des Produkts durch umfassende interne Anwendungstests mit realen Arzneimittelproben validiert. Das Harz kann zusammen mit den bestehenden AmberChrom™ XT- und CG-Chromatographieharzen für verschiedene Oligonukleotid- und Peptidreinigungsprozesse verwendet werden.
- Superior product features: increased loading capacity, higher throughput, and lower pressure requirements compared to competitors
- Versatile application: suitable for both benchtop and large-scale commercial purifications
- Validated performance through comprehensive real-world drug feed studies
- Expands DuPont's bioprocessing capabilities in high-growth therapy areas
- None.
Insights
DuPont's new chromatography resin enhances oligonucleotide/peptide purification capabilities, strengthening their position in the growing biopharma manufacturing space.
DuPont's launch of AmberChrom™ TQ1 chromatography resin represents a strategic expansion into the high-growth oligonucleotide and peptide therapeutics market. This timing is particularly relevant as these modalities continue gaining traction following breakthrough RNA-based vaccines and therapies.
The technical specifications reveal several manufacturing advantages over existing solutions. The agarose-based resin delivers increased loading capacity and higher throughput while requiring less pressure than competing products. These characteristics directly address key production bottlenecks in biopharmaceutical manufacturing, where purification efficiency significantly impacts production economics and timelines.
For bioprocess engineers, the resin's versatility is noteworthy - it handles both DMT-Off and DMT-On oligonucleotides with high yield and purity, making it suitable for diverse manufacturing scenarios from bench to commercial scale. The low-pressure operation is particularly valuable for preserving sensitive biomolecules during purification.
DuPont's approach of validating performance with real-world drug feeds demonstrates practical application understanding rather than just theoretical capabilities. This evidence-based approach helps reduce implementation risk for potential customers across the drug development spectrum.
The integration with existing AmberChrom™ resins creates a more comprehensive purification platform, potentially streamlining technology transfer and validation processes for manufacturers already using DuPont products. This ecosystem approach is increasingly important as bioprocessing facilities seek to standardize platforms across multiple products.
While incremental rather than revolutionary, this launch strengthens DuPont's competitive position in the growing oligonucleotide manufacturing space, which continues expanding as RNA therapeutics gain regulatory approvals and commercial traction.
Agarose-based chromatography resin supports purification of oligonucleotides and peptides for biopharma applications
"The introduction of DuPont™ AmberChrom™ TQ1 chromatography resin supports the accelerated development and commercialization of oligonucleotide and peptide therapeutics," said Shane Kendra, Global Bioprocessing Market Leader for DuPont Water Solutions. "In addition to expanding our capabilities, this new anion exchange chromatography resin offers exceptional performance, setting a new standard in this product class and creating new opportunities in high growth therapy areas."
The new agarose-based chromatography resin offers increased loading capacity, higher throughput, and requires less pressure than comparable competing products within the same class. These characteristics make DuPont™ AmberChrom™ TQ1 chromatography resin an excellent choice for high resolution separations and polishing, offering high purity fractions in biomolecule purifications and the separation of closely-related impurities from target molecules. Its low-pressure build-up, combined with high-yield and purity for peptides and both DMT-Off and DMT-On oligonucleotides, makes the resin suitable for use in benchtop and large-scale commercial purifications.
To support the introduction of the resin, DuPont has published comprehensive internal application studies that used real-world drug feeds to validate performance characteristics; this documentation can also assist with the integration of the product into processes at every phase from drug discovery through commercialization.
"Further expansion of DuPont's bioprocessing portfolio reflects our commitment to providing a comprehensive one-stop shop for the purification and polishing of oligonucleotides and peptides," said Kendra. "Our technical teams and scientists are continually collaborating with customers to design efficient bioprocessing solutions for every stage of the drug development journey."
DuPont™ AmberChrom™ TQ1 chromatography resin can be used in combination with existing AmberChrom™ XT and CG chromatography resins to purify various oligonucleotide feeds, or for the crude purification of peptide feeds in preparation for reverse phase chromatography.
DuPont introduced the new chromatography resin to the market during TIDES USA—a conference dedicated to accelerating oligonucleotide and peptide innovations. Hadi Fares, Ph.D, a bioprocessing application scientist with DuPont, presented application studies to demonstrate the performance capabilities of DuPont™ AmberChrom™ TQ1 chromatography resin, and how it complements existing resins within the DuPont bioprocessing portfolio.
On June 19, 2025, DuPont will host an educational webinar discussing the capabilities of DuPont™ AmberChrom™ TQ1 chromatography resin and how its loading capacity and purification efficacy can enhance purification of oligonucleotides and peptides. Register here.
Learn more about DuPont™ AmberChrom™ TQ1 chromatography resin and the broader DuPont bioprocessing portfolio.
As a global market leader in adsorbents and ion exchange resins with over 80 years of experience, DuPont bioprocessing solutions can accelerate and enhance the discovery and production of small molecule synthetics, oligonucleotides, and peptides, as well as diagnostics, by enabling complicated separations that help companies achieve their vision to manage and treat diseases.
About DuPont
DuPont (NYSE: DD) is a global innovation leader with technology-based materials and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets including electronics, transportation, construction, water, healthcare and worker safety. More information about the company, its businesses and solutions can be found at www.dupont.com. Investors can access information included on the Investor Relations section of the website at investors.dupont.com.
DuPont™, the DuPont Oval Logo, and all trademarks and service marks denoted with ™, SM or ® are owned by affiliates of DuPont de Nemours, Inc. unless otherwise noted.
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SOURCE DuPont
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