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Defence Therapeutics Provides Corporate Update as Company Executes on Strategic Priorities

The executive awards depend on share-price milestones, and further sharing-agreement settlements remain outstanding.

(Moderate)

Sentiment and the balance of points

Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.

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Defence Therapeutics (DTCFF) outlined a scientific advisory board change, executive stock awards and a sharing-agreement settlement. Its priorities include partnered Accum-enhanced antibody-drug conjugates, in-house radiotherapeutics and development options for AccuTOX.

Dr. Svetlana Selivanova resigned from the board to join its scientific advisory board. The board approved 7,000,000 restricted stock units for CEO Dr. Amie Phinney and Executive Chairman Sébastien Plouffe. They are issuable in five equal installments if the shares reach specified closing-price milestones and expire September 24, 2029.

Defence received a $249,696.72 second settlement on September 15 against 606,060 placement shares released to Sorbie Bornholm LP. Another 9,696,971 placement shares remain in escrow, with 16 settlement payments remaining.

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5 points · 0 major

How this balance works

Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.

It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.

Rhea-AI Sentiment measures something else, the tone of the wording.

0 major · 2 points

Hollow bars mark forward-looking points. How the balance works

Positive

  • Minor point$249,696.72 received as the second sharing-agreement settlement on September 15.
  • Minor point. Forward-looking: it has not happened yet and may not happen.7,000,000 executive stock units are tied to specified closing-price milestones before issuance.
  • Minor pointScientific advisory board gains Dr. Svetlana Selivanova following her board resignation.
  • Minor pointRadiotherapeutics program is evaluating both alpha- and beta-emitting radioisotopes.
  • Minor point. Forward-looking: it has not happened yet and may not happen.Development priorities include partnered Accum-enhanced antibody-drug conjugates and options for AccuTOX.

Negative

  • Moderate point. Forward-looking: it has not happened yet and may not happen.7,000,000 stock units each entitle the holder to one common share if issued.
  • Minor point. Forward-looking: it has not happened yet and may not happen.16 settlement payments remain under the sharing agreement.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Montreal, Quebec--(Newsfile Corp. - September 28, 2026) - Defence Therapeutics Inc. (CSE: DTC) (OTCQB: DTCFF) (FSE: DTC) ("Defence" or the "Company"), a publicly traded biotechnology company developing next-generation precision oncology therapeutics using its proprietary Accum® platform, is pleased to provide a corporate update as the Company continues to execute on the strategic priorities outlined in its recent letter to shareholders.

Since assuming the role of President and Chief Executive Officer in August, Dr. Amie Phinney and the Defence leadership team have focused on translating the Company's strategy into execution across its scientific programs, leadership and operations. Defence is prioritizing Accum®-enhanced antibody-drug conjugate ("ADC") partnerships, the in-house development of Accum®-enabled radiotherapeutics, and the evaluation of strategic development options for AccuTOX®.

"Our recent shareholder letter set out a focused strategy for Defence and, importantly, a commitment to demonstrate progress against it," said Dr. Phinney. "We are now moving forward with that execution, strengthening the expertise supporting our priority programs, aligning leadership incentives with long-term shareholder value creation, and deploying the capital and resources needed to advance our strategy."

To this end, Dr. Svetlana Selivanova has resigned from Defence's Board of Directors to transition to the Company's Scientific Advisory Board ("SAB"), where she will deepen her scientific engagement with the Company and contribute her expertise in radiopharmacology. Her appointment strengthens the scientific expertise supporting Defence's growing radiopharmaceutical program as the Company advances its strategy to evaluate the potential of Accum® to improve the intracellular delivery and retention of radioisotopes in tumour cells. The transition builds on Defence's strategic priority, including the appointment of Dr. Ryan Simms as Chief Operating Officer and Head of Radiopharmaceutical Programs and the expansion of the Company's development strategy to evaluate both alpha- and beta-emitting radioisotopes.

"We are very pleased that Svetlana will continue her work with Defence in a role that allows us to more directly leverage her scientific expertise," said Dr. Phinney.

The Company also announces that its Board of Directors has approved the grant of an aggregate number of 7,000,000 incentive restricted stock units ("RSUs") to Dr. Amie Phinney, President and Chief Executive Officer, and Mr. Sébastien Plouffe, Executive Chairman. The RSUs are structured as performance-based incentives tied to defined share-price milestones, aligning a significant component of leadership compensation with long-term shareholder value creation.

The RSUs will be issued in five equal installments upon the common shares of the Company achieving closing prices on the Canadian Securities Exchange at or above $0.75, $1.00, $1.25, $1.50 and $1.75, respectively. Each RSU entitles the holder to receive one common share of the Company. The RSUs expire on September 24, 2029, and remain subject to the terms of the Company's Omnibus Incentive Plan and applicable securities laws.

The Company is also pleased to provide another update on its sharing agreement dated March 6, 2026 (the "Sharing Agreement") with Sorbie Bornholm LP ("SBLP") previously described in the Company's news releases of March 9 and February 27, 2026. Further to the first settlement dated August 14, 2026, the Company has received the second Settlement in the amount of $249,696.72 as of the settlement date of September 15, 2026, against 606,060 Placement Shares released to SBLP. As of today, 9,696,971 Placement Shares are held in escrow in connection with the Sharing Agreement and there are 16 Settlement payments remaining.

Defence remains focused on the priorities communicated to shareholders: expanding opportunities to evaluate Accum® with partnered ADCs, generating foundational data and advancing its Accum®-enabled radiotherapeutics programs, and determining the optimal path forward for AccuTOX®. The Company expects to provide further updates as these initiatives progress.

About Defence Therapeutics:
Defence Therapeutics is a publicly traded biotechnology company committed to making cancer treatment more effective and safer. Using its Accum® precision drug delivery platform, Defence is working to enhance the potency of ADCs and other complex biologics at lower doses, with the goal of reducing side effects and improving access to advanced therapies. By pursing cutting edge science, and collaborating with pharma and biotech partners, Defence strives to bring transformative therapies to patients who need them most. To learn more about Defence Therapeutics and explore partnering opportunities, please visit www.defencetherapeutics.com or contact info@defencetherapeutics.com.

For further information:
Defence Therapeutics
Amie Phinney
President and Chief Executive Officer
P: (604) 306-8027
aphinney@defencetherapeutics.com  
www.defencetherapeutics.com

Cautionary Statement Regarding "Forward-Looking" Information

This release includes certain statements that may be deemed "forward-looking statements". All statements in this release, other than statements of historical facts, that address events or developments that the Company expects to occur, are forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although the Company believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in the forward-looking statements. Factors that could cause the actual results to differ materially from those in forward-looking statements include regulatory actions, market prices, and continued availability of capital and financing, and general economic, market or business conditions. Investors are cautioned that any such statements are not guarantees of future performance and actual results or developments may differ materially from those projected in the forward-looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of the Company's management on the date the statements are made. Except as required by applicable securities laws, the Company undertakes no obligation to update these forward-looking statements in the event that management's beliefs, estimates or opinions, or other factors, should change.

Neither the CSE nor its market regulator, as that term is defined in the policies of the CSE, accepts responsibility for the adequacy or accuracy of this release.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/316403

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What are the terms of Defence Therapeutics’ executive stock awards?

The board approved 7,000,000 restricted stock units for CEO Dr. Amie Phinney and Executive Chairman Sébastien Plouffe. Five equal installments are issuable when Defence’s common shares achieve Canadian Securities Exchange closing prices of at least $0.75, $1.00, $1.25, $1.50 and $1.75, respectively. Each unit entitles its holder to one common share, and the units expire September 24, 2029.

How much was Defence Therapeutics’ second sharing-agreement settlement?

Defence received $249,696.72 as of the September 15 settlement date, against 606,060 placement shares released to Sorbie Bornholm LP. A further 9,696,971 placement shares were held in escrow as of the announcement, with 16 settlement payments remaining.

Which radioisotopes is Defence Therapeutics evaluating for its Accum radiotherapeutics?

Its expanded development strategy covers alpha- and beta-emitting radioisotopes. Defence is evaluating the potential for Accum to improve their delivery into and retention in tumour cells.

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