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Esperion Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update

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Esperion (NASDAQ: ESPR) reported FY2025 total revenue of $403.1M (21% Y/Y) and Q4 revenue of $168.4M (144% Y/Y). U.S. net product revenue grew ~38% Y/Y to $159.6M for FY2025. The company announced an agreement to acquire Corstasis and Enbumyst™, and strengthened patent settlements and payer coverage.

Key financials: Q4 U.S. product sales $43.7M, collaboration revenue driven by a $90M Otsuka payment, FY net loss $22.7M, cash $167.9M, and 2026 operating expense guidance of $225M–$255M.

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Positive

  • FY2025 total revenue +21% to $403.1M
  • U.S. net product revenue +38% to $159.6M in FY2025
  • Q4 2025 total revenue +144% Y/Y to $168.4M
  • Settlement agreements restrict certain generic entry until April 2040
  • Otsuka payment of $90M tied to Japan approval and NHI listing

Negative

  • Full-year 2025 net loss of $22.7M despite Q4 net income of $61.8M
  • Selling, general & administrative expenses increased, partly from ANDA litigation
  • Some Esperion patents expire March 2036 and June 2040, leaving residual litigation exposure

Key Figures

FY25 Total Revenue: $403.1M FY25 U.S. Net Product Revenue: $159.6M Q4 2025 Total Revenue: $168.4M +5 more
8 metrics
FY25 Total Revenue $403.1M Full year 2025, up 21% Y/Y
FY25 U.S. Net Product Revenue $159.6M Full year 2025, up 38% Y/Y
Q4 2025 Total Revenue $168.4M Q4 2025, up 144% Y/Y
Q4 2025 U.S. Net Product Revenue $43.7M Q4 2025, up ~38% Y/Y
Q4 2025 Net Income $61.8M Three months ended Dec 31, 2025
FY25 Net Loss $22.7M Full year ended Dec 31, 2025
Cash & Equivalents $167.9M As of Dec 31, 2025
2026 OpEx Guidance $225M–$255M Expected 2026 operating expenses, incl. ~$15M stock comp

Market Reality Check

Price: $3.04 Vol: Volume 7,338,357 vs 20-da...
high vol
$3.04 Last Close
Volume Volume 7,338,357 vs 20-day average 3,924,186 (relative volume 1.87x). high
Technical Price $3.04 trades above 200-day MA at $2.55, still 27.19% below 52-week high.

Peers on Argus

ESPR gained 11.76% while peers were mixed: AQST +4.13%, AKBA +6.75%, SIGA -1.93%...

ESPR gained 11.76% while peers were mixed: AQST +4.13%, AKBA +6.75%, SIGA -1.93%, ORGO -1.08%, EOLS +0.75%, indicating a stock-specific reaction.

Previous Earnings Reports

5 past events · Latest: Nov 06 (Positive)
Same Type Pattern 5 events
Date Event Sentiment Move Catalyst
Nov 06 Q3 2025 earnings Positive -15.0% Strong Q3 revenue growth and guidance toward sustainable profitability.
Aug 05 Q2 2025 earnings Positive +8.7% Double‑digit revenue growth and first quarter of operating income.
May 06 Q1 2025 earnings Negative -7.1% Revenue dip versus prior year milestone and a sizeable net loss.
Mar 04 Q4 2024 earnings Positive +12.0% Strong FY24 revenue growth, prescription gains, and narrowed net loss.
Nov 07 Q3 2024 earnings Positive -4.5% Robust revenue and prescription growth with strengthened payer access.
Pattern Detected

Earnings headlines have generally been positive, but price reactions skewed slightly negative, with 3 aligned and 2 divergent moves and an average move of about -1.17% on prior earnings.

Recent Company History

Over the past five earnings cycles, Esperion reported consistent revenue growth and expanding global partnerships. Q4 2024 results showed strong top-line gains and improved net loss, followed by 2025 quarters with double‑digit revenue growth and rising U.S. net product sales. Despite this, reactions were mixed, including a -14.97% move on Q3 2025 results. The latest 2025 full‑year report continues the growth narrative and highlights progress toward profitability and global expansion, fitting into this ongoing transition story.

Historical Comparison

-1.2% avg move · Past earnings headlines moved ESPR about -1.17% on average. Today’s +11.76% post‑earnings move stand...
earnings
-1.2%
Average Historical Move earnings

Past earnings headlines moved ESPR about -1.17% on average. Today’s +11.76% post‑earnings move stands out as a materially stronger reaction versus typical results.

Earnings updates show steady revenue expansion, broader payer coverage, and a shift from sizable losses toward expected sustainable profitability beginning in 2026.

Market Pulse Summary

This announcement combines strong FY25 revenue growth, with total revenue of $403.1M and Q4 revenue ...
Analysis

This announcement combines strong FY25 revenue growth, with total revenue of $403.1M and Q4 revenue of $168.4M, alongside a shift to quarterly profitability but a full‑year net loss of $22.7M. It highlights expanding global partnerships, patent settlements extending protection into the 2040s, and pipeline progress such as ESP‑2001 for PSC. Investors may track prescription trends, collaboration payments, R&D spend, and 2026 operating expense guidance of $225M–$255M as key markers of execution.

Key Terms

ldl-c, investigational new drug, orphan drug, fast track, +2 more
6 terms
ldl-c medical
"triple combination products can lower LDL-C in up to 70%"
LDL-C stands for low-density lipoprotein cholesterol, the portion of cholesterol carried in the blood by LDL particles that is commonly linked to buildup of plaque in arteries—think of it like sticky debris that can clog pipes. Investors care because changes in LDL-C are a key measure used by regulators and clinicians to judge the effectiveness of cardiovascular drugs and devices, shape insurance coverage, and influence market demand for treatments that lower heart attack and stroke risk.
investigational new drug regulatory
"goal of submitting an IND to the U.S. Food and Drug Administration"
An investigational new drug is a medication that is still being tested in clinical trials to determine if it is safe and effective for treating a specific condition. For investors, it represents a potential breakthrough that could lead to a new treatment and significant financial gains if successful, but also carries risks since it has not yet been approved for widespread use.
orphan drug regulatory
"potential eligibility for Orphan Drug and Fast Track designations"
A drug designated for an orphan disease is a medicine developed to treat a rare condition that affects only a small number of people. Regulators often give these drugs special incentives—such as reduced costs, faster review, and temporary exclusive selling rights—to encourage development, which matters to investors because those incentives can make a small market financially viable and reduce competition, much like a temporary patent on a niche product.
fast track regulatory
"eligibility for Orphan Drug and Fast Track designations from the U.S. FDA"
A fast track designation is a regulatory label that speeds up the review and communication between a drug developer and regulators for treatments addressing serious illnesses or unmet medical needs. For investors, it matters because it can shorten development time and reduce regulatory delays—like getting a VIP lane at the airport—raising the chance of earlier market access and potential revenue, though it does not guarantee approval.
prime designation regulatory
"as well as PRIME designation from the European Medicines Agency"
A prime designation is a regulatory label given to a drug or medical product that shows strong early evidence of addressing an unmet medical need, granting the developer extra guidance, faster review milestones and increased visibility with regulators. For investors it matters because this status can shorten development time, lower regulatory risk and make a program more attractive to partners or acquirers—think of it as a fast-pass and coaching package that can increase the chances and speed of a product reaching the market.
hemodialysis medical
"end stage renal disease on hemodialysis compared to matched healthy"
Hemodialysis is a medical treatment that cleans a person’s blood when their kidneys can no longer do the job, by routing blood through a machine that filters out waste, excess fluid and adjusts salt levels—think of it as an external, mechanical kidney. It matters to investors because it drives demand for specialized machines, replacement filters, clinics, trained staff and related drugs, and is sensitive to reimbursement rules, treatment volumes and advances that can change costs or market share.

AI-generated analysis. Not financial advice.

– FY25 Total Revenue Grew 21% Y/Y to $403.1 Million; FY25 U.S. Net Product Revenue Grew 38% Y/Y to $159.6 Million

– Q4 2025 U.S. Net Product Revenue Grew ~38% Y/Y to $43.7 Million; Q4 2025 Total Revenue Grew 144% Y/Y to $168.4 Million

– Q4 Retail Prescription Equivalents Grew 34% Y/Y and 11.3% Q/Q –

– Agreement to Acquire Corstasis Therapeutics to Accelerate Growth and Expand Cardiovascular Franchise with Enbumyst™ (bumetanide nasal spray) –

– Conference Call and Webcast Today at 8:00 a.m. ET –

ANN ARBOR, Mich., March 10, 2026 (GLOBE NEWSWIRE) -- Esperion (NASDAQ: ESPR) today reported financial results for the fourth quarter and full year ended December 31, 2025, and highlighted continued commercial momentum for its bempedoic acid franchise, strong full-year revenue growth, and progress advancing its long-term strategic vision.

“2025 was a defining year for Esperion. We delivered strong growth in our U.S. cardiovascular franchise, broadened access and adoption among statin intolerant or statin-resistant patients and strengthened the durability of our business with important intellectual property and market access advances,” said Sheldon Koenig, Chief Executive Officer of Esperion. “Importantly, we used this momentum to chart our next chapter with Vision 2040 - a bold plan to build a multiproduct, innovation driven company with continued leadership in cardiometabolic disease and targeted expansion into rare hepatic and renal conditions. Our recently announced agreement to acquire Corstasis Therapeutics represents a compelling and strategically aligned opportunity that accelerates Esperion’s momentum and advances our long-term Vision 2040.”

“Looking ahead, we’re investing against clear catalysts: deeper U.S. market penetration supported by robust payer coverage, advancement of our oral triple combination program designed to rival products on the market or in development and continued geographic expansion with our global partners. We are entering 2026 with confidence, discipline, and a long-term mindset focused on creating lasting value for patients, providers, and shareholders.”

Fourth Quarter 2025 Key Accomplishments and Recent Highlights

Advancing the U.S. Commercial Strategy

Most recently, the Company expanded its commercial opportunity with an agreement to acquire Corstasis Therapeutics, a biopharmaceutical company commercializing Enbumyst (bumetanide nasal spray), the first and only nasal spray diuretic approved by the U.S. Food and Drug Administration (FDA) as a treatment for adults with edema associated with congestive heart failure (CHF), hepatic disease, and renal disease in adults. The proposed acquisition is aligned with Esperion’s Vision 2040 and is a compelling strategic fit with the Company’s established cardiometabolic commercial infrastructure and pipeline.

With an estimated 6.7 million American adults living with CHF and edema as one of the most common and defining clinical features of the disease, Enbumyst addresses a large and growing population that targets a U.S. market opportunity exceeding $4 billion. Learn more about the acquisition and Enbumyst here.

Esperion’s U.S. cardiovascular commercial business continued to demonstrate strong momentum in 2025, with meaningful gains in prescription growth, market access, and brand adoption across its bempedoic acid franchise.

  • Grew Q4 U.S. net product sales by approximately 38% Y/Y to $43.7 million and full year 2025 U.S. net product sales 38% to $159.6 million.
  • Q4 retail prescription equivalents showed 34% Y/Y and 11.3% sequential Q/Q growth.
  • Reached settlement agreements with five key ANDA filers, most recently with Alkem Laboratories Ltd. These settlements, including one with Dr. Reddy’s Laboratories, restrict generic entry by these parties until April 2040 and leave no remaining challenges regarding the validity or infringement of U.S Patent No. 7,335,799 in the pending patent litigation. Certain Esperion patents that remain subject to the pending patent litigation are scheduled to expire in March 2036, while others are scheduled to expire in June 2040.
  • Significantly strengthened access and reimbursement support for NEXLETOL and NEXLIZET, now exceeding 90% of commercial lives and 90% of Medicare beneficiaries covered, with all national commercial and Medicare payers covering all indications.
  • Enabled the expansion of unique healthcare providers prescribing NEXLETOL and NEXLIZET from 36,311 to 44,991, a 24% increase in 2025 with strengthened reimbursement and award-winning marketing and educational initiatives.
  • To leverage the strengthened reimbursement, progress in our patent protection, and anticipated U.S. guideline inclusion, the Company plans to expand its U.S. commercial efforts through enhanced sales and marketing investments.
  • Expanded partnerships with regulatory experts and others in the field to advance development of the Company’s two triple combination products. The published literature suggests that the triple combination products can lower LDL-C in up to 70%. This level of efficacy has the potential to rival existing injectable and emerging oral therapies, offering a valuable oral option for both patients and physicians. The Company expects to complete the clinical requirements and commercialize triple combinations in 2027.

Global Expansion

Esperion’s global expansion strategy accelerated in 2025, with strong performance from international partners and meaningful progress in regulatory approvals, reimbursement, and market launches across key regions.

  • Daiichi Sankyo Europe, Esperion’s strategic partner across Europe, delivered double digit annual growth across key EU markets, and expanded availability of bempedoic acid therapies across 30 countries in the European Union, with more than 700,000 patients treated to date.
    • Royalty revenue was $14.6 million, an increase of 51% from Q4 2024 and a decrease of 11% sequentially. 
    • Bempedoic acid was included as a Class I, Level A recommendation in the 2025 ESC/EAS guidelines.
    • Secured regulatory and reimbursement approval for NILEMDO in France, one of the largest markets in Europe.
    • Announced the development of oral triple combination lipid-lowering tablets, with SANTORINI simulations showing improved LDL-C goal attainment aligned with the 2025 ESC/EAS guidelines.
  • Otsuka Pharmaceutical Co., Ltd., Esperion’s strategic partner in Japan, received regulatory approval and favorable National Health Insurance price listing, which resulted in a $90 million total payment to Esperion.
    • Successful commercial launch in late 2025 sets the stage for meaningful growth in 2026.
    • Japan is the third largest global market for cardiovascular prevention, representing significant long-term growth opportunity for NEXLETOL.
  • HLS Therapeutics, Esperion’s strategic partner in Canada, announced NILEMDOTM (bempedoic acid) is now available in Canada for the reduction of LDL-cholesterol in patients at risk of cardiovascular disease, with approval for NEXLIZET expected in 2026.
  • Esperion continues to expect its partner in Israel, Neopharm Israel, to receive regulatory approval to market NEXLETOL and NEXLIZET in the first half of 2026.
  • CSL Seqirus, the Company’s partner in Australia and New Zealand, filed a marketing application in Australia for NEXLETOL and NEXLIZET in July 2025, and expects market approval in Q4 2026.

R&D Pipeline

Esperion plans to advance its promising ACLY-focused pipeline, leveraging its established leadership in ACLY biology to pursue new therapeutic opportunities and develop next-generation inhibitors designed to address multiple life-threatening diseases. ACLY is a critical metabolic enzyme positioned at the intersection of nutrient catabolism and cholesterol and fatty acid biosynthesis, making it an attractive target for broad therapeutic intervention.

  • Nominated ESP-2001, a highly specific allosteric ATP-citrate lyase inhibitor, as preclinical development candidate for the treatment of primary sclerosing cholangitis (PSC).
  • Initiated Investigational New Drug-enabling studies for ESP-2001, with the goal of submitting an IND to the U.S. Food and Drug Administration (FDA) to begin first-in-human clinical studies in 2026.
  • With an estimated prevalence of approximately 76,000 diagnosed PSC patients across the U.S. and Europe, and with no approved treatment options, ESP-2001 – a wholly owned asset for which Esperion retains exclusive global development and commercialization rights – represents a potential blockbuster market opportunity of more than $1 billion annually.
  • ESP-2001 has potential eligibility for Orphan Drug and Fast Track designations from the U.S. FDA, as well as PRIME designation from the European Medicines Agency.

Publications and Presentations

Esperion continued to advance its scientific leadership in 2025, building on the robust clinical evidence supporting its bempedoic acid products through peer reviewed publications and data presentations designed to reach and educate the healthcare providers who treat patients with cardiometabolic disease.

Presentations

  • “Bempedoic Acid and Venous Thromboembolism Risk Among Statin-Intolerant Patients: A post-hoc analysis of the CLEAR Outcomes trial” presented at the 2025 American Heart Association (AHA) Annual Scientific Sessions
    • This post-hoc analysis demonstrated bempedoic acid reduced risk of venous thromboembolism diseases (e.g., pulmonary embolism, deep vein thrombosis) by 42%.  
  • Bempedoic acid monotherapy, LDL cholesterol and cardiovascular events: a secondary analysis of the CLEAR Outcomes trial” presented at the 2025 AHA Annual Scientific Sessions
    • This post-hoc analysis demonstrated similar robust reductions in LDL-C, hsCRP, and MACE-4 as the overall trial population for the 60% of patients receiving bempedoic acid without other lipid-lowering therapies.
  • “Pharmacokinetics of Bempedoic Acid in Healthy Subjects With Normal Renal Function and Subjects With End-stage Renal Disease Receiving Hemodialysis” presented at the Americal College of Clinical Pharmacy Annual Meeting
    • A comparable pharmacokinetic, profile for bempedoic acid was observed in patients with end stage renal disease on hemodialysis compared to matched healthy volunteers supporting no dose adjustments are needed for any level of renal dysfunction, including patients receiving hemodialysis.

Publications

  • “Association of Uric Acid-Lowering Therapies on Gout Frequency with Bempedoic Acid: Clinical Insights from CLEAR Outcomes” published in JACC: Advances
    • Post-hoc analysis demonstrated similar cardiovascular benefits of bempedoic acid in patients with and without prior gout. Incidence of gout with bempedoic acid was comparable to placebo in patients with no history of gout and a normal baseline uric acid level.
  • “Lack of impact of adjunctive lipid-modifying therapy in the CLEAR Outcomes trial” published in Journal of Clinical Lipidology
    • This prespecified analysis demonstrated background lipid-modifying therapy started or intensified after randomization did not impact the overall study results as the majority of patients started these medications after experiencing a first MACE-4 event.

Fourth Quarter and Full Year 2025 Financial Results

Revenue

  • Total revenue for the three months and full year ended December 31, 2025 was $168.4 million and $403.1 million, respectively, compared to $69.1 million and $332.3 million for the comparable periods in 2024, an increase of 144% and an increase of 21%, respectively.
  • U.S. net product revenue for the three months and full year ended December 31, 2025 was $43.7 million and $159.6 million, respectively, compared to $31.6 million and $115.7 million, for the comparable periods in 2024, an increase of approximately 38% in both periods.
  • Collaboration revenue was $124.7 million and $243.6 million for the three months and full year ended December 31, 2025, respectively, compared to $37.6 million and $216.6 million for the comparable periods in 2024, an increase of 232% and an increase of 12%, respectively.
    • The increase in the three months ended December 31, 2025, was driven by the one-time payment of $90 million received from Otsuka related to regulatory approval and favorable NHI Price listing, increases in royalty sales within our partner territories and product sales to our collaboration partners from our supply agreements. The increase in the full year ended December 31, 2025, was driven by the Otsuka payment, increases in royalty sales within our partner territories and product sales to our collaboration partners from our supply agreements, partially offset by the settlement agreement milestone with DSE received in 2024.

R&D Expenses

  • Research and development expenses for the three months and full year ended December 31, 2025 were $13.9 million and $47.9 million, respectively, compared to $11.0 million and $46.2 million for the comparable periods in 2024, an increase of approximately 26% and approximately 4%, respectively.
    • The increase in research and development expenses was primarily attributable to increased costs for ongoing clinical studies related to our pediatric program.

Selling, General and Administrative (SG&A) Expenses

  • Selling, general and administrative expenses for the three months and full year ended December 31, 2025, were $41.4 million and $165.8 million, respectively, compared to $36.9 million and $163.1 million for the comparable periods in 2024, an increase of 12% and 2%, respectively.
    • The increase in selling, general, and administrative expenses was primarily related to increased legal costs associated with the ANDA litigation.

Net Income (Loss)

  • For the three months ended December 31, 2025, the Company had net income of $61.8 million and for the full year ended December 31, 2025, the Company had a net loss of $22.7 million. The Company had net losses of $21.3 million and $51.7 million for the three months and full year ended December 31, 2024, respectively.

Net Income (Loss) Per Share 

  • Basic and diluted net income per share for the three months ended December 31, 2025 was $0.26 and $0.22, respectively. Basic and diluted net loss per share for the full year ended December 31, 2025 was $0.11. Basic and diluted losses per share for the three months and full year ended December 31, 2024, were $0.11 and $0.28, respectively.

Cash and Cash Equivalents 

  • As of December 31, 2025, cash and cash equivalents totaled $167.9 million compared to $144.8 million as of December 31, 2024. The Company ended the quarter with approximately 245.2 million shares of common stock outstanding, excluding 2.0 million treasury shares. 

2026 Financial Outlook

The Company expects full year 2026 operating expenses to be in the range of $225 million to $255 million, including approximately $15 million in non-cash expenses related to stock compensation.

Conference Call and Webcast Information            
Esperion will host a conference call and webcast today at 8:00 a.m. ET to discuss the financial results and business progress.

A live audio webcast can be accessed on the investor relations section of the Esperion website. The webcast replay will be available approximately two hours after completion of the call and will be archived on the Company's website for approximately 90 days.

INDICATION
NEXLIZET and NEXLETOL are indicated:

  • bempedoic acid, a component of NEXLIZET and NEXLETOL, is indicated to reduce the risk of major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke, or coronary revascularization) in adults at increased risk for these events who are unable to take recommended statin therapy (including those not taking a statin).
  • as an adjunct to diet and exercise:
    • NEXLIZET is indicated to reduce LDL-C in adults with hypercholesterolemia, including HeFH.
    • NEXLETOL is indicated, in combination with other LDL-C lowering therapies or alone when concomitant LDL-C lowering therapy is not possible, to reduce LDL-C in adults with hypercholesterolemia, including HeFH.

IMPORTANT SAFETY INFORMATION

  • NEXLIZET and NEXLETOL are contraindicated in patients with a prior hypersensitivity to bempedoic acid or ezetimibe or any of the excipients. Serious hypersensitivity reactions including anaphylaxis, angioedema, rash, and urticaria have been reported.
  • Hyperuricemia: Bempedoic acid, a component of NEXLIZET and NEXLETOL, may increase blood uric acid levels, which may lead to gout. Monitor as clinically indicated and initiate treatment with urate-lowering drugs as appropriate.
  • Tendon Rupture: Bempedoic acid is associated with an increased risk of tendon rupture or injury. Tendon rupture occurred in 0.5% of patients treated with bempedoic acid in primary hypercholesterolemia trials, versus 0% on placebo. In the cardiovascular outcomes trial, the rates were 1.2% for bempedoic acid and 0.9% for placebo. Discontinue NEXLIZET or NEXLETOL at the first sign of tendon rupture. Consider alternative therapy in patients who have a history of tendon disorders or tendon rupture.
  • The most common adverse reactions in the primary hypercholesterolemia trials of bempedoic acid in ≥2% of patients and greater than placebo were upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, and elevated liver enzymes.
  • Adverse reactions reported in ≥2% of patients treated with ezetimibe (a component of NEXLIZET) and at an incidence greater than placebo in clinical trials were upper respiratory tract infection, diarrhea, arthralgia, sinusitis, pain in extremity, fatigue, and influenza.
  • The most common adverse reactions (incidence ≥3% and greater than placebo) observed with NEXLIZET but not observed in clinical trials of bempedoic acid or ezetimibe, were urinary tract infection, nasopharyngitis, and constipation.
  • The most common adverse reactions in the cardiovascular outcomes trial for bempedoic acid, at an incidence of ≥2% and 0.5% greater than placebo, were hyperuricemia, renal impairment, anemia, elevated liver enzymes, muscle spasms, gout, and cholelithiasis.
  • Concomitant use of NEXLIZET or NEXLETOL with greater than 20 mg of simvastatin or 40 mg of pravastatin should be avoided due to the potential for increased risk of simvastatin- or pravastatin-related myopathy. Concomitant use with fibrates may increase triglycerides and decrease high-density lipoprotein cholesterol. Monitor and adjust therapies as recommended.
  • Discontinue NEXLIZET or NEXLETOL when pregnancy is recognized unless the benefits of therapy outweigh the potential risks to the fetus. The benefits of breastfeeding should be considered along with the mother’s clinical need for NEXLIZET or NEXLETOL and any potential adverse effects on the breastfed infant from NEXLIZET or NEXLETOL or from the underlying maternal condition.

Report pregnancies to Esperion Therapeutics, Inc. Adverse Event reporting line at 1-833-377-7633.

About Esperion Therapeutics
Esperion Therapeutics, Inc. is a commercial-stage biopharmaceutical company dedicated to developing and delivering innovative cardiometabolic and rare/orphan disease therapies. The Company leverages deep domain expertise in ACLY biology to develop and commercialize transformative medicines for patients worldwide. Esperion currently markets two oral, once-daily, non-statin therapies for patients struggling to maintain their low-density lipoprotein cholesterol (LDL-C) levels and are at risk of cardiovascular disease.

With a broad U.S. commercial infrastructure and global approvals across more than 40 countries, Esperion is well positioned to serve as a partner-of-choice for global innovators seeking U.S. market access through acquisition, in-license, co-promotion and revenue share opportunities. In tandem, the Company is advancing its leadership in ACLY biology to build a diversified pipeline of novel product candidates, including treatments for Primary Sclerosing Cholangitis and renal diseases. For more information, visit esperion.com and follow Esperion on LinkedIn and X.

Forward-Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding marketing strategy and commercialization and business development plans, impact of acquisitions, current and planned operational expenses, expected profitability, future operations, commercial products, clinical development, including the timing, designs and plans for the CLEAR Outcomes study and its results, plans for potential future product candidates, financial condition and outlook, including expected cash runway and profitability, and other statements containing the words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “suggest,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions. Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Forward-looking statements involve risks and uncertainties that could cause Esperion’s actual results to differ significantly from those projected, including, without limitation, the net sales, profitability, and growth of Esperion’s commercial products, clinical activities and results, supply chain, commercial development and launch plans, business development, the outcomes and anticipated benefits of legal proceedings and settlements, and the risks detailed in Esperion’s filings with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Esperion disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law.

Esperion Contact Information:
Investors & Media:
Tiffany Aldrich
corporateteam@esperion.com
(616) 443-8438


Esperion Therapeutics, Inc.

Balance Sheet Data
(In thousands)
(Unaudited)
 
  December 31,
2025
 December 31,
2024
Cash and cash equivalents $167,852  $144,761 
Working capital  161,760   91,765 
Total assets  465,886   343,821 
Royalty sale liability  295,766   293,610 
Convertible notes, net of issuance costs  97,260   151,320 
Long-term debt  152,219   140,971 
Common stock  245   196 
Accumulated deficit  (1,623,711)  (1,601,029)
Total stockholders' deficit  (301,965)  (388,722)


Esperion Therapeutics, Inc.

Statement of Operations
(In thousands, except share and per share data)
(Unaudited)
 
Three Months Ended
December 31,
 Year Ended
December 31,
 2025   2024   2025   2024 
Revenues:     
Product sales, net$43,723  $31,561  $159,569  $115,725 
Collaboration revenue 124,723   37,552   243,566   216,589 
Total Revenues 168,446   69,113   403,135   332,314 
       
Operating expenses:       
Cost of goods sold 27,854   25,631   129,224   68,601 
Research and development 13,926   10,977   47,852   46,238 
Selling, general and administrative 41,433   36,925   165,786   163,073 
Total operating expenses 83,213   73,533   342,862   277,912 
       
Income (loss) from operations 85,233   (4,420)  60,273   54,402 
       
Interest expense (22,636)  (16,422)  (84,604)  (59,251)
Loss on extinguishment of debt    (1,683)     (54,918)
Other income, net 1,075   1,207   3,490   8,022 
Income (loss) before income taxes$63,672  $(21,318) $(20,841) $(51,745)
       
Provision for taxes on income 1,841      1,841    
Net income (loss)$61,831  $(21,318) $(22,682) $(51,745)
        
Net income (loss) per common share - basic$0.26  $(0.11) $(0.11) $(0.28)
Net income (loss) per common share - diluted$0.22  $(0.11) $(0.11) $(0.28)
       
Weighted-average shares outstanding - basic 236,682,684   195,566,916   207,865,080   187,181,856 
Weighted-average shares outstanding - diluted 284,573,449   195,566,916   207,865,080   187,181,856 
        



FAQ

How much did Esperion (ESPR) revenue grow in FY2025 and Q4 2025?

Esperion reported FY2025 total revenue of $403.1M, a 21% increase year-over-year. According to the company, Q4 2025 total revenue was $168.4M, up 144% year-over-year, driven by collaboration payments and higher product sales.

What is Esperion’s agreement to acquire Corstasis and how does Enbumyst™ fit?

Esperion agreed to acquire Corstasis to add Enbumyst™, a FDA-approved nasal diuretic for edema in CHF, hepatic, and renal disease. According to the company, the acquisition aims to expand its cardiovascular franchise and address a U.S. market opportunity exceeding $4 billion.

What did Esperion disclose about patent settlements and generic competition for NEXLETOL/NEXLIZET?

Esperion reached settlement agreements with five ANDA filers that restrict generic entry by those parties until April 2040. According to the company, these settlements leave no remaining challenges to U.S. Patent No. 7,335,799 in the pending litigation.

What is Esperion’s 2026 operating expense guidance and key cost drivers?

Esperion expects full-year 2026 operating expenses of $225M–$255M, including about $15M of non-cash stock compensation. According to the company, higher commercial investment, clinical programs, and legal costs are primary drivers of the guidance range.

How did the Otsuka payment affect Esperion’s 2025 results and global expansion plans?

A $90M payment from Otsuka for Japan regulatory approval and NHI listing materially increased Q4 collaboration revenue. According to the company, Japan launch and partner milestones support accelerated international growth and a meaningful 2026 revenue runway.
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