AgPlenus Announces Licensing & Collaboration Agreement with Bayer to Develop a New Sustainable Weed Control Solution

Rhea-AI Summary

AgPlenus Ltd., a subsidiary of Evogene Ltd., collaborates with Bayer AG to develop a sustainable herbicide using AI technology. The collaboration aims to address weed resistance challenges in agriculture by designing a novel Mode-of-Action herbicide targeting the APTH1 protein.

Agricultural Biotechnology Expert

The strategic partnership between AgPlenus and Bayer AG is poised to address a critical need in the agricultural sector - the development of a novel, sustainable herbicide. This collaboration is significant, as it combines AgPlenus's AI-driven computational modeling with Bayer's R&D and commercial prowess. The focus on a new Mode-of-Action (MoA) is particularly relevant given the increasing instances of weed resistance, which poses a threat to food security and the efficacy of current regenerative agricultural practices.

From a biotechnological perspective, targeting the APTH1 protein presents a fresh avenue for herbicide development. The AI-driven approach can potentially streamline the molecule optimization process, reducing the time and cost associated with traditional chemical synthesis. This could lead to a more diverse portfolio of crop protection agents, mitigating the risk of resistance build-up. Moreover, the introduction of a new MoA could revolutionize the herbicide market, currently valued at $42.81 billion, by offering an alternative to farmers grappling with resistant weed species.

Financial Analyst

The financial arrangement of this collaboration is noteworthy, with AgPlenus set to receive an upfront payment, research funding, milestone payments and royalties on future sales. This deal structure suggests a significant commitment from Bayer and potential long-term revenue for AgPlenus. The exclusive licensing agreement indicates Bayer's confidence in the commercial viability of the products developed from this partnership.

For investors, the focus should be on the projected timelines for development, regulatory approvals and market entry, as these factors will influence the financial returns. The potential impact on Bayer's stock could be positive, given the company's expansion of its sustainable crop protection portfolio, which aligns with growing market demand for environmentally friendly farming solutions. However, the actual financial impact will largely depend on the successful development and market adoption of the new herbicide.

Sustainability Analyst

This collaboration has significant implications for sustainable agriculture. Introducing a new MoA herbicide aligns with societal expectations towards environmentally conscious farming practices. The use of AI to design and optimize herbicides promises not only efficiency but also the potential reduction of environmental impact by minimizing the use of chemicals and focusing on target-specific action.

The success of this initiative could set a precedent for the industry, encouraging other companies to invest in AI and computational modeling for sustainable product development. It also reinforces the notion that sustainability and profitability can go hand in hand, with the promise of new solutions that are both effective and have less ecological footprint.

The collaboration will tap into the potential of artificial intelligence (AI) to design and optimize crop protection chemistry, developing a novel sustainable Mode-of-Action (MoA) broad-spectrum herbicide for farmers

REHOVOT, Israel, Feb. 21, 2024 /PRNewswire/ -- AgPlenus Ltd., a global leader in designing and developing novel sustainable crop protection products and a subsidiary of Evogene Ltd. (Nasdaq: EVGN), (TASE: EVGN), announced today the signing of a licensing & collaboration agreement with Bayer AG, a global enterprise with core competencies in the life science fields of health care and agriculture.

In collaboration with Bayer's Crop Science division, having an industry-leading R&D pipeline and portfolio of seeds & traits, crop protection, and digital farming solutions, AgPlenus will use its AI-driven computational modeling technology to design and optimize molecules identified for their broad-spectrum herbicidal activity targeting the APTH1 protein, a new mode of action identified by AgPlenus.

Herbicide market is valued at $42.81 billion in 2024[1] and is crucial for ensuring global food security. It is also an essential part of regenerative agricultural practices such as cover crops and no-till. Most commercially available herbicides are based on molecules that inhibit target proteins that are essential for weed vitality. In recent years, the global agricultural industry has been facing a growing challenge of weed resistance to the limited number of existing products available to farmers, whose challenges are further exacerbated by climate change that is causing weeds to evolve and spread.

The two companies will collaborate to optimize new molecules, identified by AgPlenus and tested by Bayer, into commercially viable candidates. The collaboration will leverage AgPlenus' proprietary computational technology, powered by Evogene's ChemPass AI tech engine, together with Bayer's extensive expertise in research, development and commercialization of crop protection products.

Under the agreement, Bayer will have the exclusive license for the development and commercialization of products developed within the collaboration. AgPlenus will be entitled to receive an upfront payment, ongoing research funding, milestone payments, and royalties based on future product sales.

"We are looking forward to the collaboration with AgPlenus, which shares our belief that the breakthrough technologies available today represent a vast potential to design and develop entirely new solutions to help farmers overcome challenges such as pest resistance, climate change, and societal expectations towards crop protection," said Rachel Rama, Head of Small Molecules at Bayer's Crop Science division. "Bringing together AgPlenus' expertise with Bayer's CropKey approach to crop protection innovation will help accelerate the delivery of essential, sustainable, and affordable solutions to farmers and set a new benchmark in the industry."

Dr. Brian Ember, CEO of AgPlenus, said: "The collaboration with Bayer is a significant step forward for AgPlenus and validates the value of our computational technology platform. Leveraging Bayer's expertise and AgPlenus's technology, our mutual goal is to provide farmers worldwide with effective tools for more sustainable crop protection by introducing a novel herbicide with a new MoA."

About AgPlenus Ltd.:

AgPlenus is a platform company designing effective and sustainable crop protection products.  At AgPlenus, we are solving pesticide resistance by infusing the discovery process with predictive biology and artificial intelligence. AgPlenus leverages the ChemPass AI tech-engine, licensed from Evogene, to discover and bring to market effective and sustainable crop protection products. Our target-based approach allows us to reduce risk and increase efficiency, so that we can deliver on our promise to defeat global pesticide resistance. AgPlenus is a subsidiary of Evogene Ltd.

For more information, please visit www.agplenus.com

About Evogene Ltd.:

Evogene (Nasdaq: EVGN, TASE: EVGN) is a computational biology company aiming to revolutionize the development of life-science based products by utilizing cutting edge technologies to increase the probability of success while reducing development time and cost. Evogene established three unique tech-engines - MicroBoost AI, ChemPass AI and GeneRator AI – leveraging Big Data and Artificial Intelligence and incorporating deep multidisciplinary understanding in life sciences. Each tech-engine is focused on the discovery and development of products based on one of the following core components: microbes (MicroBoost AI), small molecules (ChemPass AI), and genetic elements (GeneRator AI).

Evogene uses its tech-engines to develop products through subsidiaries and strategic partnerships. Evogene's subsidiaries currently utilize the tech-engines to develop human microbiome-based therapeutics by Biomica, ag-biologicals by Lavie Bio, ag-chemicals by AgPlenus, medical cannabis products by Canonic and castor varieties, for the biofuel and other industries, by Casterra.

For more information, please visit: www.evogene.com. 

Contacts

Rachel Pomerantz Gerber
Head of Investor Relations at Evogene
rachel.pomerantz@evogene.com
Tel: +972-8-9311901

Forward-Looking Statements

This press release contains "forward-looking statements" relating to future events. These statements may be identified by words such as "may", "could", "expects", "hopes" "intends", "anticipates", "plans", "believes", "scheduled", "estimates", "demonstrates" or words of similar meaning. For example, Evogene and its subsidiaries are using forward-looking statement in this press release when they discuss AgPlenus' ability to design and optimize molecules identified for their broad-spectrum herbicidal activity targeting the APTH1 protein, to create commercially viable candidates, to create effective tools for more sustainable crop protection, by introducing a novel herbicide with a new MoA and Ag Plenus' eligibility to ongoing research funding, future milestone and royalty payments. Such statements are based on current expectations, estimates, projections, and assumptions, describe opinions about future events, involve certain risks and uncertainties which are difficult to predict and are not guarantees of future performance. Therefore, actual future results, performance or achievements of Evogene and its subsidiaries may differ materially from what is expressed or implied by such forward-looking statements due to a variety of factors, many of which are beyond the control of Evogene and its subsidiaries, including, without limitation, the current war between Israel and Hamas and any worsening of the situation in Israel such as further mobilizations or escalation in the northern border of Israel, and those risk factors contained in Evogene's reports filed with the applicable securities authority. In addition, Evogene and its subsidiaries rely, and expect to continue to rely, on third parties to conduct certain activities, such as their field-trials and pre-clinical studies, and if these third parties do not successfully carry out their contractual duties, comply with regulatory requirements or meet expected deadlines, Evogene and its subsidiaries may experience significant delays in the conduct of their activities. Evogene and its subsidiaries disclaim any obligation or commitment to update these forward-looking statements to reflect future events or developments or changes in expectations, estimates, projections, and assumptions.

[1] https://www.mordorintelligence.com/industry-reports/global-herbicides-market-industry?gclid=EAIaIQobChMIqL--hsHMgAMVoJODBx2ZLQeZEAAYAiAAEgLXqvD_BwE

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SOURCE AgPlenus Ltd.

FAQ

What is AgPlenus Ltd. collaborating with Bayer AG on?

AgPlenus Ltd. is collaborating with Bayer AG to develop a sustainable Mode-of-Action herbicide using AI technology.

What is the ticker symbol for Evogene Ltd.?

The ticker symbol for Evogene Ltd. is EVGN.

What is the value of the herbicide market in 2024?

The herbicide market is valued at $42.81 billion in 2024.

What protein is the novel herbicide targeting?

The novel herbicide is targeting the APTH1 protein.

Who will have the exclusive license for the development and commercialization of products in the collaboration?

Bayer will have the exclusive license for the development and commercialization of products in the collaboration.