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Disc Medicine, Inc. (NASDAQ: IRON) is a clinical-stage biopharmaceutical company dedicated to revolutionizing the treatment of hematologic diseases through innovative therapies. The company is primarily focused on manipulating the hepcidin pathway, which is the master regulator of iron metabolism, to address ineffective red blood cell production in various hematologic conditions. By leveraging new insights into hepcidin biology, Disc Medicine strives to bring hope and improved quality of life to patients who suffer from serious blood disorders.
Disc Medicine is currently advancing several first-in-class therapeutic candidates that target fundamental red blood cell biology pathways, including heme biosynthesis and iron homeostasis. Among its leading candidates is DISC-0974, an investigational monoclonal antibody designed to suppress hepcidin production by inhibiting the hemojuvelin (HJV) co-receptor. This novel treatment has shown promising results in reducing serum hepcidin and increasing serum iron levels, leading to improvements in hemoglobin and reduced transfusion burdens in myelofibrosis (MF) patients with anemia.
The company also boasts bitopertin, an orally administered GlyT1 inhibitor that modulates heme biosynthesis. Bitopertin has demonstrated significant efficacy in reducing PPIX levels and improving sunlight tolerance in patients with erythropoietic protoporphyria (EPP) during the phase 2 BEACON study. Disc Medicine is actively working on further trials to solidify these findings and expand its therapeutic applications.
On the financial front, Disc Medicine is well-supported by a robust pipeline of both clinical and preclinical candidates aimed at transforming the landscape of hematologic treatments. Recently, the company presented compelling data at the 65th American Society of Hematology (ASH) Annual Meeting, showcasing the potential of its portfolio. Their commitment to advancing these therapies is evident from their ongoing and upcoming clinical trials, including the phase 1b/2a study of DISC-0974 in chronic kidney disease (CKD) patients with anemia and the phase 1 study of DISC-3405 in healthy volunteers.
Disc Medicine continues to foster strategic partnerships and collaborations to accelerate the development and commercialization of its products. The company's vision is to address unmet medical needs in hematology and deliver innovative therapies that can change the standard of care for patients globally.
Disc Medicine, a clinical-stage biopharmaceutical company (NASDAQ: IRON), announced an underwritten offering of 4,944,000 shares at $36 per share, expecting to raise approximately $178 million. The offering, closing on June 17, 2024, is led by Frazier Life Sciences and Logos Capital, with participation from significant institutional investors. Proceeds will fund ongoing and new clinical research, working capital, and other corporate purposes. Leerink Partners is the sole bookrunner.
Disc Medicine presented positive clinical data at the European Hematology Association (EHA) 2024 Congress. Key highlights include:
1. Bitopertin in erythropoietic protoporphyria (EPP): AURORA study results showed significant reductions in protoporphyrin IX (PPIX) and improvements in light tolerance and quality of life.
2. DISC-0974 in myelofibrosis (MF): Phase 1b trial data demonstrated durable increases in hemoglobin levels and reductions in transfusion burden.
3. DISC-3405 in healthy volunteers: Phase 1 trial showed sustained hepcidin induction and serum iron suppression.
Disc Medicine highlighted these advancements supporting their ongoing development and potential therapeutic applications.
Disc Medicine (NASDAQ:IRON), a clinical-stage biopharmaceutical firm, will present at the Jefferies Global Healthcare Conference on June 6th at 1:00 pm ET. The company focuses on developing treatments for serious hematologic diseases. A live webcast and an archived replay of the presentation will be accessible on the company's investor relations webpage.
Disc Medicine, a clinical-stage biopharmaceutical company, will present data from its hematology portfolio at the European Hematology Association (EHA) 2024 Congress in Madrid from June 13-16, 2024.
Key presentations include:
- AURORA trial: Phase 2, double-blind study of Bitopertin in erythropoietic protoporphyria.
- BEACON trial: Phase 2, open-label study of Bitopertin in erythropoietic protoporphyria.
- Phase 1b study: DISC-0974 in myelofibrosis patients with anemia, featuring a larger dataset and longer follow-up.
- Phase 1 study: Initial safety and pharmacodynamic data on DISC-3405 in healthy volunteers.
Management will discuss the data on June 14th at 8:00 am ET. Full abstracts are available on the EHA conference website.
Disc Medicine, a clinical-stage biopharmaceutical company, will participate in the H.C. Wainwright BioConnect Investor Conference on May 20th. The company focuses on developing treatments for hematologic diseases. The event will feature a fireside chat available via live webcast and archived replay on the company's website.
Disc Medicine, Inc. (NASDAQ:IRON) reported its financial results for Q1 2024, ending with $343M in cash. The AURORA trial showed positive results for bitopertin in EPP patients, reducing toxic PPIX levels and improving quality of life. The company plans to present more data from BEACON and AURORA in Q2 2024, with positive regulatory interactions expected in the second half of the year. DISC-0974 and DISC-3405 also show promising results with upcoming data releases.
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