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NurExone Receives Notice of Patent Grant in South Korea Covering ExoPTEN Technology

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NurExone (OTCQB: NRXBF) received a South Korean Notice of Patent Grant covering ExoPTEN, its lead exosome-based therapy candidate. The patent protects use of exosomes to deliver PTEN-targeted cargo for nerve injury treatment.

This grant adds to ExoPTEN patents in the US, Japan, Israel and Russia, alongside pending applications in the EU, China and other regions, and complements broader patents on extracellular vesicle production technologies.

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Positive

  • South Korean ExoPTEN patent grant enhances IP coverage in a strategic market
  • ExoPTEN patents already granted in the United States, Japan, Israel and Russia
  • Pending ExoPTEN patent applications across EU, China, Hong Kong, India, Israel and Thailand
  • Additional granted patents on extracellular vesicle production in Australia, the United States and Israel

Negative

  • None.

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Expands intellectual property protection in a strategically important market for the Company’s lead exosome-based therapy targeting nerve repair and functional recovery

TORONTO, Ontario and HAIFA, Israel, May 19, 2026 (GLOBE NEWSWIRE) -- NurExone Biologic Inc. (TSXV: NRX) (OTCQB: NRXBF) (FSE: J90) (“NurExone” or the “Company”), a biopharmaceutical company developing exosome-based regenerative therapies, today announced that the Korean Ministry of Intellectual Property (“MOIP”) has issued a Notice of Patent Grant for a patent application covering ExoPTEN, the Company’s lead therapeutic candidate.

The patent application covers key aspects of ExoPTEN, including the use of exosomes as a natural drug delivery system to carry PTEN-targeted therapeutic cargo for the treatment of nerve injury.

Dr. Lior Shaltiel, CEO of NurExone, commented: “This Notice of Patent Grant in South Korea further strengthens our global intellectual property portfolio and supports the advancement of ExoPTEN towards clinical development and commercialization. ExoPTEN is central to our drug-development strategy targeting significant unmet needs, including spinal cord injury and optic nerve damage.”

The Korean patent further strengthens NurExone’s expanding international ExoPTEN patent portfolio, which already includes granted patents in the United States, Japan, Israel, and Russia, as well as pending applications across multiple jurisdictions, including the European Union, China, Hong Kong, India, Israel (Continuation of IL277605), and Thailand.

Separately, NurExone’s broader patent portfolio includes granted patents in markets including Australia, the United States and Israel covering extracellular vesicle (EV) production technologies. Together, these patent families reflect the Company’s strategy to protect multiple layers of its exosome platform, from its lead therapeutic candidate to production technologies intended to support scalable development and future commercialization of the Company’s platform.

About NurExone

NurExone is a TSX Venture Exchange (“TSXV”), OTCQB, and Frankfurt-listed biotech company focused on developing regenerative exosome-based therapies for central nervous system injuries. Its lead product, ExoPTEN, has demonstrated strong preclinical data supporting clinical potential in treating acute spinal cord and optic nerve damage. Regulatory milestones, including obtaining the Orphan Drug Designation, facilitate the Company’s roadmap towards clinical trials in the U.S. and Europe. Commercially, the Company is expected to offer solutions to companies interested in quality exosomes and minimally invasive targeted delivery systems for other indications. NurExone has established Exo-Top Inc., a U.S. subsidiary, to anchor its North American activity and growth strategy.

For additional information and a brief interview, please watch Who is NurExone?, visit www.nurexone.com or follow NurExone on LinkedInTwitterFacebook, or YouTube.

For more information, please contact:

Dr. Lior Shaltiel
Chief Executive Officer and Director
Phone: +972-52-4803034
Email: info@nurexone.com

Russo Partners LLC
Investor and Media Relations – United States
215 Park Ave S, Suite 1905
New York, NY 10003
Phone: 212-845-4200
Email: nurexone@russopartnersllc.com

Dr. Eva Reuter
Investor Relations - Germany
Phone: +49-69-1532-5857
Email: e.reuter@dr-reuter.eu

FORWARD-LOOKING STATEMENTS

This news release contains “forwardlooking information” and “forwardlooking statements” within the meaning of applicable Canadian securities laws (collectively, “forwardlooking statements”). Forwardlooking statements are often, but not always, identified by words such as “expect”, “intend”, “plan”, “anticipate”, “believe”, “estimate”, “may”, “will”, “could”, “should” and similar expressions.

Forwardlooking statements in this news release include, without limitation, statements relating to: (i) the expected scope, timing and effect of the Korean Ministry of Intellectual Property Notice of Patent Grant and the Company’s ability to obtain and maintain patent protection in South Korea (including completion of any required formalities and payment of applicable fees); (ii) the Company’s strategy and plans to protect and expand its intellectual property portfolio for ExoPTEN and related technologies in multiple jurisdictions; and (iii) statements regarding the development, regulatory pathway, anticipated timing and progression of clinical trials and potential future commercialization of the Company’s product candidates and technologies referenced in this news release.

Forwardlooking statements are based on management’s current expectations and assumptions as of the date of this news release, including assumptions regarding: the Company’s ability to complete required patent grant formalities in South Korea; the continued availability of resources (including personnel, capital and thirdparty service providers) necessary to pursue the Company’s intellectual property strategy and development plans; and the accuracy and continued relevance of the Company’s publicly disclosed scientific and regulatory information.

Forwardlooking statements are subject to known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to differ materially, including, without limitation: risks related to intellectual property protection, maintenance and enforcement; the risk that patent rights may be challenged, narrowed or otherwise limited; earlystage development risk; the risk that preclinical results may not be predictive of clinical results; regulatory review timing and outcomes; financing and market conditions; dependence on thirdparty collaborators and suppliers; competition and technological change; and the other risk factors described in the Company’s continuous disclosure filings available, including the risks discussed under the heading "Risk Factors" on pages 44 to 51 of the Company's Annual Information Form dated August 27, 2024, copies of which is available under the Company's SEDAR+ profile at www.sedarplus.ca. These factors should be considered carefully, and readers should not place undue reliance on the forward-looking statements. Although the forward-looking statements contained in this press release are based upon what management believes to be reasonable assumptions, the Company cannot assure readers that actual results will be consistent with these forward-looking statements. These forward-looking statements are made as of the date of this press release, and the Company assumes no obligation to update or revise them to reflect new events or circumstances, except as required by law.

Neither TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release.


FAQ

What patent did NurExone (OTCQB: NRXBF) receive in South Korea in May 2026?

NurExone received a South Korean Notice of Patent Grant for its ExoPTEN technology. According to NurExone, this patent covers using exosomes as a natural drug delivery system carrying PTEN-targeted therapeutic cargo for treating nerve injury, supporting future clinical development.

How does the South Korean ExoPTEN patent impact NurExone (NRXBF) investors?

The South Korean ExoPTEN patent strengthens NurExone’s intellectual property protection in a key market. According to NurExone, it supports advancing ExoPTEN toward clinical development and commercialization, potentially reinforcing competitive positioning for its exosome-based nerve repair and functional recovery strategy.

In which countries does NurExone have granted ExoPTEN patents as of May 2026?

As of May 2026, NurExone reports ExoPTEN patents granted in the United States, Japan, Israel, Russia and now South Korea. Additional ExoPTEN patent applications are pending across multiple jurisdictions, including the European Union, China, Hong Kong, India, Israel continuation and Thailand.

What medical conditions is NurExone’s ExoPTEN candidate targeting for NRXBF shareholders?

ExoPTEN targets nerve repair and functional recovery in serious nerve injuries. According to NurExone, it is central to a drug-development strategy addressing significant unmet needs, including spinal cord injury and optic nerve damage, using exosome-based delivery of PTEN-targeted therapeutic cargo.

How does NurExone’s broader patent portfolio support its exosome platform and NRXBF value?

NurExone holds patents for extracellular vesicle production technologies in markets such as Australia, the United States and Israel. According to NurExone, these patents, together with ExoPTEN families, protect multiple layers of its exosome platform from lead candidate to scalable production.

What is ExoPTEN in NurExone’s (NRXBF) pipeline and why is IP protection important?

ExoPTEN is NurExone’s lead exosome-based therapeutic candidate for treating nerve injury. According to NurExone, ExoPTEN is central to its drug-development strategy, so patents in South Korea and other countries help protect commercialization potential and long-term platform development.