NeOnc Technologies Closes Strategic Acquisition of Advanced AI and 3D Bioprinting IP, Appointing World-Renowned Scientist Dr. Ishwar K. Puri to its Board

Rhea-AI Summary

NeOnc Technologies (NASDAQ:NTHI) has completed the acquisition of a strategic intellectual property portfolio focused on AI, 3D bioprinting, and quantum modeling technologies for $3.5 million ($500,000 cash and $3 million in stock at $25/share). The acquired technology, including U.S. Patent No. 11,788,057 B2, enables the creation of sophisticated patient-derived 3D brain tumor models.

The acquisition enhances NeOnc's drug discovery capabilities by combining AI and quantum modeling algorithms with realistic biological environments for more efficient therapeutic candidate screening. Alongside this development, the company appointed Dr. Ishwar K. Puri, Senior Vice President of Research and Innovation at USC and a globally recognized scholar, to its Board of Directors.

Positive

• None.

Negative

• Significant portion of acquisition payment ($3M) in stock may lead to dilution
• Integration of new technology into existing operations may require additional resources and time

Insights

Biotechnology Analyst

NeOnc's $3.5M acquisition of AI/3D bioprinting IP strengthens drug discovery capabilities while adding prestigious scientific leadership to accelerate CNS cancer drug development.

NeOnc Technologies has strategically acquired an intellectual property portfolio valued at $3.5 million that integrates artificial intelligence, 3D bioprinting, and quantum modeling technologies. This acquisition brings U.S. Patent No. 11,788,057 B2 under NeOnc's control, enabling the creation of sophisticated patient-derived 3D brain tumor models that more accurately mimic real biological environments.

The technology acquisition addresses a critical bottleneck in CNS cancer drug development - the preclinical screening phase. Traditional methods often fail to predict how drugs will perform in actual brain tumors, leading to high failure rates in clinical trials. By implementing high-throughput screening with patient-derived tumor models, NeOnc can now more accurately identify promising drug candidates before advancing to expensive clinical testing.

The $3.5 million transaction structure - $500,000 cash and $3 million in stock at $25 per share - preserves capital while demonstrating confidence in NeOnc's equity value. This technology will directly support NeOnc's ongoing multi-Phase 2 clinical programs and its partnership with Quazar Investment Group in the GCC region.

The appointment of Dr. Ishwar K. Puri brings exceptional scientific credibility to NeOnc's board. As USC's Senior VP of Research and Innovation, Dr. Puri oversees a major research enterprise, while his recognition in the top 0.4% of scholars by citation impact demonstrates his scientific authority. His expertise in computational modeling will be particularly valuable as NeOnc implements these advanced technologies.

The acquisition creates multiple strategic advantages: accelerated preclinical development, enhanced personalized medicine capabilities, reduced reliance on animal testing, and potential expansion beyond oncology into neurodegenerative diseases like Alzheimer's and Parkinson's. The integration of computational technologies with NeOnc's therapeutic pipeline positions the company to potentially establish a more efficient paradigm in precision oncology for CNS cancers.

CALABASAS, Calif., Aug. 25, 2025 (GLOBE NEWSWIRE) -- NeOnc Technologies Holdings, Inc. (NASDAQ:NTHI), a multi-Phase 2 clinical-stage biotechnology company pioneering therapies for central nervous system (CNS) cancers, today announced the closing of its acquisition of an intellectual property portfolio featuring artificial intelligence, 3D bioprinting, and quantum modeling technologies. This move significantly fortifies NeOnc’s drug discovery engine and helps accelerate its mission to develop therapies for complex neurological cancers.

The newly acquired IP, which includes U.S. Patent No. 11,788,057 B2, allows NeOnc to create highly sophisticated, patient-derived 3D brain tumor models. By applying proprietary AI and quantum modeling algorithms to these realistic biological environments, the company can now perform high-throughput screening of therapeutic candidates with greater speed and accuracy. The technology is designed to de-risk and shorten the preclinical development timeline, identifying the most promising drug candidates for clinical trials more efficiently.

Under the terms of the agreement, the transaction was valued at $3.5 million, consisting of $500,000 in cash and $3 million in NeOnc common stock at a price of $25 per share. The technology will be integrated into NeOnc’s core R&D operations and will support its strategic partnership with Quazar Investment Group to advance clinical trials across the GCC region.

Concurrent with the acquisition's closing, NeOnc formally welcomes Dr. Ishwar K. Puri to its Board of Directors. As the Senior Vice President of Research and Innovation at the University of Southern California (USC), Dr. Puri manages one of the nation's most prolific research enterprises. A Fellow of the AAAS, the Canadian Academy of Engineering (CAE), and the American Society of Mechanical Engineers (ASME), he is globally recognized as one of the top 0.4% of scholars by citation impact.

“Finalizing this acquisition is a transformative milestone for NeOnc, equipping us with technology that complements our clinical-stage assets,” said Amir Heshmatpour, Executive Chairman and President of NeOnc Technologies Holdings. “The technology acts much like having a supercharged lab and a supercomputer working together. It uses a patented 3D cell printing method that builds realistic mini tumors without touching or harming the cells, making testing much more accurate. Then, an AI engine scans thousands of drugs to predict which ones might work best, so we only spend time and money on the more promising options. We believe this means we should be able to speed up how quickly we find effective treatments, personalize therapies for patients using their own cells, cut down on animal testing, and potentially expand into diseases beyond brain cancer, such as Alzheimer’s and Parkinson’s. In short, it’s a game-changer that helps us move from idea to treatment faster, cheaper, and more humanely. Furthermore, having a scientist of Dr. Puri’s caliber join our Board is an incredible validation of our vision. His expertise will be invaluable as we deploy these technologies to unlock new therapeutic possibilities for patients in need.”

"It is exciting to see this powerful IP portfolio officially become part of NeOnc's innovative ecosystem," said Dr. Ishwar K. Puri. "By uniting cutting-edge computational science with NeOnc's targeted therapeutic pipeline, I believe we can build a new paradigm in precision oncology. NeOnc's commitment to tackling the toughest brain cancers, supported by its strong clinical programs and global partnerships, creates the ideal environment to translate these technological advancements into tangible patient benefits. I am eager to contribute to this vital work as a member of the Board."

ABOUT NEONC TECHNOLOGIES HOLDINGS, INC.
NeOnc Technologies Holdings, Inc. is a clinical-stage life sciences company focused on the development and commercialization of central nervous system therapeutics that are designed to address the persistent challenges in overcoming the blood-brain barrier. The company’s NEO™ drug development platform has produced a portfolio of novel drug candidates and delivery methods with patent protections extending to 2038. These proprietary chemotherapy agents have demonstrated positive effects in laboratory tests on various types of cancers and in clinical trials treating malignant gliomas. NeOnc’s NEO100™ and NEO212™therapeutics are in Phase II human clinical trials and are advancing under FDA Fast-Track and Investigational New Drug (IND) status. The company has exclusively licensed an extensive worldwide patent portfolio from the University of Southern California consisting of issued patents and pending applications related to NEO100, NEO212, and other products from the NeOnc patent family for multiple uses, including oncological and neurological conditions.

For more about NeOnc and its pioneering technology, visit neonc.com.

Important Cautions Regarding Forward Looking Statements

This press release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements can be identified by terminology such as “may,” “will,” “should,” “intend,” “expect,” “plan,” “budget,” “forecast,” “anticipate,” “believe,” “estimate,” “predict,” “potential,” “continue,” “evaluating,” or similar words. Statements that contain these words should be read carefully, as they discuss our future expectations, projections of future results of operations or financial condition, or other forward-looking information.

Examples of forward-looking statements include, among others, statements regarding whether a definitive agreement will be reached with Quazar. These statements reflect our current expectations based on information available at this time, but future events may differ materially from those anticipated.

The “Risk Factors” section of our most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, along with other cautionary language in that report or in our subsequent filings, outlines important risks and uncertainties. These may cause our actual results to differ materially from the forward-looking statements herein, including but not limited to the failure to finalize the agreement with Quazar, modifications to its terms, or alternative uses of proceeds.

We assume no obligation to revise or update any forward-looking statements, whether as a result of new information, future developments, or otherwise, except as required by applicable securities laws and regulations.

“NEO100” and “NEO212” are registered trademarks of NeOnc Technologies Holdings, Inc.

Company Contact:
info@neonc.com 

Investor Contact:
James Carbonara
Hayden IR
(646)-755-7412
James@haydenir.com 

FAQ

What did NeOnc Technologies (NTHI) acquire in its latest strategic acquisition?

NeOnc acquired an IP portfolio featuring AI, 3D bioprinting, and quantum modeling technologies for $3.5 million, including U.S. Patent No. 11,788,057 B2, which enables creation of patient-derived 3D brain tumor models.

How much did NeOnc Technologies pay for the AI and bioprinting technology acquisition?

NeOnc paid $3.5 million total, consisting of $500,000 in cash and $3 million in common stock at $25 per share.

Who is Dr. Ishwar K. Puri and why is his appointment significant for NTHI?

Dr. Puri is the Senior Vice President of Research and Innovation at USC and among the top 0.4% of cited scholars globally. His appointment to NeOnc's Board brings valuable expertise in research and innovation.

How will the new technology benefit NeOnc's drug development process?

The technology enables faster and more accurate drug screening through AI-powered analysis of 3D tumor models, potentially reducing development time and costs while improving therapeutic candidate selection.

What are the potential expansion opportunities for NeOnc Technologies beyond brain cancer?

The acquired technology could enable NeOnc to expand into other neurological diseases such as Alzheimer's and Parkinson's beyond their current focus on brain cancer.