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ORIC® Pharmaceuticals Announces Enozertinib (ORIC-114) Poster Presentation in HER2 exon 20 NSCLC at the ESMO Asia Congress 2025

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ORIC (Nasdaq: ORIC) will present clinical data for enozertinib (ORIC-114) in previously treated patients with HER2 exon 20 mutant NSCLC at the ESMO Asia Congress 2025 in Singapore (December 5–7, 2025).

The poster (Presentation 981P) is scheduled for Friday, December 5, 2025, 5:15–6:15 p.m. SGT in a poster display session.

ORIC will host a related conference call and live webcast on Saturday, December 6, 2025 at 8:00 p.m. ET; live Q&A will require pre‑registration and the webcast replay will be available via ORIC’s investor website for 90 days.

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Company to host a conference call and webcast on Saturday, December 6, 2025, at 8:00 pm ET

SOUTH SAN FRANCISCO, Calif. and SAN DIEGO, Dec. 01, 2025 (GLOBE NEWSWIRE) -- ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, today announced a poster presentation highlighting data from a Phase 1b trial of enozertinib (ORIC-114) at the ESMO Asia Congress 2025 taking place December 5-7, 2025 in Singapore. The poster will focus on data in previously treated patients with HER2 exon 20 mutant NSCLC.

Poster presentation details: 
  
Title:Enozertinib (ORIC-114), a Highly Selective, Brain Penetrant
 EGFR and HER2 Inhibitor, in Patients with HER2 Exon 20
 Mutant NSCLC: Randomized Dose Optimization
Presentation Number:981P
Session Type and Title:Poster Display session and cocktail
Session Date & Time:Friday, December 5, 2025; 5:15 – 6:15 p.m. SGT
  

Full abstracts are available for public viewing via the ESMO Asia Congress website.

Conference Call and Webcast Details
In conjunction with the ESMO Asia Congress, ORIC will host a conference call and webcast on Saturday, December 6, 2025, at 8:00 pm ET. To join the conference call via phone and participate in the live Q&A session, please pre-register online here to receive a telephone number and unique passcode required to enter the call. A live webcast and audio archive of the conference call will be available through the investor section of ORIC’s website at www.oricpharma.com. The webcast will be available for replay for 90 days following the presentation.

About ORIC Pharmaceuticals, Inc.
ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s clinical stage product candidates include (1) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib (ORIC-114), a brain-penetrant inhibitor that selectively targets EGFR exon 20, EGFR atypical, and HER2 exon 20 mutations, being developed across multiple genetically defined cancers. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to www.oricpharma.com, and follow us on X or LinkedIn.

Contact:

Dominic Piscitelli, Chief Financial Officer
dominic.piscitelli@oricpharma.com
info@oricpharma.com


FAQ

What data will ORIC (ORIC) present for enozertinib at ESMO Asia 2025?

A poster showing Phase 1b data for enozertinib in previously treated patients with HER2 exon 20 mutant NSCLC (Presentation 981P).

When and where is the ORIC poster for enozertinib presented at ESMO Asia 2025?

The poster is scheduled for December 5, 2025, 5:15–6:15 p.m. SGT at the ESMO Asia Congress in Singapore.

How can investors join ORIC’s conference call and webcast for the ESMO Asia presentation?

Pre‑register online to receive a phone number and passcode for the live call; a webcast and audio archive will be available on ORIC’s investor website.

When is ORIC’s conference call/webcast for the ESMO Asia poster and is there a replay?

The conference call and live webcast is December 6, 2025 at 8:00 p.m. ET, and the webcast replay will be available for 90 days on the investor site.

What is the session type and presentation number for ORIC’s enozertinib poster at ESMO Asia 2025?

It is a poster display session with Presentation Number 981P.
Oric Pharmaceuticals, Inc.

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