PacBio Announces First Quarter 2026 Financial Results
Rhea-AI Summary
PacBio (NASDAQ: PACB) reported Q1 2026 results for the quarter ended March 31, 2026. Revenue was $37.2M with consumables $21.8M and instrument revenue $9.7M. GAAP gross profit was $12.8M and GAAP net loss was $8.3M. Ending cash and investments were $276.0M. Company completed sale of short-read assets for $48.1M, was selected by Basecamp Research for the Trillion Gene Atlas, and provided full-year 2026 revenue guidance of $165M–$175M.
AI-generated analysis. Not financial advice.
Positive
- Completed sale of short-read assets for approximately $48.1M net cash proceeds
- GAAP gross profit of $12.8M and GAAP gross margin of 35% in Q1 2026
- Selected by Basecamp Research to power the Trillion Gene Atlas project
- EMEA revenue growth of 17% year-over-year
- Full-year 2026 revenue guidance of $165M–$175M
Negative
- Ending cash, cash equivalents, and investments declined to $276.0M from $343.1M
- Instrument revenue decreased to $9.7M from $11.0M year-over-year (down >10%)
- Non-GAAP gross margin declined to 37% from 40% (approximately 300 bps)
- GAAP operating expenses included $16.3M of litigation settlement charges in Q1 2026
News Market Reaction – PACB
On the day this news was published, PACB declined 14.55%, reflecting a significant negative market reaction. Argus tracked a trough of -14.2% from its starting point during tracking. Our momentum scanner triggered 29 alerts that day, indicating elevated trading interest and price volatility. This price movement removed approximately $87M from the company's valuation, bringing the market cap to $512.30M at that time.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Market Reality Check
Peers on Argus
PACB is up 8.23% while close peers show mixed moves: SENS +7.2%, CTKB +2.7%, but DCTH -3.02% and RXST -6.61%, suggesting a stock-specific reaction.
Previous Earnings Reports
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Feb 12 | Q4/FY 2025 earnings | Positive | -7.1% | Q4 revenue growth, 40% non-GAAP gross margin, asset sale and narrowed non-GAAP loss. |
| Nov 05 | Q3 2025 earnings | Negative | -7.0% | Revenue declined year-over-year despite better margins and lower operating expenses. |
| Aug 07 | Q2 2025 earnings | Positive | +7.1% | Revenue growth, improved non-GAAP net loss and strong system placements across Revio and Vega. |
| May 08 | Q1 2025 earnings | Negative | -6.7% | Revenue decline, sharply wider GAAP net loss and restructuring plus investigations disclosed. |
| Apr 09 | Prelim Q1 2025 | Positive | +20.8% | Preliminary revenue with maintained 2025 guidance and a sizable cost-reduction program announced. |
Earnings releases have more often led to negative or volatile reactions, but the majority of past earnings moves still aligned with the underlying news tone.
Over the last year, PacBio’s earnings reports have highlighted a shift toward consumables growth, cost control, and portfolio refocusing. Prior quarters showed improving non-GAAP gross margins, reduced operating expenses, and asset sales such as the short-read divestiture for $48.1M. Yet shares often reacted negatively, as on Feb 12, 2026 and Nov 5, 2025. Today’s Q1 2026 release continues themes of consumables strength, narrowing losses, and updated 2026 revenue guidance.
Historical Comparison
In the past year, PACB posted 5 earnings-related releases with an average move of ±1.44%. Today’s 8.23% post-earnings gain is notably larger than typical earnings reactions.
Recent earnings have emphasized a transition toward higher consumables mix, cost reductions, asset divestitures and stable-to-improving non-GAAP margins, with Q1 2026 extending these trends.
Regulatory & Risk Context
An effective Form S-3ASR shelf filed on Feb 25, 2026 allows PacBio to issue a range of securities and also register potential resales by selling stockholders, with specific amounts and terms to be set in future prospectus supplements.
Market Pulse Summary
The stock dropped -14.6% in the session following this news. A negative reaction despite signs of operational progress would have fit prior patterns where earnings updates, such as on Feb 12, 2026, triggered downside moves. Even with improved GAAP gross margin of 35% and a sharply reduced GAAP net loss of $8.3M, concerns over flat revenue of $37.2M, guidance credibility, or balance‑sheet usage under the S‑3 shelf could have weighed on sentiment.
Key Terms
gaap financial
non-gaap financial
metagenomic medical
AI-generated analysis. Not financial advice.
MENLO PARK, Calif., May 07, 2026 (GLOBE NEWSWIRE) -- PacBio (NASDAQ: PACB) today announced financial results for the quarter ended March 31, 2026.
Recent Business Highlights
- Selected by Basecamp Research to power its Trillion Gene Atlas, which is expected to result in approximately 100,000 samples being deeply sequenced from over 31 countries
- Announced a collaboration with DNAstack to power the first global federated HiFi whole genome dataset
- Expanded SPRQ-Nx beta program to more customers domestically and internationally after receiving positive feedback from initial users
- EMEA revenue grew by
17% year-over-year as a result of increased consumables demand reflecting both account expansion and higher utilization, particularly in clinical settings - Named Lucid Genomics as a PacBio Compatible partner for tertiary analysis of data generated on PacBio's long-read sequencing instruments
- Completed sale of short-read sequencing assets for net cash proceeds of approximately
$48.1 million , strengthening the balance sheet and extending cash runway
“We continue to see increasing clinical adoption of HiFi which contributed to another record quarter for consumable revenue. However, instrument revenue, particularly Vega, was lower than we had expected," said Christian Henry, President and Chief Executive Officer. "Nonetheless, we made significant progress on several important initiatives, such as our expansion of the SPRQ-Nx beta program based on the positive early feedback on the new chemistry. Based on this success, we plan to execute a broad commercial rollout to all Revio customers later this month, which we believe will further catalyze consumable growth and Revio instrument demand. Additionally, we continue to prove our ability to win large-scale projects as we were selected by Basecamp Research to power the Trillion Gene Atlas, which has the potential to produce the largest and most diverse high-fidelity metagenomic dataset in the world."
First quarter results:
| Q12026 | Q12025 | |
| Revenue(in millions) | ||
| Consumable revenue(in millions) | ||
| Instrument revenue(in millions) | ||
| Service and other revenue(in millions) | ||
| Revio™system placements | 15 | 12 |
| Vega™system placements | 27 | 28 |
| Annualized Revio pull-through per system | ~ | ~ |
| Ending cash, cash equivalents, and investments(in millions) |
Gross margin, operating expenses, net loss, and net loss per share are reported on a GAAP and non-GAAP basis. The non-GAAP measures are described below and reconciled to the corresponding GAAP measures at the end of this release.
We recorded a GAAP gross profit of
GAAP operating expenses totaled
GAAP net loss for the first quarter of 2026 was
GAAP net loss per share for the first quarter of 2026 was
2026 Financial Outlook
PacBio expects revenue for the full year 2026 to be in the range of
Quarterly Conference Call Information
Management will host a quarterly conference call today at 4:30 p.m. Eastern Time to review financial results for the first quarter ended March 31, 2026. Investors can access the call by dialing 1-888-349-0136 (or 1-412-317-0459 for international callers) and requesting to join the “PacBio Q1 Earnings Call". The call will be webcast live and available for replay at PacBio's website at https://investor.pacificbiosciences.com.
About PacBio
PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our products and technologies, which primarily consist of our HiFi long-read sequencing systems, address solutions across a broad set of research applications, including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications. For more information, please visit www.pacb.com and follow @PacBio.
PacBio products are provided for Research Use Only. Not for use in diagnostic procedures.
Statement regarding use of non‐GAAP financial measures
PacBio reports non‐GAAP results for basic net income and loss per share, net income, net loss, gross margins, gross profit (loss) and operating expenses in addition to, and not as a substitute for, or because it believes that such information is superior to, financial measures calculated in accordance with GAAP. PacBio believes that non-GAAP financial information, when taken collectively, may be helpful to investors because it provides consistency and comparability with past financial performance. However, non-GAAP financial information is presented for supplemental informational purposes only, has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with GAAP. In addition, other companies may calculate similarly titled non-GAAP measures differently or may use other measures to evaluate their performance, all of which could reduce the usefulness of PacBio’s non-GAAP financial measures as tools for comparison.
PacBio's financial measures under GAAP include substantial charges that are listed in the itemized reconciliations between GAAP and non‐GAAP financial measures included in this press release. PacBio excludes recurring charges from its non-GAAP financial statements, including amortization of acquired intangible assets and changes in fair value of contingent consideration, and further excludes infrequent and limited charges including impairment charges, restructuring-related expenses for discrete restructuring events, settlement charges, disposition of short-read assets, benefits from income taxes and other adjustments and rounding differences.
Management has excluded the effects of these items in non‐GAAP measures to assist investors in analyzing and assessing past and future operating performance. In addition, management uses non-GAAP measures to compare PacBio’s performance relative to forecasts and strategic plans and to benchmark its performance externally against competitors.
PacBio encourages investors to carefully consider its results under GAAP, as well as its supplemental non‐GAAP information and the reconciliation between these presentations, to more fully understand its business. A reconciliation of PacBio’s non-GAAP financial measures to their most directly comparable financial measure stated in accordance with GAAP has been provided in the financial statement tables included in this press release. PacBio is unable to reconcile future-looking non-GAAP guidance without unreasonable effort because certain items that impact this measure are out of PacBio's control and/or cannot be reasonably predicted at this time.
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the U.S. Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are forward-looking statements, including, but not limited to, statements relating to PacBio’s initiatives as well as the expected financial impact and timing of these plans and initiatives, including our expectations regarding SPRQ-Nx; PacBio’s financial guidance and expectations for future periods; new and continued reception of PacBio’s products and their expansion into new or existing markets; our expectations regarding our collaboration with Basecamp Research; developments affecting our industry and the markets in which we compete, including the impact of new products and technologies and tariffs; anticipated results of studies and future customer use and costs of our products and consumables, including the increasing clinical adoption of HiFi; and the availability, uses, accuracy, coverage, advantages, quality or performance of, or benefits or expected benefits of using, PacBio products or technologies. Reported results and orders for any instrument system should not be considered an indication of future performance. You should not place undue reliance on forward-looking statements because they are subject to assumptions, risks, and uncertainties and could cause actual outcomes and results to differ materially from currently anticipated results, including, but not limited to, challenges inherent in developing, manufacturing, launching, marketing and selling new products, and achieving anticipated new sales; potential cancellation of existing instrument orders; assumptions, risks and uncertainties related to the ability to attract new customers and retain and grow sales from existing customers; risks related to PacBio's ability to successfully execute and realize the benefits of acquisitions; the impact of new, increased or enhanced tariffs and export restrictions; rapidly changing technologies and extensive competition in genomic sequencing; unanticipated increases in costs or expenses; high costs of computer memory components; interruptions or delays in the supply of components or materials for, or manufacturing of, PacBio products and products under development; potential product performance and quality issues and potential delays in development timelines; the possible loss of key employees, customers, or suppliers; customers and prospective customers curtailing or suspending activities using PacBio's products; third-party claims alleging infringement of patents and proprietary rights or seeking to invalidate PacBio's patents or proprietary rights; risks associated with international operations; and other risks associated with general macroeconomic conditions and global economic or political instability, including war and other international conflicts, such as the conflicts in the Middle East. Additional factors that could materially affect actual results can be found in PacBio's most recent filings with the Securities and Exchange Commission, including PacBio's most recent reports on Forms 8-K, 10-K, and 10-Q, and include those listed under the caption “Risk Factors.” These forward-looking statements are based on current expectations and speak only as of the date hereof; except as required by law, PacBio disclaims any obligation to revise or update these forward-looking statements to reflect events or circumstances in the future, even if new information becomes available.
The unaudited condensed consolidated financial statements that follow should be read in conjunction with the notes set forth in PacBio's Quarterly Report on Form 10-Q when filed with the Securities and Exchange Commission.
Contacts
Investors:
Media:
pr@pacb.com
| Pacific Biosciences of California, Inc. Unaudited Condensed Consolidated Statements of Operations | |||||||||||
| Three Months Ended | |||||||||||
| (in thousands, except per share amounts) | March 31, 2026 | December 31, 2025 | March 31, 2025 | ||||||||
| Revenue: | |||||||||||
| Product revenue | $ | 31,534 | $ | 38,965 | $ | 31,113 | |||||
| Service and other revenue | 5,644 | 5,680 | 6,040 | ||||||||
| Total revenue | 37,178 | 44,645 | 37,153 | ||||||||
| Cost of Revenue: | |||||||||||
| Cost of product revenue(1)(3)(4) | 19,972 | 24,204 | 26,333 | ||||||||
| Cost of service and other revenue | 4,182 | 3,681 | 3,778 | ||||||||
| Amortization of acquired intangible assets | 183 | 183 | 4,345 | ||||||||
| Loss on purchase commitment(1) | — | 11 | 4,068 | ||||||||
| Total cost of revenue | 24,337 | 28,079 | 38,524 | ||||||||
| Gross profit (loss) | 12,841 | 16,566 | (1,371 | ) | |||||||
| Operating Expense: | |||||||||||
| Research and development(1) | 19,608 | 22,879 | 29,053 | ||||||||
| Sales, general and administrative(1)(3) | 31,153 | 34,051 | 40,168 | ||||||||
| Impairment charges(2) | — | — | 15,000 | ||||||||
| Settlement charges(3) | 15,400 | — | — | ||||||||
| Gain on disposal of assets(4) | (45,796 | ) | — | — | |||||||
| Amortization of acquired intangible assets(5) | 833 | 833 | 362,042 | ||||||||
| Change in fair value of contingent consideration(6) | — | — | (18,700 | ) | |||||||
| Total operating expense | 21,198 | 57,763 | 427,563 | ||||||||
| Operating loss | (8,357 | ) | (41,197 | ) | (428,934 | ) | |||||
| Interest expense | (1,740 | ) | (1,740 | ) | (1,737 | ) | |||||
| Other income, net | 2,006 | 2,768 | 4,294 | ||||||||
| Loss before income taxes | (8,091 | ) | (40,169 | ) | (426,377 | ) | |||||
| Income tax provision (benefit) | 184 | 202 | (302 | ) | |||||||
| Net loss | $ | (8,275 | ) | $ | (40,371 | ) | $ | (426,075 | ) | ||
| Net loss per share: | |||||||||||
| Basic | $ | (0.03 | ) | $ | (0.13 | ) | $ | (1.44 | ) | ||
| Diluted | $ | (0.03 | ) | $ | (0.13 | ) | $ | (1.44 | ) | ||
| Weighted average shares outstanding used in calculating net loss per share: | |||||||||||
| Basic | 305,819 | 301,907 | 296,858 | ||||||||
| Diluted | 305,819 | 301,907 | 296,858 | ||||||||
(1) Balances for the three months ended December 31, 2005 and March 31, 2025 include restructuring costs. Refer to the Reconciliation of Non-GAAP Financial Measures table below for additional information on such costs and related amounts.
(2) In-process research and development ("IPR&D") impairment charge was driven primarily by macroeconomic factors and restructuring initiatives, including the focus on long-read innovation, resulting in changes to the timing and amounts of cash flows.
(3) Includes litigation settlement charges and related legal fees in connection with the binding term sheet entered into with Personal Genomics of Taiwan, Inc during the three months ended March 31, 2026.
(4) Balances for the three months ended March 31, 2026 Include amounts related to the disposition of short-read assets, including the gain on the sale of certain assets related to our short-read DNA sequencing technology and related clustering, sequencing reagent, and detection technologies, and related non-recurring customer transition costs.
(5) Balance for the three months ended March 31, 2025 includes accelerated amortization of acquired intangible assets related to restructuring initiatives. Refer to the Reconciliation of Non-GAAP Financial Measures table below for additional information on such costs and related amounts.
(6) Change in fair value of contingent consideration was due to fair value adjustments of a milestone payment payable upon the achievement of a milestone event.
| Pacific Biosciences of California, Inc. Unaudited Condensed Consolidated Balance Sheets | ||||||
| (in thousands) | March 31, 2026 | December 31, 2025 | ||||
| Assets | ||||||
| Cash and investments | $ | 275,962 | $ | 279,506 | ||
| Accounts receivable, net | 29,350 | 35,448 | ||||
| Inventory, net | 51,022 | 49,285 | ||||
| Prepaid expenses and other current assets | 13,164 | 10,793 | ||||
| Property and equipment, net | 24,376 | 24,146 | ||||
| Operating lease right-of-use assets, net | 40,846 | 41,695 | ||||
| Restricted cash | 1,590 | 1,552 | ||||
| Intangible assets, net | 14,104 | 15,124 | ||||
| Goodwill | 317,761 | 317,761 | ||||
| Other long-term assets | 14,190 | 8,773 | ||||
| Total Assets | $ | 782,365 | $ | 784,083 | ||
| Liabilities and Stockholders' Equity | ||||||
| Accounts payable | $ | 13,609 | $ | 20,770 | ||
| Accrued expenses | 33,904 | 33,646 | ||||
| Deferred revenue | 19,884 | 19,865 | ||||
| Operating lease liabilities | 59,281 | 57,040 | ||||
| Convertible senior notes, net | 644,107 | 645,382 | ||||
| Other liabilities | 9,214 | 2,031 | ||||
| Stockholders' equity | 2,366 | 5,349 | ||||
| Total Liabilities and Stockholders' Equity | $ | 782,365 | $ | 784,083 | ||
| Pacific Biosciences of California, Inc. Reconciliation of Non-GAAP Financial Measures | ||||||||||||
| Three Months Ended | ||||||||||||
| (in thousands, except per share amounts) | March 31, 2026 | December 31, 2025 | March 31, 2025 | |||||||||
| GAAP net loss | $ | (8,275 | ) | $ | (40,371 | ) | $ | (426,075 | ) | |||
| Change in fair value of contingent consideration(1) | — | — | (18,700 | ) | ||||||||
| Settlement charges(2) | 16,804 | — | — | |||||||||
| Amortization of acquired intangible assets | 1,016 | 1,016 | 7,128 | |||||||||
| Disposition of short-read assets(3) | (45,490 | ) | — | — | ||||||||
| Income tax benefit(4) | — | — | (546 | ) | ||||||||
| Restructuring(5) | — | 1,776 | 393,788 | |||||||||
| Non-GAAP net loss | $ | (35,945 | ) | $ | (37,579 | ) | $ | (44,405 | ) | |||
| GAAP basic net loss per share | $ | (0.03 | ) | $ | (0.13 | ) | $ | (1.44 | ) | |||
| Change in fair value of contingent consideration(1) | — | — | (0.06 | ) | ||||||||
| Settlement charges(2) | 0.05 | — | — | |||||||||
| Amortization of acquired intangible assets | — | — | 0.02 | |||||||||
| Disposition of short-read assets(3) | (0.15 | ) | — | — | ||||||||
| Restructuring(5) | — | 0.01 | 1.33 | |||||||||
| Other adjustments and rounding differences | 0.01 | — | — | |||||||||
| Non-GAAP basic net loss per share | $ | (0.12 | ) | $ | (0.12 | ) | $ | (0.15 | ) | |||
| GAAP gross profit (loss) | $ | 12,841 | $ | 16,566 | $ | (1,371 | ) | |||||
| Amortization of acquired intangible assets | 183 | 183 | 4,345 | |||||||||
| Settlement charges(2) | 500 | — | — | |||||||||
| Disposition of short-read assets(3) | 306 | — | — | |||||||||
| Restructuring(5) | — | 1,072 | 12,027 | |||||||||
| Non-GAAP gross profit | $ | 13,830 | $ | 17,821 | $ | 15,001 | ||||||
| GAAP gross profit (loss) % | 35 | % | 37 | % | (4)% | |||||||
| Non-GAAP gross profit % | 37 | % | 40 | % | 40 | % | ||||||
| GAAP total operating expense | $ | 21,198 | $ | 57,763 | $ | 427,563 | ||||||
| Change in fair value of contingent consideration(1) | — | — | 18,700 | |||||||||
| Settlement charges(2) | (16,304 | ) | — | — | ||||||||
| Amortization of acquired intangible assets | (833 | ) | (833 | ) | (2,783 | ) | ||||||
| Disposition of short-read assets(3) | 45,796 | — | — | |||||||||
| Restructuring(5) | — | (704 | ) | (381,761 | ) | |||||||
| Non-GAAP total operating expense | $ | 49,857 | $ | 56,226 | $ | 61,719 | ||||||
(1) Change in fair value of contingent consideration was due to fair value adjustments of a milestone payment payable upon the achievement of a milestone event.
(2) Includes litigation settlement charges and related legal fees in connection with the binding term sheet entered into with Personal Genomics of Taiwan, Inc.
(3) Balance includes amounts related to the disposition of short-read assets, including the gain on the sale of certain assets related to our short-read DNA sequencing technology and related clustering, sequencing reagent, and detection technologies, and related non-recurring customer transition costs.
(4) A deferred income tax benefit during the three months ended March 31, 2025 is primarily related to the change in the deferred tax liability balance resulting from the accelerated amortization of acquired intangible assets and impairment of IPR&D.
(5) Restructuring-related costs incurred in connection with the 2025 plan during the three months ended December 31, 2025 and March 31, 2025 consist primarily of costs included in cost of revenue related to excess inventory and purchase commitment losses, as well as costs included in operating expenses related to employee separation, accelerated depreciation, IPR&D impairment, and accelerated amortization of acquired intangibles.
