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Palisade Bio, Inc. develops next-generation oral PDE4 inhibitor prodrugs for inflammatory and fibrotic diseases. Its lead program, PALI-2108, is a once-daily oral PDE4 inhibitor prodrug designed for targeted delivery and selective bioactivation in the ileum and colon, with clinical development focused on ulcerative colitis and Crohn’s disease.
Company news commonly covers PALI-2108 clinical and translational data, pharmacokinetic and biomarker findings, disease-conference presentations, clinical advisory activity and healthcare investor events. Updates also describe the company’s precision pharmacology strategy and the role of gut-targeted PDE4 inhibition in inflammatory bowel disease programs.
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Palisade Bio, a biopharmaceutical company focused on gastrointestinal therapies, has received Canadian Patent No. 2,942,358 for LB1148, a serine protease inhibitor that may reduce intestinal damage by neutralizing digestive enzymes. This patent extends protection until 2035. The patent covers the composition of LB1148, which has shown promising results in clinical studies for reducing post-surgical abdominal adhesions and improving gastrointestinal function. Currently, LB1148 is undergoing a Phase 2 study to evaluate its effectiveness in subjects undergoing elective bowel resection, with topline data expected in Q2 2023. The CEO emphasized the importance of strengthening the intellectual property portfolio around LB1148 as part of their development strategy.
Palisade Bio (Nasdaq: PALI) announced the enrollment of the first patient in a Phase 3 clinical trial for LB1148, conducted by its partner Newsoara Biopharma in China. This milestone is expected to advance the development of LB1148, a serine protease inhibitor aimed at protecting gastrointestinal integrity in surgery patients. The double-blind, randomized trial will evaluate LB1148's efficacy in accelerating bowel function post-abdominal surgery. Achieving clinical and regulatory milestones will trigger payments to Palisade, enhancing its financial outlook as it potentially brings LB1148 to a wider patient base.
Palisade Bio has entered definitive agreements with institutional investors to raise funds through a registered direct offering and a concurrent private placement. The company will sell 2,272,723 shares of common stock at a price of $2.64 per share. This financing is aimed at providing working capital and covering general corporate expenses. Investors will receive unregistered warrants for an equal number of shares, which can be exercised over the next five years. The closing of the offering is anticipated around April 5, 2023, pending customary closing conditions.
Palisade Bio, Inc. (NASDAQ: PALI) announced its financial results for 2022 and provided an operational update. As of December 31, 2022, the company had cash and equivalents totaling $12.4 million, supplemented by an additional $4.7 million raised in January 2023. This funding is expected to sustain operations into mid-2024. The company focuses on its Phase 2 study for LB1148, aimed at preventing post-surgical adhesions, with topline data anticipated in Q2 2023. Research and development expenses rose 169% to $6.5 million due to increased clinical activity, while general and administrative expenses decreased slightly to $8.8 million.
Palisade Bio, a clinical-stage biopharmaceutical company, announced that the European Patent Office intends to grant a patent for its application titled “Administration of Serine Protease Inhibitors to the Stomach,” expected in H2 2023. This patent supports their lead program, LB1148, which has shown promise in reducing post-surgical abdominal adhesions and improving gastrointestinal function. The company aims to fortify its global intellectual property portfolio with additional patent submissions. Clinical studies for LB1148 are ongoing, with topline data anticipated in the first half of 2023.