Welcome to our dedicated page for Phio Pharmaceuticals news (Ticker: PHIO), a resource for investors and traders seeking the latest updates and insights on Phio Pharmaceuticals stock.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical company whose news flow centers on the development of its INTASYL® gene silencing technology and lead compound PH-762. Company announcements describe INTASYL as a gene silencing platform focused on immuno-oncology therapeutics, with PH-762 targeting the PD-1 gene implicated in various forms of skin cancer.
News about Phio frequently covers clinical trial milestones for PH-762. The company has reported completion of enrollment in its ongoing Phase 1b dose escalation trial (NCT 06014086), interim pathology results in cutaneous squamous cell carcinoma, melanoma, and Merkel cell carcinoma, and safety reviews by its Safety Monitoring Committee. Updates have included detailed response rates, such as complete, near complete, and partial responses based on tumor clearance, as well as statements that no dose-limiting toxicities or clinically relevant treatment-emergent adverse effects were observed in the cohorts reported.
Phio also issues regulatory and development updates, including acceptance by the U.S. Food and Drug Administration of its nonclinical protocol study design for a toxicology study required before a pivotal trial of PH-762. Additional news items describe agreements with a U.S. manufacturer for cGMP clinical supply of PH-762 and progress toward delivering commercially viable drug product.
Investors following PHIO news will also see financing and corporate announcements, such as warrant inducement transactions, cash runway commentary, and board-level changes, including the appointment of a Lead Independent Director. The company regularly participates in investor conferences and scientific meetings, where it presents INTASYL technology and PH-762 data, and has highlighted external recognition such as PH-762 being named “Immunomodulatory Solution of the Year” in the BioTech Breakthrough Awards.
This news page aggregates these clinical, regulatory, financing, and governance updates so readers can track how Phio’s INTASYL platform and PH-762 program are progressing over time.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced that its in vivo data on PH-762, a self-delivering RNAi therapeutic, indicating tumor clearance, will be presented at the Society for Immunotherapy of Cancer (SITC) Workshop on April 21-22, 2022, in San Diego. The presentation is titled 'Locally administered immunotherapy self-delivering RNAi PH-762 results in abscopal clearance of untreated distal tumors.' The session is scheduled for April 21 from 5:20 p.m. to 6:20 p.m. PT.
This highlights Phio's commitment to developing innovative immuno-oncology treatments.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) announced positive preclinical data for PH-894, a self-delivering RNAi compound targeting BRD4. The data, to be presented at the AACR Annual Meeting 2022, show that PH-894 inhibited tumor growth in PD-1 responsive and insensitive models and enhanced the efficacy of anti-PD-1 antibody therapy on both treated and untreated distal tumors. The results highlight PH-894's potential as a standalone therapy and in combination with anti-PD-1 treatment, addressing a significant medical need for patients unresponsive to current therapies.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced its transition into a clinical-stage company with the initiation of its first clinical study for PH-762 targeting advanced melanoma. The company reported a net loss of $13.3 million for the year ended December 31, 2021, up from $8.8 million in 2020. The company holds $24.1 million in cash, sufficient to fund operations into the second quarter of 2023. Upcoming milestones include starting patient enrollment for PH-762 and new data presentations related to its pipeline in 2022.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced the upcoming presentation of new preclinical data on its RNAi compound PH-894, targeting BRD4, at the AACR Annual Meeting 2022 in New Orleans from April 8-13, 2022. The poster session will discuss PH-894's potential to provide abscopal efficacy toward untreated distal tumors and enhance systemic anti-PD-1 antibody therapy effectiveness. The presentation, led by Benjamin Cuiffo and accessible in person and virtually, is scheduled for April 13, 2022, from 9:00 AM to 12:30 PM.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced the initiation of efficacy animal studies focusing on its INTASYL-based antiviral compounds against SARS-CoV-2. This follows earlier positive laboratory results. The compounds target two virus-related and one host-related target, with three compounds selected for further testing in a validated mouse model. The INTASYL platform's efficiency highlights its potential for rapid development of antiviral therapies to combat COVID-19 variants. The company's ongoing commitment includes immuno-oncology programs while addressing the pandemic's challenges.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) received regulatory clearance from the French National Agency for the Safety of Medicines and Health Products to initiate a clinical trial for its lead product candidate, PH-762, targeting melanoma. This Phase 1b trial will assess the safety, tolerability, and anti-tumor activity of PH-762, which works by reducing PD-1 expression to enhance cancer cell recognition and destruction by immune cells. The company aims to start dosing patients in Q1 2022, marking a significant milestone in the development of its INTASYL immuno-oncology platform.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) will participate in the H.C. Wainwright Virtual BioConnect 2022 Conference, scheduled from January 10–13, 2022. Dr. Gerrit Dispersyn, the CEO, will present on the firm's innovative immuno-oncology therapeutics using its proprietary INTASYL™ RNAi platform, aimed at enhancing immune response against tumors. The presentation will be available on-demand starting at 7 a.m. EST on January 10. Interested parties can access the webcast through the company's website, where it will remain archived for 90 days.
Phio Pharmaceuticals (NASDAQ: PHIO) presented promising new data on its lead product candidate, PH-762, at the SITC 36th Annual Meeting. The study indicates that local administration of PH-762 in a hepatocarcinoma model not only inhibits the growth of treated tumors but also clears untreated distal tumors, suggesting a systemic immune response. Results showed that 80% of untreated tumors were completely cured, highlighting PH-762's potential as a new immunotherapy option with reduced systemic toxicity compared to traditional therapies. This data supports plans for a Phase 1 clinical trial in melanoma patients.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced its Q3 2021 financial results, reporting a net loss of $3.7 million or $0.28 per share, an increase from $2.3 million or $0.40 per share for Q3 2020. Cash and cash equivalents stood at $26.5 million as of September 30, 2021, expected to last until Q2 2023. The company aims to commence its first-in-human trial for PH-762 in Q1 2022 and expects to file a clinical trial application for PH-894 in H2 2022, showcasing the potential of its INTASYL technology in immuno-oncology.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced that new data indicates a systemic immune response can be triggered by its lead product candidate, PH-762, after local administration. These findings will be presented at the Society for Immunotherapy of Cancer (SITC) 36th Annual Meeting in Washington, D.C. from November 10-14, 2021. The relevant poster presentation is scheduled for November 12, 2021, at 7:00 am ET, showcasing potential advancements in immuno-oncology therapy.
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