Welcome to our dedicated page for Phio Pharmaceuticals news (Ticker: PHIO), a resource for investors and traders seeking the latest updates and insights on Phio Pharmaceuticals stock.
Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical company whose news flow centers on the development of its INTASYL® gene silencing technology and lead compound PH-762. Company announcements describe INTASYL as a gene silencing platform focused on immuno-oncology therapeutics, with PH-762 targeting the PD-1 gene implicated in various forms of skin cancer.
News about Phio frequently covers clinical trial milestones for PH-762. The company has reported completion of enrollment in its ongoing Phase 1b dose escalation trial (NCT 06014086), interim pathology results in cutaneous squamous cell carcinoma, melanoma, and Merkel cell carcinoma, and safety reviews by its Safety Monitoring Committee. Updates have included detailed response rates, such as complete, near complete, and partial responses based on tumor clearance, as well as statements that no dose-limiting toxicities or clinically relevant treatment-emergent adverse effects were observed in the cohorts reported.
Phio also issues regulatory and development updates, including acceptance by the U.S. Food and Drug Administration of its nonclinical protocol study design for a toxicology study required before a pivotal trial of PH-762. Additional news items describe agreements with a U.S. manufacturer for cGMP clinical supply of PH-762 and progress toward delivering commercially viable drug product.
Investors following PHIO news will also see financing and corporate announcements, such as warrant inducement transactions, cash runway commentary, and board-level changes, including the appointment of a Lead Independent Director. The company regularly participates in investor conferences and scientific meetings, where it presents INTASYL technology and PH-762 data, and has highlighted external recognition such as PH-762 being named “Immunomodulatory Solution of the Year” in the BioTech Breakthrough Awards.
This news page aggregates these clinical, regulatory, financing, and governance updates so readers can track how Phio’s INTASYL platform and PH-762 program are progressing over time.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced significant findings at the AACR-NCI-EORTC conference on October 7, 2021, regarding PH-894, its self-delivering RNAi compound targeting BRD4. The results indicate that PH-894 effectively silenced BRD4, enhancing T cell activation and tumor growth inhibition in vivo. This suggests PH-894 may serve as a promising immunotherapy option by reprogramming T cells. Phio is currently working on IND-enabling studies to advance PH-894 into clinical trials.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a biotechnology company specializing in immuno-oncology, announced two significant poster presentations at upcoming scientific conferences in October 2021. The first will occur at the AACR-NCI-EORTC Virtual International Conference from October 7-10, showcasing research on targeting BRD4 in T cells with self-delivering RNAi PH-894. The second presentation at the 8th Immunotherapy of Cancer Conference (ITOC8) on October 8-9 will focus on optimizing T lymphocytes for solid tumor therapy. For more details, visit their website.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced promising results from a study showcased at the ESMO Congress 2021. The study demonstrated that the INTASYL technology could cure tumors and elicit durable systemic immunity in a preclinical model targeting PD-1 and BRD4. Specifically, 83% of the treated animals showed complete tumor response, even with low dosage therapy. This research highlights INTASYL's potential as a versatile immuno-oncology therapeutic platform, with further clinical trials anticipated to validate its efficacy.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) will participate in the H.C. Wainwright 23rd Annual Global Investment Conference, taking place virtually from September 13 to 15, 2021. Dr. Gerrit Dispersyn, President & CEO, will present on September 13 at 7:00 AM ET. A webcast of the presentation will be available, with replays accessible on the company's website for 90 days. Phio focuses on developing immuno-oncology therapeutics using its proprietary INTASYL platform, aimed at enhancing immune response against tumors.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced that it will present new clinical study data at the ESMO Virtual Congress 2021 from September 16-21, 2021. The presentation will focus on dual targeting PD-1 and BRD4 using the company's proprietary INTASYL self-delivering RNAi platform, aiming to elicit persistent anti-tumor immunity following tumor resolution. The abstract number for this presentation is #4154. Archived details will be available on the Company's website in the Investors section.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) reported its financial results for Q2 2021, showing a net loss of $2.7 million. The company has $29.4 million in cash, sufficient to fund operations through Q2 2023. Phio is advancing its INTASYL™ platform, with promising preclinical data for its lead asset, PH-762, aimed at PD-1 in cancer treatment. Clinical trials are set to begin in 2022, with expected milestones including first-in-human studies for melanoma. R&D expenses increased to $1.7 million, reflecting expanded clinical preparation.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) will participate in a Fireside Chat with H.C. Wainwright on July 12, 2021, at 11 a.m. Eastern Time. The event aims to discuss the company’s advancements in immuno-oncology therapeutics utilizing its INTASYL™ RNAi platform, designed to boost immune responses against tumors. Interested listeners should register in advance to access the live audio. The webcast will be archived for 90 days on the company’s website. For more information on Phio's innovative therapies, visit their site.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced the rescheduling of its fireside chat with H.C. Wainwright, originally set for June 22, 2021. The new date is July 12, 2021, at 11 a.m. Eastern Time. Phio focuses on developing immuno-oncology therapeutics using its proprietary self-delivering RNAi (INTASYL™) platform, aimed at enhancing immune response against tumors. Investors can expect more details on the rescheduled event soon.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announces CEO Dr. Gerrit Dispersyn's participation in two key virtual events: the AGP Summer Healthcare Symposium on June 17, 2021 and a fireside chat hosted by H.C. Wainwright on June 22, 2021. These platforms will highlight the company's innovative self-delivering RNAi (INTASYL™) therapeutic platform, which aims to enhance immuno-oncology treatments. Interested parties can register for the fireside chat and access future webcasts via the company’s website.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced positive in vivo study results at the June 2021 ASCO Annual Meeting, showcasing its INTASYL™ RNAi therapy platform's efficacy in targeting BRD4 and PD-1 proteins. The dual-targeting approach led to complete tumor responses in 83% of tested mice, outperforming conventional treatments like JQ-1 and anti-PD-1 monoclonal antibodies. The study also indicated a superior safety profile for the INTASYL treatment. These findings emphasize INTASYL's potential in improving immuno-oncology therapies.
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