Polyrizon Announces Promising Permeation Kinetics Supporting Advancement of Its Intranasal Naloxone Hydrogel Program

Rhea-AI Summary

Polyrizon (Nasdaq: PLRZ) reported preclinical results for its intranasal naloxone hydrogel on December 11, 2025, showing three supporting data pillars: stability, superior mucoadhesion versus a marketed product (p < 0.0001), and rapid permeation comparable to the commercial benchmark.

The company completed permeation studies in a validated artificial membrane system and found no statistically significant difference in naloxone diffusion rates versus the reference product, indicating enhanced nasal residence time did not delay drug permeation. Polyrizon says these results support potential advancement of the candidate and highlight its Trap & Target™ hydrogel as a way to combine mucosal retention with fast onset.

Positive

• Mucoadhesion: formulation showed superior tissue retention (p < 0.0001)
• Permeation: naloxone diffusion was rapid and comparable to marketed product
• Three independent data pillars: stability, mucoadhesion, permeability support advancement

Negative

• Results are preclinical only; no human clinical efficacy or safety data yet
• Permeation did not improve versus the commercial benchmark (no speed advantage)

News Market Reaction

+11.46%

7 alerts

+11.46% News Effect

+34.7% Peak in 5 hr 12 min

+$2M Valuation Impact

$15M Market Cap

0.0x Rel. Volume

On the day this news was published, PLRZ gained 11.46%, reflecting a significant positive market reaction. Argus tracked a peak move of +34.7% during that session. Our momentum scanner triggered 7 alerts that day, indicating moderate trading interest and price volatility. This price movement added approximately $2M to the company's valuation, bringing the market cap to $15M at that time.

Data tracked by StockTitan Argus on the day of publication.

Key Figures

Mucoadhesion p-value: p < 0.0001 Annual opioid overdose deaths: more than 80,000 deaths

2 metrics

Mucoadhesion p-value p < 0.0001 Ex-vivo nasal tissue mucoadhesion vs marketed intranasal naloxone

Annual opioid overdose deaths more than 80,000 deaths U.S. CDC estimate cited for opioid overdoses annually

Market Reality Check

Price: $13.12 Vol: Volume 393,986 is well be...

low vol

$13.12 Last Close

Volume Volume 393,986 is well below the 20-day average of 9,510,406 (relative volume 0.04). low

Technical Price $11.13 is trading below the 200-day MA $218.52.

Peers on Argus

Peers show mixed moves, with stocks like ENSC up 5.33% and ADTX down 21.54%, whi...

2 Up 1 Down

Peers show mixed moves, with stocks like ENSC up 5.33% and ADTX down 21.54%, while momentum scanner names include both up and down moves, indicating stock-specific rather than sector-wide drivers for PLRZ.

Historical Context

5 past events · Latest: Dec 08 (Positive)

Pattern 5 events

Date	Event	Sentiment	Move	Catalyst
Dec 08	Regulatory interaction	Positive	-15.7%	FDA pre-submission meeting completed for PL-14 Allergy Blocker nasal spray.
Dec 04	Manufacturing milestone	Positive	+104.0%	Larger-scale PL-14 hydrogel batches met consistency, stability, quality specs.
Dec 03	Preclinical data	Positive	-3.3%	Naloxone hydrogel showed significantly stronger mucoadhesion vs marketed spray.
Dec 02	Manufacturing upscaling	Positive	+132.0%	Successful PL-14 scale-up run to support clinical trial material in 2026.
Nov 06	Preclinical antiviral data	Positive	-5.3%	PL‑16 intranasal gel showed reversible broad-spectrum viral blocking in vitro.

Pattern Detected

Positive R&D and platform updates have produced mixed reactions, with some sharp rallies and several selloffs despite constructive news, indicating inconsistent alignment between fundamentals and near-term price moves.

Recent Company History

Over the last few months, Polyrizon reported several intranasal platform milestones, including manufacturing upscaling for PL-14 on Dec 2, 2025 and a pivotal manufacturing update on Dec 2, 2025 that drove price jumps of 131.96% and 104.02%. Other positive updates, such as mucoadhesion data for naloxone and viral-blocking results for PL‑16, saw negative reactions between -3.27% and -5.31%. This naloxone permeation update extends that R&D narrative across the Trap & Target™ platform.

Regulatory & Risk Context

Active S-3 Shelf · $50,000,000

Shelf Active

Active S-3 Shelf Registration 2025-11-07

$50,000,000 registered capacity

An effective Form F-3 shelf filed on 2025-11-07 allows Polyrizon to offer up to $50,000,000 of securities over time, including ordinary shares, warrants, and units, via various distribution methods, with proceeds earmarked for general corporate purposes.

Market Pulse Summary

The stock surged +11.5% in the session following this news. A strong positive reaction aligns with P...

Analysis

The stock surged +11.5% in the session following this news. A strong positive reaction aligns with Polyrizon’s series of constructive platform updates, now adding naloxone permeation data that matches a marketed product while preserving enhanced mucoadhesion. Prior news showed both sharp rallies and selloffs, so volatility has precedent. The existing $50,000,000 Form F-3 shelf could enable future capital raises, which may influence how durable any larger move becomes once financing or development decisions follow.

Key Terms

mucoadhesion, permeation kinetics, intranasal, pharmacokinetic, +2 more

6 terms

mucoadhesion medical

"positive mucoadhesion findings-where Polyrizon’s formulation showed significantly"

Mucoadhesion is the ability of a drug, medical device or formulation to stick to mucous membranes lining the nose, mouth, throat, eyes or gut, using materials that adhere to wet tissue. For investors it matters because mucoadhesive products can deliver medicine more reliably, extend how long a drug acts, reduce dosing frequency and improve patient convenience—features that can increase a product’s effectiveness, market appeal and commercial value.

permeation kinetics medical

"announced new results ... demonstrating promising permeation kinetics that complement"

Permeation kinetics describes how quickly and how much a chemical or drug moves through a barrier such as skin, tissue or a membrane. Investors should care because this rate affects how well a product works, how safe it is, and how hard it will be to get regulatory approval—similar to how the speed at which water soaks through a sponge determines its usefulness for a task.

intranasal medical

"development of intranasal products, today announced new results"

Administration or delivery of a drug or vaccine through the nose, typically via a spray or drops that are absorbed by the nasal tissues. For investors, intranasal products can matter because they often offer easier, needle-free use, faster onset of effect, and potential cost or compliance advantages that can widen a product’s market and affect regulatory review, manufacturing complexity, and commercial prospects — similar to how a convenient app can outsell a clunky desktop program.

pharmacokinetic medical

"fast-onset pharmacokinetic behavior expected in real-world emergency scenarios"

Pharmacokinetic describes how a drug moves through and leaves the body — how it is absorbed, spread to tissues, broken down and excreted — like tracking a package from pickup to delivery and disposal. For investors, these properties determine effective dose, safety risks, how often a medicine must be taken, and how reliably it works, which in turn influence clinical trial success, regulatory approval chances, production complexity and a drug’s commercial value.

artificial membrane system technical

"completed a dedicated series of permeation studies using a validated artificial membrane system"

An artificial membrane system is a man-made barrier that copies how natural cell or tissue surfaces control what passes through, acting like a selective filter or synthetic skin. Investors care because these systems power products such as drug-delivery patches, dialysis devices, biosensors and lab tests; their technical performance, manufacturing cost, regulatory approval and patent protection directly affect a product’s market size, time to revenue and competitive edge.

opioid overdose medical

"fast-acting characteristics required for emergency opioid overdose reversal"

An opioid overdose occurs when a person takes more of an opioid drug than their body can handle, causing dangerously slow or stopped breathing, loss of consciousness, and possible death; it can result from prescription painkillers, illegal opioids, or mixing with other sedatives. Investors should care because overdose trends drive regulatory action, litigation, demand for antidotes and safer therapies, and can materially affect sales, costs, reputations and underwriting risks for drugmakers, hospitals, insurers and others — like a safety failure that reshapes a company’s financial outlook.

AI-generated analysis. Not financial advice.

Ra’anana, Israel, Dec. 11, 2025 (GLOBE NEWSWIRE) -- Polyrizon Ltd. (Nasdaq: PLRZ) (“Polyrizon” or the “Company”), a biotechnology company focusing on the development of intranasal products, today announced new results from its ongoing preclinical evaluation of its proprietary intranasal naloxone hydrogel formulation, demonstrating promising permeation kinetics that complement the Company’s previously reported stability and mucoadhesion successes.

Following the positive mucoadhesion findings-where Polyrizon’s formulation showed significantly enhanced persistence on ex-vivo nasal tissue compared to a marketed intranasal naloxone product (p < 0.0001) -the Company has completed a dedicated series of permeation studies using a validated artificial membrane system. These studies assessed the rate and extent of naloxone diffusion from Polyrizon’s hydrogel in comparison with the commercially available reference product under controlled conditions.

Importantly, despite the improved mucoadhesion demonstrated by Polyrizon’s formulation, permeation profiles remained rapid, with no statistically significant differences in permeation kinetics when compared to the marketed naloxone product. This indicates that the hydrogel’s enhanced residence time on the nasal mucosa does not impede or delay drug permeation, potentially preserving the fast-acting characteristics required for emergency opioid overdose reversal.

Collectively, the results from three independent data pillars:

1. Stability studies demonstrating robustness of the formulation,
2. Mucoadhesion studies showing superior and statistically significant tissue retention, and
3. Permeability studies confirming rapid diffusion comparable to the commercial benchmark- strongly position Polyrizon’s naloxone hydrogel candidate for potential advancement into further development stages.

These findings reinforce the potential of Polyrizon’s Trap & Target™ technology to deliver an innovative intranasal naloxone product that combines enhanced mucosal residence time with the essential fast-onset pharmacokinetic behavior expected in real-world emergency scenarios.

The need for improved naloxone delivery systems continues to grow as the opioid crisis escalates worldwide. According to the U.S. Centers for Disease Control and Prevention (CDC), in the United States alone, opioid overdoses account for more than 80,000 deaths annually, with synthetic opioids such as fentanyl driving rapid-onset, high-severity emergencies that demand fast, reliable intervention. According to Vantage Market Research the global naloxone market is expanding in response, projected to reach several billion dollars over the next few years, driven by increasing public health initiatives, broader community access programs, and regulatory support for innovative rescue products. Intranasal formulations remain the preferred route of administration due to their ease of use, rapid action, and suitability for lay responders. Within this landscape, technologies capable of enhancing mucosal retention without compromising permeation kinetics, such as Polyrizon’s Trap & Target™ hydrogel, have the potential to meaningfully elevate treatment reliability and improve real-world outcomes during opioid overdose events.

About Polyrizon

Polyrizon is a development stage biotech company specializing in the development of innovative medical device hydrogels delivered in the form of nasal sprays, which form a thin hydrogel-based shield containment barrier in the nasal cavity that can provide a barrier against viruses and allergens from contacting the nasal epithelial tissue. Polyrizon’s proprietary Capture and Contain TM, or C&C, hydrogel technology, comprised of a mixture of naturally occurring building blocks, is delivered in the form of nasal sprays, and potentially functions as a “biological mask” with a thin shield containment barrier in the nasal cavity. Polyrizon are further developing certain aspects of our C&C hydrogel technology such as the bioadhesion and prolonged retention at the nasal deposition site for intranasal delivery of drugs. Polyrizon refers to its additional technology, which is in an earlier stage of pre-clinical development, that is focused on nasal delivery of active pharmaceutical ingredients, or APIs, as Trap and Target ™, or T&T. For more information, please visit https://polyrizon-biotech.com.

Forward Looking Statements

This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 and other securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses potential advancement of its naloxone hydrogel candidate into further development stages, the potential of Polyrizon’s Trap & Target™ technology to deliver an innovative intranasal naloxone product that combines enhanced mucosal residence time with the essential fast-onset pharmacokinetic behavior expected in real-world emergency scenarios, the expected growth of the global naloxone market and the Company’s potential to meaningfully elevate treatment reliability and improve real-world outcomes during opioid overdose events. Forward-looking statements are not historical facts, and are based upon management’s current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management’s expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company’s reports filed from time to time with the Securities and Exchange Commission (“SEC”), including, but not limited to, the risks detailed in the Company’s annual report filed with the SEC on March 11, 2025 and subsequent filings with the SEC. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. Polyrizon is not responsible for the contents of third-party websites.

Contacts:

Michal Efraty

Investor Relations

IR@polyrizon-biotech.com

FAQ

What did Polyrizon (PLRZ) announce on December 11, 2025 about its naloxone hydrogel?

Polyrizon reported preclinical results showing superior mucoadhesion (p < 0.0001), robust stability, and permeation comparable to a marketed naloxone product.

Does Polyrizon's PLRZ hydrogel slow naloxone delivery compared to existing products?

No—permeation studies found no statistically significant difference in diffusion rates versus the commercial reference.

How do Polyrizon's PLRZ mucoadhesion results compare to a marketed intranasal naloxone product?

Polyrizon's formulation showed significantly enhanced persistence on ex‑vivo nasal tissue (p < 0.0001) versus the marketed product.

Do the December 11, 2025 PLRZ results mean the naloxone hydrogel is ready for clinical trials?

The company states the data position the candidate for further development, but the announcement reports preclinical results only.

What evidence supports Polyrizon's Trap & Target™ technology for naloxone (PLRZ)?

Three preclinical pillars—stability, superior mucoadhesion, and rapid permeability—are cited as supporting the technology's potential.

Will the PLRZ hydrogel change naloxone's fast‑acting profile in emergency use?

Per the announcement, enhanced mucosal residence time does not impede rapid permeation, so fast‑onset characteristics are preserved in preclinical tests.