Personalis Presents Data at AACR Annual Meeting 2021 Showcasing the Personalis ImmunoID NeXT Platform®

Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for cancer, today announced that the company will present new data in scientific posters to be presented at the American Association for Cancer Research (AACR) Annual Meeting 2021, which will be held online, April 10-15, 2021 and May 17-21, 2021.

These abstracts showcase data from ImmunoID NeXT, the first platform to enable comprehensive analysis of both a tumor and its immune microenvironment from a single sample. The ImmunoID NeXT Platform can be used to investigate the key tumor- and immune-related areas of cancer biology, consolidating multiple oncology biomarker assays into one and maximizing the biological information that can be generated from a precious tumor specimen.

Following are details and links to the scientific posters that will be presented at the online meeting.

Poster Number, Session Category and Session Title	Title & Presenter	Date	Location
399 Clinical Research (Excluding Trials)   Biomarkers Predictive of Therapeutic Benefit	Pan-cancer survey of HLA loss of heterozygosity using a robustly validated NGS-based machine learning algorithm   Presenter: Rachel Marty Pyke, PhD	April 10, 2021	Online
555 Clinical Research (Excluding Trials)   Liquid Biopsies: Circulating DNA	Longitudinal exome-scale liquid biopsy monitoring of evolving therapeutic resistance mechanisms in head and neck squamous cell carcinoma patients receiving anti-PD-1 therapy   Presenter: Charles Abbott, PhD	April 10, 2021	Online
1898 Immunology Tumor   Antigenicity/Processing and Presentation	Accurate modeling of antigen processing and MHC peptide presentation using large-scale immunopeptidomes and a novel machine learning framework   Presenter: Rachel Marty Pyke, PhD	April 10, 2021	Online
2227 Molecular and Cellular Biology / Genetics   Genomic Profiling of Tumors	Pan-cancer shedding patterns of tumor circulating cell free DNA   Presenter: Fábio Navarro, PhD	April 10, 2021	Online
2241 Molecular and Cellular Biology / Genetics   Genomic Profiling of Tumors	Profiling tumor-infiltrating immune cells using an augmented transcriptome   Presenter: Eric Levy, PhD	April 10, 2021	Online

About Personalis, Inc.

Personalis, Inc. is a leader in population sequencing and cancer genomics, with a focus on data, scale, efficiency, and quality. Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to the VA MVP. In oncology, Personalis is transforming the development of next-generation therapies by providing more comprehensive molecular data about each patient’s cancer and immune response. The Personalis NeXT Platform is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. The Personalis Clinical Laboratory is GxP aligned as well as CLIA’88-certified and CAP-accredited. For more information, please visit www.personalis.com and follow Personalis on Twitter (@PersonalisInc).

Forward-Looking Statements

All statements in this press release that are not historical are “forward-looking statements” within the meaning of U.S. securities laws, including statements relating to attributes or advantages of the Personalis NeXT Platform, Personalis’ business opportunities, leadership, plans, vision or growth, or other future events. Such forward-looking statements involve risks and uncertainties, including those related to the COVID-19 pandemic, that could cause actual results to differ materially from any anticipated results or expectations expressed or implied by such statements. Factors that could materially affect actual results can be found in Personalis’ filings with the U.S. Securities and Exchange Commission, including Personalis’ most recent reports on Forms 8-K, 10-K and 10-Q, the company’s registration statement on Form S-3 filed on December 30, 2020, and the company’s prospectus supplement filed on January 27, 2021, and include those listed under the caption “Risk Factors.” Personalis disclaims any obligation to update such forward-looking statements.

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