PolyPid Unveils a Long-Acting GLP-1 Receptor Agonists Delivery Platform Targeting the Diabetes and Weight Loss Market

Rhea-AI Summary

PolyPid (Nasdaq: PYPD) has unveiled a breakthrough long-acting GLP-1 receptor agonists delivery platform targeting diabetes and weight loss markets. The company's proprietary technology enables subcutaneous GLP-1 delivery for approximately 60 days, significantly improving upon current weekly injection standards.

The platform features linear drug release, addressing burst release issues common in weekly delivered molecules. The technology utilizes a polymer-lipid based matrix creating a protected drug reservoir, and has been clinically validated in over 1,000 patients including two Phase 3 trials with no major safety concerns. This expansion targets a market projected to reach $100 billion by 2030.

Positive

• Platform enables 60-day GLP-1 delivery versus current weekly injections, potentially improving patient adherence
• Technology clinically validated in over 1,000 patients with no major safety concerns
• Targets rapidly growing GLP-1 market projected to reach $100 billion by 2030
• Linear drug release profile overcomes burst release issues of current treatments

Negative

• Platform is still in early development stage with no specific timeline for commercialization
• Will face competition from established GLP-1 manufacturers
• Regulatory approval process could be lengthy and complex

Insights

Biotechnology Innovation Analyst

PolyPid's 60-day GLP-1 delivery platform could disrupt the booming obesity/diabetes market by significantly reducing injection frequency while leveraging clinically validated technology.

PolyPid has made a strategic move into the rapidly expanding GLP-1 receptor agonist market with a potentially game-changing drug delivery platform. The company's polymer-lipid based matrix technology aims to extend GLP-1 release to approximately 60 days from a single subcutaneous injection, dramatically improving upon the current standard weekly injection regimens.

This technology addresses two critical challenges in the current GLP-1 market: patient adherence and injection burden. By reducing administration frequency from 52 times yearly to just 6, PolyPid could significantly improve treatment persistence - a crucial factor in chronic conditions like diabetes and obesity where therapy discontinuation remains problematic.

The platform's reported linear release profile potentially offers pharmacokinetic advantages over existing products that often demonstrate burst release patterns. This could translate to fewer side effects and more consistent therapeutic effects - particularly important for GLP-1s where gastrointestinal tolerability often limits treatment.

What's particularly compelling is that this isn't merely a theoretical concept. The underlying delivery technology has been clinically validated in over 1,000 patients across multiple Phase 3 trials with a favorable safety profile. The company appears to be leveraging its existing proprietary technology expertise in a new therapeutic area rather than starting from scratch.

With the GLP-1 market projected to reach $100 billion by 2030, even capturing a small segment could transform PolyPid's commercial prospects. This expansion beyond their surgical infection prevention focus demonstrates versatility in their platform technology and potentially opens multiple revenue streams. The company appears to be positioning this innovation as complementary to their advanced-stage D-PLEX100 program rather than a pivot away from their core focus.

PolyPid's proprietary and clinically validated, prolonged-release drug delivery technology aims to subcutaneously deliver GLP-1 for approximately 60 days, compared to current standard of care of weekly injections.

The GLP-1 delivery platform expands PolyPid's product portfolio beyond the recently successful Phase 3 D-PLEX₁₀₀, demonstrating versatility of the Company's proprietary drug delivery platforms in multiple major therapeutic areas.

PETACH TIKVA, Israel, July 15, 2025 (GLOBE NEWSWIRE) -- PolyPid Ltd. (Nasdaq: PYPD) ("PolyPid" or the "Company"), a late-stage biopharma company aiming to improve surgical outcomes, today unveiled its long-acting GLP-1 receptor agonists (glucagon-like peptide-1 RA) delivery platform which aims to subcutaneously release GLP-1 RA for approximately 60 days, significantly longer than current weekly injection regimens. The platform releases GLP-1 in a linear way, overcoming the burst release seen with the current weekly delivered molecules. This discovery has the potential to significantly expand PolyPid's offering to a market which is projected to reach $100 billion by 2030.¹

"This recent discovery represents a potential paradigm shift in GLP-1 therapy delivery that could transform patient care in the rapidly expanding diabetes and weight management markets," said Dikla Czaczkes Akselbrad, Chief Executive Officer of PolyPid. "By harnessing our proprietary prolonged-release technology, we aim to provide patients with consistent, therapeutic levels of GLP-1 for approximately 60 days with a single administration, potentially eliminating the need for weekly injections. This new pipeline discovery potentially marks a significant advancement in improving medication adherence and patient outcomes, addressing a critical gap in the treatment of obesity and type 2 diabetes chronic diseases."

PolyPid's proprietary technology is a sophisticated drug delivery system consisting of a polymer-lipid based matrix that creates a protected drug reservoir. This unique matrix architecture enables controlled and continuous drug delivery in the body over a prolonged time (weeks to months) in a single application. The technology has been clinically validated in over 1,000 patients including in two Phase 3 trials with no major safety concern.

About PolyPid
PolyPid Ltd. (Nasdaq: PYPD) is a late-stage biopharma company aiming to improve surgical outcomes. Through locally administered, controlled, prolonged-release therapeutics, PolyPid’s proprietary PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients (APIs), enabling precise delivery of drugs at optimal release rates over durations ranging from several days to months. Following positive phase 3 results of D-PLEX₁₀₀, PolyPid’s lead product candidate, for the prevention of abdominal colorectal surgical site infections, New Drug Application (NDA) submission is expected in early 2026. In addition, the Company is currently in preclinical stages to test the efficacy of OncoPLEX for the treatment of solid tumors, beginning with glioblastoma.

For additional Company information, please visit http://www.polypid.com and follow us on Twitter and LinkedIn.

Forward-looking Statements

This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act and other securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses the potential benefits and advantages of long-acting GLP-1 receptor agonists delivery platform, that the discovery has the potential to significantly expand PolyPid's offering to a market which is projected to reach $100 billion by 2030, that this discovery represents a potential paradigm shift in GLP-1 therapy delivery that could transform patient care in the rapidly expanding diabetes and weight management markets and that it potentially marks a significant advancement in improving medication adherence and patient outcomes, addressing a critical gap in the treatment of obesity and type 2 diabetes chronic diseases, and the timing of the NDA submission. Forward-looking statements are not historical facts, and are based upon management’s current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management’s expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company’s reports filed from time to time with the Securities and Exchange Commission, including, but not limited to, the risks detailed in the Company’s Annual Report on Form 20-F filed on February 26, 2025. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements.

References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. PolyPid is not responsible for the contents of third-party websites.

Company Contact:
PolyPid Ltd. 
Ori Warshavsky
908-858-5995
IR@Polypid.com

Investor & IR Contact:
Arx | Capital Markets
North American Equities Desk
polypid@arxadvisory.com

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¹ (I) Goldman Sachs estimates the Diabetes and Weight loss market could reach $100 billion by 2030, driven primarily by GLP-1: https://www.goldmansachs.com/insights/articles/anti-obesity-drug-market; (II) J.P. Morgan Research forecasts that the GLP-1 market will exceed $100 billion by 2030, driven equally by diabetes and obesity usage: https://www.jpmorgan.com/insights/global-research/current-events/obesity-drugs

FAQ

What is the key innovation in PolyPid's new GLP-1 delivery platform?

PolyPid's platform enables subcutaneous GLP-1 delivery for approximately 60 days using a polymer-lipid based matrix, compared to current weekly injection requirements, with linear drug release properties.

How many patients has PolyPid's drug delivery technology been tested in?

The technology has been clinically validated in over 1,000 patients, including two Phase 3 trials, with no major safety concerns reported.

What is the market potential for PolyPid's GLP-1 delivery platform?

The GLP-1 market is projected to reach $100 billion by 2030, representing significant market opportunity for PolyPid's long-acting delivery platform.

How does PolyPid's GLP-1 delivery system work?

The system uses a proprietary polymer-lipid based matrix that creates a protected drug reservoir, enabling controlled and continuous drug delivery over weeks to months in a single application.

What advantages does PYPD's GLP-1 platform offer over current treatments?

The platform offers 60-day drug delivery versus weekly injections, linear drug release without burst release issues, and potential improved patient adherence through reduced injection frequency.