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Shuttle Pharma Announces Proposed Reverse Stock Split as Part of Strategic Nasdaq Compliance Initiative

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Shuttle Pharmaceuticals (SHPH) has announced a proposed 25-for-1 reverse stock split to maintain Nasdaq listing compliance. The split will reduce outstanding shares from 26.2 million to approximately 1.05 million shares, pending Nasdaq approval. The action will affect all common stock, including RSU grants and warrants, with fractional shares being rounded up. Shuttle Pharma, a specialty pharmaceutical company, focuses on developing radiation sensitizers to enhance radiation therapy outcomes for cancer patients while minimizing side effects. The reverse split is positioned as a strategic move to strengthen the company's long-term capital structure while ensuring continued Nasdaq listing compliance.
Shuttle Pharmaceuticals (SHPH) ha annunciato una proposta di frazionamento azionario inverso 25-contro-1 per mantenere la conformità ai requisiti di quotazione Nasdaq. La divisione ridurrà le azioni in circolazione da 26,2 milioni a circa 1,05 milioni di azioni, in attesa dell'approvazione del Nasdaq. L'operazione interesserà tutte le azioni ordinarie, comprese le concessioni di RSU e i warrant, con le azioni frazionarie arrotondate per eccesso. Shuttle Pharma, azienda farmaceutica specializzata, si concentra sullo sviluppo di sensibilizzatori alla radioterapia per migliorare i risultati del trattamento radioterapico nei pazienti oncologici, minimizzandone gli effetti collaterali. Il frazionamento inverso è presentato come una mossa strategica per rafforzare la struttura patrimoniale a lungo termine dell'azienda e garantire la continua conformità ai requisiti di quotazione Nasdaq.
Shuttle Pharmaceuticals (SHPH) ha anunciado una propuesta de división inversa de acciones de 25 por 1 para mantener el cumplimiento de la cotización en Nasdaq. La división reducirá las acciones en circulación de 26,2 millones a aproximadamente 1,05 millones, pendiente de la aprobación de Nasdaq. La acción afectará a todas las acciones ordinarias, incluidas las concesiones de RSU y los warrants, redondeando al alza las fracciones de acciones. Shuttle Pharma, una empresa farmacéutica especializada, se centra en desarrollar sensibilizadores a la radiación para mejorar los resultados de la radioterapia en pacientes con cáncer, minimizando los efectos secundarios. La división inversa se presenta como un movimiento estratégico para fortalecer la estructura de capital a largo plazo de la compañía y asegurar el cumplimiento continuo de las normas de cotización en Nasdaq.
Shuttle Pharmaceuticals(SHPH)는 나스닥 상장 요건을 유지하기 위해 25대 1 역병합을 제안했다고 발표했습니다. 이번 역병합으로 발행 주식 수는 2,620만 주에서 약 105만 주로 줄어들 예정이며, 이는 나스닥의 승인을 기다리고 있습니다. 이 조치는 RSU 부여 및 워런트를 포함한 모든 보통주에 적용되며, 소수점 주식은 올림 처리됩니다. Shuttle Pharma는 방사선 치료의 효과를 높이고 부작용을 최소화하기 위해 방사선 감작제를 개발하는 전문 제약회사입니다. 이번 역병합은 회사의 장기 자본 구조를 강화하고 나스닥 상장 요건을 지속적으로 충족하기 위한 전략적 조치로 자리매김하고 있습니다.
Shuttle Pharmaceuticals (SHPH) a annoncé une proposition de regroupement d'actions inversé au ratio de 25 pour 1 afin de maintenir la conformité aux exigences de cotation du Nasdaq. Ce regroupement réduira le nombre d'actions en circulation de 26,2 millions à environ 1,05 million d'actions, sous réserve de l'approbation du Nasdaq. Cette opération concernera toutes les actions ordinaires, y compris les attributions de RSU et les bons de souscription, les fractions d'actions étant arrondies à l'unité supérieure. Shuttle Pharma, une société pharmaceutique spécialisée, se concentre sur le développement de sensibilisateurs à la radiothérapie pour améliorer les résultats du traitement chez les patients atteints de cancer tout en minimisant les effets secondaires. Le regroupement inversé est présenté comme une démarche stratégique visant à renforcer la structure financière à long terme de l'entreprise tout en assurant le respect continu des exigences de cotation du Nasdaq.
Shuttle Pharmaceuticals (SHPH) hat einen vorgeschlagenen Reverse-Stock-Split im Verhältnis 25 zu 1 angekündigt, um die Einhaltung der Nasdaq-Listing-Anforderungen sicherzustellen. Durch den Split wird die Anzahl der ausstehenden Aktien von 26,2 Millionen auf etwa 1,05 Millionen reduziert, vorbehaltlich der Genehmigung durch die Nasdaq. Die Maßnahme betrifft alle Stammaktien, einschließlich RSU-Zuteilungen und Warrants, wobei Bruchstücke aufgerundet werden. Shuttle Pharma, ein spezialisiertes Pharmaunternehmen, konzentriert sich auf die Entwicklung von Strahlungssensibilisatoren, um die Ergebnisse der Strahlentherapie bei Krebspatienten zu verbessern und gleichzeitig Nebenwirkungen zu minimieren. Der Reverse Split wird als strategischer Schritt dargestellt, um die langfristige Kapitalstruktur des Unternehmens zu stärken und die fortlaufende Einhaltung der Nasdaq-Listing-Anforderungen zu gewährleisten.
Positive
  • Strategic move to maintain Nasdaq listing compliance
  • Strengthening of company's capital structure through share consolidation
  • Simplified share structure with 25:1 reduction in outstanding shares
Negative
  • Significant share consolidation indicates potential listing compliance issues
  • No change in underlying market capitalization or company value
  • Potential market perception concerns associated with reverse splits

Insights

Shuttle Pharma's 25:1 reverse split signals serious Nasdaq compliance issues while substantially restructuring shareholder equity positions.

The announced 25-for-1 reverse split represents a significant defensive financial maneuver for Shuttle Pharmaceuticals. This substantial ratio indicates the company is likely facing imminent delisting risk from Nasdaq, which typically requires maintaining a $1.00 minimum bid price. The dramatic consolidation will reduce outstanding shares from 26,210,037 to approximately 1,048,401 - a 96% reduction in share count.

This action carries several important implications. First, while the split mathematically adjusts share price upward by the same ratio as the reduction in shares, it doesn't fundamentally change the company's market capitalization or enterprise value. It's purely a technical adjustment to the share structure. However, historical market data shows that companies implementing reverse splits of this magnitude often experience subsequent price deterioration after the initial adjustment.

The need for such an aggressive ratio is particularly telling. Most companies opt for less severe splits (2:1, 5:1, or 10:1), so this 25:1 ratio suggests Shuttle's shares have fallen significantly below Nasdaq's threshold. While this action buys compliance time, it doesn't address the underlying financial or operational challenges that led to the price decline. The company's disclosure that this is explicitly part of a "strategic plan to maintain compliance" further confirms the defensive nature of this action rather than being tied to any positive business development.

GAITHERSBURG, Md., June 12, 2025 (GLOBE NEWSWIRE) -- Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) (“Shuttle Pharma” or the “Company”), a discovery and development stage specialty pharmaceutical company focused on improving outcomes for cancer patients treated with radiation therapy (RT), announces that its Board of Directors have approved a proposed reverse stock split of its common stock at a ratio of 25-for-1. The proposed action remains subject to approval by Nasdaq and, if approved, the Company will issue a subsequent announcement disclosing the effective date.

At the effective time of the reverse stock split, every 25 shares of the Company's issued and outstanding common stock will be automatically reclassified and combined into 1 share of common stock. This will reduce the number of issued and outstanding shares of common stock from 26,210,037 shares to approximately 1,048,401 shares, without giving effect to rounding. The split will also apply to Company common stock issuable upon the exercise of the Company's outstanding RSU grants and warrants. No fractional shares will be issued; instead, any fractional entitlements will be rounded up to the next highest whole number at the participant level.

The reverse stock split is part of Shuttle’s strategic plan to maintain compliance with Nasdaq’s continued listing requirements, while also strengthening the Company’s long-term capital structure.

About Shuttle Pharmaceuticals

Shuttle Pharma is a discovery and development stage specialty pharmaceutical company focused on improving the outcomes for cancer patients treated with radiation therapy (RT). Our mission is to improve the lives of cancer patients by developing therapies that are designed to maximize the effectiveness of RT while limiting the side effects of radiation in cancer treatment. Although RT is a proven modality for treating cancers, by developing radiation sensitizers, we aim to increase cancer cure rates, prolong patient survival and improve quality of life when used as a primary treatment or in combination with surgery, chemotherapy and immunotherapy. For more information, please visit our website at www.shuttlepharma.com.

Safe Harbor Statement

Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute “forward-looking statements.” These statements include, but are not limited to, statements concerning the development of our company. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including factors discussed in the “Risk Factors” section of Shuttle Pharma’s Annual Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on February 26, 2025, as well other SEC filings. Any forward-looking statements contained in this press release speak only as of the date hereof and, except as required by federal securities laws, Shuttle Pharmaceuticals specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

Shuttle Pharmaceuticals
Chris Cooper
Chief Executive Officer
info@shuttlepharma.com

Investor Contacts
Lytham Partners, LLC
shph@lythampartners.com 


FAQ

What is the ratio of Shuttle Pharmaceuticals (SHPH) reverse stock split?

Shuttle Pharmaceuticals has proposed a 25-for-1 reverse stock split, meaning every 25 shares will be combined into 1 share.

How many shares will SHPH have after the reverse split?

After the reverse split, SHPH's outstanding shares will reduce from 26,210,037 to approximately 1,048,401 shares.

Why is Shuttle Pharmaceuticals doing a reverse stock split?

The reverse split is part of Shuttle's strategic plan to maintain compliance with Nasdaq's continued listing requirements and strengthen its long-term capital structure.

What happens to fractional shares in SHPH's reverse split?

No fractional shares will be issued; any fractional entitlements will be rounded up to the next highest whole number at the participant level.

When will SHPH's reverse stock split take effect?

The effective date is pending Nasdaq approval and will be announced by the company in a subsequent announcement.
SHUTTLE PHARMACTCLS HLDGS INC

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Drug Manufacturers - Specialty & Generic
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GAITHERSBURG