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Shuttle Pharma Announces Reverse Stock Split will Become Effective on June 16, 2025, at 12:01 a.m., Eastern Time

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Shuttle Pharmaceuticals (NASDAQ: SHPH) has announced a 1-for-25 reverse stock split effective June 16, 2025, at 12:01 a.m. ET. The company's common stock will continue trading under the symbol SHPH on the Nasdaq Capital Market with a new CUSIP number 825693401. The split will reduce outstanding shares from 26,210,037 to approximately 1,048,401 and will apply to RSU grants and warrants. Fractional shares will be rounded up to the next whole number. This strategic move aims to maintain Nasdaq listing compliance and strengthen the company's capital structure. Shuttle Pharma, a specialty pharmaceutical company, focuses on developing radiation sensitizers to improve outcomes for cancer patients undergoing radiation therapy.
Shuttle Pharmaceuticals (NASDAQ: SHPH) ha annunciato uno frazionamento azionario inverso di tipo 1-per-25, che entrerà in vigore il 16 giugno 2025 alle 00:01 ET. Le azioni ordinarie della società continueranno a essere negoziate con il simbolo SHPH sul Nasdaq Capital Market con un nuovo numero CUSIP 825693401. Lo frazionamento ridurrà le azioni in circolazione da 26.210.037 a circa 1.048.401 e si applicherà anche alle concessioni di RSU e ai warrant. Le frazioni di azioni saranno arrotondate per eccesso al numero intero successivo. Questa mossa strategica ha l’obiettivo di mantenere la conformità ai requisiti di quotazione Nasdaq e di rafforzare la struttura patrimoniale della società. Shuttle Pharma, azienda farmaceutica specializzata, si concentra sullo sviluppo di sensibilizzatori alla radioterapia per migliorare i risultati nei pazienti oncologici sottoposti a trattamenti radioterapici.
Shuttle Pharmaceuticals (NASDAQ: SHPH) ha anunciado una división inversa de acciones de 1 por 25, que será efectiva el 16 de junio de 2025 a las 12:01 a.m. ET. Las acciones ordinarias de la compañía seguirán cotizando bajo el símbolo SHPH en el Nasdaq Capital Market con un nuevo número CUSIP 825693401. La división reducirá las acciones en circulación de 26,210,037 a aproximadamente 1,048,401 y se aplicará también a las concesiones de RSU y a los warrants. Las fracciones de acciones se redondearán hacia arriba al número entero siguiente. Esta medida estratégica busca mantener el cumplimiento con los requisitos de listado del Nasdaq y fortalecer la estructura de capital de la compañía. Shuttle Pharma, una empresa farmacéutica especializada, se enfoca en desarrollar sensibilizadores de radiación para mejorar los resultados en pacientes con cáncer que reciben terapia de radiación.
Shuttle Pharmaceuticals(NASDAQ: SHPH)는 2025년 6월 16일 오전 12시 1분(동부시간)부터 1대 25 역주식을 시행한다고 발표했습니다. 회사의 보통주는 Nasdaq Capital Market에서 SHPH 심볼로 계속 거래되며 새로운 CUSIP 번호는 825693401입니다. 이번 역주식 분할로 유통 주식 수가 26,210,037주에서 약 1,048,401주로 줄어들며, RSU 부여 및 워런트에도 적용됩니다. 소수점 주식은 다음 정수로 반올림됩니다. 이 전략적 조치는 Nasdaq 상장 요건을 유지하고 회사의 자본 구조를 강화하기 위한 것입니다. Shuttle Pharma는 방사선 감작제 개발에 집중하는 전문 제약사로, 방사선 치료를 받는 암 환자의 치료 결과를 개선하는 데 주력하고 있습니다.
Shuttle Pharmaceuticals (NASDAQ : SHPH) a annoncé un regroupement d’actions inversé au ratio de 1 pour 25, effectif à partir du 16 juin 2025 à 00h01 ET. Les actions ordinaires de la société continueront d’être négociées sous le symbole SHPH sur le Nasdaq Capital Market avec un nouveau numéro CUSIP 825693401. Ce regroupement réduira le nombre d’actions en circulation de 26 210 037 à environ 1 048 401 et s’appliquera également aux attributions de RSU et aux bons de souscription. Les fractions d’actions seront arrondies à l’unité supérieure. Cette démarche stratégique vise à maintenir la conformité aux exigences de cotation du Nasdaq et à renforcer la structure financière de la société. Shuttle Pharma, entreprise pharmaceutique spécialisée, se concentre sur le développement de sensibilisateurs à la radiothérapie pour améliorer les résultats chez les patients atteints de cancer recevant un traitement par radiothérapie.
Shuttle Pharmaceuticals (NASDAQ: SHPH) hat eine 1-zu-25 Aktiensplit-Rückführung angekündigt, die am 16. Juni 2025 um 0:01 Uhr ET wirksam wird. Die Stammaktien des Unternehmens werden weiterhin unter dem Symbol SHPH am Nasdaq Capital Market gehandelt, mit einer neuen CUSIP-Nummer 825693401. Die Rückführung reduziert die ausstehenden Aktien von 26.210.037 auf etwa 1.048.401 und gilt auch für RSU-Zuteilungen und Warrants. Bruchstücke von Aktien werden auf die nächste ganze Zahl aufgerundet. Dieser strategische Schritt zielt darauf ab, die Einhaltung der Nasdaq-Listenanforderungen sicherzustellen und die Kapitalstruktur des Unternehmens zu stärken. Shuttle Pharma, ein spezialisiertes Pharmaunternehmen, konzentriert sich auf die Entwicklung von Strahlungssensibilisatoren zur Verbesserung der Behandlungsergebnisse von Krebspatienten unter Strahlentherapie.
Positive
  • Strategic move to maintain Nasdaq listing compliance
  • Consolidation of shares may improve trading dynamics
  • No loss of value for fractional shares as they will be rounded up
Negative
  • Significant share consolidation ratio of 25:1 indicates substantial previous stock price decline
  • Reverse splits are often viewed negatively by the market
  • May indicate underlying financial or operational challenges

Insights

Shuttle Pharma's 1-for-25 reverse split aims to maintain Nasdaq listing compliance, signaling financial challenges despite strategic positioning.

Shuttle Pharmaceuticals has announced a 1-for-25 reverse stock split effective June 16, 2025, reducing outstanding shares from 26,210,037 to approximately 1,048,401. This drastic consolidation typically indicates underlying financial distress, as companies generally resort to reverse splits when share prices fall below exchange minimums. The press release explicitly confirms this is to maintain compliance with Nasdaq's continued listing requirements, suggesting the stock has likely been trading below the $1 minimum bid price required by Nasdaq.

The timing is strategic, occurring before market open on June 16 to minimize trading disruption. While reverse splits don't inherently change company value (market capitalization theoretically remains unchanged), they often face negative market reception as they signal financial struggles and can increase share price volatility. Importantly, the split applies to all outstanding securities including RSUs and warrants, maintaining proportional ownership stakes.

For investors, reverse splits historically correlate with poor short-term performance, as they reflect fundamental challenges rather than address them. Shuttle's positioning of this as "strengthening the Company's long-term capital structure" attempts to frame it positively, but doesn't change the underlying reality that this is a defensive maneuver to prevent delisting. Without accompanying operational improvements or capital infusion, reverse splits alone rarely solve the underlying issues that necessitated them in the first place.

GAITHERSBURG, Md., June 12, 2025 (GLOBE NEWSWIRE) -- Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) (“Shuttle Pharma” or the “Company”), a discovery and development stage specialty pharmaceutical company focused on improving outcomes for cancer patients treated with radiation therapy (RT) announces that the reverse stock split will become effective on June 16, 2025, at 12:01 a.m., Eastern Time. The Company’s common stock will continue to trade on The Nasdaq Capital Market (“Nasdaq”) under the existing symbol “SHPH” and will begin trading on a split-adjusted basis when the market opens on June 16, 2025. The new CUSIP number for the common stock following the reverse stock split will be 825693401.

At the effective time of the reverse stock split, every 25 shares of the Company's issued and outstanding common stock will be automatically reclassified and combined into 1 share of common stock. This will reduce the number of issued and outstanding shares of common stock from 26,210,037 shares to approximately 1,048,401 shares, without giving effect to rounding. The split will also apply to Company common stock issuable upon the exercise of the Company's outstanding RSU grants and warrants. No fractional shares will be issued; instead, any fractional entitlements will be rounded up to the next highest whole number at the participant level.

The reverse stock split is part of Shuttle’s strategic plan to maintain compliance with Nasdaq’s continued listing requirements, while also strengthening the Company’s long-term capital structure.

About Shuttle Pharmaceuticals

Shuttle Pharma is a discovery and development stage specialty pharmaceutical company focused on improving the outcomes for cancer patients treated with radiation therapy (RT). Our mission is to improve the lives of cancer patients by developing therapies that are designed to maximize the effectiveness of RT while limiting the side effects of radiation in cancer treatment. Although RT is a proven modality for treating cancers, by developing radiation sensitizers, we aim to increase cancer cure rates, prolong patient survival and improve quality of life when used as a primary treatment or in combination with surgery, chemotherapy and immunotherapy. For more information, please visit our website at www.shuttlepharma.com.

Safe Harbor Statement

Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute “forward-looking statements.” These statements include, but are not limited to, statements concerning the development of our company. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including factors discussed in the “Risk Factors” section of Shuttle Pharma’s Annual Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on February 26, 2025, as well other SEC filings. Any forward-looking statements contained in this press release speak only as of the date hereof and, except as required by federal securities laws, Shuttle Pharmaceuticals specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

Shuttle Pharmaceuticals
Chris Cooper
Chief Executive Officer
info@shuttlepharma.com

Investor Contacts
Lytham Partners, LLC
shph@lythampartners.com 


FAQ

What is the reverse stock split ratio for Shuttle Pharmaceuticals (SHPH)?

Shuttle Pharmaceuticals will implement a 1-for-25 reverse stock split, where every 25 shares will be combined into 1 share.

When will SHPH reverse stock split take effect?

The reverse stock split will become effective on June 16, 2025, at 12:01 a.m. Eastern Time, with split-adjusted trading beginning when the market opens that day.

How many shares will Shuttle Pharmaceuticals have after the reverse split?

The number of outstanding shares will be reduced from 26,210,037 to approximately 1,048,401 shares.

What happens to fractional shares in the SHPH reverse split?

Fractional share entitlements will be rounded up to the next highest whole number at the participant level.

Why is Shuttle Pharmaceuticals (SHPH) doing a reverse stock split?

The reverse split is part of Shuttle's strategic plan to maintain compliance with Nasdaq's continued listing requirements and strengthen the company's long-term capital structure.
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