Welcome to our dedicated page for Skye Bioscience news (Ticker: SKYE), a resource for investors and traders seeking the latest updates and insights on Skye Bioscience stock.
Skye Bioscience, Inc. (Nasdaq: SKYE) generates news primarily through its clinical and corporate progress in metabolic health, with a focus on obesity and overweight. The company regularly issues press releases on its Phase 2a CBeyond™ trial of nimacimab, a peripherally restricted CB1-inhibiting monoclonal antibody, and on related clinical, preclinical, and corporate milestones.
Readers of the SKYE news page can expect updates on topline and extension data from the CBeyond Phase 2a study, including weight loss outcomes, body composition findings, and analyses of rebound weight gain after treatment discontinuation. Skye’s releases have highlighted the performance of nimacimab as a monotherapy and in combination with semaglutide, reporting clinically meaningful additional weight loss, changes in waist circumference, and observations about safety, gastrointestinal tolerability, and neuropsychiatric events.
The company also publishes news on preclinical diet-induced obesity models, where nimacimab has been evaluated alone and with incretin-based therapies such as tirzepatide. These announcements describe weight loss effects, post-treatment weight maintenance, and modulation of metabolic and inflammatory pathways in animal studies. In addition, Skye reports on Phase 1b data in metabolic-associated steatotic liver disease, conference presentations at scientific and medical meetings, and participation in healthcare and investor conferences.
Corporate and regulatory news items include financial results, business updates, and collaboration agreements, such as Skye’s non-exclusive global collaboration and license agreement with Halozyme Therapeutics to use ENHANZE drug delivery technology for higher-dose subcutaneous administration of nimacimab. For investors and observers tracking developments in obesity therapeutics and CB1 inhibition, the SKYE news feed offers a centralized view of Skye’s reported clinical data, preclinical research, partnering activity, and financial disclosures over time.
Skye Bioscience announced promising preclinical results for its glaucoma treatment SBI-100, demonstrating superior efficacy over the standard care in a study published in the International Journal of Pharmaceutics. Formulated as a nanoemulsion with Carbopol® 940, SBI-100 showed a greater and longer-lasting reduction in intraocular pressure (IOP) than both latanoprost and timolol. With a maximum drop of 4.5 mmHg at 60 minutes and sustained effects for at least 480 minutes, this new formulation is aimed at transitioning to human trials soon. CEO Punit Dhillon expressed optimism for its clinical potential.
Skye Bioscience (OTCQB: SKYE) is advancing its lead product, SBI-100 Ophthalmic Emulsion, aimed at treating glaucoma. The company has partnered with CMAX Clinical Research to conduct a Phase 1 study, focusing on safety and pharmacokinetics in healthy volunteers. The trial will occur in Adelaide, Australia, with data expected by Q4 2022. SBI-100 OE shows promising results in preclinical studies, highlighting its potential to effectively lower intraocular pressure, a significant factor in glaucoma progression.
Skye Bioscience (OTCQB: SKYE) has partnered with Novotech Health Holdings to conduct a Phase 1 clinical study for its SBI-100 drug candidate aimed at treating glaucoma. This collaboration is expected to facilitate timely and cost-effective execution of the trial in Australia. The Phase 1 study is scheduled to begin in Q2 2022, with results anticipated in the latter half of the year. SBI-100 is a synthetic cannabinoid derivative designed to lower intraocular pressure, showing promising preclinical results—superior to existing glaucoma treatments.
Skye Bioscience (OTCQB: SKYE) announced the completion of a GLP nonclinical toxicology study for its SBI-100 ophthalmic nanoemulsion, a potential treatment for glaucoma. The study assessed ocular toxicity in rabbits, finding no adverse effects or histological changes. This positive outcome allows Skye to submit a clinical trial application to the Human Research Ethics Committee in Australia, aiming to initiate Phase 1 clinical trials in Q2 2022. SBI-100 is designed to provide a safer, localized delivery of cannabinoid therapy to reduce intraocular pressure, mitigating the risk of vision loss.
Skye Bioscience (OTCQB: SKYE) announced promising results from a preclinical study of its SBI-100 ophthalmic nanoemulsion, which suggests improved neuroprotective effects on retinal ganglion cells (RGCs) in glaucoma treatment. The study indicated a trend of better RGC function in treated rats compared to controls. While the structural evaluations showed no significant differences, the functional improvements warrant further investigation. Skye plans to begin its first-in-human study of SBI-100 in Q2 2022, focusing on addressing glaucoma's underlying neurodegenerative issues beyond intraocular pressure.
Skye Bioscience (OTCQB: SKYE) announced significant progress in developing its cannabinoid-based compound, SBI-100, targeting glaucoma. The company strengthened its leadership team and completed vital preclinical studies, demonstrating SBI-100's safety and efficacy. With a $7 million financing boost and a robust cash position of $11.1 million, Skye aims to commence its first-in-human Phase I study in H1 2022, expecting topline data by Q3 and a Phase II study by the end of the year. 2022 is set to be transformative as Skye advances its ophthalmology pipeline.
Skye Bioscience (OTCQB: SKYE), a biopharmaceutical firm, announced its participation in the virtual H.C. Wainwright BIOCONNECT Conference from January 10-13, 2022. CEO Punit Dhillon will present an on-demand overview on January 10 at 7 AM ET, accessible via a webcast. Virtual one-on-one meetings will also be available for institutional investors. Skye's lead program is focused on developing cannabinoid-derived treatments for glaucoma.
Skye Bioscience has appointed Keith W. Ward, PhD to its board of directors and promoted Tu Diep, MSc to Chief Development Officer. This leadership change aims to enhance the company's direction in developing cannabinoid-based therapies targeting significant unmet medical needs, particularly in treating glaucoma. Dr. Ward brings over 25 years of industry experience, while Mr. Diep, previously Senior VP of Development, has over 15 years in drug development. The company emphasizes its focus on advancing therapies in a challenging therapeutic landscape.
Skye Bioscience (OTCQB: SKYE) announced that researchers from the University of Mississippi presented two studies at the AAPS PharmSci 360 meeting. The studies focused on the effects of THCVHS, a synthetic cannabinoid, on lowering intraocular pressure (IOP) in glaucoma treatment. Findings revealed that THC-VHS nanoemulsion formulations showed better IOP reduction compared to standard treatments. The company is advancing its clinical strategy, with human trials expected to start in Q2-22, focusing on safety and efficacy for glaucoma treatment.
Skye Bioscience (OTCQB: SKYE) has signed an exclusive research agreement with Emerald Health Biotechnology Espana SLU to develop cannabinoid-derived molecules for therapeutic purposes. This agreement, dubbed the Cannabinoid Pharmaceutical Innovation Program (CPIP), aims to enhance signaling pathways in the endocannabinoid system. Skye will finance the projects and retain rights to all resulting data and intellectual property. The initiative aims to create a portfolio of proprietary products that focus on treating diseases with significant unmet needs, particularly in ophthalmology.