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Skye Bioscience, Inc. reports clinical-stage biotechnology developments focused on metabolic health disorders, obesity and overweight. The company's lead program, nimacimab, is a peripherally restricted monoclonal antibody inhibitor of the CB1 receptor being evaluated in the CBeyond Phase 2a program, including monotherapy and combination work with GLP-1 or other incretin-based therapies.
Recurring updates cover clinical data from CBeyond, higher-dose safety and pharmacokinetic work, regulatory feedback on follow-on trial design, manufacturing and formulation activities, scientific conference presentations, financial results and corporate outlooks. Skye also discusses its broader strategy of developing molecules that modulate G-protein-coupled receptors.
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Skye Bioscience (OTCQB: SKYE) announced the completion of SBI-100 Ophthalmic Emulsion production for its Phase 1 clinical trial, which focuses on treating glaucoma. The final product is expected to be clinically available in October, pending quality testing results. Clinical site initiation will occur in mid-October, followed by patient dosing starting in November. SBI-100 OE aims to effectively lower intraocular pressure (IOP) using a novel synthetic cannabinoid formulation, potentially offering a new treatment class for glaucoma, a leading cause of irreversible blindness.