ScaleReady Announces a G-Rex® Grant has been awarded to Immuneel Therapeutics

Rhea-AI Summary

ScaleReady has awarded a $150,000 G-Rex Grant to Immuneel Therapeutics to enhance CAR-T cell manufacturing in India. The grant aims to support process development for improving scalability and cost-effectiveness of production at Immuneel's 12,000 square foot GMP facility in Bengaluru. With India facing approximately 120,000 new blood cancer cases annually and 70,000 related deaths, Immuneel targets manufacturing nearly 200 drug products daily. The G-Rex Grant Program, which has increased from $20M to $30M in total funding, has awarded 200 grants with over 50 applications pending. Recipients can receive up to $300,000 and access support from ScaleReady's consortium of partners specializing in cGMP manufacturing, quality control, and CGT business operations.

Positive

• Grant award of $150,000 to support process development and manufacturing optimization
• Potential to scale production to 200 drug products per day to meet high demand
• Access to exclusive support from ScaleReady's consortium of G-Rex Grant Partners
• Expansion of total grant program funding from $20M to $30M indicating strong program success

Negative

• Current manufacturing approach requires transition due to scalability limitations
• Post-approval manufacturing changes will require additional comparability studies
• High demand of 120,000 new blood cancer cases annually creates significant production pressure

Insights

Biotechnology Analyst

Bio-Techne's G-Rex technology gains traction in India's CAR-T market through strategic grant program, advancing cell therapy manufacturing capabilities in high-need market.

The $150,000 G-Rex® Grant awarded to Immuneel Therapeutics represents a strategic market expansion for Bio-Techne's cell therapy manufacturing technology into India's burgeoning CAR-T therapy landscape. This grant addresses a critical healthcare need, with India facing approximately 120,000 new blood cancer cases annually and nearly 70,000 related deaths.

The market dynamics here are compelling - Immuneel's manufacturing requirements of 200 drug products daily highlight the substantial treatment demand and commercial potential. From a manufacturing standpoint, transitioning to G-Rex technology offers significant advantages in industrializing production while improving cost-effectiveness, crucial for broader patient access in price-sensitive markets.

What's particularly notable is the accelerating momentum of ScaleReady's grant program, which has expanded from $20M to $30M in total funding with 200 grants already awarded and over 50 applications pending. This suggests strong industry adoption of G-Rex technology and positions Bio-Techne to capture significant market share in the rapidly expanding cell therapy manufacturing sector.

For Bio-Techne, this represents a dual-benefit strategy: immediate technology licensing revenue coupled with establishing a foothold in India's emerging cell therapy market. While the individual grant amount is modest, the broader program's scale indicates meaningful revenue potential and technology validation. The geographic expansion into India's pharmaceutical manufacturing sector also diversifies Bio-Techne's market exposure beyond traditional Western markets.

ST. PAUL, Minn., June 10, 2025 /PRNewswire/ -- ScaleReady, in collaboration with Wilson Wolf Manufacturing, Bio-Techne Corporation and CellReady, today announced that Immuneel Therapeutics has been awarded a $150,000 G-Rex® Grant to support process development aimed at enhancing the scalability and cost-effectiveness of CAR-T cell manufacturing in India.

"The blood cancer burden on India's population is substantial, around 120,000 new cases of lymphoma, leukemia, and multiple myeloma are diagnosed each year. Unfortunately, almost 70,000 Indians will die every year from these afflictions, devastating the lives of their families and communities. To afford access to all Indian patients in need, and to capitalize on the immense commercial potential of our pipeline, we need to think prudently and practically about our manufacturing approach. In the short term, our manufacturing demands are almost 200 drug products per day, and this may increase as CAR-T cell therapies move closer to front line treatment. The only practical way for us to industrialize our production and produce a supply of drug product commensurate with total patient demand is to transition to G-Rex," said Dr. Lakshmikanth Gandikota, Head of R&D, MSAT Intellectual Property, and Translational Research, at Immuneel Therapeutics Limited.

"We are extremely impressed by the speed, resourcefulness, creativity, discipline, and entrepreneurialism of the team at Immuneel and are happy to see that India, as a whole, is making significant strides toward CAR-T availability. It gives us a great sense of satisfaction to be in a position to help bring hope to cancer patients in India, one G-Rex at a time," said John Wilson, CEO of Wilson Wolf and co-inventor of G-Rex.

As part of Immuneel's G-Rex Grant, they will perform process development, qualification, and validation of a G-Rex based CAR-T cell therapy production approach to dramatically increase the throughput capacity of their state-of-the-art, 12,000 square foot GMP facility. Located in Bengaluru and opened in 2021, Immuneel's Integrated Cell Therapy Development and Manufacturing Facility was the first of its kind in India and is designed to bring breakthrough cell and gene therapies to millions of patients in India. Lastly, Immuneel's G-Rex Grant will support the requisite comparability studies necessary to support a post-CAR-T approval manufacturing change from their difficult to scale low throughput all-in-one manufacturing equipment to a much simpler high throughput G-Rex centric approach.

The high popularity of ScaleReady's G-Rex Grant Program led ScaleReady to increase award funds from the original amount of $20M to a total of $30M directed towards saving recipients significant time and money by expediting the path to optimized cell and gene-modified cell therapy manufacturing. Two hundred grants have already been awarded with over 50 new applications in the queue. Each G-Rex Grant recipient can obtain up to $300,000 and gain access to exclusive support from ScaleReady's growing consortium of G-Rex Grant Partners who bring best-in-class tools and technologies as well as unparalleled knowledge and expertise in the areas of cGMP manufacturing, quality and regulatory affairs, CGT business operations, and more.

For more information about the G-Rex® Grant Program, please contact info@scaleready.com.

About ScaleReady
ScaleReady provides the field of cell and gene-modified cell therapy (CGT) with a G-Rex centric manufacturing platform that enables the world's most practical, flexible, scalable, and affordable CGT drug product development and manufacturing.

The G-Rex manufacturing platform is currently used by a rapidly growing list of over 800 organizations and is producing drug products for approximately 50% of CGT clinical trials as well as 5 commercially approved CGT drugs.

CGT entities relying on the breadth and scope of ScaleReady's expertise can expect to save years of time and millions of dollars on the path to CGT commercialization.

For more information about the ScaleReady G-Rex® Grant Program, please contact info@scaleready.com.

About Wilson Wolf Manufacturing
Wilson Wolf (www.wilsonwolf.com) is dedicated to simplifying cell and gene-modified cell (CGT) therapy research, process development, and manufacturing. This is being accomplished through its scalable G-Rex technology, which is used throughout the world in CGT applications ranging from basic research to commercial drug production.

Wilson Wolf's mission is to create hope for cancer patients, one G-Rex® device at a time.

About Bio-Techne Corporation
Bio-Techne Corporation (NASDAQ: TECH) is a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic communities. Bio-Techne, in partnership with Wilson Wolf, is creating products such as media and cytokines that are specifically tailored to G-Rex® Bioreactors, including right-sized reagent quantities in containers that are tailored to high throughput closed-system manufacturing. For more information on Bio-Techne and its brands, please visit https://www.bio-techne.com or follow the Company on social media at: Facebook, LinkedIn, Twitter or YouTube.

Contact: David Clair, Vice President, Investor Relations & Corporate Development
david.clair@bio-techne.com
612-656-4416

About CellReady LLC
CellReady is the world's first and only G-Rex centric contract development and manufacturing organization (CDMO) specializing in G-Rex based cell and gene-modified cell therapy development and manufacturing. The company offers a wide range of services to support the development and commercialization of these therapies.

CellReady's mission is to create hope for cancer patients, one G-Rex® process at a time.

About Immuneel therapeutics Private Limited
Immuneel Therapeutics Private Limited is a cutting-edge biotechnology company based in Bangalore, India, at the forefront of advancing cell and gene therapies, as well as personalized immunotherapies, for cancer patients in India. As a research-driven and fully integrated organization, Immuneel is dedicated to making next-generation cancer treatments accessible and affordable, with a strong focus on innovation and clinical impact. The company's mission is to democratize advanced therapies by developing and commercializing breakthrough solutions tailored to the needs of Indian patients. As part of its growing portfolio, Immuneel has licensed and commercialized Qartemi® (varnimcabtagene autoleucel), a CD19 CAR-T cell therapy approved by India's Central Drugs Standard Control Organization (CDSCO) for the treatment of adult B-cell non-Hodgkin lymphoma a novel therapy for blood cancer, further demonstrating its commitment to transforming cancer care in India. Immuneel has a robust pipeline of CAR-T therapies for various indications in Oncology and AutoImmune diseases

For more information, please visit: www.immuneel.com

 

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SOURCE Bio-Techne Corporation

FAQ

What is the value of the G-Rex Grant awarded to Immuneel Therapeutics?

Immuneel Therapeutics was awarded a $150,000 G-Rex Grant from ScaleReady to enhance CAR-T cell manufacturing in India.

What is the manufacturing capacity target for Immuneel's facility in India?

Immuneel aims to manufacture approximately 200 drug products per day at their 12,000 square foot GMP facility in Bengaluru.

How many G-Rex Grants has ScaleReady awarded so far?

ScaleReady has awarded 200 grants with over 50 new applications in queue, and has increased total program funding from $20M to $30M.

What is the blood cancer burden in India according to the press release?

India faces approximately 120,000 new cases of lymphoma, leukemia, and multiple myeloma annually, with nearly 70,000 deaths per year.

What is the maximum grant amount available through the G-Rex Grant Program?

Recipients can obtain up to $300,000 through the G-Rex Grant Program.