Telomir Pharmaceuticals Reports Peer-Reviewed Publication of Telomir-Zn Data Demonstrating Improved Survival and Multiple Endpoint Benefits in Wilson's Disease
Rhea-AI Summary
Telomir Pharmaceuticals (NASDAQ:TELO) announced a peer-reviewed preclinical study of Telomir-Zn in a Wilson's disease zebrafish model, published in Advances in Redox Research. Telomir-Zn showed dose-dependent survival improvement, reduced hepatic copper, better liver biomarkers, improved locomotor function, less tissue degeneration, and multiple oxidative-stress pathway benefits.
The data represent the first peer-reviewed Wilson's disease publication for Telomir-Zn and, according to Telomir, support its broader mechanistic approach, including its lead Triple-Negative Breast Cancer program cleared by the FDA for IND in April 2026.
Positive
- Preclinical Wilson's model showed dose-dependent survival improvement with Telomir-Zn
- Multiple endpoints improved: hepatic copper burden, liver biomarkers, locomotor function, tissue degeneration
- Data demonstrate reduced copper-induced oxidative stress and attenuated intracellular calcium dysregulation
- First peer-reviewed Wilson's disease publication strengthens Telomir-Zn scientific package
- Findings support mechanistic relevance for Telomir's Triple-Negative Breast Cancer program with FDA IND clearance
Negative
- None.
News Market Reaction – TELO
In the May 20 session, TELO gained 7.38%, reflecting a notable positive market reaction. Argus tracked a peak move of +4.7% during that session. Argus tracked a trough of -3.1% from its starting point during tracking. Our momentum scanner triggered 4 alerts that day, indicating moderate trading interest and price volatility.
Data tracked by StockTitan Argus on the day of publication.
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Apr 30 | IND clearance | Positive | -3.5% | FDA cleared Telomir‑Zn IND for advanced or metastatic TNBC. |
| Apr 24 | Acquisition closed | Positive | +1.4% | Closed TELI acquisition, consolidating global rights to Telomir‑Zn. |
| Mar 31 | IND submission | Positive | +14.0% | Submitted IND to FDA for Telomir‑Zn in advanced/metastatic TNBC. |
| Feb 17 | Preclinical efficacy | Positive | +5.5% | Reported broad TNBC tumor cell mortality in preclinical models. |
| Feb 05 | Mechanism data | Positive | -3.5% | Released new data on metal modulation and epigenetic mechanisms. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Positive R&D and regulatory news has often led to favorable moves, but there are notable instances where upbeat updates were followed by short-term declines.
Over the past few months, Telomir has advanced Telomir‑Zn from mechanistic preclinical work toward the clinic. Key steps included new epigenetic and metal‑modulation data on Feb 5 and broad TNBC cell‑mortality results on Feb 17. The company then submitted an IND on Mar 31, completed the TELI acquisition on Apr 24, and received FDA IND clearance on Apr 30. This publication adds further preclinical validation around oxidative stress and metal homeostasis.
Key Terms
reactive oxygen species (ROS) medical
mitochondrial dysfunction medical
ast medical
bilirubin medical
histopathological medical
triple-negative breast cancer medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
Study Published in Advances in Redox Research Demonstrated Dose-Dependent Survival Improvement, Reduced Hepatic Copper Burden, Improved Liver Biomarkers, and Reduced Tissue Degeneration in a Preclinical Wilson's Disease Model.
MIAMI, FL / ACCESS Newswire / May 20, 2026 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) ("Telomir" or the "Company"), a clinical-stage biotechnology company developing small-molecule therapeutics targeting epigenetic and metabolic drivers of cancer and age-related disease, today announced the peer-reviewed publication of preclinical data showing that Telomir-Zn produced dose-dependent survival improvement across multiple endpoints in a Wilson's disease model, supporting the biological activity of Telomir-Zn in Wilson's disease. The study, titled "Intracellular copper redox modulation disrupts ROS-Ca²⁺ amplification in an ATP7B-deficient zebrafish model of Wilson's disease," was published in Advances in Redox Research.
The publication reports that Telomir-Zn produced dose-dependent improvements across multiple endpoints in the preclinical Wilson's Disease model, including reduced copper-associated oxidative stress, reduced hepatic copper burden, improved liver injury biomarkers, attenuated intracellular calcium dysregulation, improved locomotor function, reduced tissue degeneration, and enhanced survival.
The publication is available online at:
Advances in Redox Research Publication
Wilson's disease is a rare genetic disorder caused by mutation in the ATP7B gene, resulting in impaired copper excretion and toxic copper accumulation in the liver, brain, and other organs. The condition leads to progressive oxidative stress, mitochondrial dysfunction, inflammation, and multi-organ tissue injury. Current standard-of-care treatments, primarily copper chelation agents, address systemic copper levels but do not directly target the downstream oxidative and mitochondrial injury pathways associated with disease progression.
According to the publication, Telomir-Zn demonstrated improvements across cellular and in vivo endpoints in the Wilson's disease model, including:
Reduction of copper-induced reactive oxygen species (ROS) amplification
Attenuation of intracellular calcium dysregulation associated with oxidative stress signaling
Preservation of metabolic viability under copper and peroxide challenge
Reduction of hepatic copper accumulation
Improvement in locomotor and neuromotor performance
Reduction of liver injury biomarkers, including ALT, AST, and bilirubin
Reduction of hepatorenal histopathological degeneration
Improved survival in a dose-dependent manner in the Wilson's disease model
The authors concluded that targeted modulation of labile intracellular copper pools disrupted ROS-Ca²⁺ feedback amplification, mitigated mitochondrial-associated tissue injury associated with copper overload, and produced dose-dependent improvements in survival.
This publication represents Telomir-Zn's first peer-reviewed publication in Wilson's disease and adds independently validated preclinical data across biochemical, functional, histological, and survival endpoints to the Company's scientific package. The findings further support the mechanistic relevance of Telomir-Zn's approach across pathways involving oxidative stress and dysregulated metal homeostasis, including its lead program in Triple-Negative Breast Cancer, for which the Company received FDA IND clearance in April 2026.
"This study demonstrated that modulation of intracellular copper-driven redox activity can disrupt ROS-Ca²⁺ amplification cascades associated with copper toxicity and mitochondrial injury," said Dr. Itzchak Angel, Chief Scientific Advisor of Telomir Pharmaceuticals and corresponding author of the publication.
Dr. Angel continued, "The findings support intracellular metal homeostasis and redox regulation as potentially important biological pathways across diseases involving oxidative stress, mitochondrial dysfunction, and epigenetic dysregulation, including oncology."
"This peer-reviewed publication is an important scientific milestone for Telomir-Zn. The data demonstrated meaningful improvements across a comprehensive set of endpoints in the Wilson's disease model, and we believe the findings are consistent with the broader mechanistic profile of Telomir-Zn as we advance our lead program in Triple-Negative Breast Cancer toward Phase 1/2 clinical initiation," said Erez Aminov, CEO of Telomir Pharmaceuticals.
Telomir Pharmaceuticals will continue evaluating the Wilson's disease program and potential regulatory considerations alongside advancement of its lead TNBC program toward Phase 1/2 clinical initiation.
About Telomir Pharmaceuticals
Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) is a clinical-stage biotechnology company developing small-molecule therapeutics targeting epigenetic and metabolic pathways implicated in cancer, aging, and degenerative disease. The Company's lead program, Telomir-1 (Telomir-Zn), is designed to modulate intracellular metal homeostasis and epigenetic regulation and has received IND clearance from the U.S. Food and Drug Administration for a Phase 1/2 clinical trial in Triple-Negative Breast Cancer. For more information, please visit https://telomirpharma.com/.
Forward-Looking Statements
This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by the use of words such as "anticipate," "expect," "plan," "can," "could," "would," "may," "will," "believe," "estimate," "forecast," "goal," "project," "guidance," "potential," "intend," "seek," "target" and other words of similar meaning, although not all forward-looking statements include these words. Forward-looking statements may include, but are not limited to, statements regarding the therapeutic potential, mechanism of action, development plans, regulatory pathway, safety profile, clinical utility, market opportunity, and future development of Telomir-1 (Telomir-Zn) and the Company's other product candidates. These forward-looking statements are based on current expectations, estimates, forecasts, and projections, as well as management's beliefs and assumptions, and are subject to significant risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. These risks and uncertainties include, among others, risks related to preclinical and clinical development, the ability to obtain regulatory approvals, the outcome of future studies, reliance on third parties, intellectual property protection, financing needs, market conditions, and the other risks identified in the Company's under the heading "Risk Factors" contained in the Company's Annual Report on Form 10-K and the Company's other filings with the U.S. Securities and Exchange Commission ("SEC"). Forward-looking statements contained in this press release speak only as of the date hereof, and the Company undertakes no obligation to update or revise such statements, whether as a result of new information, future events, or otherwise, except as required by applicable law.
We caution investors not to place undue reliance on the forward-looking statements contained in this press release. You are encouraged to read our filings with the SEC, available at the SEC website, and in the "Investors" section of our website, for a discussion of these and other risks and uncertainties.
Contact Information
Krystina Quintana
Email: info@telomirpharma.com
Phone: (786) 396-6723
SOURCE: Telomir Pharmaceuticals, Inc
View the original press release on ACCESS Newswire