Meissa Vaccines Appoints Frank Glavin Chief Executive Officer
“I am excited to welcome Frank to the Meissa leadership team,” said
“I’ve been working closely with Marty and the team as an advisor, and I am impressed with the differentiation of Meissa’s AttenuBlock platform in the vaccine space and the tremendous progress the company has made,” said
About Meissa’s Intranasal RSV Vaccine Candidate
Meissa’s MV-012-968, an intranasal live attenuated vaccine for RSV, is in a Phase 1c study in seronegative infants and young children (ClinicalTrials.gov Identifier: NCT04909021). Previously reported clinical data in seropositive adult and pediatric participants showed MV-012-968 was well-tolerated, appropriately attenuated, and stimulated RSV-specific mucosal IgA, despite pre-existing immunity to RSV. No vaccine is currently approved to protect against respiratory syncytial virus (RSV). RSV is a leading cause of respiratory infections, such as bronchiolitis and viral pneumonia, in infants.
About Meissa’s Intranasal Recombinant COVID-19 Vaccine Candidate
Meissa’s MV-014-212, the company’s intranasal recombinant live attenuated COVID-19 vaccine, is currently in a Phase 1 study in adults (ClinicalTrials.gov Identifier: NCT04798001). Meissa’s needle-free, intranasal COVID-19 vaccine is designed for global use to block transmission, provide durable protection, and control SARS-CoV-2 spread and variants. Previously reported preliminary clinical data from this study show a single dose of Meissa’s vaccine stimulated a nasal IgA antibody response similar to that seen after SARS-CoV-2 infection, with no serious adverse events reported and no infectious vaccine virus detected. Previously reported preclinical data demonstrate that Meissa’s intranasal COVID-19 vaccine generated both mucosal and systemic antibodies and was highly protective against wild-type SARS-CoV-2 challenge in non-human primates (NHPs).1
About AttenuBlock™: Meissa’s Intranasal Vaccine Platform
Meissa’s live attenuated intranasal vaccines are built on the company’s proprietary AttenuBlock platform to achieve appropriate attenuation, genetic stability, and optimized immunity. Injectable vaccines typically induce only serum (IgG) antibodies that circulate in the blood and are important for preventing serious lung disease. Intranasal vaccines also generate mucosal (IgA) antibodies in the nasal cavity, which are essential for blocking infection and transmission of respiratory viruses like RSV and SARS-CoV-2. Meissa’s vaccine platform and intranasal vaccine strategy are uniquely designed to confer mucosal immunity that will likely reduce transmission, if compared to injectable vaccines, provide long-lasting protection, and be a part of the global solution to controlling respiratory viruses.
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1 Tioni, et al. “One mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2.” Posted on biorxiv on
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