Upstream Bio Presents New Data from Phase 2 VIBRANT Trial of Verekitug Demonstrating Improvement in Asthma Symptom Control in Participants with CRSwNP and Comorbid Asthma at the ATS 2026 International Conference
Rhea-AI Summary
Upstream Bio (Nasdaq: UPB) reported new Phase 2 VIBRANT data on verekitug in chronic rhinosinusitis with nasal polyps (CRSwNP), including participants with comorbid asthma.
Verekitug 100 mg every 12 weeks improved ACQ-6 by placebo-adjusted LSM -0.9 at Week 24, cut rescue systemic steroids/CRSwNP surgery by 83%, improved nasal polyp and sinonasal symptom scores, and drove rapid, sustained reductions in type 2 inflammatory biomarkers. Phase 3 trials in CRSwNP and severe asthma are planned to begin dosing in Q1 2027.
AI-generated analysis. How Rhea-AI works. Not financial advice.
Positive
- Placebo-adjusted ACQ-6 improvement of -0.9 at Week 24 in comorbid asthma
- 83% reduction in rescue systemic steroids or CRSwNP surgery vs placebo
- Rapid, sustained reductions in IL-4, IL-5, IL-13 over 24 weeks
- Blood eosinophils reduced by 50% from Week 2 through Week 24
- Correlated IL-5 and eosinophil reductions (Pearson r=0.68) support mechanism
- Phase 3 registrational trials in CRSwNP and severe asthma planned for Q1 2027
Negative
- Evidence currently limited to 81-patient, 24-week Phase 2 VIBRANT trial
- Key biomarker findings derived from post hoc analyses
- Phase 3 registrational trials have not yet begun dosing
News Market Reaction – UPB
On the day this news was published, UPB declined 6.38%, reflecting a notable negative market reaction. Argus tracked a trough of -3.1% from its starting point during tracking. Our momentum scanner triggered 11 alerts that day, indicating notable trading interest and price volatility. This price movement removed approximately $31M from the company's valuation, bringing the market cap to $455.77M at that time.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Clinical trial Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Apr 17 | ATS data preview | Positive | -1.1% | Announced upcoming VIBRANT Phase 2 data posters at ATS 2026. |
| Feb 26 | Additional VIBRANT data | Positive | +2.1% | Late-breaking VIBRANT analyses in CRSwNP at AAAAI 2026. |
| Feb 11 | VALIANT top-line results | Positive | -47.2% | Positive Phase 2 VALIANT severe asthma results with significant AAER reductions. |
| Sep 02 | VIBRANT top-line results | Positive | +18.3% | Phase 2 VIBRANT met primary endpoint with strong NPS and symptom gains. |
| Jul 08 | COPD trial initiation | Positive | -0.7% | First patient dosed in Phase 2 COPD VENTURE trial for verekitug. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Clinical-trial headlines have produced mixed reactions, with an average next-day move of -5.73% and more divergences than alignments despite generally positive data.
Over the past year, Upstream Bio has steadily built the verekitug story through multiple clinical milestones. Positive top-line Phase 2 results in CRSwNP and severe asthma, additional VIBRANT analyses, and repeated conference presentations have highlighted efficacy across nasal polyp burden, asthma exacerbations and biomarkers. Some of these clinically positive updates, including the VALIANT readout, saw sharp negative price reactions, while others, like the initial VIBRANT topline, were rewarded, underscoring inconsistent trading responses to trial news.
Key Terms
asthma control questionnaire-6 (acq-6) medical
nasal polyp score (nps) medical
systemic corticosteroids medical
type 2 inflammatory biomarkers medical
thymic stromal lymphopoietin (tslp) medical
eosinophils medical
ige medical
double-blind, placebo-controlled technical
AI-generated analysis. How Rhea-AI works. Not financial advice.
– Verekitug led to statistically significant and clinically meaningful improvement in asthma symptom control as measured by the Asthma Control Questionnaire-6 (ACQ-6) in participants with CRSwNP and comorbid asthma –
– Verekitug led to improvements in nasal polyp score (NPS) in participants with and without comorbid asthma, as well as rapid and sustained reductions in blood and nasal type 2 inflammatory biomarkers –
WALTHAM, Mass., May 18, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today presented new data from the Phase 2 VIBRANT trial evaluating verekitug in participants with chronic rhinosinusitis with nasal polyps (CRSwNP). The data, presented in two posters at the American Thoracic Society (ATS) 2026 International Conference in Orlando, FL, demonstrated the positive effect of verekitug in participants with CRSwNP and comorbid asthma, as well as its impact on type 2 inflammatory biomarkers in blood and nasal secretions.
“Up to
“Treating patients with both CRSwNP and comorbid asthma effectively remains a real challenge. The improvements observed in the VIBRANT trial with verekitug across nasal polyp burden, sinonasal symptoms, and asthma symptom control—together with reductions in the biomarkers that drive this disease, both systemically and locally in the nasal mucosa—point to meaningful benefit for people living with CRSwNP and comorbid asthma,” said Joseph K. Han, MD, Professor in the Department of Otolaryngology & Head and Neck Surgery and Chief for the Division of Allergy at Old Dominion University (Eastern Virginia Medical School), and principal investigator on the VIBRANT trial. “These efficacy outcomes, combined with a quarterly dosing interval, suggest that verekitug could represent an important new treatment option for people living with these challenging conditions.”
Approximately
Verekitug also led to improvements in NPS at Week 24 in participants with and without comorbid asthma, consistent with the previously reported VIBRANT top-line results. In participants with comorbid asthma, generally greater improvements were observed across sinonasal symptom measures, including nasal congestion score (NCS), total symptom score (TSS), difficulty with sense of smell (DSS), and Lund-Mackay score, compared with participants without comorbid asthma. Among participants with comorbid asthma, verekitug reduced the need for rescue systemic corticosteroids or CRSwNP surgery by
In a separate post hoc analysis, verekitug 100 mg administered every 12 weeks led to rapid and sustained reductions in key type 2 inflammatory cytokines, including IL-4, IL-5, and IL-13, in both blood and nasal secretions over 24 weeks of treatment with generally greater reductions observed in nasal secretions. Verekitug also reduced additional mediators of local inflammation and fibrotic activity, including periostin, thymus and activation-regulated cytokine (TARC), macrophage-derived chemokine (MDC), and eotaxin-3, shedding light on the mechanisms by which a thymic stromal lymphopoietin (TSLP) receptor blockade may benefit patients with inflammatory airway disease.
Verekitug reduced blood eosinophils by
VIBRANT (NCT06164704) was a Phase 2 global, randomized, double-blind, placebo-controlled, parallel group clinical trial that evaluated the efficacy and safety of verekitug over 24 weeks in 81 adults with CRSwNP. Upstream Bio designed the VIBRANT trial using endpoints that, pending interactions with regulatory authorities, could produce data to support submissions for product approval. The Company plans to initiate dosing in Phase 3 registrational trials in both CRSwNP and severe asthma in the first quarter of 2027.
About CRSwNP
CRSwNP is a chronic inflammatory disease of the upper airway, marked by inflammation in the nose and sinuses and the presence of nasal polyps. CRSwNP has four main symptoms: runny nose or postnasal drip, nasal congestion, facial pressure and/or pain, and loss of smell and/or taste. Despite available treatments such as corticosteroids, surgery and, more recently, biologics, quality-of-life studies and post-surgical recurrence rates clearly show that many people with CRSwNP have uncontrolled symptoms that impact their daily life and that current treatments are not meeting their needs. It is estimated that CRSwNP affects up to
Nasal polyps are associated with significant disease burden and debilitating symptoms; it is estimated that over
About the Phase 2 VIBRANT Trial
The Phase 2 VIBRANT trial (NCT06164704) was a global, randomized, placebo-controlled, parallel group clinical trial, which was designed to assess the efficacy and safety of verekitug in adults with CRSwNP who were receiving concurrent intranasal corticosteroid therapy. Participants received either 100 mg of verekitug or placebo subcutaneously every 12 weeks for 24 weeks. The primary endpoint was change in endoscopic nasal polyp score at Week 24, a primary endpoint that has been used in several registrational trials for other biologic treatments for CRSwNP. Secondary endpoints included: nasal congestion score, sinus opacification, difficulty with sense of smell, total symptom score, percentage of participants requiring systemic corticosteroids or nasal polyp surgery, and time to first such interventions up to Week 24.
About Verekitug
Verekitug is a novel recombinant fully human immunoglobulin G1 (IgG1) monoclonal antibody that binds to the thymic stromal lymphopoietin (TSLP) receptor and inhibits proinflammatory signaling initiated by TSLP. It is the only known antagonist currently in clinical development that targets and inhibits the TSLP receptor.
TSLP is a cytokine that is a key driver of the inflammatory response in major allergic and inflammatory diseases, such as asthma, where disruption of TSLP signaling has been clinically validated as an effective therapeutic strategy. TSLP activation is one of the first events in the inflammatory cascade stimulated by allergens, viruses and other triggers, initiating the activation of downstream targets such as IL-4, IL-5, IL-13, IL-17 and IgE. Because TSLP is a target upstream in the inflammatory cascade, blocking the TSLP receptor presents an opportunity for a single treatment to impact the drivers of multiple pathological inflammatory processes across a broad set of diseases.
Verekitug has advanced into three separate global, placebo-controlled, randomized Phase 2 clinical trials, including the positive VIBRANT trial (NCT06164704) in patients with CRSwNP and the positive VALIANT trial (NCT06196879) in patients with severe asthma. The VENTURE trial (NCT06981078) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) is ongoing. Additionally, in May 2025, Upstream Bio initiated the VALOUR trial (NCT06966479), a long-term extension study in eligible participants with severe asthma who completed the VALIANT Phase 2 clinical trial.
About Upstream Bio
Upstream Bio is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist currently in clinical development that targets and inhibits the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. The Company has advanced this highly potent monoclonal antibody into separate Phase 2 trials for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), severe asthma, and chronic obstructive pulmonary disease (COPD). Upstream Bio’s team is committed to maximizing verekitug’s unique attributes to address the substantial unmet needs for patients underserved by today’s standard of care. To learn more, please visit www.upstreambio.com.
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “continue,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “predict,” “project,” “seeks,” “should,” “target,” “will” and variations of these words or similar expressions. Any statements in this press release that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements include, without limitation, express or implied statements regarding: the clinical development of verekitug for the treatment of severe asthma, CRSwNP and COPD, including the initiation, timing, progress and results of ongoing and planned clinical trials; expectations for future discussions with regulatory authorities and the potential of the endpoints of the Company’s clinical trials to produce data that could support submissions for product approval; the potential for verekitug to be a best-in-class treatment; expectations regarding the differentiation, safety, efficacy, tolerability, and/or extended dosing interval of verekitug; and expectations for the size and growth potential of the market for verekitug and the Company’s ability to serve that market. Any forward-looking statements in this press release are based on the Company’s current expectations, estimates and projections only as of the date of this release and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. Readers are cautioned that actual results, levels of activity, safety, efficacy, performance or events and circumstances could differ materially from those expressed or implied in the Company’s forward-looking statements due to a variety of risks and uncertainties, which include, without limitation, risks and uncertainties related to: Upstream Bio’s ability to advance verekitug through clinical development, and to obtain regulatory approval of and ultimately commercialize verekitug on the expected timeline, if at all; the initiation, timing, progress and results of clinical trials; Upstream Bio’s ability to fund its development activities and achieve development goals; Upstream Bio’s dependence on third parties to conduct clinical trials and manufacture verekitug, and commercialize verekitug, if approved; Upstream Bio’s ability to attract, hire and retain key personnel, and protect its intellectual property; Upstream Bio’s financial condition and need for substantial additional funds in order to complete development activities and commercialize verekitug, if approved; regulatory developments and approval processes of the U.S. Food and Drug Administration and comparable foreign regulatory authorities; Upstream Bio’s competitors and industry; and other risks and uncertainties described in greater detail under the caption “Risk Factors” in Upstream Bio’s most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q, as well as any subsequent filings with the SEC. Any forward-looking statements represent Upstream Bio’s views only as of today and should not be relied upon as representing its views as of any subsequent date. Upstream Bio explicitly disclaims any obligation or undertaking to update any forward-looking statements contained herein to reflect any change in its expectations or any changes in events, conditions or circumstances on which any such statement is based except to the extent required by law, and claims the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995.
Investor and Media Contact
Meggan Buckwell
Director, Corporate Communications and Investor Relations
ir@upstreambio.com
