Volition Demonstrates Utility of Rapid, Point-of-Care Finger-Prick Test in Sepsis Patients
Rhea-AI Summary
Volition (NYSE American: VNRX) reported that its Nu.Q® NETs lateral flow finger-prick prototype showed high correlation with its CE-marked automated Nu.Q® NETs laboratory assay in critically ill sepsis patients, supporting use outside centralized labs in the $3.8 billion global NETosis testing market.
According to Volition, H3.1 nucleosome levels measured from finger-prick samples on a lateral flow device tracked closely with plasma results from the lab assay, with a Spearman correlation of 0.85 and Pearson correlation of 0.881. The study, part of the SUMMIT program, used capillary and plasma samples from Intensive Care patients and indicated feasibility of rapid, point-of-care immune disruption detection, including in sepsis, across settings such as ER, ICU, doctors’ offices, or potentially at home. Volition highlighted 166 million estimated global sepsis cases and 31.5% of global deaths in 2021 linked to sepsis, and said decentralized testing could expand its addressable market, including via NGO and strategic partnerships in low-income countries.
Positive
- Lateral flow prototype showed Spearman 0.85, Pearson 0.881 vs CE-marked assay
- $3.8 billion global addressable market cited for NETosis testing
- Study supports decentralized, point-of-care use across multiple care settings
- Sepsis incidence of 166 million cases underpins large potential testing demand
- Sepsis linked to 31.5% of global deaths in 2021, per cited study
Negative
- None.
Market reaction after point-of-care clinical data: VNRX +4.14%
Following this news, VNRX has gained 4.14%, reflecting a moderate positive market reaction. Argus tracked a peak move of +7.7% during the session. Our momentum scanner has triggered 11 alerts so far, indicating notable trading interest and price volatility. The stock is currently trading at $0.74. Trading volume is exceptionally heavy at 32.4x the average, suggesting very strong buying interest.
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Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Aug 05 | liquid biopsy publication | Positive | +1.2% | Peer-reviewed publication reported validation results for Capture-Seq liquid biopsy technology. |
| Jul 30 | NETs platform evidence | Positive | +3.5% | New evidence supported Nu.Q NETs commercialization and sepsis biomarker development. |
| Jul 07 | Cancer assay data | Positive | +3.7% | Clinical data indicated prognostic value for the Nu.Q Cancer Assay. |
| Jun 17 | Sysmex collaboration | Positive | -2.1% | Collaboration targeted optimization of the Nu.Q NETs H3.1 assay. |
| Jun 07 | public offering | Negative | -22.4% | Public offering priced common shares and warrants for gross proceeds. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Recent positive Volition announcements generally aligned with gains, while the Sysmex collaboration diverged and the public offering aligned with a sharp decline.
Key Terms
NETosis medical
lateral flow technical
point-of-care medical
Spearman correlation technical
Pearson correlation technical
AI-generated analysis. How Rhea-AI works. Not financial advice.
Removes Centralized Lab Dependency for
NETosis Testing
This new lateral flow finger prick sample test could be used to rapidly identify high-risk patients in the ER or at the bedside, thereby greatly expanding the potential market beyond centralized lab testing. It also has strong potential in countries worldwide with less developed centralized laboratory infrastructure.
Dr Andrew Retter, Critical Care Lead and Medical Consultant, Volition, said: "This is a huge step forward toward our goal of making Nu.Q® NETs an easily accessible, cost-effective, minimally invasive test.
"We measured H3.1 nucleosomes in critically ill patients with sepsis, comparing a finger-prick sample read on a lateral flow device with our CE-marked laboratory assay on plasma. The two tracked closely, with a Spearman correlation of 0.85 and a Pearson correlation of 0.881.
"This is a significant step forward and a different kind of test from the one we have today. It materially reduces barriers to testing patients and facilitates nucleosome measurement at the bedside.
"The ability to rapidly identify high-risk patients at the Point-of-Care by quantifying their nucleosome levels using a finger-prick sample and simple lateral flow device could enable quicker clinical decision making and consequently better patient outcomes."
Dr. Gaetan Michel, Chief Operating Officer, Volition said: "This prototype technology has the exciting potential to strengthen our product portfolio. With recent estimates indicating approximately 166 million cases of sepsis worldwide, the potential addressable market is huge. All-cause sepsis related deaths in 2021 represented
"This is a potential gamechanger, not only in diseases where time is critical such as sepsis, but also in significantly expanding potential use cases beyond traditional hospital infrastructure. It also creates a compelling pathway into underserved low-income countries, where laboratory infrastructure may be weak or non-existent.
"By enabling decentralized testing, our total addressable market expands, and we are actively targeting NGO partnerships and strategic collaborations with companies operating in low income countries to accelerate commercialization and market penetration. "We are excited to announce this breakthrough and look forward to sharing further details of the study and commercial updates throughout the year."
Volition has previously announced results demonstrating not only correlation between whole venous blood (standard blood draw from the arm) samples utilizing its lateral flow prototype, and those of Volition's established automated Nu.Q® nucleosome assay performed in a central laboratory but also more recently, the successful detection of nucleosomes in capillary blood.
This study, part of the SUMMIT program, tested both capillary blood and plasma blood samples from hospital patients in Intensive Care using the lateral flow finger-prick prototype and the CE-marked automated assay and demonstrated significant correlation between the two formats. Results showed the feasibility of early detection of immune disruptions that can occur in a range of conditions including sepsis, simply and rapidly when using the test in a variety of settings (doctor's office, Emergency Department, Intensive Care Unit setting, or home self-test), without the need to send a blood sample to a hospital laboratory for testing.
- Data on File
- Gray, Authia P et al. Global, regional, and national sepsis incidence and mortality, 1990–2021: a systemic analysis. The Lancet Global Health, 2025; 13(12): e2013-e2026. doi: 10.1016/s2214-109x(25)00356-0
About SUMMIT (Sepsis: addressing unmet needs for disease monitoring with a rapid test)
This innovative project, aimed at developing a capillary blood-based lateral flow test for the early diagnosis of sepsis, is carried out with the financial support of the Walloon Region.
About Volition's Nu.Q® NETs Assay
The Volition Nu.Q® NETs assay is a chemiluminescent immunoassay (ChLIA) that currently runs on the Immunodiagnostic Systems (IDS) i10® automated analyzer platform. It holds a CE Mark to aid in the detection and evaluation of diseases associated with NETosis and is available in 27 European Countries.
About Volition
Volition is a multi-national company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.
Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help detect and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early detection and monitoring have the potential not only to prolong the life of patients, but also to improve their quality of life.
Volition's research and development activities are centered in Belgium, with an innovation laboratory and office in the U.S. and an office in London.
The contents found at Volition's website address are not incorporated by reference into this document and should not be considered part of this document. Such website address is included in this document as an inactive textual reference only.
Media Enquiries:
Louise Batchelor, Volition, mediarelations@volition.com +44 (0)7557 774620
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SOURCE VolitionRx Limited