Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq™ Liquid Biopsy Technology
Rhea-AI Summary
Volition (NYSE AMERICAN: VNRX) announced publication of the first peer‑reviewed paper detailing its new Capture‑Seq™ liquid biopsy technology, which isolates and analyzes >99% pure circulating tumor-derived DNA (ctDNA) from blood plasma by targeting CTCF-bound DNA.
According to Volition, the method combines physical enrichment and bioinformatic filtering to remove virtually all non-tumor cfDNA, generating highly enriched cancer-associated sequence datasets. Early studies reported no false positives and detection of 49/49 cancers in an initial cohort, 13/14 later-stage cancers in a second cohort, and, in a subsequent 81-subject blinded validation, 95% detection of stage I/II colorectal and lung cancers. The company is fast-tracking development, has filed new patents, estimates a total addressable market of approximately $23 billion for multi-cancer early detection and over $13 billion for minimal residual disease, and is in active discussions and technical evaluations with major liquid biopsy and diagnostic companies.
Positive
- Capture-Seq™ ctDNA purity >99% cancer-associated plasma DNA sequence sets reported
- First cohort performance 49/49 cancers detected with no false positives, including 23 stage I/II
- Second blinded cohort 13/14 later-stage cancers detected with 10 additional controls
- 81-subject validation cohort 95% detection of stage I/II colorectal and lung cancers
- Addressable market estimates ~$23B MCED and >$13B MRD annual TAM
- Commercialization progress Active talks and technical evaluations with large diagnostic companies
Negative
- Capture-Seq™ currently validated only in relatively small cohorts; larger studies are still underway
- Method captures only a subset of ctDNA from samples rather than all tumor-derived DNA
Market reaction after Capture-Seq clinical data: VNRX -6.28%
Following this news, VNRX has declined 6.28%, reflecting a notable negative market reaction. Argus tracked a peak move of +10.2% during the session. Our momentum scanner has triggered 57 alerts so far, indicating high trading interest and price volatility. The stock is currently trading at $0.74. Trading volume is exceptionally heavy at 33.6x the average, suggesting significant selling pressure.
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Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Jul 07 | clinical data update | Positive | +3.7% | Prognostic Nu.Q Cancer Test data and clinical certification progress |
| Jun 17 | platform collaboration | Positive | -2.1% | Sysmex collaboration to optimize the Nu.Q NETs H3.1 assay |
| Jun 07 | public offering | Negative | -22.4% | $4.6 million offering of shares and warrants priced at $1.55 |
| Jun 03 | patent application | Positive | -10.3% | New patent application covering Ebola triage and treatment monitoring |
| May 27 | commercial progress update | Positive | +0.0% | $1 million Q1 revenue and progress across multiple commercial programs |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Positive operational and clinical announcements produced mixed 24-hour reactions ranging from -10.34% to +3.7%, while the June offering was followed by -22.35%.
Key Terms
ctdna medical
cfdna medical
chip-seq technical
mced medical
mrd medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Targets
$36 Billion - Company in active discussions with global diagnostic leaders to accelerate commercialization.
Most current liquid biopsy methods involve deep sequencing of plasma DNA and bioinformatic analysis of the data produced to identify the presence of cancer in a patient. The biggest problem facing all liquid biopsy methods worldwide is that the vast majority of circulating DNA in blood plasma samples comes from healthy cells, not cancer cells. Volition's new technology employs an entirely novel approach to liquid biopsy that has overcome this hurdle and produced >
Mr. Gael Forterre, Chief Licensing Officer, Volition added:
"We are delighted that the paper detailing this breakthrough technology has been peer reviewed and published.
"We are in active discussions with several large liquid biopsy and diagnostic companies to accelerate the development of this technology, "Capture-Seq™", and indeed are in the process of undertaking technical evaluations with potential licensors.
"We believe the potential use cases for Capture-Seq™ represent a significant commercial opportunity with a Total Addressable Market on an annualized basis of approximately
Dr Jake Micallef, Chief Scientific Officer, Volition commented:
"Distinguishing cancer derived plasma DNA from healthy DNA when the two are mixed is problematic as they are chemically similar. As the cancer DNA may make up
"Our manuscript describes a new liquid biopsy chemistry for isolating CTCF-DNA from plasma. Our work on CTCF-bound DNA has revealed what we believe to be an unprecedented new discovery; that there is almost no CTCF-bound DNA in healthy plasma and almost all CTCF-bound DNA in the blood of a cancer patient is derived from cancer cells – i.e. it is virtually pure circulating tumor-derived DNA.
"Removal of background normal cell free DNA from the blood to reveal this level of tumor derived DNA has been a long term goal of liquid biopsy. I believe this is a world-first and could, in my opinion, represent the biggest scientific breakthrough in cancer testing and monitoring in recent years.
"In this published paper we report a new, two-step method for preparing pure circulating tumor DNA data sets for cancer patients:
- physical enrichment of the sample; and
- bioinformatic removal of virtually all remaining non-tumor cfDNA sequences from the DNA sequence data set.
"This new method produced >
"These methodological and technological breakthroughs represent a novel liquid biopsy method for a novel class of potentially thousands of liquid biopsy sequence biomarkers. Capture-Seq™ shows potential for both a multi-cancer early detection (MCED) approach, either alone or in combination with other tests, and the detection of Minimal Residual Disease (MRD).
"We are fast-tracking the development of Capture-Seq™ conducting further studies, including competing conditions and larger sample sets and working with oncology Key Opinion Leaders.
"Volition is, I believe, the first liquid biopsy company to focus on circulating cell free nucleoproteins and we have filed a number of new patents to protect this technology."
Dr Andrew Retter, Medical Consultant, Volition commented:
"From a clinical perspective, the proof of concept and early blinded validation results reported in this paper are extremely encouraging. In two independent cohorts we reported no false positives and detected 49/49 cancers in the first cohort (including 23 early stage I/II and 21 controls) and validated it in a second blinded cohort with 13/14 later stage cancers detected with 10 additional controls.
"We have also subsequently reported data from a blinded validation cohort of 81 subjects (colorectal and lung cancer patients = 59, healthy controls = 22) and are extremely encouraged by the results; the early-stage cancer detection of
"For patients, the potential significance is huge. If validated in larger cohorts, CTCF Capture-Seq™ could contribute to Multi-Cancer Early Detection (MCED) fulfilling a significant unmet clinical need.
"We also believe that Capture-Seq™ has the potential to play a role in cancer management, including but not limited to, Minimal Residual Disease detection and treatment monitoring, either alone or potentially in combination with other technologies too."
- Pamart, D., et al. Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy. Clin Epigenet (2026). https://doi.org/10.1186/s13148-026-02205-x
- Data on File : Volition TAM Model
About Volition
Volition is a multi-national company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.
Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help detect and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early detection and monitoring have the potential not only to prolong the life of patients, but also to improve their quality of life.
Volition's research and development activities are centered in Belgium, with an innovation laboratory and office in the U.S. and an office in London.
The contents found at Volition's website address are not incorporated by reference into this document and should not be considered part of this document. Such website address is included in this document as an inactive textual reference only.
Media Enquiries: Louise Batchelor, Volition, mediarelations@volition.com,+44 (0)7557 774620
Safe Harbor Statement
Statements contained or referenced herein, including in any associated video or link, may be "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements are those that are not statements of historical fact and instead address predictions, expectations, beliefs, plans, projections, objectives, goals, assumptions or future events or performance. Words such as "expects," "anticipates," "intends," "plans," "aims," "targets," "believes," "seeks," "estimates," "optimizing," "potential," "goal," "suggests," "could," "would," "should," "may," "will" and similar expressions identify such statements.
These forward-looking statements relate to, among other topics, Volition's expectations regarding revenue opportunities and growth; the effectiveness and availability of its blood-based diagnostic, prognostic and disease monitoring tests; its ability to develop and successfully commercialize such test platforms for the early detection and monitoring of cancer and other diseases; its expectations regarding future publications; and its success in securing, and the terms of, licensing and/or distribution agreements with third parties.
Forward-looking statements are based on current expectations, estimates and projections about Volition's business, in part on assumptions made by management. They are not guarantees of future performance and involve risks and uncertainties that are difficult to predict and that could cause actual results to differ materially from those anticipated. These risks and uncertainties include, without limitation: the results of studies testing the efficacy of Volition's tests; failure to develop and commercialize its products, which may prevent it from executing its plan of operations; failure to obtain necessary regulatory clearances or approvals; failure to achieve healthcare system or insurance reimbursement; failure of the marketplace to accept its products; failure to secure adequate intellectual property protection; the highly competitive and rapidly evolving nature of the diagnostics and disease monitoring market, which may render its products obsolete; downturns in domestic and foreign economies; and other risks identified in Volition's most recent Annual Report on Form 10-K, its Quarterly Reports on Form 10-Q, and other documents filed with the Securities and Exchange Commission.
Forward-looking statements are made as of the date hereof and, except as required by law, Volition undertakes no obligation to update them to reflect future events or circumstances.
Nu.Q®, Nucleosomics™, Capture-PCR™, Capture-Seq™ and rNuQ™ and their respective logos are trademarks and/or service marks of VolitionRx Limited and its subsidiaries. All other trademarks, service marks and trade names referred to in this press release or associated video or link are the property of their respective owners. Additionally, unless otherwise specified, all references to "$" refer to the legal currency of the United States of America.
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SOURCE VolitionRx Limited