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XORTX Announces Director Resignation

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XORTX Therapeutics (NASDAQ: XRTX) announced that board member and chairman Anthony Giovinazzo has stepped down from the board of directors for personal reasons and to pursue other interests. Co-CEO Dr. Allen Davidoff expressed appreciation for Giovinazzo’s leadership, ethics and committee work over several years.

XORTX is a late-stage clinical pharmaceutical company developing therapies targeting gout and progressive kidney disease. Its pipeline includes XRx-026 for gout, XRx-008 for ADPKD, XRx-101 for acute kidney and organ injury linked to respiratory virus infections, and early-stage programs XRx-225 and VB4-P5 for various kidney diseases.

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Positive

  • None.

Negative

  • Chairman and director Anthony Giovinazzo resigns from the board

Market Context

0.46% was the 24-hour reaction to XORTX's June 15 management update. The director resignation can be...
Analysis

0.46% was the 24-hour reaction to XORTX's June 15 management update. The director resignation can be assessed against that recent management-event record; board continuity is the relevant watchpoint, with low short positioning separately reported.

Key Figures

Announcement date: July 31, 2026 Clinically advanced products: 3 products
2 metrics
Announcement date July 31, 2026 Director resignation announcement
Clinically advanced products 3 products Company development pipeline

Historical Context

5 past events · Latest: Jun 15 (Positive)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
Jun 15 Co-CEO appointment Positive +0.5% Mika Grasso appointed co-CEO with responsibility for finance and public markets
Jun 12 Exchange delisting Positive +0.5% Company elected voluntary TSX Venture delisting while retaining Nasdaq trading
May 19 Offering closing Negative -10.8% US$5 million offering closed with shares and pre-funded warrants issued
May 14 Public offering Negative -14.1% Company priced 2,659,574 shares or warrants for US$5 million
Apr 21 Listing compliance Positive +19.6% Nasdaq confirmed compliance after shares exceeded the minimum bid requirement

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

The five recent events moved in the same direction as their categorized news sentiment, with financing announcements producing the most negative reactions.

Key Terms

adpkd, pre-clinical stage, pre-ind stage, purine metabolism, +1 more
5 terms
adpkd medical
"XRx-008 program for ADPKD"
ADPKD stands for autosomal dominant polycystic kidney disease, a hereditary condition in which numerous fluid-filled sacs form and grow in the kidneys over time, gradually crowding out healthy tissue and often leading to reduced kidney function. For investors, ADPKD matters because it represents a clear medical need that drives demand for new drugs, diagnostic tests and medical procedures, shaping clinical trial activity, regulatory decisions and long-term healthcare costs—think of it as a plumbing system where many expanding balloons reduce water flow and require costly fixes.
pre-clinical stage technical
"XRx-225, a pre-clinical stage program"
A pre-clinical stage is the early phase of developing a drug or medical product when researchers test it in cells, tissues and usually animals to check safety, dosing and whether it does what it’s supposed to before any human trials begin. For investors this is where a project is highest risk but lowest cost: results act like prototype tests that either justify bigger investment and human trials or reveal fatal flaws, affecting future value and timelines.
pre-ind stage regulatory
"VB4-P5 program, which is currently at the pre-IND stage"
The pre-IND stage is the period in drug or biologic development that comes before a company files an Investigational New Drug (IND) application with regulators to begin human clinical trials. It covers lab research, animal studies, formulation work, manufacturing scale-up and regulatory planning—think of it as the prototype and safety-testing phase before asking permission to test on people. Investors care because progress here reduces scientific and regulatory uncertainty and helps determine timelines, costs and likelihood of advancing to human trials.
purine metabolism medical
"target aberrant purine metabolism and xanthine oxidase"
The set of biochemical processes cells use to build, break down, and recycle purines — the molecular building blocks of DNA, RNA, and energy carriers like ATP. Think of it as a factory line that makes and disposes of essential parts (with waste such as uric acid); disruptions can cause diseases, provide drug targets, or create biomarkers. It matters to investors because therapies, diagnostics, and regulatory decisions tied to this pathway can affect clinical trial outcomes, product approval, and market value.
xanthine oxidase medical
"purine metabolism and xanthine oxidase to decrease"
Xanthine oxidase is a naturally occurring enzyme — think of it as a tiny chemical machine in cells — that helps break down purines into uric acid and in the process produces reactive molecules. Investors care because blocking this enzyme can lower uric acid levels and reduce damaging oxidative byproducts, making it a key drug target for conditions like gout and certain cardiovascular or kidney issues; progress or setbacks in drugs against this enzyme can affect clinical, regulatory, and market outcomes.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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CALGARY, Alberta, July 31, 2026 (GLOBE NEWSWIRE) -- XORTX Therapeutics Inc. ("XORTX" or the “Company”) (NASDAQ: XRTX | TSXV: XRTX | Frankfurt: ANU), a late-stage clinical pharmaceutical company focused on developing innovative therapies to treat gout and progressive kidney disease, announces that Anthony Giovinazzo is stepping down from the board of directors for personal reasons and to pursue other interests.

Dr. Allen Davidoff, co-CEO of XORTX, stated, “XORTX management and the board of directors extends our heartfelt appreciation for Mr. Giovinazzo’s efforts as chairman of the board during the past several years. Anthony’s contribution to XORTX spans leadership and ethics of the highest standards as Board chairman, and on key committees. We personally thank him for his time with the Company.”

About XORTX Therapeutics Inc.

XORTX is a pharmaceutical company with three clinically advanced products in development: 1) our lead program XRx-026 program for the treatment of gout; 2) XRx-008 program for ADPKD; and 3) XRx-101 for acute kidney and other acute organ injury associated with respiratory virus infections. In addition, the Company is developing XRx-225, a pre-clinical stage program for Type 2 diabetic nephropathy and recently acquired VB4-P5 program, which is currently at the pre-IND stage of development and targets both rare and prevalent forms of kidney disease. XORTX is working to advance products that target aberrant purine metabolism and xanthine oxidase to decrease or inhibit production of uric acid. At XORTX, we are dedicated to developing medications that improve the quality of life and health of individuals with gout and other important diseases.

For more information, please contact:

Allen Davidoff, Co-CEOMika Grasso, Co-CEO
adavidoff@xortx.commgrasso@xortx.com
+1 403 455 7727+1 949 244 6011
  

Neither the TSX Venture Exchange nor Nasdaq has approved or disapproved the contents of this news release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.

Forward Looking Statements

This press release contains "forward-looking statements" within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, as well as "forward-looking information" within the meaning of applicable Canadian securities laws. Forward-looking statements may be identified by the use of words such as "anticipate," "believe," "expect," "estimate," "plan," "intend," "will," "designed to," "positions," and similar expressions, and include all statements that are not statements of historical fact. These forward-looking statements include, but are not limited to, statements regarding the advancement of the Company's development programs and its strategy.

Forward-looking statements are based on the Company's current expectations and assumptions and are subject to known and unknown risks, uncertainties, and other factors that could cause actual results, performance, or achievements to differ materially from those expressed or implied by such statements. Such risks and uncertainties include, among others: the Company's need for, and ability to obtain, additional capital to fund its development programs and operations; the Company's ability to advance, and obtain regulatory approval for, the XRx-026 program and its other product candidates on the timelines currently anticipated, or at all; the evolving regulatory environment applicable to the Company's business in the United States and Canada; and the Company's ability to attract and retain qualified personnel, including its newly appointed director.

For a more detailed discussion of these and other risks and uncertainties, investors should review the disclosures contained under the heading "Risk Factors" in the Company's Annual Report on Form 20-F for the fiscal year ended December 31, 2025, and in the Company's subsequent Reports of Foreign Private Issuer on Form 6-K, each as filed with or furnished to the SEC and available at www.sec.gov, as well as in the Company's continuous disclosure documents filed with the Canadian securities regulatory authorities and available at www.sedarplus.ca.

The forward-looking statements in this press release speak only as of the date hereof. Except as required by law, the Company undertakes no obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise. Readers are cautioned not to place undue reliance on these forward-looking statements.


FAQ

Why did Anthony Giovinazzo resign from the XORTX (XRTX) board on July 31, 2026?

Anthony Giovinazzo resigned from the XORTX board for personal reasons and to pursue other interests. According to XORTX, he stepped down after serving as chairman and contributing on key board committees over several years, with management expressing strong appreciation for his service.

What role did Anthony Giovinazzo have at XORTX (XRTX) before his resignation?

Before resigning, Anthony Giovinazzo served as chairman of the board of XORTX. According to XORTX, he contributed leadership and ethics of high standards and served on key committees during his several years with the company’s board of directors.

Does XORTX (XRTX) give a reason for the board resignation announced July 31, 2026?

XORTX states that Anthony Giovinazzo is stepping down from the board for personal reasons and to pursue other interests. According to XORTX, the company highlights his past leadership and committee contributions but does not disclose additional details regarding the circumstances of his decision.

What drug development programs are in XORTX (XRTX) pipeline after the director resignation?

XORTX reports several programs: XRx-026 for gout, XRx-008 for ADPKD, and XRx-101 for virus-related acute kidney and organ injury. According to XORTX, it is also developing XRx-225 for type 2 diabetic nephropathy and VB4-P5 targeting rare and prevalent kidney diseases.

Is XORTX (XRTX) still focused on kidney and gout therapies after the board change?

Yes, XORTX remains focused on therapies for gout and progressive kidney disease. According to XORTX, its strategy targets aberrant purine metabolism and xanthine oxidase to reduce uric acid production and advance multiple clinical and pre-clinical programs addressing significant kidney-related and inflammatory conditions.