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XORTX Appoints New Director

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XORTX Therapeutics (NASDAQ: XRTX) announced the appointment of Depesh Narotam as an independent member of its board of directors, effective July 27, 2026. The board also determined his independence under Nasdaq listing standards and Canadian securities laws.

Mr. Narotam, age 43, joins the Compensation, Governance and Nominating Committee. He has over 20 years of experience in financial services, with expertise in debt financing, strategic lending solutions, market expansion and partnerships. He currently serves as a Mortgage Development Manager at Vancity and previously spent 16 years at Westminster Savings Credit Union (now Prospera Credit Union). XORTX is a late-stage clinical pharmaceutical company developing therapies for gout and progressive kidney disease, including programs XRx-026, XRx-008, XRx-101, XRx-225 and VB4-P5.

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CALGARY, Alberta, July 29, 2026 (GLOBE NEWSWIRE) -- XORTX Therapeutics Inc. ("XORTX" or the “Company”) (NASDAQ: XRTX | TSXV: XRTX | Frankfurt: ANU), a late-stage clinical pharmaceutical company focused on developing innovative therapies to treat gout and progressive kidney disease, is pleased to announce the appointment of Depesh Narotam to the board of directors as an independent director.

Depesh Narotam has been in the financial services industry for over 20 years. He has developed considerable expertise in debt financing, delivering strategic lending solutions to a diverse client base. Over the course of his career Depesh has developed a comprehensive understanding of various sectors specifically the real estate lending landscape where he has been responsible for market expansion and strategic partnerships to those that have benefited from enhanced market presence and long term performance.

Depesh Narotam

Mr. Narotam, age 43, was appointed as a director of the Company effective July 27, 2026. The board of directors has determined that Mr. Narotam is an independent director under applicable Nasdaq listing standards and Canadian securities laws. Mr. Narotam has also been appointed to serve as a member of the Compensation, Governance and Nominating Committee of the board of directors. Mr. Narotam is a resident of British Columbia, Canada and has served as a Mortgage Development Manager since December 2020 at Vancity, Canada's largest community-based credit union and a member-owned financial co-operative. Prior to joining Vancity, Mr. Narotam spent 16 years with Westminster Savings Credit Union (now Prospera Credit Union) where he held various positions in financial services including Mortgage Specialist and Business Development Manager.

About XORTX Therapeutics Inc.

XORTX is a pharmaceutical company with three clinically advanced products in development: 1) our lead program XRx-026 program for the treatment of gout; 2) XRx-008 program for ADPKD; and 3) XRx-101 for acute kidney and other acute organ injury associated with respiratory virus infections. In addition, the Company is developing XRx-225, a pre-clinical stage program for Type 2 diabetic nephropathy and recently acquired VB4-P5 program, which is currently at the pre-IND stage of development and targets both rare and prevalent forms of kidney disease. XORTX is working to advance products that target aberrant purine metabolism and xanthine oxidase to decrease or inhibit production of uric acid. At XORTX, we are dedicated to developing medications that improve the quality of life and health of individuals with gout and other important diseases.

For more information, please contact:

Allen Davidoff, Co-CEO Mika Grasso, Co-CEO
adavidoff@xortx.com mgrasso@xortx.com
+1 403 455 7727 +1 949 244 6011


Neither the TSX Venture Exchange nor Nasdaq has approved or disapproved the contents of this news release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.

Forward Looking Statements

This press release contains "forward-looking statements" within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, as well as "forward-looking information" within the meaning of applicable Canadian securities laws. Forward-looking statements may be identified by the use of words such as "anticipate," "believe," "expect," "estimate," "plan," "intend," "will," "designed to," "positions," and similar expressions, and include all statements that are not statements of historical fact. These forward-looking statements include, but are not limited to, statements regarding: the appointment of Mr. Narotam to the Company's board of directors; his anticipated contributions to the Company; and the advancement of the Company's development programs and its strategy.

Forward-looking statements are based on the Company's current expectations and assumptions and are subject to known and unknown risks, uncertainties, and other factors that could cause actual results, performance, or achievements to differ materially from those expressed or implied by such statements. Such risks and uncertainties include, among others: the Company's need for, and ability to obtain, additional capital to fund its development programs and operations; the Company's ability to advance, and obtain regulatory approval for, the XRx-026 program and its other product candidates on the timelines currently anticipated, or at all; the evolving regulatory environment applicable to the Company's business in the United States and Canada; and the Company's ability to attract and retain qualified personnel, including its newly appointed director.

For a more detailed discussion of these and other risks and uncertainties, investors should review the disclosures contained under the heading "Risk Factors" in the Company's Annual Report on Form 20-F for the fiscal year ended December 31, 2025, and in the Company's subsequent Reports of Foreign Private Issuer on Form 6-K, each as filed with or furnished to the SEC and available at www.sec.gov, as well as in the Company's continuous disclosure documents filed with the Canadian securities regulatory authorities and available at www.sedarplus.ca.

The forward-looking statements in this press release speak only as of the date hereof. Except as required by law, the Company undertakes no obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise. Readers are cautioned not to place undue reliance on these forward-looking statements.


FAQ

What management change did XORTX Therapeutics (XRTX) announce on July 29, 2026?

XORTX Therapeutics announced the appointment of Depesh Narotam as an independent director effective July 27, 2026. According to XORTX, he will also serve on the board’s Compensation, Governance and Nominating Committee, bringing over 20 years of financial services experience.

Who is Depesh Narotam, the new independent director of XORTX Therapeutics (XRTX)?

Depesh Narotam is a financial services professional with over 20 years’ experience in debt financing and strategic lending. According to XORTX, he has worked at Vancity since December 2020 and previously spent 16 years at Westminster Savings Credit Union in various roles.

What committee will Depesh Narotam join on the XORTX (XRTX) board?

Depesh Narotam will serve on the Compensation, Governance and Nominating Committee of the XORTX board. According to XORTX, his appointment as committee member and independent director became effective on July 27, 2026, following board determination of his independence.

Is Depesh Narotam considered an independent director at XORTX Therapeutics (XRTX)?

Yes, XORTX’s board determined that Depesh Narotam is an independent director under applicable Nasdaq listing standards and Canadian securities laws. According to XORTX, this status applies to his role on the board and its Compensation, Governance and Nominating Committee.

What is the professional background of XORTX (XRTX) director Depesh Narotam?

Depesh Narotam has extensive experience in real estate lending, debt financing, and business development in credit unions. According to XORTX, he is Mortgage Development Manager at Vancity and previously held roles such as Mortgage Specialist and Business Development Manager at Westminster Savings Credit Union.

What therapeutic programs is XORTX Therapeutics (XRTX) developing?

XORTX is developing several programs, including XRx-026 for gout, XRx-008 for ADPKD, and XRx-101 for acute kidney and organ injury. According to XORTX, additional programs include pre-clinical XRx-225 for Type 2 diabetic nephropathy and VB4-P5 targeting kidney disease.

What is the focus of XORTX Therapeutics (NASDAQ: XRTX) as described in this announcement?

XORTX is a late-stage clinical pharmaceutical company focused on therapies for gout and progressive kidney disease. According to XORTX, its products target aberrant purine metabolism and xanthine oxidase to reduce uric acid production and improve quality of life for affected individuals.