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Seaport Therapeutics (SPTX) Stock Price, News & Analysis

SPTX NASDAQ
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Price Move History

Daily moves over 5%
25 97 sessions, May 1, 2026 to September 18, 2026
Largest daily move
+16.6% close of July 8, 2026

Company Description

Seaport Therapeutics (NASDAQ: SPTX) is classified in the biotechnology industry within the Healthcare sector and carries a market capitalization of $1.1B.

SPTX has declined 10.8% over the past month. The last closing price was $21.39.

This page collects what Stock Titan holds for SPTX, including price data, latest news, SEC filings, insider trading activity, financial highlights, upcoming events, and short interest trends.

Stock Performance

$21.39
-1.97%
0.43
Last updated: September 18, 2026 at 16:02
-10.8%
Performance 1 month

Seaport Therapeutics (SPTX) closed at $21.39 on September 18, 2026. Over the past month, the price has lost 10.8%.

See what a $1,000 investment in SPTX would be worth today

SPTX Metrics & Rankings

Price returns through September 18, 2026. Month-to-date and YTD include the first trading day. Ranking links may use different dates.

Latest News

Seaport Therapeutics has 10 recent news articles, with the latest published 6 days ago. Of the recent coverage, 3 articles coincided with positive price movement and 6 with negative movement. Key topics include clinical trial, earnings, conferences, IPO, offering. View all SPTX news →

Insider Radar

Net Buyers
90-Day Summary
13,000
Shares Bought
0
Shares Sold
1
Transactions
Most Recent Transaction
HOMBACH ROBERT J. (Director) bought 13,000 shares @ $18.14 on June 22, 2026

Insider buying activity at Seaport Therapeutics over the past 90 days may reflect management confidence in the company's direction. Institutional investors and analysts often monitor insider purchases as a potential bullish indicator for the stock.

Based on SEC Form 4 filings over the last 90 days.

Financial Highlights

Revenue (latest FY)
Net Income (latest FY)
Operating Cash Flow

Upcoming Events

JAN
01
January 1, 2027 - June 30, 2027 Clinical

BUOY-1 topline data

Topline results from Phase 2b BUOY-1 MDD trial expected in H1 2027; trial is enrolling and may be registration-enabling.
JAN
01
January 1, 2027 - June 30, 2027 Clinical

BUOY-1 topline readout

BUOY-1 Phase 2b MDD topline readout window Jan–Jun 2027 for GlyphAllo; ~360 patients enrolling; no webcast info provided.
JAN
01
January 1, 2027 - June 30, 2027 Clinical

BUOY-1 topline results

Topline results expected for BUOY-1 Phase 2b MDD trial (potentially registration-enabling); enrollment ongoing, H1 2027 window.
JAN
01
January 1, 2028 - December 31, 2028 Clinical

Topline data expected

Topline readout expected in 2028 for GlyphAgo (SPT-320) Phase 2 trials; company to report results via press release/webcast.

Seaport Therapeutics has 4 upcoming scheduled events. The next event, "BUOY-1 topline data", is scheduled for January 1, 2027 (in 102 days). Investors can track these dates to stay informed about potential catalysts that may affect the SPTX stock price.

Short Interest History

Last 12 Months

Short interest in Seaport Therapeutics (SPTX) currently stands at 3.2 million shares, up 4.6% from the previous reporting period, representing 11.0% of the float. Since May 2026, short interest has increased by 116.0%. This moderate level of short interest indicates notable bearish positioning. With 26.0 days to cover, it would take significant time for short sellers to close their positions based on average trading volume.

Days to Cover History

Last 12 Months

Days to cover for Seaport Therapeutics (SPTX) currently stands at 26.0 days. This elevated days-to-cover ratio indicates it would take over two weeks of average trading volume for short sellers to exit their positions, suggesting potential for a short squeeze if positive news emerges. The days to cover has increased 1410.5% over the past year, indicating either rising short interest or declining trading volume. The ratio has shown significant volatility over the period, ranging from 1.7 to 30.8 days.

SPTX Company Profile & Sector Positioning

Seaport Therapeutics (SPTX) operates in the Biotechnology industry within the broader Healthcare sector and is listed on the NASDAQ.

Frequently Asked Questions

What is the current stock price of Seaport Therapeutics (SPTX)?

The current stock price of Seaport Therapeutics (SPTX) is $21.39 as of September 18, 2026.

What is the market cap of Seaport Therapeutics (SPTX)?

The market cap of Seaport Therapeutics (SPTX) is approximately $1.1B. Learn more about what market capitalization means .