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Seaport Therapeutics (SPTX) Stock Price, News & Analysis

SPTX NASDAQ
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Price Move History

Daily moves over 5%
36 131 sessions, May 1, 2026 to November 5, 2026
Largest daily move
+16.6% close of July 8, 2026
1-month change
+10.2% closing prices, October 5, 2026 to November 5, 2026

Company Description

Seaport Therapeutics (NASDAQ: SPTX) is classified in the biotechnology industry within the Healthcare sector and carries a market capitalization of $1.1B.

SPTX has gained 10.2% over the past month. The last closing price was $20.39.

This page collects what Stock Titan holds for SPTX, including price data, latest news, SEC filings, insider trading activity, upcoming events, and short interest trends.

Stock Performance

$21.21
+4.02%
+0.82
Last updated: November 6, 2026 at 12:52
+10.2%
Performance 1 month

Seaport Therapeutics (SPTX) closed at $20.39 on November 5, 2026. Over the past month, the price has gained 10.2%.

See what a $1,000 investment in SPTX would be worth today

Average down calculator for SPTX

SPTX Metrics & Rankings

Price returns through November 5, 2026. Month and year figures include the first trading day. Ranking links may use different dates.

Latest News

Seaport Therapeutics has 10 recent news articles, with the latest published 4 days ago. Of the recent coverage, 6 articles coincided with positive price movement and 4 with negative movement. Key topics include earnings, clinical trial. View all SPTX news →

Insider Radar

Net Buyers
90-Day Summary
5,000
Shares Bought
0
Shares Sold
1
Transactions
Most Recent Transaction
Torres Denice (Director) bought 5,000 shares @ $19.87 on November 3, 2026

Insider buying activity at Seaport Therapeutics over the past 90 days may reflect management confidence in the company's direction. Institutional investors and analysts often monitor insider purchases as a potential bullish indicator for the stock.

Based on SEC Form 4 filings over the last 90 days.

Financial Highlights

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Revenue (latest FY)
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Net Income (latest FY)
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Operating Cash Flow

Upcoming Events

NOV
10
November 10, 2026 - November 12, 2026 Marketing

Stifel healthcare conference

Stifel 2026 Healthcare Conference runs Nov 10–12 at Lotte New York Palace Hotel, NYC; Seaport management attending for presentations and meetings.
NOV
10
November 10, 2026 - November 12, 2026 Marketing

Investor one-on-ones

Seaport management to participate in one-on-one investor meetings during Nov 10–12 Stifel conference in New York; scheduling via company IR.
NOV
10
November 10, 2026 Marketing

Stifel conference presentation

Live presentation by Seaport Therapeutics at Stifel 2026 Healthcare Conference on Nov 10 at 4:00 p.m. EST; webcast and archived replay available.
H1
2027
H1 2027 Clinical

BUOY-1 topline data

Topline results from Phase 2b BUOY-1 MDD trial expected in H1 2027; trial is enrolling and may be registration-enabling.
H1
2027
H1 2027 Clinical

BUOY-1 topline readout

BUOY-1 Phase 2b MDD topline readout window Jan–Jun 2027 for GlyphAllo; ~360 patients enrolling; no webcast info provided.
H1
2027
H1 2027 Clinical

Phase 2/3 start window

Planned start window for Seaport's global placebo-controlled Phase 2/3 trial (first half 2027); global sites expected.
H1
2027
H1 2027 Clinical

Phase 2/3 trial start

Planned global, placebo-controlled Phase 2/3 GlyphAgo trial start window in H1 2027; sponsor Seaport Therapeutics, global sites planned.
H1
2027
H1 2027 Clinical

BUOY-1 topline results

Topline results expected for BUOY-1 Phase 2b MDD trial (potentially registration-enabling); enrollment ongoing, H1 2027 window.
H1
2027
H1 2027 Clinical

GlyphAllo Phase 2b Readout

Topline GlyphAllo Phase 2b depression data expected in H1 2027; readout window Jan–Jun 2027, may materially affect program value.
H1
2027
H1 2027 Clinical

GlyphAgo Phase 2/3 Start

Planned initiation of GlyphAgo Phase 2/3 anxiety trial in H1 2027 (Jan–Jun 2027); first patient dosing timetable and trial launch window.
YEAR
2028
2028 Clinical

Phase 2a results

Phase 2a trial results in adults with generalized anxiety disorder and sleep disturbance expected in early 2028.
YEAR
2028
2028 Clinical

Phase 2a topline data

Topline results expected for the six-week GlyphAgo Phase 2a trial in Australia; data release planned early 2028.
YEAR
2028
2028 Clinical

Phase 2a topline results

Topline results expected in early 2028 from the six-week Australian Phase 2a GlyphAgo study assessing sleep, anxiety, safety and exposure.
YEAR
2028
2028 Clinical

Topline data expected

Topline readout expected in 2028 for GlyphAgo (SPT-320) Phase 2 trials; company to report results via press release/webcast.
YEAR
2028
2028 Clinical

GlyphAgo Phase 2a Readout

GlyphAgo Phase 2a anxiety and sleep-disturbance data expected in early 2028 (Jan–Apr 2028); topline results could affect program outlook.
YEAR
2028
2028 Clinical

GlyphAgo Phase 2/3 Readout

GlyphAgo Phase 2/3 anxiety data expected by year-end 2028; full-year 2028 window for pivotal outcomes that could drive valuation.
YEAR
2028
2028 Clinical

Phase 2/3 topline data

Topline efficacy and safety readout expected for Seaport's planned global Phase 2/3 trial by end of 2028.
YEAR
2028
2028 Clinical

Phase 2/3 topline results

Topline results from the planned global Phase 2/3 GlyphAgo trial expected by end of 2028; results to inform registrational strategy.

Seaport Therapeutics has 18 upcoming scheduled events. The next event, "Stifel healthcare conference", is scheduled for November 10, 2026 (in 4 days). Investors can track these dates to stay informed about potential catalysts that may affect the SPTX stock price.

Short Interest History

Last 12 Months

Short interest in Seaport Therapeutics (SPTX) currently stands at 3.7 million shares, up 1.9% from the previous reporting period, representing 14.1% of the float. Since May 2026, short interest has increased by 154.8%.

Days to Cover History

Last 12 Months

Days to cover for Seaport Therapeutics (SPTX) currently stands at 17.9 days, up 100.3% from the previous period. The ratio is the reported short interest divided by the average daily trading volume. Since May 2026, the figure has increased by 939%. Across the settlements charted above, it has ranged from 1.7 to 30.8 days.

SPTX Company Profile & Sector Positioning

Seaport Therapeutics (SPTX) operates in the Biotechnology industry within the broader Healthcare sector and is listed on the NASDAQ.

Investors comparing SPTX often look at related companies in the same sector, including Maravai LifeSciences Holdings, Inc. (MRVI), Janux Therapeutics, Inc. (JANX), Immatics N.V. (IMTX), Odyssey Therapeutics, Inc. (ODTX), and Mannkind Corporation (MNKD). Comparing financial metrics, valuation ratios, and stock performance across these peers can help investors evaluate SPTX's relative position within its industry.

Frequently Asked Questions

The current stock price of Seaport Therapeutics (SPTX) is $21.21 as of November 6, 2026.

The market cap of Seaport Therapeutics (SPTX) is approximately $1.1B. Learn more about what market capitalization means .