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#1 CUE leads with +2,859% April 2021

CUE (Cue Biopharma, Inc.) is the best performing stock in April 2021. Following are BTX (+1,228%) and IMUX (+812%). Top performing sectors: Financial Services (+202% avg, 1 in top 10), Healthcare (+163% avg, 6 in top 10), Utilities (+144% avg, 1 in top 10).

Top Stock Gainers April 2021 - Monthly Performance Ranked

Track the top performing stocks of April 2021 ranked by monthly price gain. See which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.
2021

This ranking shows the top performing stocks and biggest stock gainers during April 2021, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

April 2021 Stock Market Momentum

This page answers a current-month trend question with data: which NYSE and NASDAQ stocks have shown the strongest price gains so far in April 2021. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?

Data as of June 20, 2026 at 8:37 AM EDT

Rank
Symbol
Company Name
Apr Gain
Market Cap
Price
Country
Sector
1
2858.54%
119.54 M
$ 28.46
United States
Healthcare
2
1228%
1.09 B
$ 9.34
United States
Financial Services
3
811.57%
193.43 M
$ 14.2
United States
Healthcare
4
385.71%
6.53 B
$ 9.31
Brazil
Utilities
5
112.83%
168.15 M
$ 1.45
United States
Consumer Cyclical
6
100.91%
186.05 M
$ 2.825
United States
Healthcare
7
89.1%
419.77 M
$ 1.24
United States
Healthcare
8
87.53%
4.28 B
$ 87.76
United States
Healthcare
9
66.46%
185.50 M
$ 17.24
10
65.35%
22.98 B
$ 90.89
Germany
Healthcare
11
64.25%
133.85 M
$ 5.9
United States
Industrials
12
62.43%
622.21 M
$ 1.62
Canada
Basic Materials
13
61.39%
301.20 M
$ 3.35
United States
Financial Services
14
59.29%
148.61 M
$ 6.01
Canada
Healthcare
15
58.02%
645.75 M
$ 6.69
United States
Industrials
16
53.06%
1.65 B
$ 14.28
Switzerland
Healthcare
17
52.79%
422.36 M
$ 1.92
China
Consumer Cyclical
18
49.95%
1.03 B
$ 23.68
United States
Industrials
19
46.6%
355.63 M
$ 3.57
Brazil
Consumer Defensive
20
46.53%
682.24 M
$ 6.7
Monaco
Industrials
21
45.97%
7.42 B
$ 88.43
United States
Consumer Cyclical
22
44.43%
484.03 M
$ 68.6
Greece
Industrials
23
44.03%
1.08 B
$ 7.04
United States
Healthcare
24
42.73%
1.99 B
$ 70.16
Greece
Industrials
25
41.85%
135.29 M
$ 15.645
United States
Consumer Cyclical
26
41.43%
2.93 B
$ 24.34
Israel
Industrials
27
40.15%
907.25 M
$ 7.18
United States
Energy
28
40.06%
1.37 B
$ 1.03
Brazil
Basic Materials
29
36.87%
263.39 M
$ 3.7
United States
Healthcare
30
36.71%
1.46 B
$ 15.02
United States
Healthcare
31
36.49%
1.58 B
$ 2.99
Mexico
Communication Services
32
36.34%
1.17 B
$ 2.94
Brazil
Basic Materials
33
35%
1.63 B
$ 6.1
United Kingdom
Communication Services
34
34.91%
25.38 B
$ 63.96
United States
Healthcare
35
33.51%
1.23 B
$ 2.41
United States
Communication Services
36
33.47%
2.63 B
$ 5
United States
Healthcare
37
32.97%
2.55 B
$ 32.43
United States
Healthcare
38
32.5%
936.15 M
$ 4.46
United States
Technology
39
30.37%
753.69 M
$ 28.55
United States
Consumer Cyclical
40
30.17%
1.61 B
$ 29.74
Bermuda
Energy
41
29.65%
1.66 B
$ 6.71
United States
Communication Services
42
29.55%
1.45 B
$ 29.12
United States
Healthcare
43
28.96%
992.38 M
$ 4.53
Guernsey
Financial Services
44
28.91%
4.32 B
$ 78.17
United States
Consumer Cyclical
45
28.72%
1.81 B
$ 12
United States
Technology
46
28.57%
2.88 B
$ 25.81
Greece
Industrials
47
28.57%
2.01 B
$ 20.16
United States
Industrials
48
28.44%
4.10 B
$ 31.38
United States
Technology
49
28.24%
1.21 B
$ 5.39
Germany
Healthcare
50
28.21%
1.03 B
$ 21.19
United States
Healthcare
51
27.79%
369.34 M
$ 17.61
United States
Consumer Cyclical
52
27.77%
1.84 B
$ 6.42
United States
Healthcare
53
27.51%
1.50 B
$ 9.13
United States
Healthcare
54
27.34%
472.77 M
$ 4.95
United States
Healthcare
55
27.07%
2.91 B
$ 30.88
United States
Technology
56
26.92%
2.04 B
$ 18.18
China
Healthcare
57
26.91%
1.59 B
$ 7.98
Bermuda
Industrials
58
26.89%
382.93 M
$ 13.53
United States
Basic Materials
59
26.69%
3.43 B
$ 8.95
United States
Financial Services
60
26.33%
6.93 B
$ 123.12
United States
Energy
61
25.84%
6.21 B
$ 125.05
United States
Consumer Cyclical
62
25.72%
211.82 M
$ 14.47
United States
Consumer Cyclical
63
25.53%
18.57 B
$ 153.93
United States
Industrials
64
25.44%
203.71 M
$ 6.7
United States
Industrials
65
25.29%
1.15 B
$ 107.21
United States
Financial Services
66
25.27%
361.75 M
$ 9
United States
Financial Services
67
24.86%
447.95 M
$ 57.56
United States
Industrials
68
24.67%
2.04 B
$ 26.08
United States
Healthcare
69
24.57%
2.97 B
$ 46.57
United States
Technology
70
24.55%
648.56 M
$ 16.76
United States
Energy
71
24.47%
630.65 M
$ 15.29
United States
Technology
72
24.47%
1.18 B
$ 111.4
United States
Basic Materials
73
24.33%
505.29 M
$ 60.66
United States
Consumer Cyclical
74
24.1%
247.36 M
$ 5.88
United States
Basic Materials
75
23.99%
916.81 M
$ 50.96
United States
Utilities
76
23.87%
173.55 M
$ 6.41
United States
Healthcare
77
23.72%
253.49 M
$ 22.15
United States
Consumer Cyclical
78
23.64%
187.35 M
$ 12.99
United States
Healthcare
79
23.46%
3.27 B
$ 19.8
United States
Healthcare
80
23.1%
437.85 M
$ 17.25
Canada
Technology
81
22.92%
3.02 B
$ 24.8
United States
Energy
82
22.91%
318.48 M
$ 3.9
United States
Healthcare
83
22.78%
547.65 M
$ 10.13
United States
Communication Services
84
22.74%
919.17 M
$ 15.53
France
Healthcare
85
22.64%
247.37 M
$ 3.23
United States
Healthcare
86
22.61%
391.76 M
$ 24.34
United States
Consumer Cyclical
87
22.56%
188.28 M
$ 11.33
United States
Consumer Cyclical
88
21.9%
777.29 M
$ 4.2
Canada
Basic Materials
89
21.83%
261.25 M
$ 2.1
Greece
Industrials
90
21.82%
9.11 B
$ 23.7
United States
Consumer Cyclical
91
21.77%
482.76 M
$ 7.38
United States
Industrials
92
21.72%
133.15 M
$ 9.34
United States
Healthcare
93
21.7%
663.69 M
$ 17.82
Mexico
Consumer Cyclical
94
21.5%
841.68 M
$ 4.71
Singapore
Financial Services
95
21.49%
876.36 M
$ 16.17
United States
Industrials
96
21.25%
264.31 M
$ 64.85
United States
Consumer Cyclical
97
21.11%
1.57 B
$ 42.54
United States
Consumer Cyclical
98
21.1%
342.23 M
$ 4.07
United States
Utilities
99
21.05%
2.70 B
$ 25.67
United States
Consumer Cyclical
100
20.83%
4.62 B
$ 30.13
Mexico
Basic Materials
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q Which stock has gained the most in April 2021?
A

CUE (Cue Biopharma, Inc.) has the highest monthly gain in this ranking for April 2021, with a gain of 2,859%. Top performers this month include CUE, BTX, IMUX.

Q What stocks gained the most in April 2021?
A

The biggest gainers in April 2021 were: CUE (+2,859%), BTX (+1,228%), IMUX (+812%), ELP (+386%), PLBY (+113%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during April 2021. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during April 2021. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which sectors performed best in April 2021?
A

The top performing sectors in April 2021 included Healthcare, Financial Services, Utilities, based on the stocks with highest monthly gains. CUE led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in April 2021. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.