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MARKET LEADERS
52-WEEK LEADER
WOLF +1544%
Wolfspeed, Inc.
2021 YTD LEADER
ENLT +4573%
Enlight Renewable Ener..
APR 2021 LEADER
CUE +2859%
Cue Biopharma, Inc.
📈 52-Week Top 5 Full List →
1 WOLF +1544.4% 2 BW +918.1% 3 BE +560.1% 4 DOCN +396.4% 5 CIEN +355.5%
📅 2021 YTD Top 5 Full List →
1 ENLT +4573.5% 2 STRL +3923.2% 3 AEHR +3765.3% 4 SNDK +3190.7% 5 LQDA +2801.3%
🗓 April 2021 Top 5 Full List →
1 CUE +2858.5% 2 BTX +1228.0% 3 IMUX +811.6% 4 ELP +385.7% 5 PLBY +112.8%
Quick Access: 52-Week 2021 YTD Apr 2021 Market Cap Dividends
#1 CUE leads with +2,859% April 2021

CUE (Cue Biopharma, Inc.) is the best performing stock in April 2021. Following are BTX (+1,228%) and IMUX (+812%). Top performing sectors: Financial Services (+201% avg, 1 in top 10), Healthcare (+154% avg, 6 in top 10), Utilities (+144% avg, 1 in top 10).

Top Stock Gainers April 2021 - Monthly Performance Ranked

Track the top performing stocks of April 2021 ranked by monthly price gain. See which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.

Best performing large-cap stocks in April 2021

BNTX BioNTech SE +65.35% $23.35B
MRNA Moderna, Inc. +34.91% $23.67B
EFX Equifax Inc. +25.53% $20.87B
IQV IQVIA Holdings Inc. +18.49% $33.65B
NET Cloudflare, Inc. +18.04% $96.65B
2021
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

This ranking shows the top performing stocks and biggest stock gainers during April 2021, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

April 2021 Stock Market Momentum

This page answers a current-month trend question with data: which NYSE and NASDAQ stocks have shown the strongest price gains so far in April 2021. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?

Data as of July 23, 2026 at 1:19 AM EDT

Rank
Symbol
Company Name
Apr Gain
Market Cap
Price
Country
Sector
1
CUE
Cue Biopharma, Inc.
2858.54%
140.54 M
$ 33.46
United States
Healthcare
2
BTX
BlackRock Innovation and Gr...
1228%
980.37 M
$ 8.4
United States
Financial Services
3
IMUX
Immunic, Inc.
811.57%
206.37 M
$ 15.15
United States
Healthcare
4
ELP
Companhia Paranaense de Ene...
385.71%
6.53 B
$ 9.31
Brazil
Utilities
5
PLBY
Playboy, Inc.
112.83%
142.18 M
$ 1.23
United States
Consumer Cyclical
6
GALT
Galectin Therapeutics Inc.
100.91%
253.22 M
$ 3.845
United States
Healthcare
7
OCGN
Ocugen, Inc.
89.1%
440.08 M
$ 1.3
United States
Healthcare
8
CELC
Celcuity Inc.
87.53%
4.47 B
$ 91.69
United States
Healthcare
9
BBQ
BBQ Holdings, Inc.
66.46%
185.50 M
$ 17.24
10
BNTX
BioNTech SE
65.35%
23.35 B
$ 92.33
Germany
Healthcare
11
NFGC
New Found Gold Corp.
62.43%
545.40 M
$ 1.42
Canada
Basic Materials
12
BRBS
Blue Ridge Bankshares, Inc.
61.39%
309.30 M
$ 3.44
United States
Financial Services
13
CYBN
Cybin Inc.
59.29%
148.61 M
$ 6.01
Canada
Healthcare
14
MRLN
Merlin, Inc.
58.02%
369.69 M
$ 3.83
United States
Industrials
15
NVCR
NovoCure Limited
53.06%
1.85 B
$ 16
Switzerland
Healthcare
16
UXIN
Uxin Limited
52.79%
338.77 M
$ 1.54
China
Consumer Cyclical
17
GNK
Genco Shipping & Trading Li...
49.95%
1.11 B
$ 25.36
United States
Industrials
18
SB
Safe Bulkers, Inc.
46.53%
758.61 M
$ 7.45
Monaco
Industrials
19
LNW
Light & Wonder, Inc.
45.97%
7.42 B
$ 88.43
United States
Consumer Cyclical
20
ESEA
Euroseas Ltd.
44.43%
514.69 M
$ 72.95
Greece
Industrials
21
ATNF
ETHZilla Corporation
44.03%
1.08 B
$ 7.04
United States
Healthcare
22
NMM
Navios Maritime Partners L.P.
42.73%
2.11 B
$ 74.3
Greece
Industrials
23
BSET
Bassett Furniture Industrie...
41.85%
180.44 M
$ 20.84
United States
Consumer Cyclical
24
ZIM
ZIM Integrated Shipping Ser...
41.43%
3.00 B
$ 24.92
Israel
Industrials
25
HPK
HighPeak Energy, Inc.
40.15%
975.48 M
$ 7.72
United States
Energy
26
ZNTL
Zentalis Pharmaceuticals, Inc.
36.87%
356.64 M
$ 5.01
United States
Healthcare
27
MNMD
Mind Medicine (MindMed) Inc.
36.71%
1.46 B
$ 15.02
United States
Healthcare
28
TV
Grupo Televisa, S.A.B.
36.49%
1.47 B
$ 2.78
Mexico
Communication Services
29
BAK
Braskem S.A.
36.34%
924.48 M
$ 2.32
Brazil
Basic Materials
30
GENI
Genius Sports Limited
35%
1.78 B
$ 6.65
United Kingdom
Communication Services
31
MRNA
Moderna, Inc.
34.91%
23.67 B
$ 59.66
United States
Healthcare
32
CLOV
Clover Health Investments, ...
33.47%
2.52 B
$ 4.79
United States
Healthcare
33
CLDX
Celldex Therapeutics, Inc.
32.97%
2.80 B
$ 35.66
United States
Healthcare
34
CRCT
Cricut, Inc.
32.5%
942.44 M
$ 4.49
United States
Technology
35
GDEN
Golden Entertainment Inc
30.37%
753.69 M
$ 28.55
United States
Consumer Cyclical
36
FLNG
FLEX LNG Ltd.
30.17%
1.69 B
$ 31.3
Bermuda
Energy
37
STGW
Stagwell Inc.
29.65%
1.80 B
$ 7.25
United States
Communication Services
38
STAA
STAAR Surgical Company
29.55%
1.21 B
$ 24.27
United States
Healthcare
39
KTB
Kontoor Brands, Inc.
28.91%
4.71 B
$ 85.3
United States
Consumer Cyclical
40
SEMR
SEMrush Holdings Inc
28.72%
1.81 B
$ 12
United States
Technology
41
SBLK
Star Bulk Carriers Corp.
28.57%
2.98 B
$ 26.68
Greece
Industrials
42
TH
Target Hospitality Corp.
28.57%
1.68 B
$ 16.82
United States
Industrials
43
EXTR
Extreme Networks, Inc.
28.44%
3.98 B
$ 30.44
United States
Technology
44
CVAC
CureVac N.V.
28.24%
1.21 B
$ 5.39
Germany
Healthcare
45
AORT
Artivion, Inc.
28.21%
1.21 B
$ 24.94
United States
Healthcare
46
NEGG
Newegg Commerce, Inc.
27.79%
286.92 M
$ 13.68
United States
Consumer Cyclical
47
TSHA
Taysha Gene Therapies, Inc.
27.77%
1.63 B
$ 5.67
United States
Healthcare
48
NVAX
Novavax, Inc.
27.51%
1.33 B
$ 8.075
United States
Healthcare
49
STTK
Shattuck Labs, Inc.
27.34%
688.61 M
$ 7.21
United States
Healthcare
50
ZLAB
Zai Lab Limited
26.92%
2.31 B
$ 20.48
China
Healthcare
51
VHI
Valhi, Inc.
26.89%
388.87 M
$ 13.74
United States
Basic Materials
52
GNW
Genworth Financial, Inc.
26.69%
3.88 B
$ 10.13
United States
Financial Services
53
CHRD
Chord Energy Corporation
26.33%
7.55 B
$ 134.19
United States
Energy
54
CROX
Crocs, Inc.
25.84%
6.72 B
$ 135.28
United States
Consumer Cyclical
55
LOVE
The Lovesac Company
25.72%
257.49 M
$ 17.59
United States
Consumer Cyclical
56
EFX
Equifax Inc.
25.53%
20.87 B
$ 173
United States
Industrials
57
OPY
Oppenheimer Holdings Inc.
25.29%
1.18 B
$ 110.55
United States
Financial Services
58
RILY
BRC Group Holdings, Inc.
25.27%
283.77 M
$ 7.06
United States
Financial Services
59
BXC
BlueLinx Holdings Inc.
24.86%
423.60 M
$ 54.43
United States
Industrials
60
PGNY
Progyny, Inc.
24.67%
2.53 B
$ 32.24
United States
Healthcare
61
OUST
Ouster, Inc.
24.57%
2.74 B
$ 40.68
United States
Technology
62
VTLE
Vital Energy, Inc.
24.55%
648.56 M
$ 16.76
United States
Energy
63
PAR
PAR Technology Corporation
24.47%
658.29 M
$ 15.96
United States
Technology
64
CTRN
Citi Trends, Inc.
24.33%
556.68 M
$ 66.83
United States
Consumer Cyclical
65
HDSN
Hudson Technologies, Inc.
24.1%
252.41 M
$ 6
United States
Basic Materials
66
UTL
Unitil Corporation
23.99%
970.06 M
$ 53.92
United States
Utilities
67
INGN
Inogen, Inc.
23.87%
174.09 M
$ 6.43
United States
Healthcare
68
JAKK
JAKKS Pacific, Inc.
23.72%
279.36 M
$ 24.41
United States
Consumer Cyclical
69
KRRO
Korro Bio, Inc.
23.64%
172.49 M
$ 11.96
United States
Healthcare
70
DYN
Dyne Therapeutics, Inc.
23.46%
3.94 B
$ 23.83
United States
Healthcare
71
DCBO
Docebo Inc.
23.1%
491.41 M
$ 19.36
Canada
Technology
72
IMAB
I-Mab
22.91%
318.48 M
$ 3.9
United States
Healthcare
73
TMCI
Treace Medical Concepts, Inc.
22.84%†
274.41 M
$ 4.23
United States
Healthcare
74
MAX
MediaAlpha, Inc.
22.78%
767.14 M
$ 14.19
United States
Communication Services
75
DBVT
DBV Technologies S.A.
22.74%
841.58 M
$ 14.22
France
Healthcare
76
HVT
Haverty Furniture Companies...
22.61%
411.24 M
$ 25.55
United States
Consumer Cyclical
77
ONEW
OneWater Marine Inc.
22.56%
213.87 M
$ 12.87
United States
Consumer Cyclical
78
NEWP
New Pacific Metals Corp.
21.9%
803.20 M
$ 4.34
Canada
Basic Materials
79
DSX
Diana Shipping Inc.
21.83%
276.17 M
$ 2.22
Greece
Industrials
80
LEVI
Levi Strauss & Co.
21.82%
9.45 B
$ 24.56
United States
Consumer Cyclical
81
PANL
Pangaea Logistics Solutions...
21.77%
490.61 M
$ 7.5
United States
Industrials
82
JYNT
The Joint Corp.
21.72%
125.59 M
$ 8.81
United States
Healthcare
83
BWMX
Betterware de México, S.A.P...
21.7%
675.60 M
$ 18.14
Mexico
Consumer Cyclical
84
TIGR
UP Fintech Holding Limited
21.5%
859.55 M
$ 4.81
Singapore
Financial Services
85
SNCY
Sun Country Airlines Holdin...
21.49%
876.36 M
$ 16.17
United States
Industrials
86
FLXS
Flexsteel Industries, Inc.
21.25%
305.47 M
$ 74.95
United States
Consumer Cyclical
87
CDZI
Cadiz Inc.
21.1%
280.85 M
$ 3.34
United States
Utilities
88
VYX
NCR Voyix Corporation
20.59%
1.09 B
$ 7.94
United States
Technology
89
MCRI
Monarch Casino & Resort, Inc.
20.52%
2.08 B
$ 117.45
United States
Consumer Cyclical
90
HCAT
Health Catalyst, Inc.
20.2%
155.18 M
$ 2.1
United States
Healthcare
91
ATRC
AtriCure, Inc.
20.18%
1.75 B
$ 34.505
United States
Healthcare
92
POOL
Pool Corporation
20.18%
7.16 B
$ 196.36
United States
Industrials
93
IIIN
Insteel Industries Inc.
20.17%
608.43 M
$ 31.43
United States
Industrials
94
VVV
Valvoline Inc.
19.98%
5.03 B
$ 39.45
United States
Consumer Cyclical
95
INVZ
Innoviz Technologies Ltd.
19.94%
146.85 M
$ 0.6634
Israel
Consumer Cyclical
96
MVBF
MVB Financial Corp.
19.81%
374.96 M
$ 29.18
United States
Financial Services
97
LTRX
Lantronix, Inc.
19.74%
255.16 M
$ 5.72
United States
Technology
98
NOA
North American Construction...
19.41%
368.32 M
$ 13.59
Canada
Energy
99
MAN
ManpowerGroup Inc.
19.35%
2.40 B
$ 51.68
United States
Industrials
100
RAIL
FreightCar America, Inc.
19.25%
255.98 M
$ 7.81
United States
Industrials
† Return measured from the start of the stock's current trading history (a recent listing or relisting), not from the start of the month.
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q Which stock has gained the most in April 2021?
A

CUE (Cue Biopharma, Inc.) has the highest monthly gain in this ranking for April 2021, with a gain of 2,859%. Top performers this month include CUE, BTX, IMUX.

Q What stocks gained the most in April 2021?
A

The biggest gainers in April 2021 were: CUE (+2,859%), BTX (+1,228%), IMUX (+812%), ELP (+386%), PLBY (+113%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during April 2021. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during April 2021. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which sectors performed best in April 2021?
A

The top performing sectors in April 2021 included Healthcare, Financial Services, Utilities, based on the stocks with highest monthly gains. CUE led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in April 2021. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.